The Experts below are selected from a list of 13920 Experts worldwide ranked by ideXlab platform

Younan Xia - One of the best experts on this subject based on the ideXlab platform.

  • Maneuvering the Migration and Differentiation of Stem Cells with Electrospun Nanofibers
    Advanced science (Weinheim Baden-Wurttemberg Germany), 2020
    Co-Authors: Jiajia Xue, Dario Pisignano, Younan Xia
    Abstract:

    Electrospun Nanofibers have been extensively explored as a class of scaffolding materials for tissue regeneration, because of their unique capability to mimic some features and functions of the extracellular matrix, including the fibrous morphology and mechanical properties, and to a certain extent the chemical/biological cues. This work reviews recent progress in applying Electrospun Nanofibers to direct the migration of stem cells and control their differentiation into specific phenotypes. First, the physicochemical properties that make Electrospun Nanofibers well-suited as a supporting material to expand stem cells by controlling their migration and differentiation are introduced. Then various systems are analyzed in conjunction with mesenchymal, neuronal, and embryonic stem cells, as well as induced pluripotent stem cells. Finally, some perspectives on the challenges and future opportunities in combining Electrospun Nanofibers with stem cells are offered to address clinical issues.

  • Moving Electrospun Nanofibers and Bioprinted Scaffolds toward Translational Applications.
    Advanced healthcare materials, 2020
    Co-Authors: Younan Xia
    Abstract:

    Over the past two decades, Electrospun Nanofibers have been actively explored for a range of applications, including those related to biomedicine, environmental science, energy harvesting, catalysis, photonics, and electronics. Regarding biomedical applications, one can readily produce nanofiber-based scaffolds with controlled compositions, structures, alignments, and functions by varying the material, design of collector, number of spinnerets, and electrospinning parameters. This report highlights both preclinical and translational applications of Electrospun Nanofibers and bioprinted constructs presented at the 2019 International Conference on Electrospinning, together with some perspectives on their future development.

  • Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications
    Chemical reviews, 2019
    Co-Authors: Jiajia Xue, Yunqian Dai, Younan Xia
    Abstract:

    Electrospinning is a versatile and viable technique for generating ultrathin fibers. Remarkable progress has been made with regard to the development of electrospinning methods and engineering of Electrospun Nanofibers to suit or enable various applications. We aim to provide a comprehensive overview of electrospinning, including the principle, methods, materials, and applications. We begin with a brief introduction to the early history of electrospinning, followed by discussion of its principle and typical apparatus. We then discuss its renaissance over the past two decades as a powerful technology for the production of Nanofibers with diversified compositions, structures, and properties. Afterward, we discuss the applications of Electrospun Nanofibers, including their use as "smart" mats, filtration membranes, catalytic supports, energy harvesting/conversion/storage components, and photonic and electronic devices, as well as biomedical scaffolds. We highlight the most relevant and recent advances related to the applications of Electrospun Nanofibers by focusing on the most representative examples. We also offer perspectives on the challenges, opportunities, and new directions for future development. At the end, we discuss approaches to the scale-up production of Electrospun Nanofibers and briefly discuss various types of commercial products based on Electrospun Nanofibers that have found widespread use in our everyday life.

  • Perspective: Aligned arrays of Electrospun Nanofibers for directing cell migration.
    APL materials, 2018
    Co-Authors: Jiajia Xue, Younan Xia
    Abstract:

    Cell migration plays an important role in a wide variety of biological processes, including embryogenesis, wound healing, inflammation, cancer metastasis, and tissue repair. Electrospun Nanofibers have been extensively explored as scaffolds to manipulate cell migration owing to their unique characteristics in mimicking the hierarchical architecture of extracellular matrix. In particular, aligned arrays of Electrospun Nanofibers are capable of guiding and promoting the directional migration of cells. The physical parameters and properties of the aligned Nanofibers, including their size, modulus, and surface chemistry, can all affect the migratory behaviors of cells, while the controlled release of growth factors and drugs from the Nanofibers can also be utilized to influence cell migration. By manipulating cell migration, Electrospun Nanofibers have been applied to promote tissue repair and help eradicate tumors in vivo. In this perspective, we highlight recent developments in collecting Electrospun Nanofibers as aligned arrays and then illustrate how the aligned Nanofibers can be utilized to manipulate cell migration.

  • Electrospun Nanofibers: New Concepts, Materials, and Applications
    Accounts of chemical research, 2017
    Co-Authors: Jiajia Xue, Jingwei Xie, Wenying Liu, Younan Xia
    Abstract:

    ConspectusElectrospinning is a simple and versatile technique that relies on the electrostatic repulsion between surface charges to continuously draw Nanofibers from a viscoelastic fluid. It has been applied to successfully produce Nanofibers, with diameters down to tens of nanometers, from a rich variety of materials, including polymers, ceramics, small molecules, and their combinations. In addition to solid Nanofibers with a smooth surface, electrospinning has also been adapted to generate Nanofibers with a number of secondary structures, including those characterized by a porous, hollow, or core–sheath structure. The surface and/or interior of such Nanofibers can be further functionalized with molecular species or nanoparticles during or after an electrospinning process. In addition, Electrospun Nanofibers can be assembled into ordered arrays or hierarchical structures by manipulation of their alignment, stacking, and/or folding. All of these attributes make Electrospun Nanofibers well-suited for a bro...

Tamer Uyar - One of the best experts on this subject based on the ideXlab platform.

  • Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications
    Hacettepe Journal of Biology and Chemistry, 2020
    Co-Authors: Brabu Balusamy, Anitha Senthamizhan, Tamer Uyar
    Abstract:

    Electrospinning has received tremendous attention in the fabrication of nanofibrous scaffolds over recent years and employed in different biomedical applications because of their biomimetic nature. Especially, the Electrospun Nanofibers exhibit several beneficial features including natural extracellular matrix (ECM), interconnected pores, large surface area, ease of functionalization and mechanical performance that holds huge importance in influencing the cell adhesion, differentiation and proliferation behaviour. To date, acknowledging the wide range of beneficial features, the Electrospun Nanofibers have been used in wound dressing and tissue engineering applications. This review summarizes various efforts have been made in these areas with several representative examples indicating use of various materials and approaches. Further the concerns for future direction regard to clinical phase transfer has been discussed.

  • Recent progress on designing Electrospun Nanofibers for colorimetric biosensing applications
    Current Opinion in Biomedical Engineering, 2020
    Co-Authors: Anitha Senthamizhan, Brabu Balusamy, Tamer Uyar
    Abstract:

    Abstract Colorimetric sensors based on Nanofibers fabricated by electrospinning have gained substantial attention owing to their exceptional features including diverse fibrous morphology, surface area, porous nature, flexibility, and distinctive benefits in functionalization. The Electrospun nanofiber–based membranes serve as excellent platforms in colorimetric detection of various biological molecules. The main emphasis of the review is to highlight very recent progress on development of Electrospun Nanofibers for detection of biomolecules in terms of their response time and high selectivity with special focus to hydrogen peroxide and l -cysteine. We present descriptive examples of the biosensing illustrating the progress in designing Electrospun-based Nanofibers as sensing probe/support. Furthermore, summary and future outlook on the designing of Electrospun Nanofibers for colorimetric biosensing is discussed.

  • Design and Development of Electrospun Nanofibers in Regenerative Medicine
    Stem Cell Biology and Regenerative Medicine, 2019
    Co-Authors: Brabu Balusamy, Anitha Senthamizhan, Tamer Uyar
    Abstract:

    The regenerative medicine field has promising solutions to overcome existing clinical challenges in the repair or regrowth of injured tissues. To date, an enormous progress has been made in developing numerous strategies for enhanced regeneration. The Nanofibers fabricated by electrospinning offer excellent characteristics mimicking the extracellular matrix that support cell adhesion, migration, and differentiation, which are responsible for the regeneration of tissues. Furthermore, due to their ease of production, cost-effectiveness, and ability to have various compositions and different morphologies, the Electrospun Nanofibers have been extensively explored for their possibilities in the regeneration of various tissues. In the present chapter, we summarize the examples of Electrospun Nanofibers fabricated for the regeneration of dermal, neural, and orthopedic tissues.

  • Functionalized Electrospun Nanofibers as Colorimetric Sensory Probe for Mercury Detection: A Review.
    Sensors (Basel Switzerland), 2019
    Co-Authors: Brabu Balusamy, Anitha Senthamizhan, Tamer Uyar
    Abstract:

    Mercury is considered the most hazardous pollutant of aquatic resources; it exerts numerous adverse effects on environmental and human health. To date, significant progress has been made in employing a variety of nanomaterials for the colorimetric detection of mercury ions. Electrospun Nanofibers exhibit several beneficial features, including a large surface area, porous nature, and easy functionalization; thus, providing several opportunities to encapsulate a variety of functional materials for sensing applications with enhanced sensitivity and selectivity, and a fast response. In this review, several examples of Electrospun nanofiber-based sensing platforms devised by utilizing the two foremost approaches, namely, direct incorporation and surface decoration envisioned for detection of mercury ions are provided. We believe these examples provide sufficient evidence for the potential use and progress of Electrospun Nanofibers toward colorimetric sensing of mercury ions. Furthermore, the summary of the review is focused on providing an insight into the future directions of designing Electrospun nanofiber-based, metal ion colorimetric sensors for practical applications.

  • Glucose sensors based on Electrospun Nanofibers: a review
    Analytical and Bioanalytical Chemistry, 2016
    Co-Authors: Anitha Senthamizhan, Brabu Balusamy, Tamer Uyar
    Abstract:

    The worldwide increase in the number of people suffering from diabetes has been the driving force for the development of glucose sensors. The recent past has devised various approaches to formulate glucose sensors using various nanostructure materials. This review presents a combined survey of these various approaches, with emphasis on the current progress in the use of Electrospun Nanofibers and their composites. Outstanding characteristics of Electrospun Nanofibers, including high surface area, porosity, flexibility, cost effectiveness, and portable nature, make them a good choice for sensor applications. Particularly, their nature of possessing a high surface area makes them the right fit for large immobilization sites, resulting in increased interaction with analytes. Thus, these Electrospun nanofiber-based glucose sensors present a number of advantages, including increased life time, which is greatly needed for practical applications. Taking all these facts into consideration, we have highlighted the latest significant developments in the field of glucose sensors across diverse approaches.

Anitha Senthamizhan - One of the best experts on this subject based on the ideXlab platform.

  • Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications
    Hacettepe Journal of Biology and Chemistry, 2020
    Co-Authors: Brabu Balusamy, Anitha Senthamizhan, Tamer Uyar
    Abstract:

    Electrospinning has received tremendous attention in the fabrication of nanofibrous scaffolds over recent years and employed in different biomedical applications because of their biomimetic nature. Especially, the Electrospun Nanofibers exhibit several beneficial features including natural extracellular matrix (ECM), interconnected pores, large surface area, ease of functionalization and mechanical performance that holds huge importance in influencing the cell adhesion, differentiation and proliferation behaviour. To date, acknowledging the wide range of beneficial features, the Electrospun Nanofibers have been used in wound dressing and tissue engineering applications. This review summarizes various efforts have been made in these areas with several representative examples indicating use of various materials and approaches. Further the concerns for future direction regard to clinical phase transfer has been discussed.

  • Recent progress on designing Electrospun Nanofibers for colorimetric biosensing applications
    Current Opinion in Biomedical Engineering, 2020
    Co-Authors: Anitha Senthamizhan, Brabu Balusamy, Tamer Uyar
    Abstract:

    Abstract Colorimetric sensors based on Nanofibers fabricated by electrospinning have gained substantial attention owing to their exceptional features including diverse fibrous morphology, surface area, porous nature, flexibility, and distinctive benefits in functionalization. The Electrospun nanofiber–based membranes serve as excellent platforms in colorimetric detection of various biological molecules. The main emphasis of the review is to highlight very recent progress on development of Electrospun Nanofibers for detection of biomolecules in terms of their response time and high selectivity with special focus to hydrogen peroxide and l -cysteine. We present descriptive examples of the biosensing illustrating the progress in designing Electrospun-based Nanofibers as sensing probe/support. Furthermore, summary and future outlook on the designing of Electrospun Nanofibers for colorimetric biosensing is discussed.

  • Design and Development of Electrospun Nanofibers in Regenerative Medicine
    Stem Cell Biology and Regenerative Medicine, 2019
    Co-Authors: Brabu Balusamy, Anitha Senthamizhan, Tamer Uyar
    Abstract:

    The regenerative medicine field has promising solutions to overcome existing clinical challenges in the repair or regrowth of injured tissues. To date, an enormous progress has been made in developing numerous strategies for enhanced regeneration. The Nanofibers fabricated by electrospinning offer excellent characteristics mimicking the extracellular matrix that support cell adhesion, migration, and differentiation, which are responsible for the regeneration of tissues. Furthermore, due to their ease of production, cost-effectiveness, and ability to have various compositions and different morphologies, the Electrospun Nanofibers have been extensively explored for their possibilities in the regeneration of various tissues. In the present chapter, we summarize the examples of Electrospun Nanofibers fabricated for the regeneration of dermal, neural, and orthopedic tissues.

  • Functionalized Electrospun Nanofibers as Colorimetric Sensory Probe for Mercury Detection: A Review.
    Sensors (Basel Switzerland), 2019
    Co-Authors: Brabu Balusamy, Anitha Senthamizhan, Tamer Uyar
    Abstract:

    Mercury is considered the most hazardous pollutant of aquatic resources; it exerts numerous adverse effects on environmental and human health. To date, significant progress has been made in employing a variety of nanomaterials for the colorimetric detection of mercury ions. Electrospun Nanofibers exhibit several beneficial features, including a large surface area, porous nature, and easy functionalization; thus, providing several opportunities to encapsulate a variety of functional materials for sensing applications with enhanced sensitivity and selectivity, and a fast response. In this review, several examples of Electrospun nanofiber-based sensing platforms devised by utilizing the two foremost approaches, namely, direct incorporation and surface decoration envisioned for detection of mercury ions are provided. We believe these examples provide sufficient evidence for the potential use and progress of Electrospun Nanofibers toward colorimetric sensing of mercury ions. Furthermore, the summary of the review is focused on providing an insight into the future directions of designing Electrospun nanofiber-based, metal ion colorimetric sensors for practical applications.

  • Glucose sensors based on Electrospun Nanofibers: a review
    Analytical and Bioanalytical Chemistry, 2016
    Co-Authors: Anitha Senthamizhan, Brabu Balusamy, Tamer Uyar
    Abstract:

    The worldwide increase in the number of people suffering from diabetes has been the driving force for the development of glucose sensors. The recent past has devised various approaches to formulate glucose sensors using various nanostructure materials. This review presents a combined survey of these various approaches, with emphasis on the current progress in the use of Electrospun Nanofibers and their composites. Outstanding characteristics of Electrospun Nanofibers, including high surface area, porosity, flexibility, cost effectiveness, and portable nature, make them a good choice for sensor applications. Particularly, their nature of possessing a high surface area makes them the right fit for large immobilization sites, resulting in increased interaction with analytes. Thus, these Electrospun nanofiber-based glucose sensors present a number of advantages, including increased life time, which is greatly needed for practical applications. Taking all these facts into consideration, we have highlighted the latest significant developments in the field of glucose sensors across diverse approaches.

Nelson Torto - One of the best experts on this subject based on the ideXlab platform.

  • A review of opportunities for Electrospun Nanofibers in analytical chemistry.
    Analytica chimica acta, 2011
    Co-Authors: Samuel Chigome, Nelson Torto
    Abstract:

    Challenges associated with analyte and matrix complexities and the ever increasing pressure from all sectors of industry for alternative analytical devices, have necessitated the development and application of new materials in analytical chemistry. To date, nanomaterials have emerged as having excellent properties for analytical chemistry applications mainly due to their large surface area to volume ratio and the availability of a wide variety of chemical and morphological modification methods. Of the available nanofibrous material fabrication methods, electrospinning has emerged as the most versatile. It is the aim of this contribution to highlight some of the recent developments that harness the great potential shown by Electrospun Nanofibers for application in analytical chemistry. The review discusses the use of Electrospun Nanofibers as a platform for low resolution separation or as a chromatographic sorbent bed for high resolution separation. It concludes by discussing the applications of Electrospun Nanofibers in detection systems with a specific focus on the development of simple Electrospun nanofiber based colorimetric probes.

  • Electrospun Nanofibers as sorbent material for solid phase extraction
    The Analyst, 2011
    Co-Authors: Samuel Chigome, Godfred Darko, Nelson Torto
    Abstract:

    Electrospinning has emerged as the most versatile technique for nanofiber fabrication. Owing to their large surface area to volume ratio, Electrospun Nanofibers have the potential to serve as a good sorbent material for solid phase extraction (SPE) based techniques. The ability to incorporate a variety of functionalities prior or post-electrospinning presents a platform to tune the sorbents for specific applications. It is the aim of this contribution to highlight some of the recent developments that harness the great potential of Electrospun Nanofibers as sorbents for SPE. The review discusses the various ways in which the electrospinning technique addresses two important parameters for sorbent material, which are sorptive capacity and selectivity. It concludes by presenting and discussing the potential for development of SPE format technology and configurations based on Electrospun Nanofibers.

Seeram Ramakrishna - One of the best experts on this subject based on the ideXlab platform.

  • Electrospun Nanofibers for personal protection in mines
    Chemical Engineering Journal, 2021
    Co-Authors: Rulin Liu, Gang Zhou, Ziqian Liu, Seeram Ramakrishna
    Abstract:

    Abstract Dust in mine poses a huge threat to miner’s health. Through a comprehensive review of the research of different types of coal dust, we summarize the highly efficient dust control/protection methods in this paper, including spray dust fall, chemical dust suppression, coal seam water injection, dust collector removal, and individual protection. Furthermore, we discussed the challenges in the above methods, highlighting that personal protection strategy can effectively prevent the respirable dust, thereby reducing the probability of pneumoconiosis. Via a critical study of various current personal protective materials, we arrived that nanomaterials, especially the Electrospun Nanofibers, are potential candidates for personal protection in coal mines due to the advantages of simple technology, high efficiency, low resistance, controllable structure, the potential for reusability, and long life.

  • Electrospun Nanofibers: Work for medicine?
    Frontiers of Materials Science in China, 2010
    Co-Authors: Susan Liao, Casey K Chan, Seeram Ramakrishna
    Abstract:

    Attempts have been made to fabricate nanofibrous scaffolds to mimic the chemical composition and structural properties of the extracellular matrix (ECM) for tissue/organ replacement. Nanofiber scaffolds with various patterns have been successfully produced from synthetic and natural polymers through a relatively simple technique of electrospinning. The resulting patterns can mimic some of the diverse tissue-specific orientation and three-dimensional (3D) fibrous structures. Studies on cell-nanofiber interactions, including studies on stem cells, have revealed the importance of nanotopography on cell adhesion, proliferation and differentiation. Furthermore, clinical application of Electrospun Nanofibers including wound healing, tissue regeneration, drug delivery and stem cell therapy are highly feasible due to the ease and flexibility of fabrication of making nanofiber with this cost-effective method using electrospinning. In this review, we have highlighted the current state of the art and provided future perspectives on Electrospun nanofiber in medical applications.

  • Biomimetic Electrospun Nanofibers for tissue regeneration
    Biomedical Materials, 2006
    Co-Authors: Susan Liao, Bojun Li, Casey K Chan, Zuwei Ma, Seeram Ramakrishna
    Abstract:

    Nanofibers exist widely in human tissue with different patterns. Electrospinning nanotechnology has recently gained a new impetus due to the introduction of the concept of biomimetic Nanofibers for tissue regeneration. The advanced electrospinning technique is a promising method to fabricate a controllable continuous nanofiber scaffold similar to the natural extracellular matrix. Thus, the biomedical field has become a significant possible application field of Electrospun fibers. Although electrospinning has developed rapidly over the past few years, Electrospun Nanofibers are still at a premature research stage. Further comprehensive and deep studies on Electrospun Nanofibers are essential for promoting their biomedical applications. Current Electrospun fiber materials include natural polymers, synthetic polymers and inorganic substances. This review briefly describes several typically Electrospun nanofiber materials or composites that have great potential for tissue regeneration, and describes their fabrication, advantages, drawbacks and future prospects.