The Experts below are selected from a list of 107544 Experts worldwide ranked by ideXlab platform

Ray Welland - One of the best experts on this subject based on the ideXlab platform.

Andrew Mcdonald - One of the best experts on this subject based on the ideXlab platform.

Eric Mire - One of the best experts on this subject based on the ideXlab platform.

  • Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons
    Current Biology - CB, 2018
    Co-Authors: Fanny Mann, Elsa Bazellieres, Mélanie Hocine, Sophie Chauvet, Thomas Jungas, Alice Davy, Eric Mire
    Abstract:

    The corpus callosum is the largest commissure in the brain, whose main function is to Ensure Communication between homotopic regions of the cerebral cortex. During fetal development, corpus callosum axons (CCAs) grow toward and across the brain midline and then away on the contralateral hemisphere to their targets. A particular feature of this circuit, which raises a key developmental question, is that the outgoing trajectory of post-crossing CCAs is mirror-symmetric with the incoming trajectory of pre-crossing axons. Here, we show that post-crossing CCAs switch off their response to axon guidance cues, among which the secreted Semaphorin-3C (Sema3C), that act as attractants for pre-crossing axons on their way to the midline. This change is concomitant with an upregulation of the surface protein Ephrin-B1, which acts in CCAs to inhibit Sema3C signaling via interaction with the Neuropilin-1 (Nrp1) receptor. This silencing activity is independent of Eph receptors and involves a N-glycosylation site (N-139) in the extracellular domain of Ephrin-B1. Together, our results reveal a molecular mechanism, involving interaction between the two unrelated guidance receptors Ephrin-B1 and Nrp1, that is used to control the navigation of post-crossing axons in the corpus callosum.

Mohamed Jemni - One of the best experts on this subject based on the ideXlab platform.

  • mobile sign language translation system for deaf community
    Conference on Web Accessibility, 2012
    Co-Authors: Mehrez Boulares, Mohamed Jemni
    Abstract:

    Nowadays, web technologies are a very efficient way to Ensure Communication between a large and heterogeneous audience. Furthermore, web information is mainly based on textual and multimedia content and consequently, some people with special needs, such as deaf and hard of hearing people, have difficulties to access to information or to communicate with hearing people. This problem is due to the lack of services that facilitate sign language learning for hearing people or text translation into sign language for persons with hearing impairment. In this context, we present in this paper a new approach based on web services, X3D and android operating system to build a mobile translation system from text into sign language using virtual signing agent. The main feature of this work is that it can be used to learn sign language and to provide sign language translation of written text for people with hearing impairment.

  • W4A - Mobile sign language translation system for deaf community
    Proceedings of the International Cross-Disciplinary Conference on Web Accessibility - W4A '12, 2012
    Co-Authors: Mehrez Boulares, Mohamed Jemni
    Abstract:

    Nowadays, web technologies are a very efficient way to Ensure Communication between a large and heterogeneous audience. Furthermore, web information is mainly based on textual and multimedia content and consequently, some people with special needs, such as deaf and hard of hearing people, have difficulties to access to information or to communicate with hearing people. This problem is due to the lack of services that facilitate sign language learning for hearing people or text translation into sign language for persons with hearing impairment. In this context, we present in this paper a new approach based on web services, X3D and android operating system to build a mobile translation system from text into sign language using virtual signing agent. The main feature of this work is that it can be used to learn sign language and to provide sign language translation of written text for people with hearing impairment.

Céline Revenu - One of the best experts on this subject based on the ideXlab platform.

  • Zebrafish as a Model for the Study of Live in vivo Processive Transport in Neurons.
    Frontiers in cell and developmental biology, 2019
    Co-Authors: Valérie Bercier, Marion Rosello, Filippo Del Bene, Céline Revenu
    Abstract:

    Motor proteins are responsible for transport of vesicles and organelles within the cell cytoplasm. They interact with the actin cytoskeleton and with microtubules to Ensure Communication and supply throughout the cell. Much work has been done in vitro and in silico to unravel the key players, including the dynein motor complex, the kinesin and myosin superfamilies, and their interacting regulatory complexes, but there is a clear need for in vivo data as recent evidence suggests previous models might not recapitulate physiological conditions. The zebrafish embryo provides an excellent system to study these processes in intact animals due to the ease of genetic manipulation and the optical transparency allowing live imaging. We present here the advantages of the zebrafish embryo as a system to study live in vivo processive transport in neurons and provide technical recommendations for successful analysis.