The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform

Kimberly Yolton - One of the best experts on this subject based on the ideXlab platform.

Sharon K. Sagiv - One of the best experts on this subject based on the ideXlab platform.

Toshitaka Nabeshima - One of the best experts on this subject based on the ideXlab platform.

  • Prenatal Exposure to phencyclidine produces abnormal behaviour and NMDA receptor expression in postpubertal mice.
    The international journal of neuropsychopharmacology, 2009
    Co-Authors: Takayoshi Mamiya, Kazuya Toriumi, Akihiro Mouri, Masayuki Hiramatsu, Hyoung-chun Kim, Li Bo Zou, Taku Nagai, Toshitaka Nabeshima
    Abstract:

    Several studies have shown the disruptive effects of non-competitive N-methyl-d-aspartate (NMDA) receptor antagonists on neurobehavioural development. Based on the neurodevelopment hypothesis of schizophrenia, there is growing interest in animal models treated with NMDA antagonists at developing stages to investigate the pathogenesis of psychological disturbances in humans. Previous studies have reported that perinatal treatment with phencyclidine (PCP) impairs the development of neuronal systems and induces schizophrenia-like behaviour. However, the adverse effects of Prenatal Exposure to PCP on behaviour and the function of NMDA receptors are not well understood. This study investigated the long-term effects of Prenatal Exposure to PCP in mice. The Prenatal PCP-treated mice showed hypersensitivity to a low dose of PCP in locomotor activity and impairment of recognition memory in the novel object recognition test at age 7 wk. Meanwhile, the Prenatal Exposure reduced the phosphorylation of NR1, although it increased the expression of NR1 itself. Furthermore, these behavioural changes were attenuated by atypical antipsychotic treatment. Taken together, Prenatal Exposure to PCP produced long-lasting behavioural deficits, accompanied by the abnormal expression and dysfunction of NMDA receptors in postpubertal mice. It is worth investigating the influences of disrupted NMDA receptors during the Prenatal period on behaviour in later life.

Xin Zhang - One of the best experts on this subject based on the ideXlab platform.

  • The effects of Prenatal Exposure to temperature extremes on birth outcomes: the case of China
    Journal of Population Economics, 2020
    Co-Authors: Xi Chen, Chih Ming Tan, Xiaobo Zhang, Xin Zhang
    Abstract:

    This paper investigates the effects of Prenatal Exposure to extreme temperatures on birth outcomes—specifically, the log of birth weight and an indicator for low birth weight—using a nationally representative dataset on rural China. During the time period we examine (1991–2000), indoor air conditioning was not widely available and migration was limited, allowing us to address identification issues endemic in the climate change literature related to adaptation and location sorting. We find substantial heterogeneity in the effects of extreme temperature Exposure on birth outcomes. In particular, Prenatal Exposure to heat waves has stronger negative effects than Exposure to cold spells on surviving births.

  • The Effects of Prenatal Exposure to Temperature Extremes on Birth Outcomes
    Social Science Research Network, 2020
    Co-Authors: Xi Chen, Chih Ming Tan, Xiaobo Zhang, Xin Zhang
    Abstract:

    This paper investigates the effects of Prenatal Exposure to extreme temperatures on birth outcomes – specifically, the log of birth weight and an indicator for low birth weight – using a nationally representative dataset in rural China. During the span of our data (i.e., 1991–2000), indoor air-conditioning was not widely available and migration was limited, allowing us to address identification issues endemic in the climate change literature related to adaptation and location sorting. We find substantial heterogeneity in the effects of extreme temperature Exposure on birth outcomes. In particular, Prenatal Exposure to heat waves has stronger negative effects than Exposure to cold spells on survivors.

Virginia Rauh - One of the best experts on this subject based on the ideXlab platform.

  • Longitudinal effects of Prenatal Exposure to air pollutants on self‐regulatory capacities and social competence
    Journal of child psychology and psychiatry and allied disciplines, 2016
    Co-Authors: Amy Margolis, Julie Herbstman, Katie S. Davis, Valerie Thomas, Deliang Tang, Ya Wang, Shuang Wang, Frederica P. Perera, Bradley S. Peterson, Virginia Rauh
    Abstract:

    Background We evaluated the influence of Prenatal Exposure to widespread urban air pollutants on the development of self-regulation and social competence in a longitudinal prospective cohort of children born to nonsmoking minority women in New York City. Methods Air pollutant Exposure was estimated categorically by level of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in maternal blood collected at delivery, providing a biomarker of maternal Exposure to PAH over a 2- to 3-month period. Deficient emotional self-regulation (DESR) was defined as moderate elevations on three specific scales of the child behavior checklist (anxious/depressed, aggressive behavior, and attention problems). We used generalized estimating equations to assess the influence of Prenatal Exposure to PAH on DESR in children at 3–5, 7, 9, and 11 years of age, adjusted for gender and race/ethnicity. Next, we assessed the association of Prenatal Exposure to PAH with social competence, as measured by the social responsiveness scale (SRS), the association of impaired self-regulation with social competence, and whether impairment in self-regulation mediated the association of Prenatal Exposure to PAH with social competence. Results We detected a significant interaction (at p = .05) of Exposure with time, in which the developmental trajectory of self-regulatory capacity was delayed in the exposed children. Multiple linear regression revealed a positive association between presence of PAH-DNA adducts and problems with social competence (p 

  • seven year neurodevelopmental scores and Prenatal Exposure to chlorpyrifos a common agricultural pesticide
    Environmental Health Perspectives, 2011
    Co-Authors: Virginia Rauh, Dana B Barr, Frederica P. Perera, Srikesh Arunajadai, Megan K Horton, Lori Hoepner, Robin M. Whyatt
    Abstract:

    Background: In a longitudinal birth cohort study of inner-city mothers and children (Columbia Center for Children’s Environmental Health), we have previously reported that Prenatal Exposure to chlo...

  • effect of Prenatal Exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner city children
    Environmental Health Perspectives, 2006
    Co-Authors: Frederica P. Perera, Robin M. Whyatt, Dana B Barr, Deliang Tang, Virginia Rauh, Lori Hoepner, Weiyann Tsai, Diurka Diaz, David Camann
    Abstract:

    Our prospective cohort study of nonsmoking African-American and Dominican mothers and children in New York City is evaluating the role of Prenatal Exposure to urban pollutants, including polycyclic aromatic hydrocarbons (PAHs), environmental tobacco smoke (ETS), and pesticides, in the pathogenesis of neurobehavioral disorders. We used the Bayley Scales of Infant Development to evaluate the effects on child mental and psychomotor development of Prenatal Exposure to airborne PAHs monitored during pregnancy by personal air sampling. Behavioral development was assessed by the Child Behavior Checklist. We adjusted for potential confounders including sociodemographic factors and Prenatal Exposure to ETS and chlorpyrifos. Prenatal Exposure to PAHs was not associated with psychomotor development index or behavioral problems. However, high Prenatal Exposure to PAHs (upper quartile) was associated with lower mental development index at age 3 [β= –5.69; 95% confidence interval (CI), –9.05 to –2.33; p < 0.01]. The odds of cognitive developmental delay were also significantly greater for children with high Prenatal Exposure (odds ratio = 2.89; 95% CI, 1.33 to 6.25; p = 0.01). General estimated equation analysis showed a significant age × PAH effect on mental development (p = 0.01), confirming the age-specific regression findings. Further adjustment for lead did not alter the relationships. There were no differences in effect sizes by ethnicity. The results require confirmation but suggest that environmental PAHs at levels recently encountered in New York City air may adversely affect children’s cognitive development at 3 years of age, with implications for school performance.