The Experts below are selected from a list of 166428 Experts worldwide ranked by ideXlab platform
S. Fabiansson - One of the best experts on this subject based on the ideXlab platform.
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Recent progress in Exposure Assessment and its interaction with the risk analysis process
Trends in Food Science & Technology, 2008Co-Authors: Ph. Verger, S. FabianssonAbstract:The Exposure Assessment for chemicals in food is a crucial component of the risk Assessment process and is part of the practices of expert committees and panels. Its combination with the toxicological evaluation results in characterisation of the risk for human health. According to article 22 of Regulation (EC) No. 178/2002, data are needed to permit European Food Safety Authority (EFSA) to carry out its mainstay risk Assessment activities. A critical element in the conduct of risk Assessments is therefore the Exposure Assessment which combines data on concentrations of a chemical substance or a biological agent in foods with data on the quantity of those foods consumed across the European Union (EU). The methodology can equally be applied to harmful as well as beneficial substances with regard to food components that are naturally present, food additives, food supplements, contaminants and pesticide residues. The aim of the present paper is to describe the most recent evolutions and the short-term perspectives for Exposure Assessment driven by the progress of the risk analysis process itself and to describe the scientific and technical challenges to take into account the Exposure Assessment as an internal expertise within the EFSA including the creation of databases for food consumption, food composition and food contamination.
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Recent progress in Exposure Assessment and its interaction with the risk analysis process
Trends in Food Science and Technology, 2008Co-Authors: Ph. Verger, S. FabianssonAbstract:The Exposure Assessment for chemicals in food is a crucial component of the risk Assessment process and is part of the practices of expert committees and panels. Its combination with the toxicological evaluation results in characterisation of the risk for human health. According to article 22 of Regulation (EC) No. 178/2002, data are needed to permit European Food Safety Authority (EFSA) to carry out its mainstay risk Assessment activities. A critical element in the conduct of risk Assessments is therefore the Exposure Assessment which combines data on concentrations of a chemical substance or a biological agent in foods with data on the quantity of those foods consumed across the European Union (EU). The methodology can equally be applied to harmful as well as beneficial substances with regard to food components that are naturally present, food additives, food supplements, contaminants and pesticide residues. The aim of the present paper is to describe the most recent evolutions and the short-term perspectives for Exposure Assessment driven by the progress of the risk analysis process itself and to describe the scientific and technical challenges to take into account the Exposure Assessment as an internal expertise within the EFSA including the creation of databases for food consumption, food composition and food contamination. All rights reserved, Elsevier
Michael Jerrett - One of the best experts on this subject based on the ideXlab platform.
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creating national air pollution models for population Exposure Assessment in canada
Environmental Health Perspectives, 2011Co-Authors: Perry Hystad, Michael Brauer, Eleanor Setton, Alejandro Cervantes, Karla Poplawski, Steeve Deschenes, Aaron Van Donkelaar, L N Lamsal, Randall V Martin, Michael JerrettAbstract:Background: Population Exposure Assessment methods that capture local-scale pollutant variability are needed for large-scale epidemiological studies and surveillance, policy, and regulatory purpose...
Dick Heederik - One of the best experts on this subject based on the ideXlab platform.
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DREAM: a method for semi-quantitative dermal Exposure Assessment.
The Annals of Occupational Hygiene, 2003Co-Authors: Berna Van-wendel-de-joode, Dick Heederik, Roel Vermeulen, Derk H. Brouwer, Joop J. Van Hemmen, Hans KromhoutAbstract:This paper describes a new method (DREAM) for structured, semi-quantitative dermal Exposure Assessment for chemical or biological agents that can be used in occupational hygiene or epidemiology. It is anticipated that DREAM could serve as an initial Assessment of dermal Exposure, amongst others, resulting in a ranking of tasks and subsequently jobs. DREAM consists of an inventory and evaluation part. Two examples of dermal Exposure of workers of a car-construction company show that DREAM characterizes tasks and gives insight into Exposure mechanisms, forming a basis for systematic Exposure reduction. DREAM supplies estimates for Exposure levels on the outside clothing layer as well as on skin, and provides insight into the distribution of dermal Exposure over the body. Together with the ranking of tasks and people, this provides information for measurement strategies and helps to determine who, where and what to measure. In addition to dermal Exposure Assessment, the systematic description of dermal Exposure pathways helps to prioritize and determine most adequate measurement strategies and methods. DREAM could be a promising approach for structured, semi-quantitative, dermal Exposure Assessment.
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characterization of dust Exposure for the study of chronic occupational lung disease a comparison of different Exposure Assessment strategies
American Journal of Epidemiology, 2000Co-Authors: Dick Heederik, Michael D. AttfieldAbstract:Various Exposure Assessment strategies were compared in the study of the relation between dust Exposure and 11-year lung function change in 1,172 miners with 36,824 concurrently measured personal dust samples available from the 1969-1981 US National Study of Coal Workers' Pneumoconiosis. A miner's average Exposure was assessed by calculating average Exposures based on dust samples taken from each individual and by using different job Exposure matrices (JEMs) with different underlying Exposure categorizations, based on occupational categories, job title, mine, and time, to obtain average Exposure estimates. For each grouping procedure, intragroup and intergroup variances and the pooled standard error of the mean were calculated to assess relative efficiency. The results show that considerable variation in slopes of Exposure-response relations was found using different Exposure Assessment strategies. Standard errors of the slopes of the Exposure-response relations with Exposure on an individual basis compared with JEMs. Exposure Assessment on an individual basis was extremely sensitive to the number of Exposure measurements per individual. The study demonstrates the advantages and disadvantages of different Exposure Assessment strategies and shows the need for explicit publication of Exposure Assessment strategies for epidemiologic studies. Careful Assessment of the influence of misclassification error in the Exposure Assessment on Exposure-response modeling is warranted.
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Occupational Exposure Assessment: investigating why Exposure measurements vary.
Applied Occupational and Environmental Hygiene, 1994Co-Authors: Dick Heederik, Fintan HurleyAbstract:In recent years occupational Exposure Assessment has received increasing attention in the scientific literature. This attention has mainly been focused on Exposure Assessment in epidemiology. Recently, two important and widely recognized working group meetings have set the stage for retrospective Exposure Assessment in epidemiology. In Europe a so-called concerted action was completely devoted to retrospective Exposure Assessment in epidemiology. Almost all these activities focus on retrospective Exposure Assessment. As a consequence, so-called qualitative or semi-quantitative Exposure estimation strategies receive most attention. Exposure monitoring and quantitative Exposure estimation in epidemiology received little attention, while strategies are as underdeveloped as for other Exposure Assessment strategies. Therefore a workshop was organized at the First International Scientific Conference of the International Occupational Hygiene Association (Brussels, December 10, 1992) to establish the {open_quotes}state of the art{close_quotes} in research of quantitative occupational Exposure Assessment. Because underlying phenomenons that cause Exposure variability are similar for epidemiological Exposure Assessment, compliance testing, and other strategies applied in occupational hygiene, discussion was not limited to epidemiology. 3 refs.
Ph. Verger - One of the best experts on this subject based on the ideXlab platform.
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Recent progress in Exposure Assessment and its interaction with the risk analysis process
Trends in Food Science & Technology, 2008Co-Authors: Ph. Verger, S. FabianssonAbstract:The Exposure Assessment for chemicals in food is a crucial component of the risk Assessment process and is part of the practices of expert committees and panels. Its combination with the toxicological evaluation results in characterisation of the risk for human health. According to article 22 of Regulation (EC) No. 178/2002, data are needed to permit European Food Safety Authority (EFSA) to carry out its mainstay risk Assessment activities. A critical element in the conduct of risk Assessments is therefore the Exposure Assessment which combines data on concentrations of a chemical substance or a biological agent in foods with data on the quantity of those foods consumed across the European Union (EU). The methodology can equally be applied to harmful as well as beneficial substances with regard to food components that are naturally present, food additives, food supplements, contaminants and pesticide residues. The aim of the present paper is to describe the most recent evolutions and the short-term perspectives for Exposure Assessment driven by the progress of the risk analysis process itself and to describe the scientific and technical challenges to take into account the Exposure Assessment as an internal expertise within the EFSA including the creation of databases for food consumption, food composition and food contamination.
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Recent progress in Exposure Assessment and its interaction with the risk analysis process
Trends in Food Science and Technology, 2008Co-Authors: Ph. Verger, S. FabianssonAbstract:The Exposure Assessment for chemicals in food is a crucial component of the risk Assessment process and is part of the practices of expert committees and panels. Its combination with the toxicological evaluation results in characterisation of the risk for human health. According to article 22 of Regulation (EC) No. 178/2002, data are needed to permit European Food Safety Authority (EFSA) to carry out its mainstay risk Assessment activities. A critical element in the conduct of risk Assessments is therefore the Exposure Assessment which combines data on concentrations of a chemical substance or a biological agent in foods with data on the quantity of those foods consumed across the European Union (EU). The methodology can equally be applied to harmful as well as beneficial substances with regard to food components that are naturally present, food additives, food supplements, contaminants and pesticide residues. The aim of the present paper is to describe the most recent evolutions and the short-term perspectives for Exposure Assessment driven by the progress of the risk analysis process itself and to describe the scientific and technical challenges to take into account the Exposure Assessment as an internal expertise within the EFSA including the creation of databases for food consumption, food composition and food contamination. All rights reserved, Elsevier
Keith Tait - One of the best experts on this subject based on the ideXlab platform.
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Validation of the Workplace Exposure Assessment Expert System (WORKBOOK)
American Industrial Hygiene Association Journal, 1997Co-Authors: Keith Tait, Maharshi MehtaAbstract:A validation study was conducted to evaluate the accuracy, reliability, and effectiveness of the workplace Exposure Assessment expert system WORKBOOK (Version 1.0), a software system for evaluating and controlling occupational health risks. The application was developed to assist qualified people in performing Exposure Assessments under the guidance of professional hygienists. Fifty Assessments were conducted, representing a wide variety of operations and involving technical staff at five U.S. and international facilities that conduct pharmaceutical research and development, manufacture bulk drug substances and dosage products, and produce medical devices. Important issues examined by the study include (1) assessing the competency and comprehension of users, (2) implementing Exposure Assessments, (3) examining the accuracy and reliability of WORKBOOK'S conclusions and recommendations, (4) improving the Exposure Assessment model and software, and (5) providing training and support services. Despite its ori...
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The Workplace Exposure Assessment Workbook (WORKBOOK)
Applied Occupational and Environmental Hygiene, 1993Co-Authors: Keith TaitAbstract:Abstract Workplace Exposure Assessment models assist knowledgeable, qualified people (e.g., safety and health professionals, chemists, and engineers) to evaluate employee Exposures under the review of a professional hygienist. The Workplace Exposure Assessment Workbook (WORKBOOK) is a qualitative logic model that provides a systematic means for directing industrial hygiene decisions and actions. It has several fundamental functions: compiling an initial characterization of the facility, defining Homogeneous Exposure Groups (HEGs), performing Workplace Exposure Assessments (WEAs), performing Appropriate Monitoring Programs (AMPs), implementing the “hierarchy of controls,” verifying workplace controls, and determining periodic reviews. WORKBOOK can be used in conjunction with other Exposure Assessment tools such as numerical models, monitoring programs, and statistical methods. Tait, K. The Workplace Exposure Assessment Workbook (WORKBOOK). Appl. Occup. Environ. Hyg. 8(1):55-68; 1993.
