The Experts below are selected from a list of 4029 Experts worldwide ranked by ideXlab platform
Yahui Wei - One of the best experts on this subject based on the ideXlab platform.
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reproductive Toxicity of rhizoma sparganii sparganium stoloniferum buch ham in mice mechanisms of anti angiogenesis and anti Estrogen pharmacologic activities
Journal of Ethnopharmacology, 2011Co-Authors: Jie Sun, Shao Wang, Yahui WeiAbstract:Abstract Ethnopharmacological relevance Indications and preliminary studies of Rhizoma Sparganii (RS) suggest its pharmacological mechanism is involved with endocrine/angiogenesis functions. We therefore studied its potential Toxicity on reproduction in mice. Materials and methods Reproductive Toxicity of 100, 200 and 400 mg/kg RS extract were studied in pregnant ICR mice and its offspring. The embryos’ fibroblast growth factor-1 (FGF-1), vascular endothelial growth factor (VEGF) and Estrogen receptor-α (ER-α) were evaluated as targets of endocrine/angiogenesis by immunohistochemical test. Results The offspring of treated mice (100, 200 and 400 mg/kg RS extract) during their pregnancy had various pathological conditions, suggesting an abnormal FGF signaling phenomenon during pregnancy. Embryos from the 400 mg/kg group had significantly depressed levels of FGF-1 ( P P P Conclusions These results implicate a FGF signaling abnormality in vivo and indicate that RS has anti-angiogenesis and anti-Estrogen Toxicity effects in pregnant rodents.
Mikhail Y Kochukov - One of the best experts on this subject based on the ideXlab platform.
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nongenomic signaling pathways of Estrogen Toxicity
Toxicological Sciences, 2010Co-Authors: Cheryl S Watson, Yow Jiun Jeng, Mikhail Y KochukovAbstract:XenoEstrogens can affect the healthy functioning of a variety of tissues by acting as potent Estrogens via nongenomic signaling pathways or by interfering with those actions of multiple physiological Estrogens. Collectively, our and other studies have compared a wide range of Estrogenic compounds, including some closely structurally related subgroups. The Estrogens that have been studied include environmental contaminants of different subclasses, dietary Estrogens, and several prominent physiological metabolites. By comparing the nongenomic signaling and functional responses to these compounds, we have begun to address the structural requirements for their actions through membrane Estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes that eventually integrate at the level of mitogen-activated protein kinase activities to coordinately regulate broad cellular destinies, such as proliferation, apoptosis, or differentiation.
Jie Sun - One of the best experts on this subject based on the ideXlab platform.
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reproductive Toxicity of rhizoma sparganii sparganium stoloniferum buch ham in mice mechanisms of anti angiogenesis and anti Estrogen pharmacologic activities
Journal of Ethnopharmacology, 2011Co-Authors: Jie Sun, Shao Wang, Yahui WeiAbstract:Abstract Ethnopharmacological relevance Indications and preliminary studies of Rhizoma Sparganii (RS) suggest its pharmacological mechanism is involved with endocrine/angiogenesis functions. We therefore studied its potential Toxicity on reproduction in mice. Materials and methods Reproductive Toxicity of 100, 200 and 400 mg/kg RS extract were studied in pregnant ICR mice and its offspring. The embryos’ fibroblast growth factor-1 (FGF-1), vascular endothelial growth factor (VEGF) and Estrogen receptor-α (ER-α) were evaluated as targets of endocrine/angiogenesis by immunohistochemical test. Results The offspring of treated mice (100, 200 and 400 mg/kg RS extract) during their pregnancy had various pathological conditions, suggesting an abnormal FGF signaling phenomenon during pregnancy. Embryos from the 400 mg/kg group had significantly depressed levels of FGF-1 ( P P P Conclusions These results implicate a FGF signaling abnormality in vivo and indicate that RS has anti-angiogenesis and anti-Estrogen Toxicity effects in pregnant rodents.
Cheryl S Watson - One of the best experts on this subject based on the ideXlab platform.
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nongenomic signaling pathways of Estrogen Toxicity
Toxicological Sciences, 2010Co-Authors: Cheryl S Watson, Yow Jiun Jeng, Mikhail Y KochukovAbstract:XenoEstrogens can affect the healthy functioning of a variety of tissues by acting as potent Estrogens via nongenomic signaling pathways or by interfering with those actions of multiple physiological Estrogens. Collectively, our and other studies have compared a wide range of Estrogenic compounds, including some closely structurally related subgroups. The Estrogens that have been studied include environmental contaminants of different subclasses, dietary Estrogens, and several prominent physiological metabolites. By comparing the nongenomic signaling and functional responses to these compounds, we have begun to address the structural requirements for their actions through membrane Estrogen receptors in the pituitary, in comparison to other tissues, and to gain insights into their typical non-monotonic dose-response behavior. Their multiple inputs into cellular signaling begin processes that eventually integrate at the level of mitogen-activated protein kinase activities to coordinately regulate broad cellular destinies, such as proliferation, apoptosis, or differentiation.
Shao Wang - One of the best experts on this subject based on the ideXlab platform.
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reproductive Toxicity of rhizoma sparganii sparganium stoloniferum buch ham in mice mechanisms of anti angiogenesis and anti Estrogen pharmacologic activities
Journal of Ethnopharmacology, 2011Co-Authors: Jie Sun, Shao Wang, Yahui WeiAbstract:Abstract Ethnopharmacological relevance Indications and preliminary studies of Rhizoma Sparganii (RS) suggest its pharmacological mechanism is involved with endocrine/angiogenesis functions. We therefore studied its potential Toxicity on reproduction in mice. Materials and methods Reproductive Toxicity of 100, 200 and 400 mg/kg RS extract were studied in pregnant ICR mice and its offspring. The embryos’ fibroblast growth factor-1 (FGF-1), vascular endothelial growth factor (VEGF) and Estrogen receptor-α (ER-α) were evaluated as targets of endocrine/angiogenesis by immunohistochemical test. Results The offspring of treated mice (100, 200 and 400 mg/kg RS extract) during their pregnancy had various pathological conditions, suggesting an abnormal FGF signaling phenomenon during pregnancy. Embryos from the 400 mg/kg group had significantly depressed levels of FGF-1 ( P P P Conclusions These results implicate a FGF signaling abnormality in vivo and indicate that RS has anti-angiogenesis and anti-Estrogen Toxicity effects in pregnant rodents.