The Experts below are selected from a list of 105 Experts worldwide ranked by ideXlab platform

Mark B. Abelson - One of the best experts on this subject based on the ideXlab platform.

David G Binion - One of the best experts on this subject based on the ideXlab platform.

  • increased prevalence of Environmental Allergy in patients with crohn s disease
    The Journal of Allergy and Clinical Immunology, 2004
    Co-Authors: M L Chudnow, Michael B Levy, Kevin J Kelly, David G Binion
    Abstract:

    Abstract Rationale Patients with Crohn's disease (CD) have been clinically observed to have seasonal variations in disease activity. Factors contributing to seasonal disease flare have not been characterized. We hypothesized that CD patients may have increased rates of atopy and seasonal allergen sensitivity, which may underlie seasonal exacerbation. Methods Thirty-seven patients with documented CD were prospectively recruited from an adult gastroenterology clinic. After informed consent was obtained, a questionnaire was administered and skin prick testing to 16 Environmental allergens, including controls, was performed. A wheal 3 mm greater than control was considered positive. CD age at diagnosis, disease distribution and behavior was recorded. Results Twenty-three of 37 or 62% of patients tested positive to at least one Environmental allergen. Twenty-one or 57% of patients had rhinitis and 2 patients had asthma. Sensitivity to seasonal allergens was identified in 46% of patients (ragweed 27%, grass 24%, trees 35% and mold 19%). The majority of patients with sensitivity to seasonal allergens had small bowel involvement (82%). 100% of CD patients with seasonal Allergy were diagnosed before age 40. Conclusions There is a high prevalence of Environmental Allergy in patients with CD. Small bowel involvement and diagnosis prior to age 40 were characteristic clinical features. The high rate of pollen and mold Allergy may play a role in seasonal exacerbations of CD.

Antonio G. Secchi - One of the best experts on this subject based on the ideXlab platform.

A Corvetta - One of the best experts on this subject based on the ideXlab platform.

  • What can occur after the interruption of specific immunotherapy with dust mite allergens in atopic dermatitis?
    Allergy: European Journal of Allergy and Clinical Immunology, 2012
    Co-Authors: Alessia Santucci, G Cortellini, A Corvetta
    Abstract:

    Atopic dermatitis is a multifactorial chronic inflammatory disease whose unpredictable clinical course, with a typical skin lesions localization and often associated to other allergic pathologies. The evolution is influenced by a complex genetic basis (atopic diathesis) and multiple triggering factors. Specific immunotherapy with house dust mite allergens has recently been reported to be effective in adult with atopic eczema who are sensitized to these allergens. We described a case of 23 year old man with a story of atopic dermatitis since 18 months year old. He was a student, he hasn't a family allergic anamnesis. When he was a child, prick test for food and inhalants resulted negative, at the age of 12 became sensitized to dermatophagoides and to some cosmetic preservants, fragrances and thymerosal by contact (SIDAPA Italian society of allergology and dermatology in professional and Environmental Allergy). The patient was periodically treated with topical emollient, corticosteroids and tacrolimus, plus non sedating antihistamines. After 4 years he began to suffered of persistent rhinitis and then intermittent mild asthma, also the atopic eczema get worse. So the patient underwent to subcutaneous specific immunotherapy with house mite allergens which includes the Der p1 and Der p2, regularly for about 5 years. Naturally his skin symptoms regressed and also the respiratory disease improved, he could reduce the consumption of drugs. Specific IgE antibodies against dermatophagoides get down. After 5 years he interrupted this immunotherapy, but after 2 months he expressed widespread itch and a recidivous eruption of dermatitis, while respiratory symptoms were steady. The patient was treated with tacrolimus 0.03% once a day for 3 months and with emollients, he obtained a good improvement, then he was controlled only with moisturizers. Subcutaneous specific immunoptherapy is complementary to the usual treatements for atopic dermatitis, but as in this case has a important rule in maintain a state of controlled disease.

Ikuo Hirano - One of the best experts on this subject based on the ideXlab platform.

  • Eosinophilic esophagitis: Pathophysiology and optimal management
    Current Gastroenterology Reports, 2009
    Co-Authors: Carol Garrean, Ikuo Hirano
    Abstract:

    Eosinophilic esophagitis (EoE) is an increasingly recognized disease characterized by esophageal symptoms accompanied by increased esophageal mucosal eosinophilia. The reasons for the increasing prevalence and understanding of the pathogenesis of EoE are areas of active investigation. Food and Environmental Allergy, host immunologic predisposition, and interactions with gastroesophageal reflux disease have emerged as important aspects of the disease. The optimal management of EoE is controversial and evolving. Therapeutic options include medical therapy with acid suppression, corticosteroids, and biologic agents. Elimination diets and endoscopic esophageal dilation have shown effectiveness. Management strategies for individual patients range from clinical observation to multimodal therapy, depending on the clinical presentation.