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Rui L Reis - One of the best experts on this subject based on the ideXlab platform.

  • gellan gum injectable hydrogels for cartilage tissue Engineering applications in vitro studies and preliminary in vivo evaluation
    Tissue Engineering Part A, 2010
    Co-Authors: Joao T Oliveira, Tircia C Santos, Luis Martins, Ricardo Picciochi, Alexandra P Marques, Antonio G Castro, Nuno M Neves, Joao F Mano, Rui L Reis
    Abstract:

    Gellan gum is a polysaccharide that we have previously proposed for applications in the cartilage tissue Engineering Field. In this work, gellan gum hydrogels were tested for their ability to be us...

  • natural origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue Engineering applications
    Advanced Drug Delivery Reviews, 2007
    Co-Authors: P B Malafaya, Gabriel A Silva, Rui L Reis
    Abstract:

    The present paper intends to overview a wide range of natural–origin polymers with special focus on proteins and polysaccharides (the systems more inspired on the extracellular matrix) that are being used in research, or might be potentially useful as carriers systems for active biomolecules or as cell carriers with application in the tissue Engineering Field targeting several biological tissues. The combination of both applications int oa single material has proven to be very challenging though. The paper presents also some examples of commercially available natural–origin polymers with applications in research or in clinical use in several applications. As it is recognized, this class of polymers is being widely used due to their similarities with the extracellular matrix, high chemical versatility, typically good biological performance and inherent cellular interaction and, also very significant, the cell or enzyme-controlled degradability. These biocharacteristics classify the natural–origin polymers as one of the most attractive options to be used in the tissue Engineering Field and drug delivery applications. © 2007 Elsevier B.V. All rights reserved.

Matthew J Realff - One of the best experts on this subject based on the ideXlab platform.

  • Machine learning: Overview of the recent progresses and implications for the process systems Engineering Field
    Computers and Chemical Engineering, 2018
    Co-Authors: Jay H. Lee, Joohyun Shin, Matthew J Realff
    Abstract:

    Machine learning (ML) has recently gained in popularity, spurred by well-publicized advances like deep learning and widespread commercial interest in big data analytics. Despite the enthusiasm, some renowned experts of the Field have expressed skepticism, which is justifiable given the disappointment with the previous wave of neural networks and other AI techniques. On the other hand, new fundamental advances like the ability to train neural networks with a large number of layers for hierarchical feature learning may present significant new technological and commercial opportunities. This paper critically examines the main advances in deep learning. In addition, connections with another ML branch of reinforcement learning are elucidated and its role in control and decision problems is discussed. Implications of these advances for the Fields of process and energy systems Engineering are also discussed.

Shengwei Mei - One of the best experts on this subject based on the ideXlab platform.

Robert Langer - One of the best experts on this subject based on the ideXlab platform.

Jay H. Lee - One of the best experts on this subject based on the ideXlab platform.

  • Machine learning: Overview of the recent progresses and implications for the process systems Engineering Field
    Computers and Chemical Engineering, 2018
    Co-Authors: Jay H. Lee, Joohyun Shin, Matthew J Realff
    Abstract:

    Machine learning (ML) has recently gained in popularity, spurred by well-publicized advances like deep learning and widespread commercial interest in big data analytics. Despite the enthusiasm, some renowned experts of the Field have expressed skepticism, which is justifiable given the disappointment with the previous wave of neural networks and other AI techniques. On the other hand, new fundamental advances like the ability to train neural networks with a large number of layers for hierarchical feature learning may present significant new technological and commercial opportunities. This paper critically examines the main advances in deep learning. In addition, connections with another ML branch of reinforcement learning are elucidated and its role in control and decision problems is discussed. Implications of these advances for the Fields of process and energy systems Engineering are also discussed.