The Experts below are selected from a list of 789 Experts worldwide ranked by ideXlab platform
Patricia S. Walker - One of the best experts on this subject based on the ideXlab platform.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUND A new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-linked HA, and a smooth consistency—which should promote long-lasting corrections and a smooth, natural look and feel postinjection. OBJECTIVE The objective was to compare the effectiveness and safety of these smooth-gel HA dermal fillers with bovine collagen for nasolabial fold (NLF) correction. METHODS AND MATERIALS A total of 439 subjects with moderate or severe NLFs received one of three types of smooth-gel HA dermal filler (in one NLF) and cross-linked bovine collagen (in the other NLF) and were evaluated for ≤24 weeks. RESULTS All three HA dermal fillers achieved considerably longer-lasting clinical correction than bovine collagen; 81% to 90% of HA dermal filler–treated NLFs maintained a clinically significant improvement from baseline for ≥6 months. Up to 88% of subjects preferred the HA dermal fillers over bovine collagen. All fillers were similarly well tolerated. CONCLUSION The smooth-gel HA dermal fillers offer longer-lasting correction than bovine collagen—which may lessen the frequency that repeat treatments are needed. Also, they were preferred by the vast majority of subjects—which should promote patient satisfaction.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUNDA new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-link
Gary D. Monheit - One of the best experts on this subject based on the ideXlab platform.
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comparative physical properties of hyaluronic acid dermal fillers
Dermatologic Surgery, 2009Co-Authors: Jeffrey J Kablik, Gary D. Monheit, Liping Yu, Grace Chang, Julia B GershkovichAbstract:BACKGROUND Hyaluronic acid (HA) fillers are becoming the material of choice for use in cosmetic soft tissue and dermal correction. HA fillers appear to be similar, but their physical characteristics can be quite different. These differences have the potential to affect the ability of the physician to provide the patient with a natural and enduring result. OBJECTIVE The objective of this article is to discuss the key physical properties and methods used in characterizing dermal fillers. These methods were then used to analyze several well-known commercially available fillers. METHODS AND MATERIALS Analytical methods were employed to generate data on the properties of various fillers. The measured physical properties were concentration, gel-to-fluid ratio, HA gel concentration, degree of HA modification, percentage of cross-linking, swelling, modulus, and particle size. RESULTS The results demonstrated that commercial fillers exhibit a wide variety of properties. CONCLUSION Combining the objective factors that influence filler performance with clinical experience will provide the patient with the optimal product for achieving the best cosmetic result. A careful review of these gel characteristics is essential in determining filler selection, performance, and patient expectations.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUND A new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-linked HA, and a smooth consistency—which should promote long-lasting corrections and a smooth, natural look and feel postinjection. OBJECTIVE The objective was to compare the effectiveness and safety of these smooth-gel HA dermal fillers with bovine collagen for nasolabial fold (NLF) correction. METHODS AND MATERIALS A total of 439 subjects with moderate or severe NLFs received one of three types of smooth-gel HA dermal filler (in one NLF) and cross-linked bovine collagen (in the other NLF) and were evaluated for ≤24 weeks. RESULTS All three HA dermal fillers achieved considerably longer-lasting clinical correction than bovine collagen; 81% to 90% of HA dermal filler–treated NLFs maintained a clinically significant improvement from baseline for ≥6 months. Up to 88% of subjects preferred the HA dermal fillers over bovine collagen. All fillers were similarly well tolerated. CONCLUSION The smooth-gel HA dermal fillers offer longer-lasting correction than bovine collagen—which may lessen the frequency that repeat treatments are needed. Also, they were preferred by the vast majority of subjects—which should promote patient satisfaction.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUNDA new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-link
Leslie Baumann - One of the best experts on this subject based on the ideXlab platform.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUND A new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-linked HA, and a smooth consistency—which should promote long-lasting corrections and a smooth, natural look and feel postinjection. OBJECTIVE The objective was to compare the effectiveness and safety of these smooth-gel HA dermal fillers with bovine collagen for nasolabial fold (NLF) correction. METHODS AND MATERIALS A total of 439 subjects with moderate or severe NLFs received one of three types of smooth-gel HA dermal filler (in one NLF) and cross-linked bovine collagen (in the other NLF) and were evaluated for ≤24 weeks. RESULTS All three HA dermal fillers achieved considerably longer-lasting clinical correction than bovine collagen; 81% to 90% of HA dermal filler–treated NLFs maintained a clinically significant improvement from baseline for ≥6 months. Up to 88% of subjects preferred the HA dermal fillers over bovine collagen. All fillers were similarly well tolerated. CONCLUSION The smooth-gel HA dermal fillers offer longer-lasting correction than bovine collagen—which may lessen the frequency that repeat treatments are needed. Also, they were preferred by the vast majority of subjects—which should promote patient satisfaction.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUNDA new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-link
Jane A Thomas - One of the best experts on this subject based on the ideXlab platform.
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safety and effectiveness of hyaluronic acid fillers in skin of color
Journal of Cosmetic Dermatology, 2009Co-Authors: Pearl E Grimes, Jane A Thomas, Diane K. MurphyAbstract:OBJECTIVES: To assess the safety and effectiveness of hyaluronic acid (HA) fillers in skin of color. METHODS: Two prospective studies followed up subjects with Fitzpatrick skin phototypes of IV, V, or VI for 24 weeks after dermal filler injections. In a double-blind, randomized study, subjects were injected with one of three high concentration (24 mg/mL) HA fillers (Juvederm Ultra, Ultra Plus, and 30) in one nasolabial fold and Zyplast collagen in the other. In an open-label, randomized study, subjects received one of three low concentration (5.5 mg/mL) HA fillers (Hylaform, Hylaform Plus, and Captique) in both nasolabial folds. RESULTS: A total of 160 subjects (a subset of 439 study subjects) were randomized and treated with one of the three high concentration fillers, and 119 subjects were randomized and treated with one of the three low concentration fillers. For subjects treated with the high concentration fillers there were no occurrences of hypersensitivity or hypertrophic scarring, and no increased incidence of hyperpigmentation or hypopigmentation in non-Caucasian vs. Caucasian subjects. For subjects treated with the low concentration fillers there were no occurrences of keloid formation, hypertrophic scarring, hypopigmentation, hypersensitivity, and three instances of mild hyperpigmentation. For all of the fillers the majority of subjects maintained >/=1 point improvement in nasolabial fold severity scores through 24 weeks. CONCLUSIONS: All of the HA fillers were well tolerated in individuals with skin of color and demonstrated effectiveness throughout the 24 week period. Furthermore, the fillers provided smooth, natural-looking wrinkle correction in darker skin types.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUND A new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-linked HA, and a smooth consistency—which should promote long-lasting corrections and a smooth, natural look and feel postinjection. OBJECTIVE The objective was to compare the effectiveness and safety of these smooth-gel HA dermal fillers with bovine collagen for nasolabial fold (NLF) correction. METHODS AND MATERIALS A total of 439 subjects with moderate or severe NLFs received one of three types of smooth-gel HA dermal filler (in one NLF) and cross-linked bovine collagen (in the other NLF) and were evaluated for ≤24 weeks. RESULTS All three HA dermal fillers achieved considerably longer-lasting clinical correction than bovine collagen; 81% to 90% of HA dermal filler–treated NLFs maintained a clinically significant improvement from baseline for ≥6 months. Up to 88% of subjects preferred the HA dermal fillers over bovine collagen. All fillers were similarly well tolerated. CONCLUSION The smooth-gel HA dermal fillers offer longer-lasting correction than bovine collagen—which may lessen the frequency that repeat treatments are needed. Also, they were preferred by the vast majority of subjects—which should promote patient satisfaction.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUNDA new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-link
Ava Shamban - One of the best experts on this subject based on the ideXlab platform.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUND A new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-linked HA, and a smooth consistency—which should promote long-lasting corrections and a smooth, natural look and feel postinjection. OBJECTIVE The objective was to compare the effectiveness and safety of these smooth-gel HA dermal fillers with bovine collagen for nasolabial fold (NLF) correction. METHODS AND MATERIALS A total of 439 subjects with moderate or severe NLFs received one of three types of smooth-gel HA dermal filler (in one NLF) and cross-linked bovine collagen (in the other NLF) and were evaluated for ≤24 weeks. RESULTS All three HA dermal fillers achieved considerably longer-lasting clinical correction than bovine collagen; 81% to 90% of HA dermal filler–treated NLFs maintained a clinically significant improvement from baseline for ≥6 months. Up to 88% of subjects preferred the HA dermal fillers over bovine collagen. All fillers were similarly well tolerated. CONCLUSION The smooth-gel HA dermal fillers offer longer-lasting correction than bovine collagen—which may lessen the frequency that repeat treatments are needed. Also, they were preferred by the vast majority of subjects—which should promote patient satisfaction.
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comparison of smooth gel hyaluronic acid dermal fillers with cross linked bovine collagen a multicenter double masked randomized within subject study
Dermatologic Surgery, 2007Co-Authors: Leslie Baumann, Ava Shamban, Mary P Lupo, Jane A Thomas, Diane K. Murphy, Gary D. Monheit, Patricia S. WalkerAbstract:BACKGROUNDA new family of next-generation non-animal hyaluronic acid (HA) dermal fillers was approved by the FDA in June 2006. Compared with other HA fillers available in the United States at the time of writing, these new fillers have a higher concentration of HA, higher concentration of cross-link
