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Florian Lang - One of the best experts on this subject based on the ideXlab platform.

  • steroid hormone release as well as renal water and Electrolyte Excretion of mice expressing pkb sgk resistant gsk3
    Pflügers Archiv: European Journal of Physiology, 2008
    Co-Authors: Krishna M Boini, Madhuri Bhandaru, Andreas F Mack, Florian Lang
    Abstract:

    Insulin and insulin-like growth factor (IGF1) participate in the regulation of renal Electrolyte Excretion. Insulin- and IGF1-dependent signaling includes phosphatidylinositide-3 (PI3)-kinase, phosphoinositide-dependent kinase PDK1 as well as protein kinase B (PKB) and serum and glucocorticoid inducible kinase (SGK) isoforms, which in turn phosphorylate and thus inhibit glycogen synthase kinase GSK3α,β. Replacement of the serines in the PKB/SGK consensus sequences by alanine (gsk3 KI ) confers resistance of GSK3 to PKB/SGK. To explore the role of PKB/SGK-dependent inhibition of GSK3 in the regulation of water/Electrolyte metabolism, mice carrying the PKB/SGK resistant mutant (gsk3 KI ) were compared to their wild-type littermates (gsk3 WT ). Body weight was similar in gsk3 KI and gsk3 WT mice. Plasma aldosterone at 10 a.m. and corticosterone concentrations at 5 p.m. were significantly lower, but 24-h urinary aldosterone was significantly higher, and corticosterone Excretion tended to be higher in gsk3 KI than in gsk3 WT mice. Food and water intake, fecal Excretion, glomerular filtration rate, urinary flow rate, urine osmolarity, as well as urinary Na+, K+, urea Excretion were significantly larger, and plasma Na+, urea, but not K+ concentration, were significantly lower in gsk3 KI than in gsk3 WT mice. Body temperature was significantly higher in gsk3 KI than in gsk3 WT mice. When allowed to choose between tap water and saline, gsk3 WT mice drank more saline, whereas gsk3 KI mice drank similar large volumes of tap water and saline. During high-salt diet, urinary vasopressin Excretion increased to significantly higher levels in gsk3 KI than in gsk3 WT mice. After water deprivation, body weight decreased faster in gsk3 KI than in gsk3 WT mice. Blood pressure, however, was significantly higher in gsk3 KI than in gsk3 WT mice. The observations disclose a role of PKB/SGK-dependent GSK3 activity in the regulation of steroid hormone release, renal water and Electrolyte Excretion and blood pressure control.

  • steroid hormone release as well as renal water and Electrolyte Excretion of mice expressing pkb sgk resistant gsk3
    Pflügers Archiv: European Journal of Physiology, 2008
    Co-Authors: Krishna M Boini, Madhuri Bhandaru, Andreas F Mack, Florian Lang
    Abstract:

    Insulin and insulin-like growth factor (IGF1) participate in the regulation of renal Electrolyte Excretion. Insulin- and IGF1-dependent signaling includes phosphatidylinositide-3 (PI3)-kinase, phosphoinositide-dependent kinase PDK1 as well as protein kinase B (PKB) and serum and glucocorticoid inducible kinase (SGK) isoforms, which in turn phosphorylate and thus inhibit glycogen synthase kinase GSK3alpha,beta. Replacement of the serines in the PKB/SGK consensus sequences by alanine (gsk3 ( KI )) confers resistance of GSK3 to PKB/SGK. To explore the role of PKB/SGK-dependent inhibition of GSK3 in the regulation of water/Electrolyte metabolism, mice carrying the PKB/SGK resistant mutant (gsk3 ( KI )) were compared to their wild-type littermates (gsk3 ( WT ) ). Body weight was similar in gsk3 ( KI ) and gsk3 ( WT ) mice. Plasma aldosterone at 10 A.M: . and corticosterone concentrations at 5 P.M: . were significantly lower, but 24-h urinary aldosterone was significantly higher, and corticosterone Excretion tended to be higher in gsk3 ( KI ) than in gsk3 ( WT ) mice. Food and water intake, fecal Excretion, glomerular filtration rate, urinary flow rate, urine osmolarity, as well as urinary Na+, K+, urea Excretion were significantly larger, and plasma Na+, urea, but not K+ concentration, were significantly lower in gsk3 ( KI ) than in gsk3 ( WT ) mice. Body temperature was significantly higher in gsk3 ( KI ) than in gsk3 ( WT ) mice. When allowed to choose between tap water and saline, gsk3 ( WT ) mice drank more saline, whereas gsk3 ( KI ) mice drank similar large volumes of tap water and saline. During high-salt diet, urinary vasopressin Excretion increased to significantly higher levels in gsk3 ( KI ) than in gsk3 ( WT ) mice. After water deprivation, body weight decreased faster in gsk3 ( KI ) than in gsk3 ( WT ) mice. Blood pressure, however, was significantly higher in gsk3 ( KI ) than in gsk3 ( WT ) mice. The observations disclose a role of PKB/SGK-dependent GSK3 activity in the regulation of steroid hormone release, renal water and Electrolyte Excretion and blood pressure control.

Krishna M Boini - One of the best experts on this subject based on the ideXlab platform.

  • steroid hormone release as well as renal water and Electrolyte Excretion of mice expressing pkb sgk resistant gsk3
    Pflügers Archiv: European Journal of Physiology, 2008
    Co-Authors: Krishna M Boini, Madhuri Bhandaru, Andreas F Mack, Florian Lang
    Abstract:

    Insulin and insulin-like growth factor (IGF1) participate in the regulation of renal Electrolyte Excretion. Insulin- and IGF1-dependent signaling includes phosphatidylinositide-3 (PI3)-kinase, phosphoinositide-dependent kinase PDK1 as well as protein kinase B (PKB) and serum and glucocorticoid inducible kinase (SGK) isoforms, which in turn phosphorylate and thus inhibit glycogen synthase kinase GSK3α,β. Replacement of the serines in the PKB/SGK consensus sequences by alanine (gsk3 KI ) confers resistance of GSK3 to PKB/SGK. To explore the role of PKB/SGK-dependent inhibition of GSK3 in the regulation of water/Electrolyte metabolism, mice carrying the PKB/SGK resistant mutant (gsk3 KI ) were compared to their wild-type littermates (gsk3 WT ). Body weight was similar in gsk3 KI and gsk3 WT mice. Plasma aldosterone at 10 a.m. and corticosterone concentrations at 5 p.m. were significantly lower, but 24-h urinary aldosterone was significantly higher, and corticosterone Excretion tended to be higher in gsk3 KI than in gsk3 WT mice. Food and water intake, fecal Excretion, glomerular filtration rate, urinary flow rate, urine osmolarity, as well as urinary Na+, K+, urea Excretion were significantly larger, and plasma Na+, urea, but not K+ concentration, were significantly lower in gsk3 KI than in gsk3 WT mice. Body temperature was significantly higher in gsk3 KI than in gsk3 WT mice. When allowed to choose between tap water and saline, gsk3 WT mice drank more saline, whereas gsk3 KI mice drank similar large volumes of tap water and saline. During high-salt diet, urinary vasopressin Excretion increased to significantly higher levels in gsk3 KI than in gsk3 WT mice. After water deprivation, body weight decreased faster in gsk3 KI than in gsk3 WT mice. Blood pressure, however, was significantly higher in gsk3 KI than in gsk3 WT mice. The observations disclose a role of PKB/SGK-dependent GSK3 activity in the regulation of steroid hormone release, renal water and Electrolyte Excretion and blood pressure control.

  • steroid hormone release as well as renal water and Electrolyte Excretion of mice expressing pkb sgk resistant gsk3
    Pflügers Archiv: European Journal of Physiology, 2008
    Co-Authors: Krishna M Boini, Madhuri Bhandaru, Andreas F Mack, Florian Lang
    Abstract:

    Insulin and insulin-like growth factor (IGF1) participate in the regulation of renal Electrolyte Excretion. Insulin- and IGF1-dependent signaling includes phosphatidylinositide-3 (PI3)-kinase, phosphoinositide-dependent kinase PDK1 as well as protein kinase B (PKB) and serum and glucocorticoid inducible kinase (SGK) isoforms, which in turn phosphorylate and thus inhibit glycogen synthase kinase GSK3alpha,beta. Replacement of the serines in the PKB/SGK consensus sequences by alanine (gsk3 ( KI )) confers resistance of GSK3 to PKB/SGK. To explore the role of PKB/SGK-dependent inhibition of GSK3 in the regulation of water/Electrolyte metabolism, mice carrying the PKB/SGK resistant mutant (gsk3 ( KI )) were compared to their wild-type littermates (gsk3 ( WT ) ). Body weight was similar in gsk3 ( KI ) and gsk3 ( WT ) mice. Plasma aldosterone at 10 A.M: . and corticosterone concentrations at 5 P.M: . were significantly lower, but 24-h urinary aldosterone was significantly higher, and corticosterone Excretion tended to be higher in gsk3 ( KI ) than in gsk3 ( WT ) mice. Food and water intake, fecal Excretion, glomerular filtration rate, urinary flow rate, urine osmolarity, as well as urinary Na+, K+, urea Excretion were significantly larger, and plasma Na+, urea, but not K+ concentration, were significantly lower in gsk3 ( KI ) than in gsk3 ( WT ) mice. Body temperature was significantly higher in gsk3 ( KI ) than in gsk3 ( WT ) mice. When allowed to choose between tap water and saline, gsk3 ( WT ) mice drank more saline, whereas gsk3 ( KI ) mice drank similar large volumes of tap water and saline. During high-salt diet, urinary vasopressin Excretion increased to significantly higher levels in gsk3 ( KI ) than in gsk3 ( WT ) mice. After water deprivation, body weight decreased faster in gsk3 ( KI ) than in gsk3 ( WT ) mice. Blood pressure, however, was significantly higher in gsk3 ( KI ) than in gsk3 ( WT ) mice. The observations disclose a role of PKB/SGK-dependent GSK3 activity in the regulation of steroid hormone release, renal water and Electrolyte Excretion and blood pressure control.

Martin J Shipley - One of the best experts on this subject based on the ideXlab platform.

  • urinary Electrolyte Excretion in 24 hours and blood pressure in the intersalt study i estimates of reliability the intersalt cooperative research group
    American Journal of Epidemiology, 1994
    Co-Authors: Alan R Dyer, Martin J Shipley, Paul Elliott
    Abstract:

    This is the first of two reports dealing with the reliability of measurements of 24-hour urinary Electrolyte Excretion and blood pressure and estimates of Electrolyte-blood pressure associations in INTERSALT, an international study of the relations of Electrolyte Excretion and other factors to blood pressure, involving more than 10,000 persons from 52 centers in 32 countries. This first report describes methods for estimating reliability, taking into account age and sex, and provides estimates for several urinary variables, blood pressure, and pulse rate. The second report (Am J Epidemiol 1994; 139:940-51) uses these estimates of reliability and multivariate procedures to correct multiple regression coefficients from regressions of blood pressure on 24-hour urinary sodium and potassium Excretion, body mass index, and alcohol intake for "regression dilution bias." Age- and sex-adjusted estimates of reliability were computed from data on 805 INTERSALT participants with repeat measurements. These estimates ranged from 0.37 to 0.40 for 24-hour urinary sodium, from 0.47 to 0.52 for potassium, from 0.32 to 0.36 for the sodium:potassium ratio, from 0.64 to 0.69 for calcium, from 0.59 to 0.65 for creatinine, from 0.49 to 0.57 for urinary volume, from 0.49 to 0.51 for magnesium, from 0.58 to 0.62 for pulse, from 0.69 to 0.74 for systolic blood pressure, and from 0.63 to 0.67 for diastolic blood pressure. In addition, estimates of within- and between-person covariances among Electrolytes indicated that about half of the observed covariance for sodium and potassium Excretion in a single 24-hour urine collection was due to within-person covariation in Excretion.

  • urinary Electrolyte Excretion in 24 hours and blood pressure in the intersalt study ii estimates of Electrolyte blood pressure associations corrected for regression dilution bias the intersalt cooperative research group
    American Journal of Epidemiology, 1994
    Co-Authors: Alan R Dyer, Paul Elliott, Martin J Shipley
    Abstract:

    This is the second of two reports dealing with the reliability of measurements of 24-hour urinary Electrolyte Excretion and blood pressure and estimates of Electrolyte-blood pressure associations in INTERSALT, an international study of the relations of Electrolyte Excretion and other factors to blood pressure, involving more than 10,000 persons from 52 centers in 32 countries. The first report (Am J Epidemiol 1994; 139:927-39) described methods of estimating reliability, taking into account age and sex, and provided estimates for several urinary variables, blood pressure, and pulse rate. This second report uses these estimates of reliability and multivariate procedures to correct associations with blood pressure for "regression dilution bias." In these analyses, the estimated mean change in systolic blood pressure associated with a 100-mmol decrease in sodium intake was -3.1 mmHg with adjustment for age, sex, body mass index, and alcohol intake. For potassium, the estimated mean change in systolic pressure associated with a 15-mmol increase in potassium intake was -1.0 mmHg. These estimates are 44%-50% larger than those previously reported in INTERSALT, based on simple corrections for reliability. Furthermore, compared with previously reported INTERSALT values, the estimated mean change in systolic pressure per unit of change in body mass index decreased by about 5% and that for consumption of > or = 300 ml of absolute alcohol per week increased by about 6%. These results further clarify the observed INTERSALT associations of systolic blood pressure with 24-hour urinary sodium and potassium Excretion, body mass index, and alcohol intake.

Paul Elliott - One of the best experts on this subject based on the ideXlab platform.

  • urinary Electrolyte Excretion in 24 hours and blood pressure in the intersalt study i estimates of reliability the intersalt cooperative research group
    American Journal of Epidemiology, 1994
    Co-Authors: Alan R Dyer, Martin J Shipley, Paul Elliott
    Abstract:

    This is the first of two reports dealing with the reliability of measurements of 24-hour urinary Electrolyte Excretion and blood pressure and estimates of Electrolyte-blood pressure associations in INTERSALT, an international study of the relations of Electrolyte Excretion and other factors to blood pressure, involving more than 10,000 persons from 52 centers in 32 countries. This first report describes methods for estimating reliability, taking into account age and sex, and provides estimates for several urinary variables, blood pressure, and pulse rate. The second report (Am J Epidemiol 1994; 139:940-51) uses these estimates of reliability and multivariate procedures to correct multiple regression coefficients from regressions of blood pressure on 24-hour urinary sodium and potassium Excretion, body mass index, and alcohol intake for "regression dilution bias." Age- and sex-adjusted estimates of reliability were computed from data on 805 INTERSALT participants with repeat measurements. These estimates ranged from 0.37 to 0.40 for 24-hour urinary sodium, from 0.47 to 0.52 for potassium, from 0.32 to 0.36 for the sodium:potassium ratio, from 0.64 to 0.69 for calcium, from 0.59 to 0.65 for creatinine, from 0.49 to 0.57 for urinary volume, from 0.49 to 0.51 for magnesium, from 0.58 to 0.62 for pulse, from 0.69 to 0.74 for systolic blood pressure, and from 0.63 to 0.67 for diastolic blood pressure. In addition, estimates of within- and between-person covariances among Electrolytes indicated that about half of the observed covariance for sodium and potassium Excretion in a single 24-hour urine collection was due to within-person covariation in Excretion.

  • urinary Electrolyte Excretion in 24 hours and blood pressure in the intersalt study ii estimates of Electrolyte blood pressure associations corrected for regression dilution bias the intersalt cooperative research group
    American Journal of Epidemiology, 1994
    Co-Authors: Alan R Dyer, Paul Elliott, Martin J Shipley
    Abstract:

    This is the second of two reports dealing with the reliability of measurements of 24-hour urinary Electrolyte Excretion and blood pressure and estimates of Electrolyte-blood pressure associations in INTERSALT, an international study of the relations of Electrolyte Excretion and other factors to blood pressure, involving more than 10,000 persons from 52 centers in 32 countries. The first report (Am J Epidemiol 1994; 139:927-39) described methods of estimating reliability, taking into account age and sex, and provided estimates for several urinary variables, blood pressure, and pulse rate. This second report uses these estimates of reliability and multivariate procedures to correct associations with blood pressure for "regression dilution bias." In these analyses, the estimated mean change in systolic blood pressure associated with a 100-mmol decrease in sodium intake was -3.1 mmHg with adjustment for age, sex, body mass index, and alcohol intake. For potassium, the estimated mean change in systolic pressure associated with a 15-mmol increase in potassium intake was -1.0 mmHg. These estimates are 44%-50% larger than those previously reported in INTERSALT, based on simple corrections for reliability. Furthermore, compared with previously reported INTERSALT values, the estimated mean change in systolic pressure per unit of change in body mass index decreased by about 5% and that for consumption of > or = 300 ml of absolute alcohol per week increased by about 6%. These results further clarify the observed INTERSALT associations of systolic blood pressure with 24-hour urinary sodium and potassium Excretion, body mass index, and alcohol intake.

Andreas F Mack - One of the best experts on this subject based on the ideXlab platform.

  • steroid hormone release as well as renal water and Electrolyte Excretion of mice expressing pkb sgk resistant gsk3
    Pflügers Archiv: European Journal of Physiology, 2008
    Co-Authors: Krishna M Boini, Madhuri Bhandaru, Andreas F Mack, Florian Lang
    Abstract:

    Insulin and insulin-like growth factor (IGF1) participate in the regulation of renal Electrolyte Excretion. Insulin- and IGF1-dependent signaling includes phosphatidylinositide-3 (PI3)-kinase, phosphoinositide-dependent kinase PDK1 as well as protein kinase B (PKB) and serum and glucocorticoid inducible kinase (SGK) isoforms, which in turn phosphorylate and thus inhibit glycogen synthase kinase GSK3α,β. Replacement of the serines in the PKB/SGK consensus sequences by alanine (gsk3 KI ) confers resistance of GSK3 to PKB/SGK. To explore the role of PKB/SGK-dependent inhibition of GSK3 in the regulation of water/Electrolyte metabolism, mice carrying the PKB/SGK resistant mutant (gsk3 KI ) were compared to their wild-type littermates (gsk3 WT ). Body weight was similar in gsk3 KI and gsk3 WT mice. Plasma aldosterone at 10 a.m. and corticosterone concentrations at 5 p.m. were significantly lower, but 24-h urinary aldosterone was significantly higher, and corticosterone Excretion tended to be higher in gsk3 KI than in gsk3 WT mice. Food and water intake, fecal Excretion, glomerular filtration rate, urinary flow rate, urine osmolarity, as well as urinary Na+, K+, urea Excretion were significantly larger, and plasma Na+, urea, but not K+ concentration, were significantly lower in gsk3 KI than in gsk3 WT mice. Body temperature was significantly higher in gsk3 KI than in gsk3 WT mice. When allowed to choose between tap water and saline, gsk3 WT mice drank more saline, whereas gsk3 KI mice drank similar large volumes of tap water and saline. During high-salt diet, urinary vasopressin Excretion increased to significantly higher levels in gsk3 KI than in gsk3 WT mice. After water deprivation, body weight decreased faster in gsk3 KI than in gsk3 WT mice. Blood pressure, however, was significantly higher in gsk3 KI than in gsk3 WT mice. The observations disclose a role of PKB/SGK-dependent GSK3 activity in the regulation of steroid hormone release, renal water and Electrolyte Excretion and blood pressure control.

  • steroid hormone release as well as renal water and Electrolyte Excretion of mice expressing pkb sgk resistant gsk3
    Pflügers Archiv: European Journal of Physiology, 2008
    Co-Authors: Krishna M Boini, Madhuri Bhandaru, Andreas F Mack, Florian Lang
    Abstract:

    Insulin and insulin-like growth factor (IGF1) participate in the regulation of renal Electrolyte Excretion. Insulin- and IGF1-dependent signaling includes phosphatidylinositide-3 (PI3)-kinase, phosphoinositide-dependent kinase PDK1 as well as protein kinase B (PKB) and serum and glucocorticoid inducible kinase (SGK) isoforms, which in turn phosphorylate and thus inhibit glycogen synthase kinase GSK3alpha,beta. Replacement of the serines in the PKB/SGK consensus sequences by alanine (gsk3 ( KI )) confers resistance of GSK3 to PKB/SGK. To explore the role of PKB/SGK-dependent inhibition of GSK3 in the regulation of water/Electrolyte metabolism, mice carrying the PKB/SGK resistant mutant (gsk3 ( KI )) were compared to their wild-type littermates (gsk3 ( WT ) ). Body weight was similar in gsk3 ( KI ) and gsk3 ( WT ) mice. Plasma aldosterone at 10 A.M: . and corticosterone concentrations at 5 P.M: . were significantly lower, but 24-h urinary aldosterone was significantly higher, and corticosterone Excretion tended to be higher in gsk3 ( KI ) than in gsk3 ( WT ) mice. Food and water intake, fecal Excretion, glomerular filtration rate, urinary flow rate, urine osmolarity, as well as urinary Na+, K+, urea Excretion were significantly larger, and plasma Na+, urea, but not K+ concentration, were significantly lower in gsk3 ( KI ) than in gsk3 ( WT ) mice. Body temperature was significantly higher in gsk3 ( KI ) than in gsk3 ( WT ) mice. When allowed to choose between tap water and saline, gsk3 ( WT ) mice drank more saline, whereas gsk3 ( KI ) mice drank similar large volumes of tap water and saline. During high-salt diet, urinary vasopressin Excretion increased to significantly higher levels in gsk3 ( KI ) than in gsk3 ( WT ) mice. After water deprivation, body weight decreased faster in gsk3 ( KI ) than in gsk3 ( WT ) mice. Blood pressure, however, was significantly higher in gsk3 ( KI ) than in gsk3 ( WT ) mice. The observations disclose a role of PKB/SGK-dependent GSK3 activity in the regulation of steroid hormone release, renal water and Electrolyte Excretion and blood pressure control.