The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
T Oshika - One of the best experts on this subject based on the ideXlab platform.
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effects of pilocarpine and tropicamide on blood aqueous barrier permeability in man
Investigative Ophthalmology & Visual Science, 1992Co-Authors: Mikiro Mori, M Araie, Masahiko Sakurai, T OshikaAbstract:The time courses of changes in the effects of topical pilocarpine and tropicamide on the index of the blood-aqueous barrier permeability to plasma Protein (Pin) were determined in normal volunteers. Before and after drug instillation in one Eye, Protein concentration in the anterior chamber (Ca) was determined from aqueous flare intensity with a laser flare-cell meter and from aqueous flow by fluorophotometry. The Pin was calculated from the Ca, plasma Protein concentration, and aqueous flow. One percent pilocarpine produced a maximum increase of 21 ± 10% in the Ca (mean ± SEM, n = 10), no significant change in the aqueous flow (n = 5), and a maximum increase of 29 ± 10% in the Pin (n = 10). Three percent pilocarpine produced a maximum increase of 55 ± 11% in the Ca (n = 8), a maximum increase of 34 ± 13% in the aqueous flow (n = 5), and a maximum increase of 74 ± 18% in the Pin (n = 8). Tropicamide (0.4%) produced a maximum decrease of 17 ± 7% in the Ca (n = 8), a maximum decrease of 15 ± 11% in the aqueous flow (n = 8), and a maximum decrease of 24 ± 13% in the Pin (n = 8). The results indicated that pilocarpine increased the blood-aqueous barrier permeability to plasma Protein in a dose-dependent manner and that tropicamide reduced it. Invest Ophthalmol Vis Sci 33:416-423,1992
Mikiro Mori - One of the best experts on this subject based on the ideXlab platform.
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effects of pilocarpine and tropicamide on blood aqueous barrier permeability in man
Investigative Ophthalmology & Visual Science, 1992Co-Authors: Mikiro Mori, M Araie, Masahiko Sakurai, T OshikaAbstract:The time courses of changes in the effects of topical pilocarpine and tropicamide on the index of the blood-aqueous barrier permeability to plasma Protein (Pin) were determined in normal volunteers. Before and after drug instillation in one Eye, Protein concentration in the anterior chamber (Ca) was determined from aqueous flare intensity with a laser flare-cell meter and from aqueous flow by fluorophotometry. The Pin was calculated from the Ca, plasma Protein concentration, and aqueous flow. One percent pilocarpine produced a maximum increase of 21 ± 10% in the Ca (mean ± SEM, n = 10), no significant change in the aqueous flow (n = 5), and a maximum increase of 29 ± 10% in the Pin (n = 10). Three percent pilocarpine produced a maximum increase of 55 ± 11% in the Ca (n = 8), a maximum increase of 34 ± 13% in the aqueous flow (n = 5), and a maximum increase of 74 ± 18% in the Pin (n = 8). Tropicamide (0.4%) produced a maximum decrease of 17 ± 7% in the Ca (n = 8), a maximum decrease of 15 ± 11% in the aqueous flow (n = 8), and a maximum decrease of 24 ± 13% in the Pin (n = 8). The results indicated that pilocarpine increased the blood-aqueous barrier permeability to plasma Protein in a dose-dependent manner and that tropicamide reduced it. Invest Ophthalmol Vis Sci 33:416-423,1992
Swagata Dasgupta - One of the best experts on this subject based on the ideXlab platform.
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Preparation, characterization, and in vitro release study of curcumin-loaded cataractous Eye Protein isolate films
Emergent Materials, 2019Co-Authors: Sultana Parveen, Pooja Ghosh, Satarupa Gupta, Aritra Mitra, Swagata DasguptaAbstract:Curcumin, a naturally occurring polyphenol despite having therapeutic properties, has limited application due to its poor solubility in aqueous medium. The aim of this study is to explore a new Protein source developed as a Protein film, for the delivery of curcumin. The cataractous Eye Protein isolate (CEPI) is a mixture of Proteins obtained after phacoemulsification surgery of the Eye lens. The films have been prepared from the discarded CEPI and investigated for potential applications as a delivery system for curcumin. The films were prepared using glycerol as the plasticizer and glutaraldehyde as the cross-linker. The mechanical properties of the films were monitored by using nanoindentation techniques (NINT). The curcumin-loaded films were characterized by Fourier transform spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), and thermogravimetric analysis (TGA) which established the incorporation of curcumin in the Protein matrix. The loading efficiency of the films was found to be dependent on the degree of cross-linking of the films. In vitro release studies showed an initial burst release followed by a sustained release. The release rate is higher at pH 4.5 compared with pH 7.4. The released aliquots of curcumin-loaded films also exhibit antibacterial effects against Staphylococcus aureus. Our findings will be generally beneficial for the further reshaping of Protein films as potential delivery carriers. Graphical abstract
Masahiko Sakurai - One of the best experts on this subject based on the ideXlab platform.
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effects of pilocarpine and tropicamide on blood aqueous barrier permeability in man
Investigative Ophthalmology & Visual Science, 1992Co-Authors: Mikiro Mori, M Araie, Masahiko Sakurai, T OshikaAbstract:The time courses of changes in the effects of topical pilocarpine and tropicamide on the index of the blood-aqueous barrier permeability to plasma Protein (Pin) were determined in normal volunteers. Before and after drug instillation in one Eye, Protein concentration in the anterior chamber (Ca) was determined from aqueous flare intensity with a laser flare-cell meter and from aqueous flow by fluorophotometry. The Pin was calculated from the Ca, plasma Protein concentration, and aqueous flow. One percent pilocarpine produced a maximum increase of 21 ± 10% in the Ca (mean ± SEM, n = 10), no significant change in the aqueous flow (n = 5), and a maximum increase of 29 ± 10% in the Pin (n = 10). Three percent pilocarpine produced a maximum increase of 55 ± 11% in the Ca (n = 8), a maximum increase of 34 ± 13% in the aqueous flow (n = 5), and a maximum increase of 74 ± 18% in the Pin (n = 8). Tropicamide (0.4%) produced a maximum decrease of 17 ± 7% in the Ca (n = 8), a maximum decrease of 15 ± 11% in the aqueous flow (n = 8), and a maximum decrease of 24 ± 13% in the Pin (n = 8). The results indicated that pilocarpine increased the blood-aqueous barrier permeability to plasma Protein in a dose-dependent manner and that tropicamide reduced it. Invest Ophthalmol Vis Sci 33:416-423,1992
M Araie - One of the best experts on this subject based on the ideXlab platform.
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effects of pilocarpine and tropicamide on blood aqueous barrier permeability in man
Investigative Ophthalmology & Visual Science, 1992Co-Authors: Mikiro Mori, M Araie, Masahiko Sakurai, T OshikaAbstract:The time courses of changes in the effects of topical pilocarpine and tropicamide on the index of the blood-aqueous barrier permeability to plasma Protein (Pin) were determined in normal volunteers. Before and after drug instillation in one Eye, Protein concentration in the anterior chamber (Ca) was determined from aqueous flare intensity with a laser flare-cell meter and from aqueous flow by fluorophotometry. The Pin was calculated from the Ca, plasma Protein concentration, and aqueous flow. One percent pilocarpine produced a maximum increase of 21 ± 10% in the Ca (mean ± SEM, n = 10), no significant change in the aqueous flow (n = 5), and a maximum increase of 29 ± 10% in the Pin (n = 10). Three percent pilocarpine produced a maximum increase of 55 ± 11% in the Ca (n = 8), a maximum increase of 34 ± 13% in the aqueous flow (n = 5), and a maximum increase of 74 ± 18% in the Pin (n = 8). Tropicamide (0.4%) produced a maximum decrease of 17 ± 7% in the Ca (n = 8), a maximum decrease of 15 ± 11% in the aqueous flow (n = 8), and a maximum decrease of 24 ± 13% in the Pin (n = 8). The results indicated that pilocarpine increased the blood-aqueous barrier permeability to plasma Protein in a dose-dependent manner and that tropicamide reduced it. Invest Ophthalmol Vis Sci 33:416-423,1992
