The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Isabelle Arnulf - One of the best experts on this subject based on the ideXlab platform.
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gba mutations are associated with rapid Eye Movement sleep behavior disorder
Annals of clinical and translational neurology, 2015Co-Authors: Isabelle Arnulf, Jean-françois Gagnon, Ronald B. Postuma, Ziv Ganor, Anat Mirelman, Anat Barshira, Yves Dauvilliers, Alex Desautels, Claire S LeblondAbstract:Rapid Eye Movement sleep behavior disorder and GBA mutations are both associated with Parkinson's disease. The GBA gene was sequenced in idiopathic rapid Eye Movement sleep behavior disorder patients (n = 265), and compared to controls (n = 2240). Rapid Eye Movement sleep behavior disorder questionnaire was performed in an independent Parkinson's disease cohort (n = 120). GBA mutations carriers had an OR of 6.24 (10.2% in patients vs. 1.8% in controls, P < 0.0001) for rapid Eye Movement sleep behavior disorder, and among Parkinson's disease patients, the OR for mutation carriers to have probable rapid Eye Movement sleep behavior disorder was 3.13 (P = 0.039). These results demonstrate that rapid Eye Movement sleep behavior disorder is associated with GBA mutations, and that combining genetic and prodromal data may assist in identifying individuals susceptible to Parkinson's disease.
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do the Eyes scan dream images during rapid Eye Movement sleep evidence from the rapid Eye Movement sleep behaviour disorder model
Brain, 2010Co-Authors: Isabelle Arnulf, Laurene Leclairvisonneau, Delphine Oudiette, Bertrand Gaymard, Smaranda LeusemenescuAbstract:Rapid Eye Movements and complex visual dreams are salient features of human rapid Eye Movement sleep. However, it remains to be elucidated whether the Eyes scan dream images, despite studies that have retrospectively compared the direction of rapid Eye Movements to the dream recall recorded after having awakened the sleeper. We used the model of rapid Eye Movement sleep behaviour disorder (when patients enact their dreams by persistence of muscle tone) to determine directly whether the Eyes move in the same directions as the head and limbs. In 56 patients with rapid Eye Movement sleep behaviour disorder and 17 healthy matched controls, the Eye Movements were monitored by electrooculography in four (right, left, up and down) directions, calibrated with a target and synchronized with video and sleep monitoring. The rapid Eye Movement sleep behaviour disorder-associated behaviours occurred 2.1 times more frequently during rapid Eye Movement sleep with than without rapid Eye Movements, and more often during or after rapid Eye Movements than before. Rapid Eye Movement density, index and complexity were similar in patients with rapid Eye Movement sleep behaviour disorder and controls. When rapid Eye Movements accompanied goal-oriented motor behaviour during rapid Eye Movement sleep behaviour disorder (e.g. grabbing a fictive object, hand greetings, climbing a ladder), which happened in 19 sequences, 82% were directed towards the action of the patient (same plane and direction). When restricted to the determinant rapid Eye Movements, the concordance increased to 90%. Rapid Eye Movements were absent in 38–42% of behaviours. This directional coherence between limbs, head and Eye Movements during rapid Eye Movement sleep behaviour disorder suggests that, when present, rapid Eye Movements imitate the scanning of the dream scene. Since the rapid Eye Movements are similar in subjects with and without rapid Eye Movement sleep behaviour disorder, this concordance can be extended to normal rapid Eye Movement sleep.
Bertrand Gaymard - One of the best experts on this subject based on the ideXlab platform.
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horizontal and vertical Eye Movement metrics what is important
Clinical Neurophysiology, 2013Co-Authors: Cecilia Bonnet, Jaromir Hanuska, Jan Rusz, Sophie Rivaudpechoux, Tomas Sieger, Veronika Majerova, Tereza Serranova, Bertrand GaymardAbstract:Abstract Objective To assist other Eye Movement investigators in the design and analysis of their studies. Methods We examined basic saccadic Eye Movements and smooth pursuit in the horizontal and vertical directions with video-oculography in a group of 145 healthy subjects between 19 and 82years of age. Results Gender and education level did not influence Eye Movement metrics. With age, the latency of leftward and vertical pro- and antisaccades increased ( p p p p p Conclusions Some Eye Movement metrics must be separated by the direction of Movement, others according to subject age, while others may be pooled. Significance This study provides important information for new oculomotor laboratories concerning the constitution of subject groups and the analysis of Eye Movement metrics.
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do the Eyes scan dream images during rapid Eye Movement sleep evidence from the rapid Eye Movement sleep behaviour disorder model
Brain, 2010Co-Authors: Isabelle Arnulf, Laurene Leclairvisonneau, Delphine Oudiette, Bertrand Gaymard, Smaranda LeusemenescuAbstract:Rapid Eye Movements and complex visual dreams are salient features of human rapid Eye Movement sleep. However, it remains to be elucidated whether the Eyes scan dream images, despite studies that have retrospectively compared the direction of rapid Eye Movements to the dream recall recorded after having awakened the sleeper. We used the model of rapid Eye Movement sleep behaviour disorder (when patients enact their dreams by persistence of muscle tone) to determine directly whether the Eyes move in the same directions as the head and limbs. In 56 patients with rapid Eye Movement sleep behaviour disorder and 17 healthy matched controls, the Eye Movements were monitored by electrooculography in four (right, left, up and down) directions, calibrated with a target and synchronized with video and sleep monitoring. The rapid Eye Movement sleep behaviour disorder-associated behaviours occurred 2.1 times more frequently during rapid Eye Movement sleep with than without rapid Eye Movements, and more often during or after rapid Eye Movements than before. Rapid Eye Movement density, index and complexity were similar in patients with rapid Eye Movement sleep behaviour disorder and controls. When rapid Eye Movements accompanied goal-oriented motor behaviour during rapid Eye Movement sleep behaviour disorder (e.g. grabbing a fictive object, hand greetings, climbing a ladder), which happened in 19 sequences, 82% were directed towards the action of the patient (same plane and direction). When restricted to the determinant rapid Eye Movements, the concordance increased to 90%. Rapid Eye Movements were absent in 38–42% of behaviours. This directional coherence between limbs, head and Eye Movements during rapid Eye Movement sleep behaviour disorder suggests that, when present, rapid Eye Movements imitate the scanning of the dream scene. Since the rapid Eye Movements are similar in subjects with and without rapid Eye Movement sleep behaviour disorder, this concordance can be extended to normal rapid Eye Movement sleep.
Yves Dauvilliers - One of the best experts on this subject based on the ideXlab platform.
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gba mutations are associated with rapid Eye Movement sleep behavior disorder
Annals of clinical and translational neurology, 2015Co-Authors: Isabelle Arnulf, Jean-françois Gagnon, Ronald B. Postuma, Ziv Ganor, Anat Mirelman, Anat Barshira, Yves Dauvilliers, Alex Desautels, Claire S LeblondAbstract:Rapid Eye Movement sleep behavior disorder and GBA mutations are both associated with Parkinson's disease. The GBA gene was sequenced in idiopathic rapid Eye Movement sleep behavior disorder patients (n = 265), and compared to controls (n = 2240). Rapid Eye Movement sleep behavior disorder questionnaire was performed in an independent Parkinson's disease cohort (n = 120). GBA mutations carriers had an OR of 6.24 (10.2% in patients vs. 1.8% in controls, P < 0.0001) for rapid Eye Movement sleep behavior disorder, and among Parkinson's disease patients, the OR for mutation carriers to have probable rapid Eye Movement sleep behavior disorder was 3.13 (P = 0.039). These results demonstrate that rapid Eye Movement sleep behavior disorder is associated with GBA mutations, and that combining genetic and prodromal data may assist in identifying individuals susceptible to Parkinson's disease.
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consistent abnormalities in metabolic network activity in idiopathic rapid Eye Movement sleep behaviour disorder
Brain, 2014Co-Authors: Shichun Peng, Yves Dauvilliers, Jian Wang, Huiwei Zhang, David Eidelberg, Chuantao ZuoAbstract:Rapid Eye Movement sleep behaviour disorder has been evaluated using Parkinson’s disease-related metabolic network. It is unknown whether this disorder is itself associated with a unique metabolic network. 18F-fluorodeoxyglucose positron emission tomography was performed in 21 patients (age 65.0 ± 5.6 years) with idiopathic rapid Eye Movement sleep behaviour disorder and 21 age/gender-matched healthy control subjects (age 62.5 ± 7.5 years) to identify a disease-related pattern and examine its evolution in 21 hemi-parkinsonian patients (age 62.6 ± 5.0 years) and 16 moderate parkinsonian patients (age 56.9 ± 12.2 years). We identified a rapid Eye Movement sleep behaviour disorder-related metabolic network characterized by increased activity in pons, thalamus, medial frontal and sensorimotor areas, hippocampus, supramarginal and inferior temporal gyri, and posterior cerebellum, with decreased activity in occipital and superior temporal regions. Compared to the healthy control subjects, network expressions were elevated (P < 0.0001) in the patients with this disorder and in the parkinsonian cohorts but decreased with disease progression. Parkinson’s disease-related network activity was also elevated (P < 0.0001) in the patients with rapid Eye Movement sleep behaviour disorder but lower than in the hemi-parkinsonian cohort. Abnormal metabolic networks may provide markers of idiopathic rapid Eye Movement sleep behaviour disorder to identify those at higher risk to develop neurodegenerative parkinsonism.
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the improvement of Movement and speech during rapid Eye Movement sleep behaviour disorder in multiple system atrophy
Brain, 2011Co-Authors: Valerie Cochen De Cock, Delphine Oudiette, Rachel Debs, Smaranda Leu, Fatai Radji, Michel Tiberge, Sophie Bayard, Emmanuel Roze, Marie Vidailhet, Yves DauvilliersAbstract:Multiple system atrophy is an atypical parkinsonism characterized by severe motor disabilities that are poorly levodopa responsive. Most patients develop rapid Eye Movement sleep behaviour disorder. Because parkinsonism is absent during rapid Eye Movement sleep behaviour disorder in patients with Parkinson's disease, we studied the Movements of patients with multiple system atrophy during rapid Eye Movement sleep. Forty-nine non-demented patients with multiple system atrophy and 49 patients with idiopathic Parkinson's disease were interviewed along with their 98 bed partners using a structured questionnaire. They rated the quality of Movements, vocal and facial expressions during rapid Eye Movement sleep behaviour disorder as better than, equal to or worse than the same activities in an awake state. Sleep and Movements were monitored using video-polysomnography in 22/49 patients with multiple system atrophy and in 19/49 patients with Parkinson's disease. These recordings were analysed for the presence of parkinsonism and cerebellar syndrome during rapid Eye Movement sleep Movements. Clinical rapid Eye Movement sleep behaviour disorder was observed in 43/49 (88%) patients with multiple system atrophy. Reports from the 31/43 bed partners who were able to evaluate Movements during sleep indicate that 81% of the patients showed some form of improvement during rapid Eye Movement sleep behaviour disorder. These included improved Movement (73% of patients: faster, 67%; stronger, 52%; and smoother, 26%), improved speech (59% of patients: louder, 55%; more intelligible, 17%; and better articulated, 36%) and normalized facial expression (50% of patients). The rate of improvement was higher in Parkinson's disease than in multiple system atrophy, but no further difference was observed between the two forms of multiple system atrophy (predominant parkinsonism versus cerebellar syndrome). Video-monitored Movements during rapid Eye Movement sleep in patients with multiple system atrophy revealed more expressive faces, and Movements that were faster and more ample in comparison with facial expression and Movements during wakefulness. These Movements were still somewhat jerky but lacked any visible parkinsonism. Cerebellar signs were not assessable. We conclude that parkinsonism also disappears during rapid Eye Movement sleep behaviour disorder in patients with multiple system atrophy, but this improvement is not due to enhanced dopamine transmission because these patients are not levodopa-sensitive. These data suggest that these Movements are not influenced by extrapyramidal regions; however, the influence of abnormal cerebellar control remains unclear. The transient disappearance of parkinsonism here is all the more surprising since no treatment (even dopaminergic) provides a real benefit in this disabling disease.
Habib Benali - One of the best experts on this subject based on the ideXlab platform.
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the coeruleus subcoeruleus complex in rapid Eye Movement sleep behaviour disorders in parkinson s disease
Brain, 2013Co-Authors: Daniel Garcialorenzo, Smaranda Leusemenescu, Clarisse Longo Dos Santos, Claire Ewenczyk, Cecile Gallea, Graziella Quattrocchi, Patricia Pita Lobo, Cyril Poupon, Habib BenaliAbstract:In Parkinson’s disease, rapid Eye Movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid Eye Movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid Eye Movement sleep behaviour disorder in Parkinson’s disease is not precisely known; however, the locus subcoeruleus in the brainstem has been implicated as this structure blocks muscle tone during normal rapid Eye Movement sleep in animal models and can be damaged in Parkinson’s disease. Here, we studied the integrity of the locus coeruleus/subcoeruleus complex in patients with Parkinson’s disease using combined neuromelanin-sensitive, structural and diffusion magnetic resonance imaging approaches. We compared 24 patients with Parkinson’s disease and rapid Eye Movement sleep behaviour disorder, 12 patients without rapid Eye Movement sleep behaviour disorder and 19 age- and gender-matched healthy volunteers. All subjects underwent clinical examination and characterization of rapid Eye Movement sleep using video-polysomnography and multimodal imaging at 3 T. Using neuromelanin-sensitive imaging, reduced signal intensity was evident in the locus coeruleus/subcoeruleus area in patients with Parkinson’s disease that was more marked in patients with than those without rapid Eye Movement sleep behaviour disorder. Reduced signal intensity correlated with the percentage of abnormally increased muscle tone during rapid Eye Movement sleep. The results confirmed that this complex is affected in Parkinson’s disease and showed a gradual relationship between damage to this structure, presumably the locus subcoeruleus, and abnormal muscle tone during rapid Eye Movement sleep, which is the cardinal marker of rapid Eye Movement sleep behaviour disorder. In longitudinal studies, the technique may also provide early markers of non-dopaminergic Parkinson’s disease pathology to predict the occurrence of Parkinson’s disease.
Delphine Oudiette - One of the best experts on this subject based on the ideXlab platform.
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the improvement of Movement and speech during rapid Eye Movement sleep behaviour disorder in multiple system atrophy
Brain, 2011Co-Authors: Valerie Cochen De Cock, Delphine Oudiette, Rachel Debs, Smaranda Leu, Fatai Radji, Michel Tiberge, Sophie Bayard, Emmanuel Roze, Marie Vidailhet, Yves DauvilliersAbstract:Multiple system atrophy is an atypical parkinsonism characterized by severe motor disabilities that are poorly levodopa responsive. Most patients develop rapid Eye Movement sleep behaviour disorder. Because parkinsonism is absent during rapid Eye Movement sleep behaviour disorder in patients with Parkinson's disease, we studied the Movements of patients with multiple system atrophy during rapid Eye Movement sleep. Forty-nine non-demented patients with multiple system atrophy and 49 patients with idiopathic Parkinson's disease were interviewed along with their 98 bed partners using a structured questionnaire. They rated the quality of Movements, vocal and facial expressions during rapid Eye Movement sleep behaviour disorder as better than, equal to or worse than the same activities in an awake state. Sleep and Movements were monitored using video-polysomnography in 22/49 patients with multiple system atrophy and in 19/49 patients with Parkinson's disease. These recordings were analysed for the presence of parkinsonism and cerebellar syndrome during rapid Eye Movement sleep Movements. Clinical rapid Eye Movement sleep behaviour disorder was observed in 43/49 (88%) patients with multiple system atrophy. Reports from the 31/43 bed partners who were able to evaluate Movements during sleep indicate that 81% of the patients showed some form of improvement during rapid Eye Movement sleep behaviour disorder. These included improved Movement (73% of patients: faster, 67%; stronger, 52%; and smoother, 26%), improved speech (59% of patients: louder, 55%; more intelligible, 17%; and better articulated, 36%) and normalized facial expression (50% of patients). The rate of improvement was higher in Parkinson's disease than in multiple system atrophy, but no further difference was observed between the two forms of multiple system atrophy (predominant parkinsonism versus cerebellar syndrome). Video-monitored Movements during rapid Eye Movement sleep in patients with multiple system atrophy revealed more expressive faces, and Movements that were faster and more ample in comparison with facial expression and Movements during wakefulness. These Movements were still somewhat jerky but lacked any visible parkinsonism. Cerebellar signs were not assessable. We conclude that parkinsonism also disappears during rapid Eye Movement sleep behaviour disorder in patients with multiple system atrophy, but this improvement is not due to enhanced dopamine transmission because these patients are not levodopa-sensitive. These data suggest that these Movements are not influenced by extrapyramidal regions; however, the influence of abnormal cerebellar control remains unclear. The transient disappearance of parkinsonism here is all the more surprising since no treatment (even dopaminergic) provides a real benefit in this disabling disease.
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do the Eyes scan dream images during rapid Eye Movement sleep evidence from the rapid Eye Movement sleep behaviour disorder model
Brain, 2010Co-Authors: Isabelle Arnulf, Laurene Leclairvisonneau, Delphine Oudiette, Bertrand Gaymard, Smaranda LeusemenescuAbstract:Rapid Eye Movements and complex visual dreams are salient features of human rapid Eye Movement sleep. However, it remains to be elucidated whether the Eyes scan dream images, despite studies that have retrospectively compared the direction of rapid Eye Movements to the dream recall recorded after having awakened the sleeper. We used the model of rapid Eye Movement sleep behaviour disorder (when patients enact their dreams by persistence of muscle tone) to determine directly whether the Eyes move in the same directions as the head and limbs. In 56 patients with rapid Eye Movement sleep behaviour disorder and 17 healthy matched controls, the Eye Movements were monitored by electrooculography in four (right, left, up and down) directions, calibrated with a target and synchronized with video and sleep monitoring. The rapid Eye Movement sleep behaviour disorder-associated behaviours occurred 2.1 times more frequently during rapid Eye Movement sleep with than without rapid Eye Movements, and more often during or after rapid Eye Movements than before. Rapid Eye Movement density, index and complexity were similar in patients with rapid Eye Movement sleep behaviour disorder and controls. When rapid Eye Movements accompanied goal-oriented motor behaviour during rapid Eye Movement sleep behaviour disorder (e.g. grabbing a fictive object, hand greetings, climbing a ladder), which happened in 19 sequences, 82% were directed towards the action of the patient (same plane and direction). When restricted to the determinant rapid Eye Movements, the concordance increased to 90%. Rapid Eye Movements were absent in 38–42% of behaviours. This directional coherence between limbs, head and Eye Movements during rapid Eye Movement sleep behaviour disorder suggests that, when present, rapid Eye Movements imitate the scanning of the dream scene. Since the rapid Eye Movements are similar in subjects with and without rapid Eye Movement sleep behaviour disorder, this concordance can be extended to normal rapid Eye Movement sleep.
