The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
Prachar J - One of the best experts on this subject based on the ideXlab platform.
-
Is the central channel of nuclear pore complex really the Exclusive Gateway for macromolecular transport
Neoplasma, 2002Co-Authors: Prachar JAbstract:Examination of many nuclear pore complexes revealed in some of them very thin filaments presumably RNA with accompanying proteins, directing from inner nucleus to the edge of the complex. On one representative micrograph it is shown that this strand continues in the same direction through central part of the complex most probably through the peripheral channel. Next route of the strand is through the tunnel of a hollow rod - subunit of the cytoplasmic ring.
Dipo Majekodunmi - One of the best experts on this subject based on the ideXlab platform.
-
Complex Routing with Gateways
Business Process Automation with ProcessMaker 3.1, 2017Co-Authors: Dipo MajekodunmiAbstract:At this point, you have become proficient in designing and building processes in ProcessMaker. So far we have built a complete process using only one type of Gateway element: the Exclusive Gateway.
Melissa Jacobs - One of the best experts on this subject based on the ideXlab platform.
-
Groups want Trump to close loophole allowing illegal immigrants to abuse tax credits
2017Co-Authors: Melissa JacobsAbstract:The Individual Tax Identification Number (ITIN) unlocks an Exclusive Gateway for non-citizens to receive monies meant for working, low-income Americans.
Thomas U. Schwartz - One of the best experts on this subject based on the ideXlab platform.
-
Architectural Nucleoporins Nup157/170 and Nup133 Are Structurally Related and Descend from a Second Ancestral Element
Journal of Biological Chemistry, 2009Co-Authors: James R.r. Whittle, Thomas U. SchwartzAbstract:Abstract The nuclear pore complex (NPC) constitutes one of the largest protein assemblies in the eukaryotic cell and forms the Exclusive Gateway to the nucleus. The stable, ∼15–20-MDa scaffold ring of the NPC is built from two multiprotein complexes arranged around a central 8-fold axis. Here we present crystal structures of two large architectural units, yNup170979–1502 and hNup107658–925·hNup133517–1156, each a constituent of one of the two multiprotein complexes. Conservation of domain arrangement and of tertiary structure suggests that Nup157/170 and Nup133 derived from a common ancestor. Together with the previously established ancestral coatomer element (ACE1), these two elements constitute the major α-helical building blocks of the NPC scaffold and define its branched, lattice-like architecture, similar to vesicle coats like COPII. We hypothesize that the extant NPC evolved early during eukaryotic evolution from a rudimentary structure composed of several identical copies of a few ancestral elements, later diversified and specified by gene duplication.
James R.r. Whittle - One of the best experts on this subject based on the ideXlab platform.
-
Architectural Nucleoporins Nup157/170 and Nup133 Are Structurally Related and Descend from a Second Ancestral Element
Journal of Biological Chemistry, 2009Co-Authors: James R.r. Whittle, Thomas U. SchwartzAbstract:Abstract The nuclear pore complex (NPC) constitutes one of the largest protein assemblies in the eukaryotic cell and forms the Exclusive Gateway to the nucleus. The stable, ∼15–20-MDa scaffold ring of the NPC is built from two multiprotein complexes arranged around a central 8-fold axis. Here we present crystal structures of two large architectural units, yNup170979–1502 and hNup107658–925·hNup133517–1156, each a constituent of one of the two multiprotein complexes. Conservation of domain arrangement and of tertiary structure suggests that Nup157/170 and Nup133 derived from a common ancestor. Together with the previously established ancestral coatomer element (ACE1), these two elements constitute the major α-helical building blocks of the NPC scaffold and define its branched, lattice-like architecture, similar to vesicle coats like COPII. We hypothesize that the extant NPC evolved early during eukaryotic evolution from a rudimentary structure composed of several identical copies of a few ancestral elements, later diversified and specified by gene duplication.