The Experts below are selected from a list of 1008 Experts worldwide ranked by ideXlab platform
Henrik Kehlet - One of the best experts on this subject based on the ideXlab platform.
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Effect of thoracic epidural Etidocaine 1.5% on somatosensory evoked potentials, cortisol and glucose during cholecystectomy.
Acta anaesthesiologica Scandinavica, 1992Co-Authors: Joergen B. Dahl, Jacob Rosenberg, Henrik KehletAbstract:The effect of thoracic (T7-8) epidural Etidocaine 1.5%, 9 ml, and continuous per- and postoperative epidural infusion of Etidocaine 1.5%, 4 ml/h, on early (less than 500 ms) somatosensory evoked potentials (SEPs), and cortisol and glucose in plasma during cholecystectomy, was examined in ten patients. Spread of analgesia (pin-prick) was T3 (T1-T3) to L2 (T11-L3) 35 min after injection of Etidocaine, and T3 (T2-T4) to T12 (T8-L4) 3 h after surgical incision (median (range)). Before operation, epidural Etidocaine had no significant effects on peak-to-peak amplitude of SEPs to electrical stimulation at the L1, T10 or T6 dermatomal level (P greater than 0.09). SEPs were abolished in only two patients at T6, and no patient had SEPs abolished at T10 or L1. The plasma concentrations of cortisol and glucose were significantly increased 20 min after surgical incision and remained increased throughout the study. No correlation was found between the block-induced decrease in the peak-to-peak amplitude at T6 or T10 and increase in plasma cortisol, except for a negative correlation at T10 and the initial increase in cortisol (Rs = 0.72, P = 0.03). In conclusion, thoracic epidural administration of 9 ml of Etidocaine 1.5% does not provide total afferent somatic blockade assessed by SEP and the stress response to cholecystectomy.
Håkan Edström - One of the best experts on this subject based on the ideXlab platform.
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Etidocaine in retrobulbar anaesthesia. A comparison with mepivacaine.
Acta Ophthalmologica, 2009Co-Authors: William Thorburn, A.‐m. Thorn‐alquist, Håkan EdströmAbstract:: A new long-acting local anaesthetic, Etidocaine (Duranest) has been compared to mepivacaine (Carbocaine) in retrobulbar anaesthesia in a double-blind trial including 45 patients. Solutions used were Etidocaine 0.5% and 1% and mepivacaine 1%, all without adrenaline. The onset time was short and no difference was found between the solutions. The duration of analgesia and motor block was significantly longer with Etidocaine 1% compared to mepivacaine 1%. In a following open study with Etidocaine 1% and mepivacaine 1% about 80% of the the patients in the Etidocaine group never experienced any post-operative pain compared to about 50% in the mepivacaine group. No signs of local or systemic toxicity were noted in the studies.
Joergen B. Dahl - One of the best experts on this subject based on the ideXlab platform.
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Effect of thoracic epidural Etidocaine 1.5% on somatosensory evoked potentials, cortisol and glucose during cholecystectomy.
Acta anaesthesiologica Scandinavica, 1992Co-Authors: Joergen B. Dahl, Jacob Rosenberg, Henrik KehletAbstract:The effect of thoracic (T7-8) epidural Etidocaine 1.5%, 9 ml, and continuous per- and postoperative epidural infusion of Etidocaine 1.5%, 4 ml/h, on early (less than 500 ms) somatosensory evoked potentials (SEPs), and cortisol and glucose in plasma during cholecystectomy, was examined in ten patients. Spread of analgesia (pin-prick) was T3 (T1-T3) to L2 (T11-L3) 35 min after injection of Etidocaine, and T3 (T2-T4) to T12 (T8-L4) 3 h after surgical incision (median (range)). Before operation, epidural Etidocaine had no significant effects on peak-to-peak amplitude of SEPs to electrical stimulation at the L1, T10 or T6 dermatomal level (P greater than 0.09). SEPs were abolished in only two patients at T6, and no patient had SEPs abolished at T10 or L1. The plasma concentrations of cortisol and glucose were significantly increased 20 min after surgical incision and remained increased throughout the study. No correlation was found between the block-induced decrease in the peak-to-peak amplitude at T6 or T10 and increase in plasma cortisol, except for a negative correlation at T10 and the initial increase in cortisol (Rs = 0.72, P = 0.03). In conclusion, thoracic epidural administration of 9 ml of Etidocaine 1.5% does not provide total afferent somatic blockade assessed by SEP and the stress response to cholecystectomy.
William Thorburn - One of the best experts on this subject based on the ideXlab platform.
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Etidocaine in retrobulbar anaesthesia. A comparison with mepivacaine.
Acta Ophthalmologica, 2009Co-Authors: William Thorburn, A.‐m. Thorn‐alquist, Håkan EdströmAbstract:: A new long-acting local anaesthetic, Etidocaine (Duranest) has been compared to mepivacaine (Carbocaine) in retrobulbar anaesthesia in a double-blind trial including 45 patients. Solutions used were Etidocaine 0.5% and 1% and mepivacaine 1%, all without adrenaline. The onset time was short and no difference was found between the solutions. The duration of analgesia and motor block was significantly longer with Etidocaine 1% compared to mepivacaine 1%. In a following open study with Etidocaine 1% and mepivacaine 1% about 80% of the the patients in the Etidocaine group never experienced any post-operative pain compared to about 50% in the mepivacaine group. No signs of local or systemic toxicity were noted in the studies.
Jacob Rosenberg - One of the best experts on this subject based on the ideXlab platform.
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Effect of thoracic epidural Etidocaine 1.5% on somatosensory evoked potentials, cortisol and glucose during cholecystectomy.
Acta anaesthesiologica Scandinavica, 1992Co-Authors: Joergen B. Dahl, Jacob Rosenberg, Henrik KehletAbstract:The effect of thoracic (T7-8) epidural Etidocaine 1.5%, 9 ml, and continuous per- and postoperative epidural infusion of Etidocaine 1.5%, 4 ml/h, on early (less than 500 ms) somatosensory evoked potentials (SEPs), and cortisol and glucose in plasma during cholecystectomy, was examined in ten patients. Spread of analgesia (pin-prick) was T3 (T1-T3) to L2 (T11-L3) 35 min after injection of Etidocaine, and T3 (T2-T4) to T12 (T8-L4) 3 h after surgical incision (median (range)). Before operation, epidural Etidocaine had no significant effects on peak-to-peak amplitude of SEPs to electrical stimulation at the L1, T10 or T6 dermatomal level (P greater than 0.09). SEPs were abolished in only two patients at T6, and no patient had SEPs abolished at T10 or L1. The plasma concentrations of cortisol and glucose were significantly increased 20 min after surgical incision and remained increased throughout the study. No correlation was found between the block-induced decrease in the peak-to-peak amplitude at T6 or T10 and increase in plasma cortisol, except for a negative correlation at T10 and the initial increase in cortisol (Rs = 0.72, P = 0.03). In conclusion, thoracic epidural administration of 9 ml of Etidocaine 1.5% does not provide total afferent somatic blockade assessed by SEP and the stress response to cholecystectomy.