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Robert R. Wolfe - One of the best experts on this subject based on the ideXlab platform.

  • Essential Amino Acid supplement lowers intrahepatic lipid despite excess alcohol consumption
    2019
    Co-Authors: Melynda S Coker, Robert R. Wolfe, Kaylee Ladd, Jimin Kim, Carl J Murphy, Ryan Decort, Bradley R Newcomer, Robert H Coker
    Abstract:

    Excess alcohol consumption is a top risk factor for death and disability. Fatty liver will likely develop and the risk of liver disease increases. We have previously demonstrated that an Essential Amino Acid supplement (EAAS) improved protein synthesis and reduced intrahepatic lipid in the elderly. The purpose of this exploratory pilot study was to initiate the evaluation of EAAS on intrahepatic lipid (IHL), body composition, and blood lipids in individuals with mild to moderate alcohol use disorder (AUD). Following consent, determination of eligibility, and medical screening, 25 participants (18 males at 38 ± 15 years/age and 7 females at 34 ± 18 years/age) were enrolled and randomly assigned to one of two dosages: a low dose (LD: 8 g of EAAS twice/day (BID)) or high dose (HD: 13 g of EAAS BID). Five of the twenty-five enrolled participants dropped out of the intervention. Both groups consumed the supplement BID for 4 weeks. Pre- and post-EAAS administration, IHL was determined using magnetic resonance imaging/spectroscopy, body composition was analyzed using dual-energy X-ray absorptiometry, and blood parameters were measured by LabCorp. T-tests were used for statistical analysis and considered significant at p < 0.05. While there was no significant change in IHL in the LD group, there was a significant 23% reduction in IHL in the HD group (p = 0.02). Fat mass, lean tissue mass, bone mineral content, and blood lipids were not altered. Post-EAAS phosphatidylethanol was elevated and remained unchanged in LD at 407 ± 141 ng/mL and HD at 429 ± 196 ng/mL, indicating chronic and excess alcohol consumption. The HD of the proprietary EAAS formulation consumed BID seemed to lower IHL in individuals with mild to moderate AUD. We suggest that further studies in a larger cohort be conducted to more completely address this important area of investigation.

  • Essential Amino Acid enriched meal replacement promotes superior net protein balance in older overweight adults
    Clinical Nutrition, 2019
    Co-Authors: Robert H Coker, Kenneth Shin, Kristen Scholten, Michelle Johannsen, Jean Tsigonis, Ilyoung Kim, Scott E Schutzler, Robert R. Wolfe
    Abstract:

    Summary Background & aims Older individuals are susceptible to the loss of muscle and accumulation of fat. To address this problem, we have compared protein kinetics following consumption of an Essential Amino Acid (EAA)-enriched meal replacement (EMR) to consumption of a high-protein meal replacement beverage (Bariatric Advantage, BA) using stable isotope methodology. Methods Eight older (67 ± 2), obese (35 ± 2 kg/m2) female and male participants completed two studies using a randomized, crossover design in which they ingested each meal replacement. The isotopic tracers L-[2H5]phenylalanine & L-[2H2]tyrosine were delivered via primed, continuous intravenous infusion throughout a basal period and following consumption of EMR or BA. We determined changes in whole body protein synthesis (PS), protein breakdown (PB), and net protein balance (NB) from fasted states via analysis of plasma samples by LC-ESI-MS. Results PS was higher (P = 0.03) and PB was less (P = 0.005) with EMR in comparison to BA. As a result, NB was much greater (P = 0.00003) following the ingestion of EMR as compared to BA. Conclusions In comparison with BA, which has a higher amount of intact protein that any other meal replacement, EMR promoted a greater increment in NB. These data support the potential efficacy of EMR as a meal replacement for the preservation of lean tissue mass during weight loss in older, overweight individuals.

  • a high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by Essential Amino Acids in the elderly
    American Journal of Physiology-endocrinology and Metabolism, 2006
    Co-Authors: Asle Aarsland, Melinda Sheffieldmoore, Christos S Katsanos, Hisamine Kobayashi, Robert R. Wolfe
    Abstract:

    This study was designed to evaluate the effects of enriching an Essential Amino Acid (EAA) mixture with leucine on muscle protein metabolism in elderly and young individuals. Four (2 elderly and 2 ...

  • Essential Amino Acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    The Journal of Clinical Endocrinology and Metabolism, 2004
    Co-Authors: Douglas Paddonjones, Robert R. Wolfe, Melinda Sheffieldmoore, Randall J Urban, Arthur P Sanford, Asle Aarsland, Arny A Ferrando
    Abstract:

    We determined whether Essential Amino Acid and carbohydrate supplementation could offset the catabolic response to prolonged inactivity. Major outcome measures included mixed muscle fractional synthetic rate (FSR), phenylalanine net balance, lean leg mass, and leg extension strength. On d 1 and 28, vastus lateralis muscle biopsies and femoral arterio-venous blood samples were obtained during a primed constant infusion of l-[ring-(2)H(5)]phenylalanine. Net balance and FSR were calculated over 16 h, during which the control group (CON) received a nutritionally mixed meal every 5 h (0830, 1330, and 1830 h). The experimental group (EXP) also consumed 16.5 g Essential Amino Acids and 30 g carbohydrate (1100, 1600, and 2100 h). The dietary regimen was maintained during bedrest. FSR was higher in the EXP group on d 1 (EXP, 0.099 +/- 0.008%/h; CON: 0.075 +/- 0.005%/h) and d 28 (EXP, 0.093 +/- 0.006%/h; CON, 0.055 +/- 0.007%/h). Lean leg mass was maintained throughout bedrest in the EXP group (+0.2 +/- 0.3 kg), but fell in the CON group (-0.4 +/- 0.1 kg). Strength loss was more pronounced in the CON group (EXP, -8.8 +/- 1.4 kg; CON, -17.8 +/- 4.4 kg). Essential Amino Acid and carbohydrate supplementation may represent a viable intervention for individuals at risk of sarcopenia due to immobility or prolonged bedrest.

  • Essential Amino Acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    The Journal of Clinical Endocrinology and Metabolism, 2004
    Co-Authors: Douglas Paddonjones, Robert R. Wolfe, Melinda Sheffieldmoore, Randall J Urban, Arthur P Sanford, Asle Aarsland, Arny A Ferrando
    Abstract:

    We determined whether Essential Amino Acid and carbohydrate supplementation could offset the catabolic response to prolonged inactivity. Major outcome measures included mixed muscle fractional synthetic rate (FSR), phenylalanine net balance, lean leg mass, and leg extension strength. On d 1 and 28, vastus lateralis muscle biopsies and femoral arterio-venous blood samples were obtained during a primed constant infusion of l-[ring-2H5]phenylalanine. Net balance and FSR were calculated over 16 h, during which the control group (CON) received a nutritionally mixed meal every 5 h (0830, 1330, and 1830 h). The experimental group (EXP) also consumed 16.5 g Essential Amino Acids and 30 g carbohydrate (1100, 1600, and 2100 h). The dietary regimen was maintained during bedrest. FSR was higher in the EXP group on d 1 (EXP, 0.099 ± 0.008%/h; CON: 0.075 ± 0.005%/h) and d 28 (EXP, 0.093 ± 0.006%/h; CON, 0.055 ± 0.007%/h). Lean leg mass was maintained throughout bedrest in the EXP group (+0.2 ± 0.3 kg), but fell in the ...

Hiroaki Nakamura - One of the best experts on this subject based on the ideXlab platform.

  • 2020 chitranjan s ranawat award perioperative Essential Amino Acid supplementation suppresses rectus femoris muscle atrophy and accelerates early functional recovery following total knee arthroplasty
    Journal of Bone and Joint Surgery-british Volume, 2020
    Co-Authors: Hideki Ueyama, Narihiro Kanemoto, Yoshiki Taniguchi, Yukihide Minoda, Hiroaki Nakamura
    Abstract:

    AIMS The aim of this study was to assess the effectiveness of perioperative Essential Amino Acid (EAA) supplementation to prevent rectus femoris muscle atrophy and facilitate early recovery of function after total knee arthroplasty (TKA). METHODS The study involved 60 patients who underwent unilateral TKA for primary knee osteo-arthritis (OA). This was a double-blind, placebo-controlled, randomized control trial with patients randomly allocated to two groups, 30 patients each: the Essential Amino Acid supplementation (9 g daily) and placebo (lactose powder, 9 g daily) groups. Supplementation and placebo were provided from one week before to two weeks after surgery. The area of the rectus femoris muscle were measured by ultrasound imaging one month before surgery and one, two, three, and four weeks postoperatively. The serum albumin level, a visual analogue knee pain score, and mobility were also measured at each time point. The time to recovery of activities of daily living (ADLs) was recorded. Postoperative nutrition and physiotherapy were identical in both groups. RESULTS The mean relative change from baseline was as follows for the Amino Acid group: 116% in rectus femoris muscle area (71% to 206%); 95% in serum albumin (80% to 115%) and 39% in VAS pain (0% to 100%) at four weeks after surgery. These values in the placebo group were: 97% in muscle area (68 to 155); 89% in serum albumin (71% to 100%) and 56% in VAS pain four weeks after surgery (0% to 100%). All changes were statistically significant (p < 0.05). The mean time to recovery of ADLs was shorter in the Amino Acid group compared with the placebo group (p = 0.005). CONCLUSION Perioperative Essential Amino Acid supplementation prevents rectus femoris muscle atrophy and accelerates early functional recovery after TKA. Cite this article: Bone Joint J 2020;102-B(6 Supple A):10-18.

  • 2020 chitranjan s ranawat award perioperative Essential Amino Acid supplementation suppresses rectus femoris muscle atrophy and accelerates early functional recovery following total knee arthroplasty
    Journal of Bone and Joint Surgery-british Volume, 2020
    Co-Authors: Hideki Ueyama, Narihiro Kanemoto, Yoshiki Taniguchi, Yukihide Minoda, Hiroaki Nakamura
    Abstract:

    Aims The aim of this study was to assess the effectiveness of perioperative Essential Amino Acid (EAA) supplementation to prevent rectus femoris muscle atrophy and facilitate early recovery of func...

Arny A Ferrando - One of the best experts on this subject based on the ideXlab platform.

  • Essential Amino Acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    The Journal of Clinical Endocrinology and Metabolism, 2004
    Co-Authors: Douglas Paddonjones, Robert R. Wolfe, Melinda Sheffieldmoore, Randall J Urban, Arthur P Sanford, Asle Aarsland, Arny A Ferrando
    Abstract:

    We determined whether Essential Amino Acid and carbohydrate supplementation could offset the catabolic response to prolonged inactivity. Major outcome measures included mixed muscle fractional synthetic rate (FSR), phenylalanine net balance, lean leg mass, and leg extension strength. On d 1 and 28, vastus lateralis muscle biopsies and femoral arterio-venous blood samples were obtained during a primed constant infusion of l-[ring-(2)H(5)]phenylalanine. Net balance and FSR were calculated over 16 h, during which the control group (CON) received a nutritionally mixed meal every 5 h (0830, 1330, and 1830 h). The experimental group (EXP) also consumed 16.5 g Essential Amino Acids and 30 g carbohydrate (1100, 1600, and 2100 h). The dietary regimen was maintained during bedrest. FSR was higher in the EXP group on d 1 (EXP, 0.099 +/- 0.008%/h; CON: 0.075 +/- 0.005%/h) and d 28 (EXP, 0.093 +/- 0.006%/h; CON, 0.055 +/- 0.007%/h). Lean leg mass was maintained throughout bedrest in the EXP group (+0.2 +/- 0.3 kg), but fell in the CON group (-0.4 +/- 0.1 kg). Strength loss was more pronounced in the CON group (EXP, -8.8 +/- 1.4 kg; CON, -17.8 +/- 4.4 kg). Essential Amino Acid and carbohydrate supplementation may represent a viable intervention for individuals at risk of sarcopenia due to immobility or prolonged bedrest.

  • Essential Amino Acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    The Journal of Clinical Endocrinology and Metabolism, 2004
    Co-Authors: Douglas Paddonjones, Robert R. Wolfe, Melinda Sheffieldmoore, Randall J Urban, Arthur P Sanford, Asle Aarsland, Arny A Ferrando
    Abstract:

    We determined whether Essential Amino Acid and carbohydrate supplementation could offset the catabolic response to prolonged inactivity. Major outcome measures included mixed muscle fractional synthetic rate (FSR), phenylalanine net balance, lean leg mass, and leg extension strength. On d 1 and 28, vastus lateralis muscle biopsies and femoral arterio-venous blood samples were obtained during a primed constant infusion of l-[ring-2H5]phenylalanine. Net balance and FSR were calculated over 16 h, during which the control group (CON) received a nutritionally mixed meal every 5 h (0830, 1330, and 1830 h). The experimental group (EXP) also consumed 16.5 g Essential Amino Acids and 30 g carbohydrate (1100, 1600, and 2100 h). The dietary regimen was maintained during bedrest. FSR was higher in the EXP group on d 1 (EXP, 0.099 ± 0.008%/h; CON: 0.075 ± 0.005%/h) and d 28 (EXP, 0.093 ± 0.006%/h; CON, 0.055 ± 0.007%/h). Lean leg mass was maintained throughout bedrest in the EXP group (+0.2 ± 0.3 kg), but fell in the ...

Hideki Ueyama - One of the best experts on this subject based on the ideXlab platform.

  • 2020 chitranjan s ranawat award perioperative Essential Amino Acid supplementation suppresses rectus femoris muscle atrophy and accelerates early functional recovery following total knee arthroplasty
    Journal of Bone and Joint Surgery-british Volume, 2020
    Co-Authors: Hideki Ueyama, Narihiro Kanemoto, Yoshiki Taniguchi, Yukihide Minoda, Hiroaki Nakamura
    Abstract:

    AIMS The aim of this study was to assess the effectiveness of perioperative Essential Amino Acid (EAA) supplementation to prevent rectus femoris muscle atrophy and facilitate early recovery of function after total knee arthroplasty (TKA). METHODS The study involved 60 patients who underwent unilateral TKA for primary knee osteo-arthritis (OA). This was a double-blind, placebo-controlled, randomized control trial with patients randomly allocated to two groups, 30 patients each: the Essential Amino Acid supplementation (9 g daily) and placebo (lactose powder, 9 g daily) groups. Supplementation and placebo were provided from one week before to two weeks after surgery. The area of the rectus femoris muscle were measured by ultrasound imaging one month before surgery and one, two, three, and four weeks postoperatively. The serum albumin level, a visual analogue knee pain score, and mobility were also measured at each time point. The time to recovery of activities of daily living (ADLs) was recorded. Postoperative nutrition and physiotherapy were identical in both groups. RESULTS The mean relative change from baseline was as follows for the Amino Acid group: 116% in rectus femoris muscle area (71% to 206%); 95% in serum albumin (80% to 115%) and 39% in VAS pain (0% to 100%) at four weeks after surgery. These values in the placebo group were: 97% in muscle area (68 to 155); 89% in serum albumin (71% to 100%) and 56% in VAS pain four weeks after surgery (0% to 100%). All changes were statistically significant (p < 0.05). The mean time to recovery of ADLs was shorter in the Amino Acid group compared with the placebo group (p = 0.005). CONCLUSION Perioperative Essential Amino Acid supplementation prevents rectus femoris muscle atrophy and accelerates early functional recovery after TKA. Cite this article: Bone Joint J 2020;102-B(6 Supple A):10-18.

  • 2020 chitranjan s ranawat award perioperative Essential Amino Acid supplementation suppresses rectus femoris muscle atrophy and accelerates early functional recovery following total knee arthroplasty
    Journal of Bone and Joint Surgery-british Volume, 2020
    Co-Authors: Hideki Ueyama, Narihiro Kanemoto, Yoshiki Taniguchi, Yukihide Minoda, Hiroaki Nakamura
    Abstract:

    Aims The aim of this study was to assess the effectiveness of perioperative Essential Amino Acid (EAA) supplementation to prevent rectus femoris muscle atrophy and facilitate early recovery of func...

Asle Aarsland - One of the best experts on this subject based on the ideXlab platform.

  • a high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by Essential Amino Acids in the elderly
    American Journal of Physiology-endocrinology and Metabolism, 2006
    Co-Authors: Asle Aarsland, Melinda Sheffieldmoore, Christos S Katsanos, Hisamine Kobayashi, Robert R. Wolfe
    Abstract:

    This study was designed to evaluate the effects of enriching an Essential Amino Acid (EAA) mixture with leucine on muscle protein metabolism in elderly and young individuals. Four (2 elderly and 2 ...

  • Essential Amino Acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    The Journal of Clinical Endocrinology and Metabolism, 2004
    Co-Authors: Douglas Paddonjones, Robert R. Wolfe, Melinda Sheffieldmoore, Randall J Urban, Arthur P Sanford, Asle Aarsland, Arny A Ferrando
    Abstract:

    We determined whether Essential Amino Acid and carbohydrate supplementation could offset the catabolic response to prolonged inactivity. Major outcome measures included mixed muscle fractional synthetic rate (FSR), phenylalanine net balance, lean leg mass, and leg extension strength. On d 1 and 28, vastus lateralis muscle biopsies and femoral arterio-venous blood samples were obtained during a primed constant infusion of l-[ring-(2)H(5)]phenylalanine. Net balance and FSR were calculated over 16 h, during which the control group (CON) received a nutritionally mixed meal every 5 h (0830, 1330, and 1830 h). The experimental group (EXP) also consumed 16.5 g Essential Amino Acids and 30 g carbohydrate (1100, 1600, and 2100 h). The dietary regimen was maintained during bedrest. FSR was higher in the EXP group on d 1 (EXP, 0.099 +/- 0.008%/h; CON: 0.075 +/- 0.005%/h) and d 28 (EXP, 0.093 +/- 0.006%/h; CON, 0.055 +/- 0.007%/h). Lean leg mass was maintained throughout bedrest in the EXP group (+0.2 +/- 0.3 kg), but fell in the CON group (-0.4 +/- 0.1 kg). Strength loss was more pronounced in the CON group (EXP, -8.8 +/- 1.4 kg; CON, -17.8 +/- 4.4 kg). Essential Amino Acid and carbohydrate supplementation may represent a viable intervention for individuals at risk of sarcopenia due to immobility or prolonged bedrest.

  • Essential Amino Acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    The Journal of Clinical Endocrinology and Metabolism, 2004
    Co-Authors: Douglas Paddonjones, Robert R. Wolfe, Melinda Sheffieldmoore, Randall J Urban, Arthur P Sanford, Asle Aarsland, Arny A Ferrando
    Abstract:

    We determined whether Essential Amino Acid and carbohydrate supplementation could offset the catabolic response to prolonged inactivity. Major outcome measures included mixed muscle fractional synthetic rate (FSR), phenylalanine net balance, lean leg mass, and leg extension strength. On d 1 and 28, vastus lateralis muscle biopsies and femoral arterio-venous blood samples were obtained during a primed constant infusion of l-[ring-2H5]phenylalanine. Net balance and FSR were calculated over 16 h, during which the control group (CON) received a nutritionally mixed meal every 5 h (0830, 1330, and 1830 h). The experimental group (EXP) also consumed 16.5 g Essential Amino Acids and 30 g carbohydrate (1100, 1600, and 2100 h). The dietary regimen was maintained during bedrest. FSR was higher in the EXP group on d 1 (EXP, 0.099 ± 0.008%/h; CON: 0.075 ± 0.005%/h) and d 28 (EXP, 0.093 ± 0.006%/h; CON, 0.055 ± 0.007%/h). Lean leg mass was maintained throughout bedrest in the EXP group (+0.2 ± 0.3 kg), but fell in the ...