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Dominique Laurier - One of the best experts on this subject based on the ideXlab platform.
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mortality from internal and External Radiation exposure in a cohort of male german uranium millers 1946 2008
International Archives of Occupational and Environmental Health, 2015Co-Authors: Michaela Kreuzer, Dominique Laurier, Florian Dufey, Dennis Nowak, J W Marsh, Maria Schnelzer, M Sogl, Linda WalshAbstract:Purpose To examine exposure–response relationships between ionizing Radiation and several mortality outcomes in a subgroup of 4,054 men of the German uranium miner cohort study, who worked between 1946 and 1989 in milling facilities, but never underground or in open pit mines.
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0266 mortality in the french cohort of nuclear workers monitored for External Radiation exposure0266 mortality in the french cohort of nuclear workers monitored for External Radiation exposure
Occupational and Environmental Medicine, 2014Co-Authors: Klervi Leuraud, E Samson, Sylvaine Caerlorho, A Acker, Olivier Laurent, Pierre Laroche, Bernard Le Guen, D Hubert, David B Richardson, Dominique LaurierAbstract:Objectives Understanding the effect of chronic low dose Radiation exposure is crucial for Radiation protection. This study analyses mortality of workers monitored for External Radiation exposure while employed at three major French nuclear companies. Method The cohort includes all workers employed at least one year by CEA, AREVA NC or EDF between 1950 and 1994, monitored for Radiation exposure and alive on 1 January 1968. The mortality follow-up was to 2004. Vital status and causes of death were obtained from national registries. Standardised mortality ratios were assessed using national rates as the reference. Results A total of 59 004 workers were followed-up for an average of 25 years. Mean age at end of follow-up was 56 years. Less than 1% of workers were lost to follow-up. 6310 deaths occurred between 1968 and 2004 including 2547 cancer deaths. A strong healthy worker effect was observed (all-cause SMR = 0.61, 95%-CI: 0.60–0.63). Significant excess mortality was observed for pleura cancer (SMR= 1.71, 95%-CI: 1.24–2.30) and for melanoma (SMR= 1.43, 95%-CI: 1.04–1.92), with no significant trend in SMRs for these outcomes across categories of cumulative Radiation exposure. Conclusions This analysis of French nuclear workers confirms a healthy worker effect but also an excess risk of death from pleura cancer and melanoma. This cohort study is the most informative ever conducted in France among nuclear workers.
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mortality associated with chronic External Radiation exposure in the french combined cohort of nuclear workers
Occupational and Environmental Medicine, 2013Co-Authors: C Metzflamant, E Samson, Sylvaine Caerlorho, A Acker, Olivier Laurent, D Hubert, David B Richardson, Dominique LaurierAbstract:Objective The long-term effects of protracted low level ionising Radiation exposure are investigated in a combined analysis of French nuclear workers employed by the Commissariat a l9Energie Atomique (CEA), AREVA Nuclear Cycle (AREVA NC) and Electricite de France (EDF). Associations between cumulative External Radiation dose and mortality due to solid cancers, leukaemia and circulatory disease were examined. Methods All workers hired by CEA, AREVA NC and EDF between 1950 and 1994 who were employed for at least 1 year, badge-monitored for Radiation exposure and alive on 1 January 1968 were included. Individual data of annual exposure to penetrating photons (X-rays and gamma rays) were reconstructed for each worker. Estimates of Radiation dose–mortality associations were obtained using a linear excess relative risk (ERR) Poisson regression model. Results Among the 59 021 nuclear workers, 2312 died of solid cancer, 78 of leukaemia and 1468 of circulatory diseases during the 1968–2004 period. Approximately 72% of the cohort had a non-zero cumulative Radiation dose estimate, with a mean cumulative dose of 22.5 mSv. Positive but non-significant ERR/Sv were observed for all solid cancers, leukaemia excluding chronic lymphocytic leukaemia (CLL), ischaemic heart diseases and cerebrovascular diseases. A significant ERR/Sv was found for myeloid leukaemia. Conclusions This is the first combined analysis of major French cohorts of nuclear workers. Results were consistent with risks estimated in other nuclear worker cohorts and illustrate the potential of a further joint international study to yield direct risk estimates in support to Radiation protection standards.
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solid cancer mortality associated with chronic External Radiation exposure at the french atomic energy commission and nuclear fuel company
Radiation Research, 2011Co-Authors: C Metzflamant, E Samson, Sylvaine Caerlorho, A Acker, Dominique LaurierAbstract:Abstract Studies of nuclear workers make it possible to directly quantify the risks associated with ionizing Radiation exposure at low doses and low dose rates. Studies of the CEA (Commissariat a l'Energie Atomique) and AREVA Nuclear Cycle (AREVA NC) cohort, currently the most informative such group in France, describe the long-term risk to nuclear workers associated with External exposure. Our aim is to assess the risk of mortality from solid cancers among CEA and AREVA NC nuclear workers and its association with External Radiation exposure. Standardized mortality ratios (SMRs) were calculated and internal Poisson regressions were conducted, controlling for the main confounding factors [sex, attained age, calendar period, company and socioeconomic status (SES)]. During the period 1968–2004, there were 2,035 solid cancers among the 36,769 CEA-AREVA NC workers. Cumulative External Radiation exposure was assessed for the period 1950–2004, and the mean cumulative dose was 12.1 mSv. Mortality rates for all ca...
C Metzflamant - One of the best experts on this subject based on the ideXlab platform.
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mortality associated with chronic External Radiation exposure in the french combined cohort of nuclear workers
Occupational and Environmental Medicine, 2013Co-Authors: C Metzflamant, E Samson, Sylvaine Caerlorho, A Acker, Olivier Laurent, D Hubert, David B Richardson, Dominique LaurierAbstract:Objective The long-term effects of protracted low level ionising Radiation exposure are investigated in a combined analysis of French nuclear workers employed by the Commissariat a l9Energie Atomique (CEA), AREVA Nuclear Cycle (AREVA NC) and Electricite de France (EDF). Associations between cumulative External Radiation dose and mortality due to solid cancers, leukaemia and circulatory disease were examined. Methods All workers hired by CEA, AREVA NC and EDF between 1950 and 1994 who were employed for at least 1 year, badge-monitored for Radiation exposure and alive on 1 January 1968 were included. Individual data of annual exposure to penetrating photons (X-rays and gamma rays) were reconstructed for each worker. Estimates of Radiation dose–mortality associations were obtained using a linear excess relative risk (ERR) Poisson regression model. Results Among the 59 021 nuclear workers, 2312 died of solid cancer, 78 of leukaemia and 1468 of circulatory diseases during the 1968–2004 period. Approximately 72% of the cohort had a non-zero cumulative Radiation dose estimate, with a mean cumulative dose of 22.5 mSv. Positive but non-significant ERR/Sv were observed for all solid cancers, leukaemia excluding chronic lymphocytic leukaemia (CLL), ischaemic heart diseases and cerebrovascular diseases. A significant ERR/Sv was found for myeloid leukaemia. Conclusions This is the first combined analysis of major French cohorts of nuclear workers. Results were consistent with risks estimated in other nuclear worker cohorts and illustrate the potential of a further joint international study to yield direct risk estimates in support to Radiation protection standards.
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solid cancer mortality associated with chronic External Radiation exposure at the french atomic energy commission and nuclear fuel company
Radiation Research, 2011Co-Authors: C Metzflamant, E Samson, Sylvaine Caerlorho, A Acker, Dominique LaurierAbstract:Abstract Studies of nuclear workers make it possible to directly quantify the risks associated with ionizing Radiation exposure at low doses and low dose rates. Studies of the CEA (Commissariat a l'Energie Atomique) and AREVA Nuclear Cycle (AREVA NC) cohort, currently the most informative such group in France, describe the long-term risk to nuclear workers associated with External exposure. Our aim is to assess the risk of mortality from solid cancers among CEA and AREVA NC nuclear workers and its association with External Radiation exposure. Standardized mortality ratios (SMRs) were calculated and internal Poisson regressions were conducted, controlling for the main confounding factors [sex, attained age, calendar period, company and socioeconomic status (SES)]. During the period 1968–2004, there were 2,035 solid cancers among the 36,769 CEA-AREVA NC workers. Cumulative External Radiation exposure was assessed for the period 1950–2004, and the mean cumulative dose was 12.1 mSv. Mortality rates for all ca...
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External Radiation exposure and mortality in a cohort of french nuclear workers
Occupational and Environmental Medicine, 2007Co-Authors: M Tellelamberton, E Samson, Sylvaine Caer, D Bergot, Denis Bard, Francis Bermann, J M Gelas, J M Giraud, P Hubert, C MetzflamantAbstract:Objective: To analyse the effect of External Radiation exposure on the mortality of French nuclear workers. Methods: A cohort of 29 204 workers employed between 1950 and 1994 at the French Atomic Energy Commission (Commissariat a l’Energie Atomique (CEA)) or at the General Company of Nuclear Fuel (COmpagnie GEnerale des MAtieres nucleaires (Cogema, now Areva NC)) was followed up for an average of 17.8 years. Standardised mortality ratios (SMRs) were computed with reference to French mortality rates. Dose-effect relationship were analysed through trend tests and Poisson regression, with linear and log-linear models. Results: The mean exposure to X and gamma Radiation was 8.3 mSv (16.9 mSv for exposed worker population). A total of 1842 deaths occurred between 1968 and 1994. A healthy worker effect was observed, the number of deaths in the cohort being 59% of the number expected from national mortality statistics. Among the 21 main cancer sites studied, a statistically significant excess was observed only for skin melanoma, and an excess of borderline statistical significance was observed for multiple myeloma. A dose-effect relationship was observed for leukaemia after exclusion of chronic lymphoid leukaemia (CLL). The relative risk observed for non-CLL leukaemia, n = 20, was 4.1 per 100 mSv (90% CI 1.4 to 12.2), linear model and 2.2 per 100 mSv (90% CI 1.2 to 3.3), log-linear model. Significant dose-effect relationship were also observed for causes of deaths associated with alcohol consumption: mouth and pharynx cancer, cirrhosis and alcoholic psychosis and External causes of death. Conclusion: The risk of leukaemia increases with increasing exposure to External Radiation; this is consistent with published results on other nuclear workers cohorts.
E Samson - One of the best experts on this subject based on the ideXlab platform.
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0266 mortality in the french cohort of nuclear workers monitored for External Radiation exposure0266 mortality in the french cohort of nuclear workers monitored for External Radiation exposure
Occupational and Environmental Medicine, 2014Co-Authors: Klervi Leuraud, E Samson, Sylvaine Caerlorho, A Acker, Olivier Laurent, Pierre Laroche, Bernard Le Guen, D Hubert, David B Richardson, Dominique LaurierAbstract:Objectives Understanding the effect of chronic low dose Radiation exposure is crucial for Radiation protection. This study analyses mortality of workers monitored for External Radiation exposure while employed at three major French nuclear companies. Method The cohort includes all workers employed at least one year by CEA, AREVA NC or EDF between 1950 and 1994, monitored for Radiation exposure and alive on 1 January 1968. The mortality follow-up was to 2004. Vital status and causes of death were obtained from national registries. Standardised mortality ratios were assessed using national rates as the reference. Results A total of 59 004 workers were followed-up for an average of 25 years. Mean age at end of follow-up was 56 years. Less than 1% of workers were lost to follow-up. 6310 deaths occurred between 1968 and 2004 including 2547 cancer deaths. A strong healthy worker effect was observed (all-cause SMR = 0.61, 95%-CI: 0.60–0.63). Significant excess mortality was observed for pleura cancer (SMR= 1.71, 95%-CI: 1.24–2.30) and for melanoma (SMR= 1.43, 95%-CI: 1.04–1.92), with no significant trend in SMRs for these outcomes across categories of cumulative Radiation exposure. Conclusions This analysis of French nuclear workers confirms a healthy worker effect but also an excess risk of death from pleura cancer and melanoma. This cohort study is the most informative ever conducted in France among nuclear workers.
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mortality associated with chronic External Radiation exposure in the french combined cohort of nuclear workers
Occupational and Environmental Medicine, 2013Co-Authors: C Metzflamant, E Samson, Sylvaine Caerlorho, A Acker, Olivier Laurent, D Hubert, David B Richardson, Dominique LaurierAbstract:Objective The long-term effects of protracted low level ionising Radiation exposure are investigated in a combined analysis of French nuclear workers employed by the Commissariat a l9Energie Atomique (CEA), AREVA Nuclear Cycle (AREVA NC) and Electricite de France (EDF). Associations between cumulative External Radiation dose and mortality due to solid cancers, leukaemia and circulatory disease were examined. Methods All workers hired by CEA, AREVA NC and EDF between 1950 and 1994 who were employed for at least 1 year, badge-monitored for Radiation exposure and alive on 1 January 1968 were included. Individual data of annual exposure to penetrating photons (X-rays and gamma rays) were reconstructed for each worker. Estimates of Radiation dose–mortality associations were obtained using a linear excess relative risk (ERR) Poisson regression model. Results Among the 59 021 nuclear workers, 2312 died of solid cancer, 78 of leukaemia and 1468 of circulatory diseases during the 1968–2004 period. Approximately 72% of the cohort had a non-zero cumulative Radiation dose estimate, with a mean cumulative dose of 22.5 mSv. Positive but non-significant ERR/Sv were observed for all solid cancers, leukaemia excluding chronic lymphocytic leukaemia (CLL), ischaemic heart diseases and cerebrovascular diseases. A significant ERR/Sv was found for myeloid leukaemia. Conclusions This is the first combined analysis of major French cohorts of nuclear workers. Results were consistent with risks estimated in other nuclear worker cohorts and illustrate the potential of a further joint international study to yield direct risk estimates in support to Radiation protection standards.
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solid cancer mortality associated with chronic External Radiation exposure at the french atomic energy commission and nuclear fuel company
Radiation Research, 2011Co-Authors: C Metzflamant, E Samson, Sylvaine Caerlorho, A Acker, Dominique LaurierAbstract:Abstract Studies of nuclear workers make it possible to directly quantify the risks associated with ionizing Radiation exposure at low doses and low dose rates. Studies of the CEA (Commissariat a l'Energie Atomique) and AREVA Nuclear Cycle (AREVA NC) cohort, currently the most informative such group in France, describe the long-term risk to nuclear workers associated with External exposure. Our aim is to assess the risk of mortality from solid cancers among CEA and AREVA NC nuclear workers and its association with External Radiation exposure. Standardized mortality ratios (SMRs) were calculated and internal Poisson regressions were conducted, controlling for the main confounding factors [sex, attained age, calendar period, company and socioeconomic status (SES)]. During the period 1968–2004, there were 2,035 solid cancers among the 36,769 CEA-AREVA NC workers. Cumulative External Radiation exposure was assessed for the period 1950–2004, and the mean cumulative dose was 12.1 mSv. Mortality rates for all ca...
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External Radiation exposure and mortality in a cohort of french nuclear workers
Occupational and Environmental Medicine, 2007Co-Authors: M Tellelamberton, E Samson, Sylvaine Caer, D Bergot, Denis Bard, Francis Bermann, J M Gelas, J M Giraud, P Hubert, C MetzflamantAbstract:Objective: To analyse the effect of External Radiation exposure on the mortality of French nuclear workers. Methods: A cohort of 29 204 workers employed between 1950 and 1994 at the French Atomic Energy Commission (Commissariat a l’Energie Atomique (CEA)) or at the General Company of Nuclear Fuel (COmpagnie GEnerale des MAtieres nucleaires (Cogema, now Areva NC)) was followed up for an average of 17.8 years. Standardised mortality ratios (SMRs) were computed with reference to French mortality rates. Dose-effect relationship were analysed through trend tests and Poisson regression, with linear and log-linear models. Results: The mean exposure to X and gamma Radiation was 8.3 mSv (16.9 mSv for exposed worker population). A total of 1842 deaths occurred between 1968 and 1994. A healthy worker effect was observed, the number of deaths in the cohort being 59% of the number expected from national mortality statistics. Among the 21 main cancer sites studied, a statistically significant excess was observed only for skin melanoma, and an excess of borderline statistical significance was observed for multiple myeloma. A dose-effect relationship was observed for leukaemia after exclusion of chronic lymphoid leukaemia (CLL). The relative risk observed for non-CLL leukaemia, n = 20, was 4.1 per 100 mSv (90% CI 1.4 to 12.2), linear model and 2.2 per 100 mSv (90% CI 1.2 to 3.3), log-linear model. Significant dose-effect relationship were also observed for causes of deaths associated with alcohol consumption: mouth and pharynx cancer, cirrhosis and alcoholic psychosis and External causes of death. Conclusion: The risk of leukaemia increases with increasing exposure to External Radiation; this is consistent with published results on other nuclear workers cohorts.
Etsuji Suzuki - One of the best experts on this subject based on the ideXlab platform.
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associations between childhood thyroid cancer and External Radiation dose after the fukushima daiichi nuclear power plant accident
Epidemiology, 2018Co-Authors: Toshihide Tsuda, Akiko Tokinobu, Eiji Yamamoto, Etsuji SuzukiAbstract:To the Editor:In 2011, the Great East Japan Earthquake and subsequent tsunami hit the Fukushima Daiichi Nuclear Power Plant, causing it to release radioactive elements. Six months later, Fukushima Prefecture started thyroid gland examinations to determine the effects of Radiation on incidence of thy
David B Richardson - One of the best experts on this subject based on the ideXlab platform.
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0266 mortality in the french cohort of nuclear workers monitored for External Radiation exposure0266 mortality in the french cohort of nuclear workers monitored for External Radiation exposure
Occupational and Environmental Medicine, 2014Co-Authors: Klervi Leuraud, E Samson, Sylvaine Caerlorho, A Acker, Olivier Laurent, Pierre Laroche, Bernard Le Guen, D Hubert, David B Richardson, Dominique LaurierAbstract:Objectives Understanding the effect of chronic low dose Radiation exposure is crucial for Radiation protection. This study analyses mortality of workers monitored for External Radiation exposure while employed at three major French nuclear companies. Method The cohort includes all workers employed at least one year by CEA, AREVA NC or EDF between 1950 and 1994, monitored for Radiation exposure and alive on 1 January 1968. The mortality follow-up was to 2004. Vital status and causes of death were obtained from national registries. Standardised mortality ratios were assessed using national rates as the reference. Results A total of 59 004 workers were followed-up for an average of 25 years. Mean age at end of follow-up was 56 years. Less than 1% of workers were lost to follow-up. 6310 deaths occurred between 1968 and 2004 including 2547 cancer deaths. A strong healthy worker effect was observed (all-cause SMR = 0.61, 95%-CI: 0.60–0.63). Significant excess mortality was observed for pleura cancer (SMR= 1.71, 95%-CI: 1.24–2.30) and for melanoma (SMR= 1.43, 95%-CI: 1.04–1.92), with no significant trend in SMRs for these outcomes across categories of cumulative Radiation exposure. Conclusions This analysis of French nuclear workers confirms a healthy worker effect but also an excess risk of death from pleura cancer and melanoma. This cohort study is the most informative ever conducted in France among nuclear workers.
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mortality associated with chronic External Radiation exposure in the french combined cohort of nuclear workers
Occupational and Environmental Medicine, 2013Co-Authors: C Metzflamant, E Samson, Sylvaine Caerlorho, A Acker, Olivier Laurent, D Hubert, David B Richardson, Dominique LaurierAbstract:Objective The long-term effects of protracted low level ionising Radiation exposure are investigated in a combined analysis of French nuclear workers employed by the Commissariat a l9Energie Atomique (CEA), AREVA Nuclear Cycle (AREVA NC) and Electricite de France (EDF). Associations between cumulative External Radiation dose and mortality due to solid cancers, leukaemia and circulatory disease were examined. Methods All workers hired by CEA, AREVA NC and EDF between 1950 and 1994 who were employed for at least 1 year, badge-monitored for Radiation exposure and alive on 1 January 1968 were included. Individual data of annual exposure to penetrating photons (X-rays and gamma rays) were reconstructed for each worker. Estimates of Radiation dose–mortality associations were obtained using a linear excess relative risk (ERR) Poisson regression model. Results Among the 59 021 nuclear workers, 2312 died of solid cancer, 78 of leukaemia and 1468 of circulatory diseases during the 1968–2004 period. Approximately 72% of the cohort had a non-zero cumulative Radiation dose estimate, with a mean cumulative dose of 22.5 mSv. Positive but non-significant ERR/Sv were observed for all solid cancers, leukaemia excluding chronic lymphocytic leukaemia (CLL), ischaemic heart diseases and cerebrovascular diseases. A significant ERR/Sv was found for myeloid leukaemia. Conclusions This is the first combined analysis of major French cohorts of nuclear workers. Results were consistent with risks estimated in other nuclear worker cohorts and illustrate the potential of a further joint international study to yield direct risk estimates in support to Radiation protection standards.
