The Experts below are selected from a list of 5316 Experts worldwide ranked by ideXlab platform
Niayesh Tafazoli - One of the best experts on this subject based on the ideXlab platform.
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an observational epidemiological study of Febrile Convulsion due to urinary tract infection
Journal of nephropathology, 2019Co-Authors: Mitra Naseri, Eltham Bakhtiari, Niayesh TafazoliAbstract:Introduction: Febrile Convulsion (FC) is the most common seizure disorder in childhood. Few studies focused on epidemiologic characteristics of urinary tract infections accompanied by FC. Objectives: To evaluate prevalence and incidence rates of FC among children with urinary tract infection. Patients and Methods: An observational study in epidemiology was performed in nephrology clinic of a tertiary children hospital from June 2002 to 2016. Totally 1242 cases were followed and those aged 6-60 months enrolled in the study. Demographic characteristics were compared between patients with and without FC. Results: 784 cases including 704 girls (89.8%) and 80 boys (10.2%) enrolled. Twenty-five patients (3.18%) presented with FC. FC occurred in 25 of 503 cases (5%) with Febrile urinary tract infection. Twenty girls and 5 boys were in FC and 684 girls and 75 boys were in non-FC groups (P= 0.1). The average age in FC and non-FC groups were 15.52±8.4 and 25.16± 16 months respectively (P=0.004). Patients were divided into 2 age sub-groups: 6-24 and 26-60 months. A significantly higher number of cases in FC compared with non-FC group were in age subgroup of 6-24 months (P=0.028). Conclusion: Our study revealed a prevalence rate of 3.18% and an incidence rate of 5% for FC among children with urinary tract infection. Also FC subjects had a significantly younger age at presentation than non-FC cases. We found that FC as presentation of urinary tract infection occurred up to 3 years old, and there is no significant gender difference between FC and non-FC cases
Amrita Ghimire - One of the best experts on this subject based on the ideXlab platform.
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simple Febrile Convulsion and iron deficiency anemia a co relation in nepalese children
American Journal of Public Health Research, 2015Co-Authors: Tejesh Malla, K K Malla, Brijesh Sathian, Prabha Chettri, Sandip Singh, Amrita GhimireAbstract:Simple Febrile Convulsion is the most common central nervous system disease seen in children. There are hypotheses that thresh hold of neuron excitation maybe affected by iron deficiency anemia. This study was done to find out a co-relation between iron deficiency anemia and simple Febrile Convulsion. The prospective comparative study was conducted at Manipal Teaching Hospital, Pokhara, Nepal 162 children admitted in the pediatric ward were selected and divided into two groups, Febrile Convulsion (Cases) and other causes of fever with no Convulsion (Control). Blood was sent for each child for complete blood count, peripheral smear blood indices and iron profile. Statistical analysis was done using SPSS version 19. A p value <0.05 was considered statistically significant. The patients and controls were 22.55 ±10.220 and 21.64±12.959 months of mean age, respectively. The peak of mean temperature on admission was in the Febrile Convulsion group than controls. (57/92) 61.95 % of cases and 15/70) 21.42% of controls anemic (P< 0.001). Moreover, the group with Febrile Convulsion had significantly lower blood indices, such as Hb, MCV, MCH, MCHC and RDW, compared to control group (P< 0.001).Iron deficiency anemia was significantly higher in cases compared to controls(p<0.001) Iron supplementation can probably increase the threshold of neuron excitation in fever and help prevent Febrile Convulsion in children.
Jing Jane Tsai - One of the best experts on this subject based on the ideXlab platform.
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risk factors for a first Febrile Convulsion in children a population study in southern taiwan
Epilepsia, 1999Co-Authors: Chao Ching Huang, Shan Tair Wang, Ying Chao Chang, Mei Chih Huang, Yunchan Chi, Jing Jane TsaiAbstract:Summary: Purpose: To identify risk factors for a first Febrile Convulsion among 3-year-old children by a matched case-control population study. Methods: All 11,714 neonatal survivors born in Tainan City between October 1989 and September 1991 were enrolled. At age 3, 10,460 children were available for telephone survey for Febrile Convulsions, and were confirmed by home visit interviews. Those without history of seizure were randomly matched to each Febrile Convulsion case by age, gender, and residence district. Results: Two hundred fifty six children had Febrile Convulsions, and 218 of them and their matched controls were available for analysis. The Febrile Convulsion cases had significantly more Febrile episodes (four or more) per year (33.0 vs. 22.5%; p = 0.021), and cases had a higher percentage of developmental delay (3.7 vs. 0.4%; p = 0.046) and a higher percentage of Febrile Convulsions in their siblings (12 vs. 0.4%; p = 0.011) than controls. The other sociodemographic, environmental, and biologic variables showed no differences between cases and controls. Step-wise logistic regression showed a highly significant independent association between Febrile Convulsions and history of Febrile Convulsions in the siblings, and a moderate one between Febrile Convulsions and the number of Febrile episodes per year. Conclusions: The presence of Febrile Convulsions in the siblings and the number of fever episodes per year were the independent and significant predictors of Febrile Convulsion for an individual case in our population-based sample.
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Differences in factors influencing the familial aggregation of Febrile Convulsion in population and hospital patients
Acta neurologica Scandinavica, 1996Co-Authors: Jing Jane Tsai, Chao Ching Huang, Mei Chih Huang, F. W. Lung, Ying Chao ChangAbstract:Socio-demographic data, initial clinical manifestations, outcome and family aggregation of Febrile Convulsion (FC) were compared between 85 population and 364 multicenter patients More patients presented with clustering of seizures and had recurrence of FC in multicenter group than in population group. Multicenter patients had more fever episodes per year, more day-care attendance and a higher incidence of FC history in their parents. The odds ratio of FC in the siblings was 6 :1 in population group and 12 :1 in multicenter group. Lower socioeconomic status influenced the presence of FC in the sibling of population group. Instead, FC histories in the father and paternal cousins of probands had influence on the presence of FC in the siblings of multicenter group. We conclude that the population FC sample rather than the hospital sample is the more representative. And there are differences not only in the clinical manifestations but also in the effect of environmental and genetic influences on the family aggregation in population and hospital patients.
Ying Chao Chang - One of the best experts on this subject based on the ideXlab platform.
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risk factors for a first Febrile Convulsion in children a population study in southern taiwan
Epilepsia, 1999Co-Authors: Chao Ching Huang, Shan Tair Wang, Ying Chao Chang, Mei Chih Huang, Yunchan Chi, Jing Jane TsaiAbstract:Summary: Purpose: To identify risk factors for a first Febrile Convulsion among 3-year-old children by a matched case-control population study. Methods: All 11,714 neonatal survivors born in Tainan City between October 1989 and September 1991 were enrolled. At age 3, 10,460 children were available for telephone survey for Febrile Convulsions, and were confirmed by home visit interviews. Those without history of seizure were randomly matched to each Febrile Convulsion case by age, gender, and residence district. Results: Two hundred fifty six children had Febrile Convulsions, and 218 of them and their matched controls were available for analysis. The Febrile Convulsion cases had significantly more Febrile episodes (four or more) per year (33.0 vs. 22.5%; p = 0.021), and cases had a higher percentage of developmental delay (3.7 vs. 0.4%; p = 0.046) and a higher percentage of Febrile Convulsions in their siblings (12 vs. 0.4%; p = 0.011) than controls. The other sociodemographic, environmental, and biologic variables showed no differences between cases and controls. Step-wise logistic regression showed a highly significant independent association between Febrile Convulsions and history of Febrile Convulsions in the siblings, and a moderate one between Febrile Convulsions and the number of Febrile episodes per year. Conclusions: The presence of Febrile Convulsions in the siblings and the number of fever episodes per year were the independent and significant predictors of Febrile Convulsion for an individual case in our population-based sample.
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Differences in factors influencing the familial aggregation of Febrile Convulsion in population and hospital patients
Acta neurologica Scandinavica, 1996Co-Authors: Jing Jane Tsai, Chao Ching Huang, Mei Chih Huang, F. W. Lung, Ying Chao ChangAbstract:Socio-demographic data, initial clinical manifestations, outcome and family aggregation of Febrile Convulsion (FC) were compared between 85 population and 364 multicenter patients More patients presented with clustering of seizures and had recurrence of FC in multicenter group than in population group. Multicenter patients had more fever episodes per year, more day-care attendance and a higher incidence of FC history in their parents. The odds ratio of FC in the siblings was 6 :1 in population group and 12 :1 in multicenter group. Lower socioeconomic status influenced the presence of FC in the sibling of population group. Instead, FC histories in the father and paternal cousins of probands had influence on the presence of FC in the siblings of multicenter group. We conclude that the population FC sample rather than the hospital sample is the more representative. And there are differences not only in the clinical manifestations but also in the effect of environmental and genetic influences on the family aggregation in population and hospital patients.
Janis F Yao - One of the best experts on this subject based on the ideXlab platform.
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observational safety study of Febrile Convulsion following first dose mmrv vaccination in a managed care setting
Vaccine, 2009Co-Authors: Steven J Jacobsen, Bradley Ackerson, Trung N Tran, Tonia Jones, Janis F YaoAbstract:Abstract Background A combined measles, mumps, rubella, varicella live vaccine (MMRV, Merck and Co., Inc., US) was recently licensed in the US. Pre-licensure clinical trial data showed a significant increase in fever in days 5–12 following MMRV vaccination as compared to the vaccines given separately (MMR + V). This post-licensure retrospective cohort study was undertaken to assess the incidence of Febrile Convulsion following MMRV. Methods Children ages 12–60 months who received a first dose of MMRV in February 2006–June 2007 in a managed care organization were included in the study. Subjects were optimally matched on age, sex, and calendar date of vaccination to children who received MMR + V concomitantly in November 2003–January 2006, before MMRV licensure. Potential cases of Febrile Convulsion were identified through administrative data and adjudicated by expert panel, according to pre-specified criteria. Results During the 30 days post-vaccination, there were 128 and 94 potential Convulsion cases among the 31,298 children in the MMRV and MMR + V cohorts, respectively. After review of available medical charts and adjudication, there were 84 cases of confirmed Febrile Convulsion, 44 (1.41/1000) and 40 (1.28/1000) in the MMRV and MMR + V cohorts, respectively (RR = 1.10, 95% CI = 0.72, 1.69). In days 5–12 following vaccination, a pre-specified period of interest, the respective numbers were 22 (0.70/1000) and 10 (0.32/1000) (RR = 2.20, 95% CI = 1.04, 4.65). Conclusion These data suggest that the risk of Febrile Convulsion is increased in days 5–12 following vaccination with MMRV as compared to MMR + V given separately during the same visit, when post-vaccination fever and rash are also increased in clinical trials. While there was no evidence of an increase in the overall month following vaccination, the elevated risk during this time period should be communicated and needs to be balanced with the potential benefit of a combined vaccine.
