The Experts below are selected from a list of 49560 Experts worldwide ranked by ideXlab platform
J.-m. Badet - One of the best experts on this subject based on the ideXlab platform.
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Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France
European Journal of Cancer, 2019Co-Authors: A. Auperin, R. Obongo, F.r. Ferrand, N. Saroul, F. Janot, S. Albert, G. Andry, E. Babin, C. Bach, J.-m. BadetAbstract:BACKGROUND: Head and neck mucosal melanoma (HNMM) is aggressive and rare, with a poor prognosis because of its high metastatic potential. The two main subtypes are sinonasal (sinonasal mucosal melanoma [SNMM]) and oral cavity (oral cavity mucosal melanoma [OCMM]). Consensual therapeutic guidelines considering the primary tumour site and tumour-node-metastasis (TNM) stage are not well established. MATERIAL & METHODS: Patients with HNMM from the prospective national French Rare Head and Neck Cancer Expert Network database between 2000 and 2017 were included. Clinical characteristics, treatment modalities, outcomes and prognostic factors were analysed. RESULTS: In total, 314 patients were included. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 49.4% and 24.7%, respectively, in the surgery group; no long-term survivors were observed when surgery was not feasible. Moreover, even after surgery, a high recurrence rate was reported with a median PFS of 22 months. In multivariate analysis, Union for International Cancer Control (UICC) stage and tumour site correlated with PFS and OS. Postoperative radiotherapy (PORT) improved the PFS but not OS in patients with small (T3) SNMM and OCMM tumours. Nodal involvement was more frequent in patients with OCMM (p < 10-4), although, as in SNMM, it was not a significant prognostic predictor. CONCLUSION: Even early HNMM was associated with poor oncologic outcomes due to distant metastases despite surgical resection with clear margins. Lymph node metastases had no impact on the prognosis, suggesting treatment de-escalation in cervical node management. PORT might be useful for local control.
C T J Hulshof - One of the best experts on this subject based on the ideXlab platform.
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comparing the use of an online Expert health Network against common information sources to answer health questions
Journal of Medical Internet Research, 2012Co-Authors: Martijn D F Rhebergen, Annet Lenderink, Frank J H Van Dijk, C T J HulshofAbstract:Background: Many workers have questions about occupational safety and health (OSH). It is unknown whether workers are able to find correct, evidence-based answers to OSH questions when they use common information sources, such as websites, or whether they would benefit from using an easily accessible, free-of-charge online Network of OSH Experts providing advice. Objective: To assess the rate of correct, evidence-based answers to OSH questions in a group of workers who used an online Network of OSH Experts (intervention group) compared with a group of workers who used common information sources (control group). Methods: In a quasi-experimental study, workers in the intervention and control groups were randomly offered 2 questions from a pool of 16 standardized OSH questions. Both questions were sent by mail to all participants, who had 3 weeks to answer them. The intervention group was instructed to use only the online Network ArboAntwoord, a Network of about 80 OSH Experts, to solve the questions. The control group was instructed that they could use all information sources available to them. To assess answer correctness as the main study outcome, 16 standardized correct model answers were constructed with the help of reviewers who performed literature searches. Subsequently, the answers provided by all participants in the intervention (n = 94 answers) and control groups (n = 124 answers) were blinded and compared with the correct model answers on the degree of correctness. Results: Of the 94 answers given by participants in the intervention group, 58 were correct (62%), compared with 24 of the 124 answers (19%) in the control group, who mainly used informational websites found via Google. The difference between the 2 groups was significant (rate difference = 43%, 95% confidence interval [CI] 30%–54%). Additional analysis showed that the rate of correct main conclusions of the answers was 85 of 94 answers (90%) in the intervention group and 75 of 124 answers (61%) in the control group (rate difference = 29%, 95% CI 19%–40%). Remarkably, we could not identify differences between workers who provided correct answers and workers who did not on how they experienced the credibility, completeness, and applicability of the information found (P > .05). Conclusions: Workers are often unable to find correct answers to OSH questions when using common information sources, generally informational websites. Because workers frequently misjudge the quality of the information they find, other strategies are required to assist workers in finding correct answers. Expert advice provided through an online Expert Network can be effective for this purpose. As many people experience difficulties in finding correct answers to their health questions, Expert Networks may be an attractive new source of information for health fields in general.
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an online Expert Network for high quality information on occupational safety and health cross sectional study of user satisfaction and impact
BMC Medical Informatics and Decision Making, 2011Co-Authors: Martijn D F Rhebergen, Annet Lenderink, Frank J H Van Dijk, C T J HulshofAbstract:Many people have difficulties finding information on health questions, including occupational safety and health (OSH) issues. One solution to alleviate these difficulties could be to offer questioners free-of-charge, online access to a Network of OSH Experts who provide tailored, high-quality information. The aim of this study was to assess whether Network quality, respectively information quality, as perceived by the questioners, is associated with questioners' overall satisfaction and to explore the impact of the information received on questioners' knowledge, work and work functioning. We evaluated the experiences of OSH questioners with the online Network ArboAntwoord.com over a two-year period. In this Network, approximately 80 qualified Experts are available to answer OSH questions. By means of a questionnaire, we assessed questioners' overall satisfaction with the Network, whether the Network was user-friendly, easily accessible and easy to handle and whether the information provided was complete, applicable and received in a timely manner. The impact of the information on questioners' knowledge, work or work functioning was explored with seven questions. In the study period, 460 unique OSH questioners asked 851 OSH questions. In total, 205 of the 460 questioners completed the questionnaire (response rate 45%). Of the responders, 71% were satisfied with the ArboAntwoord Network. Multiple logistic regression analysis showed that the applicability of the information had a positive influence on the questioners' overall satisfaction (OR = 16.0, 95% CI: 7.0-36.4). Also, user friendliness of the Network (OR = 3.3, 95% CI: 1.3-8.6) and completeness of the information provided (OR = 3.0, 95% CI: 1.3-6.8) were positively related to the questioners' satisfaction. For 74% of the questioners, the information helped to increase their knowledge and understanding. Overall, 25% of the questioners indicated that the received information improved their work, work functioning or health. A free-of-charge, online Expert Network in the field of OSH can be a useful strategy to provide OSH questioners with applicable, complete and timely information that may help improve safety and health at work. This study provides more insight in how to satisfy Network questioners and about the potential impact of provided information on OSH.
A. Auperin - One of the best experts on this subject based on the ideXlab platform.
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Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France
European Journal of Cancer, 2019Co-Authors: A. Auperin, R. Obongo, F.r. Ferrand, N. Saroul, F. Janot, S. Albert, G. Andry, E. Babin, C. Bach, J.-m. BadetAbstract:BACKGROUND: Head and neck mucosal melanoma (HNMM) is aggressive and rare, with a poor prognosis because of its high metastatic potential. The two main subtypes are sinonasal (sinonasal mucosal melanoma [SNMM]) and oral cavity (oral cavity mucosal melanoma [OCMM]). Consensual therapeutic guidelines considering the primary tumour site and tumour-node-metastasis (TNM) stage are not well established. MATERIAL & METHODS: Patients with HNMM from the prospective national French Rare Head and Neck Cancer Expert Network database between 2000 and 2017 were included. Clinical characteristics, treatment modalities, outcomes and prognostic factors were analysed. RESULTS: In total, 314 patients were included. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 49.4% and 24.7%, respectively, in the surgery group; no long-term survivors were observed when surgery was not feasible. Moreover, even after surgery, a high recurrence rate was reported with a median PFS of 22 months. In multivariate analysis, Union for International Cancer Control (UICC) stage and tumour site correlated with PFS and OS. Postoperative radiotherapy (PORT) improved the PFS but not OS in patients with small (T3) SNMM and OCMM tumours. Nodal involvement was more frequent in patients with OCMM (p < 10-4), although, as in SNMM, it was not a significant prognostic predictor. CONCLUSION: Even early HNMM was associated with poor oncologic outcomes due to distant metastases despite surgical resection with clear margins. Lymph node metastases had no impact on the prognosis, suggesting treatment de-escalation in cervical node management. PORT might be useful for local control.
Meena Sundaresan - One of the best experts on this subject based on the ideXlab platform.
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life cycle emissions of alternative fuels for transportation dealing with uncertainties
Research Papers in Economics, 2001Co-Authors: Fernando J Contadini, Robert M Moore, Daniel Sperling, Meena SundaresanAbstract:A principal motivation for introducing alternative fuels is to reduce air pollution and greenhouse gas emissions. A comprehensive evaluation of the reductions must include all Life Cycle activities from the vehicle operation to the feedstock extraction. This paper focuses on the fuel upstream activities only. We compare the results and methods of the three most comprehensive existing fuel upstream models in the U.S.A. and we explore the differences and uncertainties of these types of analyses. To explicitly include the impact of uncertainties, we create a new model using the following approaches: - Instead of using a single value as input, the new model deals with ranges around the most probable value - Ranges are discussed and calibrated by an Expert Network, in terms of their relative probability. - Probabilistic function techniques are applied to study the impact of the uncertainties on the model output. The paper also presents the rationale and benefits of using each of the alternative approaches that are discussed and reviewed.
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Life-Cycle Emissions of Alternative Fuels for Transportation: Dealing with Uncertanties
SAE Technical Paper Series, 2000Co-Authors: J. Fernando Contadini, Robert M Moore, Daniel Sperling, Meena SundaresanAbstract:Author(s): Contadini, J. Fernando; Moore, Robert M.; Sperling, Daniel; Sundaresan, Meena | Abstract: A principal motivation for introducing alternative fuels is to reduce air pollution and greenhouse gas emissions. A comprehensive evaluation of the reductions must include all Life Cycle activities from the vehicle operation to the feedstock extraction. This paper focuses on the fuel upstream activities only. We compare the results and methods of the three most comprehensive existing fuel upstream models in the U.S.A. and we explore the differences and uncertainties of these types of analyses. To explicitly include the impact of uncertainties, we create a new model using the following approaches:- Instead of using a single value as input, the new model deals with ranges around the most probable value- Ranges are discussed and calibrated by an Expert Network, in terms of their relative probability.- Probabilistic function techniques are applied to study the impact of the uncertainties on the model output.The paper also presents the rationale and benefits of using each of the alternative approaches that are discussed and reviewed.
Martijn D F Rhebergen - One of the best experts on this subject based on the ideXlab platform.
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comparing the use of an online Expert health Network against common information sources to answer health questions
Journal of Medical Internet Research, 2012Co-Authors: Martijn D F Rhebergen, Annet Lenderink, Frank J H Van Dijk, C T J HulshofAbstract:Background: Many workers have questions about occupational safety and health (OSH). It is unknown whether workers are able to find correct, evidence-based answers to OSH questions when they use common information sources, such as websites, or whether they would benefit from using an easily accessible, free-of-charge online Network of OSH Experts providing advice. Objective: To assess the rate of correct, evidence-based answers to OSH questions in a group of workers who used an online Network of OSH Experts (intervention group) compared with a group of workers who used common information sources (control group). Methods: In a quasi-experimental study, workers in the intervention and control groups were randomly offered 2 questions from a pool of 16 standardized OSH questions. Both questions were sent by mail to all participants, who had 3 weeks to answer them. The intervention group was instructed to use only the online Network ArboAntwoord, a Network of about 80 OSH Experts, to solve the questions. The control group was instructed that they could use all information sources available to them. To assess answer correctness as the main study outcome, 16 standardized correct model answers were constructed with the help of reviewers who performed literature searches. Subsequently, the answers provided by all participants in the intervention (n = 94 answers) and control groups (n = 124 answers) were blinded and compared with the correct model answers on the degree of correctness. Results: Of the 94 answers given by participants in the intervention group, 58 were correct (62%), compared with 24 of the 124 answers (19%) in the control group, who mainly used informational websites found via Google. The difference between the 2 groups was significant (rate difference = 43%, 95% confidence interval [CI] 30%–54%). Additional analysis showed that the rate of correct main conclusions of the answers was 85 of 94 answers (90%) in the intervention group and 75 of 124 answers (61%) in the control group (rate difference = 29%, 95% CI 19%–40%). Remarkably, we could not identify differences between workers who provided correct answers and workers who did not on how they experienced the credibility, completeness, and applicability of the information found (P > .05). Conclusions: Workers are often unable to find correct answers to OSH questions when using common information sources, generally informational websites. Because workers frequently misjudge the quality of the information they find, other strategies are required to assist workers in finding correct answers. Expert advice provided through an online Expert Network can be effective for this purpose. As many people experience difficulties in finding correct answers to their health questions, Expert Networks may be an attractive new source of information for health fields in general.
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an online Expert Network for high quality information on occupational safety and health cross sectional study of user satisfaction and impact
BMC Medical Informatics and Decision Making, 2011Co-Authors: Martijn D F Rhebergen, Annet Lenderink, Frank J H Van Dijk, C T J HulshofAbstract:Many people have difficulties finding information on health questions, including occupational safety and health (OSH) issues. One solution to alleviate these difficulties could be to offer questioners free-of-charge, online access to a Network of OSH Experts who provide tailored, high-quality information. The aim of this study was to assess whether Network quality, respectively information quality, as perceived by the questioners, is associated with questioners' overall satisfaction and to explore the impact of the information received on questioners' knowledge, work and work functioning. We evaluated the experiences of OSH questioners with the online Network ArboAntwoord.com over a two-year period. In this Network, approximately 80 qualified Experts are available to answer OSH questions. By means of a questionnaire, we assessed questioners' overall satisfaction with the Network, whether the Network was user-friendly, easily accessible and easy to handle and whether the information provided was complete, applicable and received in a timely manner. The impact of the information on questioners' knowledge, work or work functioning was explored with seven questions. In the study period, 460 unique OSH questioners asked 851 OSH questions. In total, 205 of the 460 questioners completed the questionnaire (response rate 45%). Of the responders, 71% were satisfied with the ArboAntwoord Network. Multiple logistic regression analysis showed that the applicability of the information had a positive influence on the questioners' overall satisfaction (OR = 16.0, 95% CI: 7.0-36.4). Also, user friendliness of the Network (OR = 3.3, 95% CI: 1.3-8.6) and completeness of the information provided (OR = 3.0, 95% CI: 1.3-6.8) were positively related to the questioners' satisfaction. For 74% of the questioners, the information helped to increase their knowledge and understanding. Overall, 25% of the questioners indicated that the received information improved their work, work functioning or health. A free-of-charge, online Expert Network in the field of OSH can be a useful strategy to provide OSH questioners with applicable, complete and timely information that may help improve safety and health at work. This study provides more insight in how to satisfy Network questioners and about the potential impact of provided information on OSH.
