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Vanessa Valdiglesias - One of the best experts on this subject based on the ideXlab platform.

  • effects of exposure to oil spills on human health updated review
    Journal of Toxicology and Environmental Health-part B-critical Reviews, 2016
    Co-Authors: Blanca Laffon, Eduardo Pasaro, Vanessa Valdiglesias
    Abstract:

    ABSTRACTOil spills may involve health risks for people participating in the cleanup operations and coastal inhabitants, given the toxicological properties of the oil components. In spite of this, only after a few major oil spills (crude oil or fuel oil no. 6) have studies on effects of exposure to diverse aspects of human health been performed. Previously, Aguilera et al. (2010) examined all documents published to that date dealing with any type of human health outcome in populations exposed to oil spills. The aim of the present review was to compile all new information available and determine whether evidence reported supports the existence of an association between exposure and adverse human health risks. Studies were classified in three groups according to type of health outcome addressed: (i) effects on mental health, (ii) physical/physiological effects, and (iii) genotoxic, immunotoxic, and Endocrine Toxicity. New studies published on oil-spill-exposed populations—coastal residents in the vicinity of...

  • Effects of exposure to oil spills on human health: Updated review
    Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 2016
    Co-Authors: Blanca Laffon, Eduardo Pasaro, Vanessa Valdiglesias
    Abstract:

    Oil spills may involve health risks for people participating in the cleanup operations and coastal inhabitants, given the toxicological properties of the oil components. In spite of this, only after a few major oil spills (crude oil or fuel oil no. 6) have studies on effects of exposure to diverse aspects of human health been performed. Previously, Aguilera et al. (2010) examined all documents published to that date dealing with any type of human health outcome in populations exposed to oil spills. The aim of the present review was to compile all new information available and determine whether evidence reported supports the existence of an association between exposure and adverse human health risks. Studies were classified in three groups according to type of health outcome addressed: (i) effects on mental health, (ii) physical/physiological effects, and (iii) genotoxic, immunotoxic, and Endocrine Toxicity. New studies published on oil-spill-exposed populations-coastal residents in the vicinity of the spills or participants in cleanup operations-provide additional support to previous evidence on adverse health effects related to exposure regarding different parameters in all three categories considered. Some of the observed effects even indicated that several symptoms may persist for some years after exposure. Hence, (1) health protection in these individuals should be a matter of concern; and (2) health risk assessment needs to be carried out not only at the time of exposure but also for prolong periods following exposure, to enable early detection of any potential exposure-related harmful effects.

Blanca Laffon - One of the best experts on this subject based on the ideXlab platform.

  • effects of exposure to oil spills on human health updated review
    Journal of Toxicology and Environmental Health-part B-critical Reviews, 2016
    Co-Authors: Blanca Laffon, Eduardo Pasaro, Vanessa Valdiglesias
    Abstract:

    ABSTRACTOil spills may involve health risks for people participating in the cleanup operations and coastal inhabitants, given the toxicological properties of the oil components. In spite of this, only after a few major oil spills (crude oil or fuel oil no. 6) have studies on effects of exposure to diverse aspects of human health been performed. Previously, Aguilera et al. (2010) examined all documents published to that date dealing with any type of human health outcome in populations exposed to oil spills. The aim of the present review was to compile all new information available and determine whether evidence reported supports the existence of an association between exposure and adverse human health risks. Studies were classified in three groups according to type of health outcome addressed: (i) effects on mental health, (ii) physical/physiological effects, and (iii) genotoxic, immunotoxic, and Endocrine Toxicity. New studies published on oil-spill-exposed populations—coastal residents in the vicinity of...

  • Effects of exposure to oil spills on human health: Updated review
    Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 2016
    Co-Authors: Blanca Laffon, Eduardo Pasaro, Vanessa Valdiglesias
    Abstract:

    Oil spills may involve health risks for people participating in the cleanup operations and coastal inhabitants, given the toxicological properties of the oil components. In spite of this, only after a few major oil spills (crude oil or fuel oil no. 6) have studies on effects of exposure to diverse aspects of human health been performed. Previously, Aguilera et al. (2010) examined all documents published to that date dealing with any type of human health outcome in populations exposed to oil spills. The aim of the present review was to compile all new information available and determine whether evidence reported supports the existence of an association between exposure and adverse human health risks. Studies were classified in three groups according to type of health outcome addressed: (i) effects on mental health, (ii) physical/physiological effects, and (iii) genotoxic, immunotoxic, and Endocrine Toxicity. New studies published on oil-spill-exposed populations-coastal residents in the vicinity of the spills or participants in cleanup operations-provide additional support to previous evidence on adverse health effects related to exposure regarding different parameters in all three categories considered. Some of the observed effects even indicated that several symptoms may persist for some years after exposure. Hence, (1) health protection in these individuals should be a matter of concern; and (2) health risk assessment needs to be carried out not only at the time of exposure but also for prolong periods following exposure, to enable early detection of any potential exposure-related harmful effects.

  • Initial study on the effects of Prestige oil on human health.
    Environment International, 2006
    Co-Authors: Beatriz Pérez-cadahía, Eduardo Pasaro, Anunciación Lafuente, T. Cabaleiro, Josefina Méndez, Blanca Laffon
    Abstract:

    AbstractThe big oil tanker Prestige wrecked at 130 miles from the coast of Galicia, on the Northwest of Spain, in November 19, 2002. During theaccident over 40,000 tons of oil were spilled, and along the next weeks 22,000 more reached the shore in the way of three black tides. A greatnumber of people participated in the cleaning tasks. The objective of this study was to initially evaluate the damage caused by Prestige oil inexposed individuals both from the cytogenetic and the Endocrine points of view. Exposure level was determined by analysing volatile organiccompounds in the environment and heavy metals in blood. Cytogenetic damage was determined by sister chromatid exchanges (SCE), andplasmatic prolactin and cortisol levels were used as biomarkers of Endocrine Toxicity. Finally we have determined the possible influence of GSTgenetic polymorphisms (GSTM1 and GSTT1 deletion polymorphisms, GSTP1 Ala105Val) on the evaluated effects. The exposed population wasclassified according to the performed cleaning tasks in three groups: volunteers that collaborated for 1 week (N=25), hired manual workers(N=20) and hired high-pressure cleaner workers (N=23). The control population consisted of 42 individuals. Exposure to Prestige oil causedcytogenetic damage in exposed individuals, being its effect influenced by age, sex, tobacco consumption and GSTM1 polymorphism. With regardto Endocrine Toxicity, our results showed that xenobiotics present in Prestige oil induced alterations in hormonal status, and thus it may beconsidered as an Endocrine disruptor. Therefore, the selected parameters have shown to be good indicators of Toxicity related to exposure toPrestige oil. In addition, data obtained point to the importance of using protective devices in preventing the effects related to the exposure.© 2006 Elsevier Ltd. All rights reserved.

Eduardo Pasaro - One of the best experts on this subject based on the ideXlab platform.

  • effects of exposure to oil spills on human health updated review
    Journal of Toxicology and Environmental Health-part B-critical Reviews, 2016
    Co-Authors: Blanca Laffon, Eduardo Pasaro, Vanessa Valdiglesias
    Abstract:

    ABSTRACTOil spills may involve health risks for people participating in the cleanup operations and coastal inhabitants, given the toxicological properties of the oil components. In spite of this, only after a few major oil spills (crude oil or fuel oil no. 6) have studies on effects of exposure to diverse aspects of human health been performed. Previously, Aguilera et al. (2010) examined all documents published to that date dealing with any type of human health outcome in populations exposed to oil spills. The aim of the present review was to compile all new information available and determine whether evidence reported supports the existence of an association between exposure and adverse human health risks. Studies were classified in three groups according to type of health outcome addressed: (i) effects on mental health, (ii) physical/physiological effects, and (iii) genotoxic, immunotoxic, and Endocrine Toxicity. New studies published on oil-spill-exposed populations—coastal residents in the vicinity of...

  • Effects of exposure to oil spills on human health: Updated review
    Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 2016
    Co-Authors: Blanca Laffon, Eduardo Pasaro, Vanessa Valdiglesias
    Abstract:

    Oil spills may involve health risks for people participating in the cleanup operations and coastal inhabitants, given the toxicological properties of the oil components. In spite of this, only after a few major oil spills (crude oil or fuel oil no. 6) have studies on effects of exposure to diverse aspects of human health been performed. Previously, Aguilera et al. (2010) examined all documents published to that date dealing with any type of human health outcome in populations exposed to oil spills. The aim of the present review was to compile all new information available and determine whether evidence reported supports the existence of an association between exposure and adverse human health risks. Studies were classified in three groups according to type of health outcome addressed: (i) effects on mental health, (ii) physical/physiological effects, and (iii) genotoxic, immunotoxic, and Endocrine Toxicity. New studies published on oil-spill-exposed populations-coastal residents in the vicinity of the spills or participants in cleanup operations-provide additional support to previous evidence on adverse health effects related to exposure regarding different parameters in all three categories considered. Some of the observed effects even indicated that several symptoms may persist for some years after exposure. Hence, (1) health protection in these individuals should be a matter of concern; and (2) health risk assessment needs to be carried out not only at the time of exposure but also for prolong periods following exposure, to enable early detection of any potential exposure-related harmful effects.

  • Initial study on the effects of Prestige oil on human health.
    Environment International, 2006
    Co-Authors: Beatriz Pérez-cadahía, Eduardo Pasaro, Anunciación Lafuente, T. Cabaleiro, Josefina Méndez, Blanca Laffon
    Abstract:

    AbstractThe big oil tanker Prestige wrecked at 130 miles from the coast of Galicia, on the Northwest of Spain, in November 19, 2002. During theaccident over 40,000 tons of oil were spilled, and along the next weeks 22,000 more reached the shore in the way of three black tides. A greatnumber of people participated in the cleaning tasks. The objective of this study was to initially evaluate the damage caused by Prestige oil inexposed individuals both from the cytogenetic and the Endocrine points of view. Exposure level was determined by analysing volatile organiccompounds in the environment and heavy metals in blood. Cytogenetic damage was determined by sister chromatid exchanges (SCE), andplasmatic prolactin and cortisol levels were used as biomarkers of Endocrine Toxicity. Finally we have determined the possible influence of GSTgenetic polymorphisms (GSTM1 and GSTT1 deletion polymorphisms, GSTP1 Ala105Val) on the evaluated effects. The exposed population wasclassified according to the performed cleaning tasks in three groups: volunteers that collaborated for 1 week (N=25), hired manual workers(N=20) and hired high-pressure cleaner workers (N=23). The control population consisted of 42 individuals. Exposure to Prestige oil causedcytogenetic damage in exposed individuals, being its effect influenced by age, sex, tobacco consumption and GSTM1 polymorphism. With regardto Endocrine Toxicity, our results showed that xenobiotics present in Prestige oil induced alterations in hormonal status, and thus it may beconsidered as an Endocrine disruptor. Therefore, the selected parameters have shown to be good indicators of Toxicity related to exposure toPrestige oil. In addition, data obtained point to the importance of using protective devices in preventing the effects related to the exposure.© 2006 Elsevier Ltd. All rights reserved.

Gerald A Leblanc - One of the best experts on this subject based on the ideXlab platform.

  • tributyltin synergizes with 20 hydroxyecdysone to produce Endocrine Toxicity
    Toxicological Sciences, 2011
    Co-Authors: Ying H Wang, Gwijun Kwon, Hong Li, Gerald A Leblanc
    Abstract:

    One of the great challenges facing modern toxicology is in predicting the hazard associated with chemical mixtures. The development of effective means of predicting the Toxicity of chemical mixtures requires an understanding of how chemicals interact to produce nonadditive outcomes (e.g., synergy). We hypothesized that tributyltin would elicit Toxicity in daphnids (Daphnia magna) by exaggerating physiological responses to 20-hydroxyecdysone signaling via synergistic activation of the retinoid X receptor (RXR):ecdysteroid receptor (EcR) complex. Using reporter gene assays, we demonstrated that RXR, alone, is activated by a variety of ligands including tributyltin, whereas RXR:EcR heterodimers were not activated by tributyltin. However, tributyltin, in combination with the daphnid EcR ligand 20hydroxyecdysone, caused concentration-dependent, synergistic activation of the RXR:EcR reporter. Electrophoretic mobility shift assays revealed that tributyltin did not enhance the activity of 20-hydroxyecdysone by increasing binding of the receptor complex to a DR-4 DNA-binding site. Exposure of daphnids to elevated concentrations of 20-hydroxyecdysone caused premature and incomplete ecdysis resulting in death. Tributyltin exaggerated this effect of exogenous 20-hydroxyecdysone. Further, exposure of daphnids to tributyltin enhanced the inductive effects of 20-hydroxyecdysone on expression of the 20-hydroxyecdysoneinducible gene HR3. Continuous, prolonged exposure of maternal daphnids to concentrations of tributyltin resulted in mortality concurrent with molting. Taken together, these results demonstrate that xenobiotics, such as tributyltin, can interact with RXR to influence gene expression regulated by the heterodimeric partner to RXR. The result of such interactions can be Toxicity due to inappropriate or exaggerated hormonal signaling. The application of the in vitro/in vivo approach used in this study is discussed in relation to modeling of nonadditive interactions among constituents of chemical mixtures.

  • testosterone fatty acid esterification a unique target for the Endocrine Toxicity of tributyltin to gastropods
    Integrative and Comparative Biology, 2005
    Co-Authors: Gerald A Leblanc, Meredith P Gooding, Robin M Sternberg
    Abstract:

    SYNOPSIS. Over the past thirty years, a global occurrence of sexual aberration has occurred whereby females among populations of prosobranch snails exhibit male sex characteristics. This condition, called imposex, has been causally associated with exposure to the biocide tributyltin. Tributyltin-exposed, imposex snails typically have elevated levels of testosterone which have led to the postulate that this Endocrine dysfunction is responsible for imposex. This overview describes recent evidence that supports this postulate. Gastropods maintain circulating testosterone levels and administration of testosterone to females or castrates stimulates male sex differentiation in several snail species. Studies in the mud snail ( Ilyanassa obsoleta) have shown that gastropods utilize a unique strategy for regulating free testosterone levels. Excess testosterone is converted to fatty acid esters by the action of a testosterone-inducible, high capacity/low affinity enzyme, acyl-CoA:testosterone acyl transferase, and stored within the organisms. Free testosterone levels are regulated during the reproductive cycle apparently due to changes in esterification/desterification suggesting that testosterone functions in the reproductive cycle of the organisms. Testosterone esterification provides a unique target in the testosterone regulatory machinery of snails that is altered by tributyltin. Indeed, imposex and free testosterone levels were elevated in field collected snails containing high tin levels, while testosteronefatty acid ester pools were reduced in these organisms. These observations indicate that tributyltin elevates free testosterone by reducing the retention of testosterone as fatty acid-esters. This Endocrine effect of tributyltin may be responsible for imposex.

Jia He - One of the best experts on this subject based on the ideXlab platform.