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Aimin Chen - One of the best experts on this subject based on the ideXlab platform.
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childhood polybrominated diphenyl ether pbde exposure and Executive Function in children in the home study
International Journal of Hygiene and Environmental Health, 2018Co-Authors: Ann M Vuong, Kimberly Yolton, Kendra L Poston, Changchun Xie, Glenys M Webster, Andreas Sjodin, Joseph M Braun, Kim N Dietrich, Bruce P Lanphear, Aimin ChenAbstract:Prenatal exposure to polybrominated diphenyl ethers (PBDEs) have been reported to impair Executive Function in children, but little is known whether childhood PBDE exposures play a role. Using the Health Outcomes and Measures of the Environment (HOME) Study, a prospective birth cohort in the greater Cincinnati area, we investigated the association between repeated measures of PBDEs during childhood and Executive Function at 8 years in 208 children and whether effect modification by child sex was present. We used child serum collected at 1, 2, 3, 5, and 8 years to measure PBDEs. The Behavior Rating Inventory of Executive Function was completed by parents to assess Executive Function at 8 years. We used multiple informant models to examine childhood PBDEs during several exposure windows. Null associations were observed between early childhood PBDEs and Executive Function. However, we observed significant adverse associations between a 10-fold increase in concurrent concentrations of BDE-28 (β=4.6, 95% CI 0.5, 8.7) and BDE-153 (β=4.8, 95% CI 0.8, 8.8) with behavioral regulation. In addition, PBDEs at 8 years were significantly associated with poorer emotional and impulse control. No associations were noted between childhood PBDEs and metacognition or global Executive Function. However, child sex significantly modified the associations, with significantly poorer Executive Function among males with higher concurrent BDE-153, and null associations in females. Our study findings suggest that concurrent PBDE exposures during childhood may be associated with poorer Executive Function, specifically behavior regulation. Males may also be more sensitive to adverse associations of concurrent PBDEs on Executive Function.
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prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and Executive Function in school age children
Environmental Research, 2016Co-Authors: Ann M Vuong, Kimberly Yolton, Glenys M Webster, Andreas Sjodin, Joseph M Braun, Kim N Dietrich, Bruce P Lanphear, Aimin Chen, Antonia M CalafatAbstract:Executive Function is a critical behavioral trait rarely studied in relation to potential neurotoxicants. Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl substances (PFASs) has been associated with adverse neurodevelopment, but there is limited research on Executive Function. Data from 256 mother-child pairs in the Health Outcomes and Measures of the Environment Study, a prospective birth cohort (2003-2006, Cincinnati, OH), was used to examine maternal serum PBDEs and PFASs and Executive Function in children ages 5 and 8 years. Maternal serum PBDEs and PFASs were measured at 16±3 weeks gestation. Executive Function was assessed with the parent-rated Behavior Rating Inventory of Executive Function (BRIEF), which yields composite measures: behavioral regulation index, metacognition index, and global Executive composite. Higher BRIEF scores indicate Executive Function impairments. Linear mixed models and generalized estimating equations were used to estimate covariate-adjusted associations between PBDEs and PFASs and Executive Function. A 10-fold increase in BDE-153 was associated with poorer behavior regulation (β=3.23, 95% CI 0.60, 5.86). Higher odds of having a score ≥60 in behavior regulation (OR=3.92, 95% CI 1.76, 8.73) or global Executive Functioning (OR=2.34, 95% CI 1.05, 5.23) was observed with increased BDE-153. Each ln-unit increase in perfluorooctane sulfonate (PFOS) was associated with poorer behavior regulation (β=3.14, 95% CI 0.68, 5.61), metacognition (β=3.10, 95% CI 0.62, 5.58), and global Executive Functioning (β=3.38, 95% CI 0.86, 5.90). However, no association was observed between perfluorooctanoate (PFOA) and Executive Function. Prenatal exposures to BDE-153 and PFOS may be associated with Executive Function deficits in school-age children.
Eugene K Emory - One of the best experts on this subject based on the ideXlab platform.
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Executive Function and the frontal lobes a meta analytic review
Neuropsychology Review, 2006Co-Authors: Julie A Alvarez, Eugene K EmoryAbstract:Currently, there is debate among scholars regarding how to operationalize and measure Executive Functions. These Functions generally are referred to as “supervisory” cognitive processes because they involve higher level organization and execution of complex thoughts and behavior. Although conceptualizations vary regarding what mental processes actually constitute the “Executive Function” construct, there has been a historical linkage of these “higher-level” processes with the frontal lobes. In fact, many investigators have used the term “frontal Functions” synonymously with “Executive Functions” despite evidence that contradicts this synonymous usage. The current review provides a critical analysis of lesion and neuroimaging studies using three popular Executive Function measures (Wisconsin Card Sorting Test, Phonemic Verbal Fluency, and Stroop Color Word Interference Test) in order to examine the validity of the Executive Function construct in terms of its relation to activation and damage to the frontal lobes. Empirical lesion data are examined via meta-analysis procedures along with formula derivatives. Results reveal mixed evidence that does not support a one-to-one relationship between Executive Functions and frontal lobe activity. The paper concludes with a discussion of the implications of construing the validity of these neuropsychological tests in anatomical, rather than cognitive and behavioral, terms.
Peter K. Isquith - One of the best experts on this subject based on the ideXlab platform.
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ecological assessment of Executive Function in traumatic brain injury
Developmental Neuropsychology, 2004Co-Authors: Peter K. Isquith, Gerard A. GioiaAbstract:Executive dysFunction is a common outcome in children who have sustained traumatic brain injury (TBI). Appropriate assessment of these complex interrelated regulatory Functions is critical to plan for the necessary interventions yet present a challenge to our traditional methodologies. Ecological validity has become an increasingly important focus in neuropsychological assessment with particular relevance for the Executive Functions, which coordinate one's cognitive and behavioral capacities with real-world demand situations. The Behavior Rating Inventory of Executive Function (BRIEF) was developed to capture the real-world behavioral manifestations of Executive dysFunction. Its development and various forms of validity, including ecological validity, are described. Application of the BRIEF's methodology to the assessment of Executive dysFunction in TBI is provided. We advocate a multilevel approach to understanding Executive Function outcome in TBI, including traditional test-based measures of Executive Function, real-world behavioral manifestation of Executive dysFunction, and the environmental system factors that impact the child. In this model, ecologically valid assessment of Executive dysFunction provides an important bridge toward understanding the impact of component-level (i.e., test-based) deficits on the child's everyday adaptive Functioning, which can assist the definition of targets for intervention.
Bruce P Lanphear - One of the best experts on this subject based on the ideXlab platform.
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childhood polybrominated diphenyl ether pbde exposure and Executive Function in children in the home study
International Journal of Hygiene and Environmental Health, 2018Co-Authors: Ann M Vuong, Kimberly Yolton, Kendra L Poston, Changchun Xie, Glenys M Webster, Andreas Sjodin, Joseph M Braun, Kim N Dietrich, Bruce P Lanphear, Aimin ChenAbstract:Prenatal exposure to polybrominated diphenyl ethers (PBDEs) have been reported to impair Executive Function in children, but little is known whether childhood PBDE exposures play a role. Using the Health Outcomes and Measures of the Environment (HOME) Study, a prospective birth cohort in the greater Cincinnati area, we investigated the association between repeated measures of PBDEs during childhood and Executive Function at 8 years in 208 children and whether effect modification by child sex was present. We used child serum collected at 1, 2, 3, 5, and 8 years to measure PBDEs. The Behavior Rating Inventory of Executive Function was completed by parents to assess Executive Function at 8 years. We used multiple informant models to examine childhood PBDEs during several exposure windows. Null associations were observed between early childhood PBDEs and Executive Function. However, we observed significant adverse associations between a 10-fold increase in concurrent concentrations of BDE-28 (β=4.6, 95% CI 0.5, 8.7) and BDE-153 (β=4.8, 95% CI 0.8, 8.8) with behavioral regulation. In addition, PBDEs at 8 years were significantly associated with poorer emotional and impulse control. No associations were noted between childhood PBDEs and metacognition or global Executive Function. However, child sex significantly modified the associations, with significantly poorer Executive Function among males with higher concurrent BDE-153, and null associations in females. Our study findings suggest that concurrent PBDE exposures during childhood may be associated with poorer Executive Function, specifically behavior regulation. Males may also be more sensitive to adverse associations of concurrent PBDEs on Executive Function.
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prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and Executive Function in school age children
Environmental Research, 2016Co-Authors: Ann M Vuong, Kimberly Yolton, Glenys M Webster, Andreas Sjodin, Joseph M Braun, Kim N Dietrich, Bruce P Lanphear, Aimin Chen, Antonia M CalafatAbstract:Executive Function is a critical behavioral trait rarely studied in relation to potential neurotoxicants. Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl substances (PFASs) has been associated with adverse neurodevelopment, but there is limited research on Executive Function. Data from 256 mother-child pairs in the Health Outcomes and Measures of the Environment Study, a prospective birth cohort (2003-2006, Cincinnati, OH), was used to examine maternal serum PBDEs and PFASs and Executive Function in children ages 5 and 8 years. Maternal serum PBDEs and PFASs were measured at 16±3 weeks gestation. Executive Function was assessed with the parent-rated Behavior Rating Inventory of Executive Function (BRIEF), which yields composite measures: behavioral regulation index, metacognition index, and global Executive composite. Higher BRIEF scores indicate Executive Function impairments. Linear mixed models and generalized estimating equations were used to estimate covariate-adjusted associations between PBDEs and PFASs and Executive Function. A 10-fold increase in BDE-153 was associated with poorer behavior regulation (β=3.23, 95% CI 0.60, 5.86). Higher odds of having a score ≥60 in behavior regulation (OR=3.92, 95% CI 1.76, 8.73) or global Executive Functioning (OR=2.34, 95% CI 1.05, 5.23) was observed with increased BDE-153. Each ln-unit increase in perfluorooctane sulfonate (PFOS) was associated with poorer behavior regulation (β=3.14, 95% CI 0.68, 5.61), metacognition (β=3.10, 95% CI 0.62, 5.58), and global Executive Functioning (β=3.38, 95% CI 0.86, 5.90). However, no association was observed between perfluorooctanoate (PFOA) and Executive Function. Prenatal exposures to BDE-153 and PFOS may be associated with Executive Function deficits in school-age children.
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impact of early life bisphenol a exposure on behavior and Executive Function in children
Pediatrics, 2011Co-Authors: Joseph M Braun, Kimberly Yolton, Kim N Dietrich, Antonia M Calafat, Amy E Kalkbrenner, Bruce P LanphearAbstract:To estimate the impact of gestational and childhood bis- phenol A (BPA) exposures on behavior and Executive Function at 3 years of age and to determine whether child gender modified those associations. METHODS: We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respec- tively. Behavior and Executive Function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P).
Ann M Vuong - One of the best experts on this subject based on the ideXlab platform.
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childhood polybrominated diphenyl ether pbde exposure and Executive Function in children in the home study
International Journal of Hygiene and Environmental Health, 2018Co-Authors: Ann M Vuong, Kimberly Yolton, Kendra L Poston, Changchun Xie, Glenys M Webster, Andreas Sjodin, Joseph M Braun, Kim N Dietrich, Bruce P Lanphear, Aimin ChenAbstract:Prenatal exposure to polybrominated diphenyl ethers (PBDEs) have been reported to impair Executive Function in children, but little is known whether childhood PBDE exposures play a role. Using the Health Outcomes and Measures of the Environment (HOME) Study, a prospective birth cohort in the greater Cincinnati area, we investigated the association between repeated measures of PBDEs during childhood and Executive Function at 8 years in 208 children and whether effect modification by child sex was present. We used child serum collected at 1, 2, 3, 5, and 8 years to measure PBDEs. The Behavior Rating Inventory of Executive Function was completed by parents to assess Executive Function at 8 years. We used multiple informant models to examine childhood PBDEs during several exposure windows. Null associations were observed between early childhood PBDEs and Executive Function. However, we observed significant adverse associations between a 10-fold increase in concurrent concentrations of BDE-28 (β=4.6, 95% CI 0.5, 8.7) and BDE-153 (β=4.8, 95% CI 0.8, 8.8) with behavioral regulation. In addition, PBDEs at 8 years were significantly associated with poorer emotional and impulse control. No associations were noted between childhood PBDEs and metacognition or global Executive Function. However, child sex significantly modified the associations, with significantly poorer Executive Function among males with higher concurrent BDE-153, and null associations in females. Our study findings suggest that concurrent PBDE exposures during childhood may be associated with poorer Executive Function, specifically behavior regulation. Males may also be more sensitive to adverse associations of concurrent PBDEs on Executive Function.
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prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and Executive Function in school age children
Environmental Research, 2016Co-Authors: Ann M Vuong, Kimberly Yolton, Glenys M Webster, Andreas Sjodin, Joseph M Braun, Kim N Dietrich, Bruce P Lanphear, Aimin Chen, Antonia M CalafatAbstract:Executive Function is a critical behavioral trait rarely studied in relation to potential neurotoxicants. Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl substances (PFASs) has been associated with adverse neurodevelopment, but there is limited research on Executive Function. Data from 256 mother-child pairs in the Health Outcomes and Measures of the Environment Study, a prospective birth cohort (2003-2006, Cincinnati, OH), was used to examine maternal serum PBDEs and PFASs and Executive Function in children ages 5 and 8 years. Maternal serum PBDEs and PFASs were measured at 16±3 weeks gestation. Executive Function was assessed with the parent-rated Behavior Rating Inventory of Executive Function (BRIEF), which yields composite measures: behavioral regulation index, metacognition index, and global Executive composite. Higher BRIEF scores indicate Executive Function impairments. Linear mixed models and generalized estimating equations were used to estimate covariate-adjusted associations between PBDEs and PFASs and Executive Function. A 10-fold increase in BDE-153 was associated with poorer behavior regulation (β=3.23, 95% CI 0.60, 5.86). Higher odds of having a score ≥60 in behavior regulation (OR=3.92, 95% CI 1.76, 8.73) or global Executive Functioning (OR=2.34, 95% CI 1.05, 5.23) was observed with increased BDE-153. Each ln-unit increase in perfluorooctane sulfonate (PFOS) was associated with poorer behavior regulation (β=3.14, 95% CI 0.68, 5.61), metacognition (β=3.10, 95% CI 0.62, 5.58), and global Executive Functioning (β=3.38, 95% CI 0.86, 5.90). However, no association was observed between perfluorooctanoate (PFOA) and Executive Function. Prenatal exposures to BDE-153 and PFOS may be associated with Executive Function deficits in school-age children.