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Chengguang Lin - One of the best experts on this subject based on the ideXlab platform.
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Long-term survival outcome and Failure Pattern after intensity-modulated radiotherapy for nasopharyngeal carcinoma
Chinese Journal of Radiation Oncology, 2018Co-Authors: Yunming Tian, Fei Han, Lei Zeng, Ming-zhu Liu, Li Bai, Xiaopeng Zhong, Yu-hong Lan, Chengguang Lin, Shaomin Huang, Xiaowu DengAbstract:Objective To analyze the 10-year survival outcome and Failure Patterns for patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT), aiming to provide reference for optimized treatment for NPC. Methods Clinical data of 866 patients with NPC receiving IMRT from January 2001 to December 2008 were retrospectively analyzed. Survival analysis was performed using the Kaplan-Meier estimator. Univariate analysis was carried out by log-rank test and multivariate analysis was performed using Cox proportional hazards model. Results The median follow-up time was 132 months. The 10-year local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), progression-free survival (PFS) and disease specific survival (DSS) were 92.0%, 83.4%, 75.7% and 78.6%, respectively. A total of 210 patients died including 124 patients (59.0%) from distant metastasis, which was the primary cause of death, and 47(22.3%) from local regional recurrence. Independent negative factors of DSS included age>50 years (P=0.00), LDH≥245 IU/L (P=0.00), Hb 20 cm3(P=0.00). The 10-year LRFS, DMFS and DSS of stage Ⅱ NPC patients did not significantly differ after IMRT alone and chemoradiotherapy (P=0.83, 0.22, 0.23). For patients with stage Ⅲ NPC, the 10-year LRFS and DSS in the chemoradiotherapy arm were significantly higher than those in the IMRT alone (P=0.01, 0.01), whereas no statistical significance was observed in the DMFS between two groups (P=0.14). The overall survival of stage Ⅳa+ Ⅳb NPC patients is relatively poor. Conclusions IMRT can improve the long-term survival of NPC patients. Distant metastasis is the primary Failure Pattern. Patients with stage Ⅰ-Ⅱ NPC can obtain satisfactory survival outcomes after IMRT alone. The addition of chemotherapy can further enhance the LRFS and DSS of stage Ⅲ NPC patients. However, the optimal therapeutic strategy remains to be urgently investigated for stage Ⅳa+ Ⅳb NPC patients. Key words: Nasopharyngeal neoplasms/intensity-modulated radiotherapy; Failure Pattern; Prognosis
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long term outcomes of intensity modulated radiotherapy for 868 patients with nasopharyngeal carcinoma an analysis of survival and treatment toxicities
Radiotherapy and Oncology, 2014Co-Authors: Xueming Sun, Fei Han, Shaomin Huang, Xiaowu Deng, Chunyan Chen, Chong Zhao, Weiwei Xiao, Chengguang LinAbstract:Abstract Background and purpose To evaluate the long-term survival outcomes and toxicity of NPC patients treated with intensity-modulated radiotherapy (IMRT). Materials and methods From May 2001 to October 2008, 868 non-metastatic NPC patients treated by IMRT were analyzed retrospectively. The Radiation Therapy Oncology Group (RTOG) criteria were used to assess toxicity. Results With a median follow-up of 50months (range, 5–115months), the 5-year estimated disease specific survival (DSS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS) and distant metastasis-free survival (DMFS) were 84.7%, 91.8%, 96.4% and 84.6%, respectively. Of the 868 patients, 186 (21.3%) developed Failure after treatment. Distant metastasis was the major Failure Pattern after treatment. The 5-year OS rate in patients with stage I, II, III, and IVa–b were 100.0%, 94.3%, 83.6%, and 70.5%, respectively. The 5-year LRFS rate in patients with stage T1, T2, T3, and T4 disease were 100.0%, 96.0%, 90.4%, and 83.3%, respectively ( χ 2 =26.32, P χ 2 =65.54, P Conclusion IMRT for NPC yielded excellent survival outcomes, and distant metastasis was the most commonly seen Failure Pattern after treatment. The role of concurrent chemotherapy for advanced locoregional stage NPC patients needs to be further investigated. Treatment-related toxicities were well tolerable. However, the incidence of brain radiation damage was relatively high, especially for patients with advanced T-stage.
Jens Overgaard - One of the best experts on this subject based on the ideXlab platform.
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long term age dependent Failure Pattern after breast conserving therapy or mastectomy among danish lymph node negative breast cancer patients
Radiotherapy and Oncology, 2016Co-Authors: Tinne Laurberg, Christina D Lyngholm, Peer Christiansen, Jan Alsner, Jens OvergaardAbstract:Abstract Purpose To describe long-term Failure Pattern after early-stage breast cancer in relation to local treatment (breast-conserving therapy (BCT) or mastectomy) and age. Materials and methods Cohort study with balanced 5-year age groups and prospectively collected data; 813 Danish lymph-node-negative breast cancer patients diagnosed in 1989–98 and treated with mastectomy ( N =515) or BCT ( N =298) and no adjuvant systemic treatment. Results The 20-year local recurrence (LR) risk was 20% after BCT; 8.7% after mastectomy. LR developed in mastectomy patients within the first 10years; in BCT patients throughout the entire 20-year period. Younger patients' (⩽45years) 20-year LR risk was generally higher than older patients' (>45years) (19% vs. 5%, p In younger patients, LR was significantly associated with distant metastasis (DM) (hazard ratio (HR)=2.7(1.8–4.2)) and 20-year breast-cancer mortality (HR=2.7(1.7–4.4)). BCT was associated with higher 20-year breast-cancer mortality (HR=1.5(1.0–2.4)) and higher 20-year all-cause mortality (HR=1.7(1.2–2.5)) than mastectomy. In older patients, LR was not associated with DM, and breast-cancer mortality was similar for BCT and mastectomy. Conclusion BCT patients with no adjuvant systemic treatment developed LR throughout 20-year period and faced higher LR risk than mastectomy patients. LR was associated with DM among younger patients, and younger BCT patients had higher mortality than younger mastectomy patients.
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Failure Pattern and salvage treatment after radical treatment of head and neck cancer
Acta Oncologica, 2016Co-Authors: Anja Pagh, Cai Grau, Jens OvergaardAbstract:AbstractPurpose The aim of the study was to test the hypothesis that head and neck cancer (HNC) patients benefit from specialized follow-up (FU), as this strategy ensures timely detection of relapses for successful salvage treatment. This was done by evaluation of the Pattern of Failure, the temporal distribution of recurrences, and the outcome of salvage treatment in a contemporary cohort of HNC patients.Methods The study evaluated a cohort of 2062 consecutive patients treated with curative intent at Aarhus University Hospital from 1 January 2000 to 31 December 2013. The database of DAHANCA contained recordings of recurrent disease in 567 patients with primary tumors of the larynx, pharynx, oral cavity, nasal cavity, paranasal sinuses and salivary glands. A review of medical records was performed in order to update and supplement the database.Results Failures of the 567 patients were primarily in T-site (65%) followed by N-site (36%) and M-site (22%). The vast majority of the first recurrences occurred w...
Yining Ding - One of the best experts on this subject based on the ideXlab platform.
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shear behaviour of steel fibre reinforced self consolidating concrete beams based on the modified compression field theory
Composite Structures, 2012Co-Authors: Yining Ding, Fasheng Zhang, Fernando Torgal, Yulin ZhangAbstract:Abstract A series of steel fibre reinforced self-consolidating concrete (SFRSCC) beams have been tested to investigate the influence of steel fibres and the combined effect of fibres and stirrups on the deflection and cracking, ultimate loads and Failure Pattern. The experiment indicates that the shear strength increases clearly with the increasing of fibre content. The combination of steel fibres and stirrups demonstrates a positive composite effect on the ultimate load, ductility and Failure Pattern of concrete beam. This study also examines the feasibility of applying the modified compression field theory (MCFT) for the suitable assessment of shear resistance in fibre and steel rebar reinforced self-consolidating concrete beams. For fibre reinforced concrete member, a theoretical method is proposed based on the MCFT. The proposed ultimate shear capacity model was verified by the comparison with different test results.
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study on residual behaviour and flexural toughness of fibre cocktail reinforced self compacting high performance concrete after exposure to high temperature
Construction and Building Materials, 2011Co-Authors: Yining Ding, Cecilia Azevedo, Jose Aguiar, Said JalaliAbstract:This paper analyzed the effect of different fibres on the residual compressive strength, the ultimate load and flexural toughness, the Failure Pattern and the fracture energy of self compacting high performance concrete (SCHPC) after exposure to various high temperature. The micro polypropylene fibre (PP fibre) could mitigate the spalling of SCHPC member significantly, but did not show clear effect on the mechanic properties of concrete. The macro steel fibre (SF) reinforced SCHPC showed higher flexural toughness and ultimate load before and after high temperatures. The mechanical properties of hybrid fibre reinforced SCHPC (HFSCHPC) after heating were better than that of mono fibre reinforced SCHPC. The Failure mode changed from pull-out of steel fibres at lower temperature to broken down of steel fibres at higher temperature. The use of hybrid fibre can be effective in providing the residual strength and Failure Pattern and in improving the toughness and fracture energy of SCHPC after high temperature.
Xiang Ao - One of the best experts on this subject based on the ideXlab platform.
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on the Failure Pattern of sandstone impacted by high velocity water jet
International Journal of Impact Engineering, 2015Co-Authors: Yiyu Lu, Fei Huang, Xiang AoAbstract:Abstract Impingement of rocks by high-velocity water jets causes the erosion of structures, yet is also the principal process for non-traditional drilling and cutting methods, such as hydrodemolition, hydrodynamic fragmentation and cavitating drilling. The Failure Patterns of rocks subjected to water jets with different velocities vary greatly. Based on the theoretical studies, lots of experiments were conducted selecting water jets with velocities ranging from 157 ± 1 m/s to 774 ± 1 m/s. Scanning electron microscopy (SEM) was used to examine the fracture morphology in order to better understand the damage mechanism of sandstone. It's indicated that it will experience three different Failure Patterns in the bulk of sandstone under different jet velocities: (i) the center broken pit surrounded with a circumferential crack on the surface when the jet velocity is above a threshold value between 157 m/s and 316 m/s; (ii) the internal fractures constituted of circumferential fractures, radial fractures and the conical fractures; (iii) the macrocracks on the side surface, which change from transverse cracks to split-like cracks with the increment of jet velocity.
Ziad Salameh - One of the best experts on this subject based on the ideXlab platform.
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the effect of different full coverage crown systems on fracture resistance and Failure Pattern of endodontically treated maxillary incisors restored with and without glass fiber posts
Journal of Endodontics, 2008Co-Authors: Ziad Salameh, Roberto Sorrentino, Hani F Ounsi, Walid Sadig, Fadi Atiyeh, Marco FerrariAbstract:Abstract The aim of this study was to compare the fracture resistance and Failure Pattern of endodontically treated maxillary incisors restored using composite resin with or without fiber-reinforced composite (FRC) posts under different types of full-coverage crowns. The null hypothesis tested was that fracture resistance and the Failure Pattern of these teeth were not affected by the use of FRC posts or by the type of full-coverage crown. One hundred twenty maxillary incisors were endodontically treated and divided into 4 groups of 30 each. Each group was divided into two subgroups: restoration with or without fiber post. PFM crowns were placed in group 1, Empress II crowns in group 2, SR Adoro crowns in group 3, and Cercon crowns in group 4. Fracture tests were performed by loading specimens to fracture. Data were analyzed with two-way analysis of variance (α = 0.05). The type of crown was not a significant factor affecting fracture resistance (p = 0.4), whereas the presence of a post was (p = 0.001). Both the presence of post and the type of crown had a significant influence on the proportion of restorable versus unrestorable fractures. Although prosthodontics textbooks do not generally advocate the placement of fiber posts in endodontically treated incisors, the results of this study indicate that the use of fiber posts in such teeth increases their resistance to fracture and improves the prognosis in case of fracture.
