The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Renée Ventura-clapier - One of the best experts on this subject based on the ideXlab platform.
-
Exercise training, Energy Metabolism, and heart failure.
Applied Physiology Nutrition and Metabolism, 2009Co-Authors: Renée Ventura-clapierAbstract:Energy Metabolism is at the crossroad of cell function and dysfunction. Cardiac and skeletal muscle cells, the Energy Metabolism of which is high, fluctuating, and adaptable to the special needs of the body, have developed sophisticated strategies for synthesizing, transferring, and utilizing Energy in accordance with the needs of the body. Adaptation to endurance training mainly involves energetic remodelling in skeletal muscles, but less is known for the cardiac muscle. Alterations in Energy Metabolism participate in many pathophysiological processes, among which is heart failure. Because endurance training improves symptoms and quality of life and decreases mortality rate and hospitalization, it is increasingly recognized as a beneficial practice for heart failure patients. The mechanisms involved in the beneficial effects of exercise training are far from being understood. Proper evaluation of these mechanisms is thus a major health issue for populations living in industrialized countries. This review mainly focuses on oxidative Metabolism and intracellular Energy transfer in muscles and the heart, their alterations in heart failure, and the effects of endurance exercise training.
-
Exercise training, Energy Metabolism, and heart failure.
Applied physiology nutrition and metabolism = Physiologie appliquee nutrition et metabolisme, 2009Co-Authors: Renée Ventura-clapierAbstract:Energy Metabolism is at the crossroad of cell function and dysfunction. Cardiac and skeletal muscle cells, the Energy Metabolism of which is high, fluctuating, and adaptable to the special needs of the body, have developed sophisticated strategies for synthesizing, transferring, and utilizing Energy in accordance with the needs of the body. Adaptation to endurance training mainly involves energetic remodelling in skeletal muscles, but less is known for the cardiac muscle. Alterations in Energy Metabolism participate in many pathophysiological processes, among which is heart failure. Because endurance training improves symptoms and quality of life and decreases mortality rate and hospitalization, it is increasingly recognized as a beneficial practice for heart failure patients. The mechanisms involved in the beneficial effects of exercise training are far from being understood. Proper evaluation of these mechanisms is thus a major health issue for populations living in industrialized countries. This review...
-
Energy Metabolism in heart failure
The Journal of Physiology, 2004Co-Authors: Renée Ventura-clapier, Anne Garnier, Vladimir VekslerAbstract:Heart failure (HF) is a syndrome resulting from the inability of the cardiac pump to meet the Energy requirements of the body. Despite intensive work, the pathogenesis of the cardiac intracellular abnormalities that result from HF remains incompletely understood. Factors that lead to abnormal contraction and relaxation in the failing heart include metabolic pathway abnormalities that result in decreased Energy production, Energy transfer and Energy utilization. Heart failure also affects the periphery. Patients suffering from heart failure always complain of early muscular fatigue and exercise intolerance. This is linked in part to intrinsic alterations of skeletal muscle, among which decreases in the mitochondrial ATP production and in the transfer of Energy through the phosphotransfer kinases play an important role. Alterations in Energy Metabolism that affect both cardiac and skeletal muscles argue for a generalized metabolic myopathy in heart failure. Recent evidence shows that decreased expression of mitochondrial transcription factors and mitochondrial proteins are involved in mechanisms causing the Energy starvation in heart failure. This review will focus on Energy Metabolism alterations in long-term chronic heart failure with only a few references to compensated hypertrophy when necessary. It will briefly describe the Energy Metabolism of normal heart and skeletal muscles and their alterations in chronic heart failure. It is beyond the scope of this review to address the metabolic switches occurring in compensated hypertrophy; readers could refer to well-documented reviews on this subject.
Pietro Cortelli - One of the best experts on this subject based on the ideXlab platform.
-
Energy Metabolism Impairment in Migraine.
Current medicinal chemistry, 2019Co-Authors: Sabina Cevoli, Valentina Favoni, Pietro CortelliAbstract:Migraine is a common disabling neurological disorder which is characterised by a recurring headache associated with a variety of sensory and autonomic symptoms. The pathophysiology of migraine remains not entirely understood, although many mechanisms involving the central and peripheral nervous system are now becoming clear. In particular, it is widely accepted that migraine is associated with Energy metabolic impairment of the brain. The purpose of this review is to present an updated overview of the Energy Metabolism involvement in the migraine pathophysiology. Several biochemical, morphological and magnetic resonance spectroscopy studies have confirmed the presence of Energy production deficiency together with an increment of Energy consumption in migraine patients. An increment of Energy demand over a certain threshold creates metabolic and biochemical preconditions for the onset of the migraine attack. The defect of oxidative Energy Metabolism in migraine is generalized. It remains to be determined if the mitochondrial deficit in migraine is primary or secondary. Riboflavin and Co-Enzyme Q10, both physiologically implicated in mitochondrial respiratory chain functioning, are effective in migraine prophylaxis, supporting the hypothesis that improving brain Energy Metabolism may reduce the susceptibility to migraine.
Vladimir Veksler - One of the best experts on this subject based on the ideXlab platform.
-
Energy Metabolism in heart failure
The Journal of Physiology, 2004Co-Authors: Renée Ventura-clapier, Anne Garnier, Vladimir VekslerAbstract:Heart failure (HF) is a syndrome resulting from the inability of the cardiac pump to meet the Energy requirements of the body. Despite intensive work, the pathogenesis of the cardiac intracellular abnormalities that result from HF remains incompletely understood. Factors that lead to abnormal contraction and relaxation in the failing heart include metabolic pathway abnormalities that result in decreased Energy production, Energy transfer and Energy utilization. Heart failure also affects the periphery. Patients suffering from heart failure always complain of early muscular fatigue and exercise intolerance. This is linked in part to intrinsic alterations of skeletal muscle, among which decreases in the mitochondrial ATP production and in the transfer of Energy through the phosphotransfer kinases play an important role. Alterations in Energy Metabolism that affect both cardiac and skeletal muscles argue for a generalized metabolic myopathy in heart failure. Recent evidence shows that decreased expression of mitochondrial transcription factors and mitochondrial proteins are involved in mechanisms causing the Energy starvation in heart failure. This review will focus on Energy Metabolism alterations in long-term chronic heart failure with only a few references to compensated hypertrophy when necessary. It will briefly describe the Energy Metabolism of normal heart and skeletal muscles and their alterations in chronic heart failure. It is beyond the scope of this review to address the metabolic switches occurring in compensated hypertrophy; readers could refer to well-documented reviews on this subject.
Priscilla I. Spach - One of the best experts on this subject based on the ideXlab platform.
-
Alcoholism and myocardial Energy Metabolism.
Alcoholism clinical and experimental research, 1994Co-Authors: Carol C. Cunningham, Priscilla I. SpachAbstract:A review of the effects of chronic ethanol consumption on myocardial Energy Metabolism in animal models reveals that alterations in cardiac function are not accompanied by changes in the levels of the high-Energy metabolites, ATP, and creatine phosphate. There are minor alterations in mitochondrial ultrastructure and function that appear to be accentuated by lowered nutrient intake. Observations to date indicate that, in animal models, there is an interaction between chronic ethanol consumption and caloric deprivation in eliciting alterations in myocardial Energy Metabolism. Furthermore, ethanol-related ultrastructural changes and depressed mitochondrial function are much more demonstrable in liver than in heart, suggesting strongly that the myocardium is less susceptible to the deleterious effects of alcohol than is the liver.
Abram Katz - One of the best experts on this subject based on the ideXlab platform.
-
skeletal muscle Energy Metabolism fiber types fatigue and adaptability
Experimental Cell Research, 2010Co-Authors: Hakan Westerblad, Joseph D Bruton, Abram KatzAbstract:Skeletal muscles cope with a large range of activities, from being able to support the body weight during long periods of upright standing to perform explosive movements in response to an unexpected threat. This requires systems for Energy Metabolism that can provide Energy during long periods of moderately increased Energy consumption as well as being able to rapidly increasing the rate of Energy production more than 100-fold in response to explosive contractions. In this short review we discuss how muscles can deal with these divergent demands. We first outline the major Energy Metabolism pathways in skeletal muscle. Next we describe metabolic differences between different muscle fiber types. Contractile performance declines during intense activation, i.e. fatigue develops, and we discuss likely underlying mechanisms. Finally, we discuss the ability of muscle fibers to adapt to altered demands, and mechanisms behind these adaptations. The accumulated experimental evidence forces us to conclude that most aspects of Energy Metabolism involve multiple and overlapping signaling pathways, which indicates that the control of Energy Metabolism is too important to depend on one single molecule or mechanism.