The Experts below are selected from a list of 5091 Experts worldwide ranked by ideXlab platform

Russ Hauser - One of the best experts on this subject based on the ideXlab platform.

  • Perinatal urinary benzophenone-3 concentrations and glucose levels among women from a Fertility Clinic
    Environmental health : a global access science source, 2020
    Co-Authors: Zifan Wang, Andrea Bellavia, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Russ Hauser, Antonia M. Calafat, Lidia Mínguez-alarcón, Tamarra James-todd
    Abstract:

    Subfertile women have higher risk of glucose intolerance during pregnancy. Studies suggest associations between several endocrine disrupting chemicals (EDCs) and pregnancy glucose levels. However, the association between benzophenone-3 (BP-3), an EDC widely found in sunscreen, and pregnancy glucose levels remains unclear. We aimed to assess the association between perinatal exposures to BP-3 and pregnancy glucose levels in subfertile women. We evaluated 217 women from a prospective cohort based at a Fertility Clinic who had urinary BP-3 concentrations measured during 3-month preconception, first and/or second trimesters, and blood glucose measured at glucose load tests (GLTs) during late pregnancy. Multivariable linear and logistic regression models were used to assess associations between time-specific BP-3 in quartiles (Q1 – Q4) and mean glucose levels, as well as odds of abnormal GLT (glucose level ≥ 140 mg/dL), adjusting for potential confounders. Effect modification was assessed by age, season, BMI, inFertility diagnosis, sex of fetus (es) and physical activity. Women with higher first trimester BP-3 concentrations had lower mean glucose levels [mean glucose (95% CI) for Q4 vs Q1 = 103.4 (95.0, 112.5) vs. 114.6 (105.8, 124.2) mg/dL]. Women with higher second trimester BP-3 concentrations had lower odds of abnormal GLT [OR (95% CI) for Q3 vs. Q1 = 0.12 (0.01, 0.94)]. The associations between BP-3 and glucose levels were modified by several factors: women with female-factor inFertility, urine collected during summer, older age, lower BMI, or carried female fetus (es) had the strongest inverse associations between BP-3 and glucose levels, while no associations were observed in the remaining subgroups. Time-specific inverse associations between BP-3 and pregnancy glucose levels existed in subfertile women, and especially among certain subgroups of this high-risk-population.

  • association of self reported personal care product use with blood glucose levels measured during pregnancy among women from a Fertility Clinic
    Science of The Total Environment, 2019
    Co-Authors: Andrea Bellavia, Lidia Minguezalarcon, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Russ Hauser, Tamarra Jamestodd
    Abstract:

    Abstract Background Personal care products (PCPs), known sources of endocrine disrupting chemicals (EDCs) such as phthalates and parabens, are widely used among women of reproductive age. EDCs have been linked to pregnancy complications such as gestational diabetes (GDM), and PCP use could represent a modifiable source of exposure in this sensitive time window. Yet, to our knowledge, no study has directly evaluated the association between pregnancy use of PCP and late pregnancy glucose levels, established risk factors for complications such as GDM. Methods A total of 233 women from the Environment and Reproductive Health (EARTH) Study had data available on 1st and/or 2nd trimester PCP use, assessed through self-reported use over the previous 24 h, and blood glucose levels after the glucose loading test (GLT), taken at late 2nd trimester. Associations between each individual PCP and total PCP with glucose levels were evaluated in multivariable adjusted linear regression models. Results Both positive and negative differences in glucose levels were observed when comparing users vs. non-users of several PCPs including 2nd trimester use of deodorant (adjusted mean difference: 12.2 mg/dL, 95% CI: −0.6, 24.9); bar soap (6.9 mg/dL, 95% CI: −0.9, 14.7 mg/dL); and liquid soap (−13.3, 95% CI: −26.8, 0.1 mg/dL), and 1st trimester use of sunscreen (−14.6 mg/dL, 95% CI: −27.8, −1.5 mg/dL). Total number of PCPs used in the 2nd trimester was also associated with higher glucose levels, with the largest difference of 20 mg/dL when comparing individuals who used eight vs none PCPs (95% CI: 3–37). Conclusions In a pregnancy cohort of women seeking care at a Fertility Clinic, we found the use of several PCPs to be positively or negatively associated with glucose levels in the late second trimester, which may reflect increased risk of GDM and subsequent perinatal outcomes. These results strengthen the role of product use as a potentially modifiable source of EDCs that may impact glucose levels.

  • urinary triclosan concentrations and semen quality among men from a Fertility Clinic
    Environmental Research, 2019
    Co-Authors: Feiby L. Nassan, Lidia Minguezalarcon, Jennifer B Ford, John C. Petrozza, Paige L Williams, Antonia M. Calafat, Ramace Dadd, Russ Hauser
    Abstract:

    Abstract Background Triclosan, a widely-used antimicrobial in personal care products, has shown endocrine disrupting activity in experimental studies. However, there is limited evidence from epidemiologic studies on health effects. Objective To examine the association between urinary triclosan concentrations and semen quality. Methods A total of 262 men enrolled in the Environmental and Reproductive Health (EARTH) Study provided 581 paired urine and semen samples (2009–2017). Urinary triclosan concentrations were quantified and semen analysis was evaluated according to WHO guidelines. We used linear mixed regression models to estimate the associations between specific gravity-adjusted urinary triclosan concentrations with semen parameters, with a random intercept to account for multiple samples per man and adjusting for age, body mass index (BMI), smoking, physical activity, sexual abstinence time, and season and year of samples’ collection. Results Men had a mean (standard deviation) age of 36.6 (5.24) years and BMI of 27.9 (5.94) kg/m2. Seventy four percent of the samples had detectable (>2.3 μg/L) concentrations. We did not observe significant dose response trends between SG-adjusted urinary triclosan concentrations and semen parameters. However, in the adjusted analysis, compared to men with non-detectable triclosan concentrations in the lowest quartile, those in the second, third, and fourth quartiles had −1.32% (95%CI: –2.04, −0.59), −0.91% (95%CI: –1.63, –0.18), and −0.46% (95%CI: –1.25, 0.33) lower percent morphologically normal sperm, respectively. Similarly, a lower percentage of morphologically normal sperm was found among men with detectable triclosan concentrations, compared to men with non-detectable triclosan [–0.96% (95% CI: –1.57, −0.35)]. In sensitivity analyses, there was stronger negative associations on the percent morphologically normal sperm in the earlier time period due to the significant negative trend in detectable triclosan concentrations over time. Conclusion Despite the lack of observed dose response relationship, we found consistent patterns of lower percent morphologically normal sperm for men with urinary triclosan in the 2nd or 3rd quartile compared to undetectable concentrations.This association was stronger for samples obtained prior to 2013 when triclosan was more often detectable in urine.

  • exposure to fine particulate matter and ovarian reserve among women from a Fertility Clinic
    Epidemiology, 2019
    Co-Authors: Audrey J. Gaskins, Lidia Minguezalarcon, Jorge E. Chavarro, Irene Souter, Kelvin C Fong, Sarah Abdelmessih, Brent A Coull, Joel Schwartz, Itai Kloog, Russ Hauser
    Abstract:

    Background:An increasing number of studies have linked air pollution to decreased Fertility. Whether this is due to an effect on ovarian reserve is unknown.Method:Our study included 632 women attending the Massachusetts General Hospital Fertility Center (2004–2015) who had a measured antral follicle

  • urinary concentrations of parabens mixture and pregnancy glucose levels among women from a Fertility Clinic
    Environmental Research, 2019
    Co-Authors: Andrea Bellavia, Lidia Minguezalarcon, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Antonia M. Calafat, Yu-han Chiu, Florence M Brown, Russ Hauser
    Abstract:

    Abstract Background A number of endocrine disrupting chemicals (EDC) have been associated with gestational diabetes (GDM) risk factors. However, no human study has investigated the association between pregnancy exposure to parabens, a class of EDCs, and pregnancy glucose levels, a risk factor for GDM. Furthermore, little is known about this association in subfertile women—a group at high risk of GDM. Methods A total of 241 women from the Environment and Reproductive Health Study had data available on 1st and/or 2nd trimester urinary methylparaben, propylparaben, and butylparaben concentrations, and blood glucose levels after the glucose loading test (GLT), a non-fasting 50 g glucose loading test taken at late 2nd trimester. Trimester-specific associations between specific gravity adjusted methylparaben, butylparaben, and propylparaben with adjusted mean of pregnancy glucose levels were evaluated in linear regression models, using quartiles of each paraben's distribution, and as a paraben mixture, using mutual adjustment and Bayesian kernel machine regression (BKMR), a recently proposed method for investigating chemical mixtures that flexibly models the joint effect of chemicals. Results Investigating parabens one at the time did not provide any significant results. When investigating parabens as a chemical mixture with both multiple regression and BKMR, we observed positive associations of butylparaben (e.g comparing the 4th and 1st quartiles) with glucose levels, for both the 1st trimester (adjusted difference=12.5 mg/dL; 95% CI: 0.9, 24.2) and 2nd trimester (adjusted difference=11.2 mg/dL; 95% CI: 0.2, 22.3), and a negative association between 1st trimester propylparaben and glucose (adjusted difference=−22.3 mg/dL; 95% CI: −43.2, −1.4). Conclusions We found 1st trimester butylparaben and propylparaben urinary concentrations to be associated with glucose levels in a pregnancy cohort of women at high risk of GDM, even after adjusting for potential confounders. Because exposure to parabens is widespread, these findings may suggest further investigating the effects of this chemical class on pregnancy health.

Paige L Williams - One of the best experts on this subject based on the ideXlab platform.

  • dietary patterns and ovarian reserve among women attending a Fertility Clinic
    Fertility and Sterility, 2020
    Co-Authors: Lidia Minguezalarcon, Paige L Williams, Audrey J. Gaskins, Ana B Maldonadocarceles, Irene Souter, Mariel Arvizu, Jennifer B Ford
    Abstract:

    Objective To investigate the associations between dietary patterns and antral follicle count (AFC), a marker of ovarian reserve. Design Prospective cohort study. Setting Fertility center at an academic hospital. Patient(s) A total of 363 women seeking preconception evaluation and inFertility care at the Massachusetts General Hospital who participated in the Environment and Reproductive Health Study. Intervention(s) None. At enrollment, women reported diet through a food frequency questionnaire, from which we computed three dietary pattern adherence scores: the Mediterranean diet, the Fertility diet, and the ProFertility diet. Main Outcome Measure(s) The AFC was assessed with a transvaginal ultrasound performed on the third day of an unstimulated menstrual cycle or on the third day of a P withdrawal bleed. Result(s) Higher adherence to the three dietary patterns examined were unrelated to AFC. The multivariable adjusted AFC means and 95% confidence intervals for women in the highest compared with the lowest quartile of adherence score were 13.9 (13.0–14.9) and 13.5 (12.6–14.4) for the Mediterranean diet, 14.0 (13.2–14.9) and 13.5 (12.7–14.3) for the Fertility diet, and 12.5 (11.6–13.5) and 13.3 (12.5–14.2) for the ProFertility diet. Conclusion(s) Dietary patterns were unrelated to AFC among a cohort of women presenting at a Fertility center. Due to the limited and heterogeneous current evidence, it is important to evaluate this association in further studies, and in particular among women from the general population.

  • Perinatal urinary benzophenone-3 concentrations and glucose levels among women from a Fertility Clinic
    Environmental health : a global access science source, 2020
    Co-Authors: Zifan Wang, Andrea Bellavia, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Russ Hauser, Antonia M. Calafat, Lidia Mínguez-alarcón, Tamarra James-todd
    Abstract:

    Subfertile women have higher risk of glucose intolerance during pregnancy. Studies suggest associations between several endocrine disrupting chemicals (EDCs) and pregnancy glucose levels. However, the association between benzophenone-3 (BP-3), an EDC widely found in sunscreen, and pregnancy glucose levels remains unclear. We aimed to assess the association between perinatal exposures to BP-3 and pregnancy glucose levels in subfertile women. We evaluated 217 women from a prospective cohort based at a Fertility Clinic who had urinary BP-3 concentrations measured during 3-month preconception, first and/or second trimesters, and blood glucose measured at glucose load tests (GLTs) during late pregnancy. Multivariable linear and logistic regression models were used to assess associations between time-specific BP-3 in quartiles (Q1 – Q4) and mean glucose levels, as well as odds of abnormal GLT (glucose level ≥ 140 mg/dL), adjusting for potential confounders. Effect modification was assessed by age, season, BMI, inFertility diagnosis, sex of fetus (es) and physical activity. Women with higher first trimester BP-3 concentrations had lower mean glucose levels [mean glucose (95% CI) for Q4 vs Q1 = 103.4 (95.0, 112.5) vs. 114.6 (105.8, 124.2) mg/dL]. Women with higher second trimester BP-3 concentrations had lower odds of abnormal GLT [OR (95% CI) for Q3 vs. Q1 = 0.12 (0.01, 0.94)]. The associations between BP-3 and glucose levels were modified by several factors: women with female-factor inFertility, urine collected during summer, older age, lower BMI, or carried female fetus (es) had the strongest inverse associations between BP-3 and glucose levels, while no associations were observed in the remaining subgroups. Time-specific inverse associations between BP-3 and pregnancy glucose levels existed in subfertile women, and especially among certain subgroups of this high-risk-population.

  • association of self reported personal care product use with blood glucose levels measured during pregnancy among women from a Fertility Clinic
    Science of The Total Environment, 2019
    Co-Authors: Andrea Bellavia, Lidia Minguezalarcon, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Russ Hauser, Tamarra Jamestodd
    Abstract:

    Abstract Background Personal care products (PCPs), known sources of endocrine disrupting chemicals (EDCs) such as phthalates and parabens, are widely used among women of reproductive age. EDCs have been linked to pregnancy complications such as gestational diabetes (GDM), and PCP use could represent a modifiable source of exposure in this sensitive time window. Yet, to our knowledge, no study has directly evaluated the association between pregnancy use of PCP and late pregnancy glucose levels, established risk factors for complications such as GDM. Methods A total of 233 women from the Environment and Reproductive Health (EARTH) Study had data available on 1st and/or 2nd trimester PCP use, assessed through self-reported use over the previous 24 h, and blood glucose levels after the glucose loading test (GLT), taken at late 2nd trimester. Associations between each individual PCP and total PCP with glucose levels were evaluated in multivariable adjusted linear regression models. Results Both positive and negative differences in glucose levels were observed when comparing users vs. non-users of several PCPs including 2nd trimester use of deodorant (adjusted mean difference: 12.2 mg/dL, 95% CI: −0.6, 24.9); bar soap (6.9 mg/dL, 95% CI: −0.9, 14.7 mg/dL); and liquid soap (−13.3, 95% CI: −26.8, 0.1 mg/dL), and 1st trimester use of sunscreen (−14.6 mg/dL, 95% CI: −27.8, −1.5 mg/dL). Total number of PCPs used in the 2nd trimester was also associated with higher glucose levels, with the largest difference of 20 mg/dL when comparing individuals who used eight vs none PCPs (95% CI: 3–37). Conclusions In a pregnancy cohort of women seeking care at a Fertility Clinic, we found the use of several PCPs to be positively or negatively associated with glucose levels in the late second trimester, which may reflect increased risk of GDM and subsequent perinatal outcomes. These results strengthen the role of product use as a potentially modifiable source of EDCs that may impact glucose levels.

  • urinary triclosan concentrations and semen quality among men from a Fertility Clinic
    Environmental Research, 2019
    Co-Authors: Feiby L. Nassan, Lidia Minguezalarcon, Jennifer B Ford, John C. Petrozza, Paige L Williams, Antonia M. Calafat, Ramace Dadd, Russ Hauser
    Abstract:

    Abstract Background Triclosan, a widely-used antimicrobial in personal care products, has shown endocrine disrupting activity in experimental studies. However, there is limited evidence from epidemiologic studies on health effects. Objective To examine the association between urinary triclosan concentrations and semen quality. Methods A total of 262 men enrolled in the Environmental and Reproductive Health (EARTH) Study provided 581 paired urine and semen samples (2009–2017). Urinary triclosan concentrations were quantified and semen analysis was evaluated according to WHO guidelines. We used linear mixed regression models to estimate the associations between specific gravity-adjusted urinary triclosan concentrations with semen parameters, with a random intercept to account for multiple samples per man and adjusting for age, body mass index (BMI), smoking, physical activity, sexual abstinence time, and season and year of samples’ collection. Results Men had a mean (standard deviation) age of 36.6 (5.24) years and BMI of 27.9 (5.94) kg/m2. Seventy four percent of the samples had detectable (>2.3 μg/L) concentrations. We did not observe significant dose response trends between SG-adjusted urinary triclosan concentrations and semen parameters. However, in the adjusted analysis, compared to men with non-detectable triclosan concentrations in the lowest quartile, those in the second, third, and fourth quartiles had −1.32% (95%CI: –2.04, −0.59), −0.91% (95%CI: –1.63, –0.18), and −0.46% (95%CI: –1.25, 0.33) lower percent morphologically normal sperm, respectively. Similarly, a lower percentage of morphologically normal sperm was found among men with detectable triclosan concentrations, compared to men with non-detectable triclosan [–0.96% (95% CI: –1.57, −0.35)]. In sensitivity analyses, there was stronger negative associations on the percent morphologically normal sperm in the earlier time period due to the significant negative trend in detectable triclosan concentrations over time. Conclusion Despite the lack of observed dose response relationship, we found consistent patterns of lower percent morphologically normal sperm for men with urinary triclosan in the 2nd or 3rd quartile compared to undetectable concentrations.This association was stronger for samples obtained prior to 2013 when triclosan was more often detectable in urine.

  • urinary concentrations of parabens mixture and pregnancy glucose levels among women from a Fertility Clinic
    Environmental Research, 2019
    Co-Authors: Andrea Bellavia, Lidia Minguezalarcon, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Antonia M. Calafat, Yu-han Chiu, Florence M Brown, Russ Hauser
    Abstract:

    Abstract Background A number of endocrine disrupting chemicals (EDC) have been associated with gestational diabetes (GDM) risk factors. However, no human study has investigated the association between pregnancy exposure to parabens, a class of EDCs, and pregnancy glucose levels, a risk factor for GDM. Furthermore, little is known about this association in subfertile women—a group at high risk of GDM. Methods A total of 241 women from the Environment and Reproductive Health Study had data available on 1st and/or 2nd trimester urinary methylparaben, propylparaben, and butylparaben concentrations, and blood glucose levels after the glucose loading test (GLT), a non-fasting 50 g glucose loading test taken at late 2nd trimester. Trimester-specific associations between specific gravity adjusted methylparaben, butylparaben, and propylparaben with adjusted mean of pregnancy glucose levels were evaluated in linear regression models, using quartiles of each paraben's distribution, and as a paraben mixture, using mutual adjustment and Bayesian kernel machine regression (BKMR), a recently proposed method for investigating chemical mixtures that flexibly models the joint effect of chemicals. Results Investigating parabens one at the time did not provide any significant results. When investigating parabens as a chemical mixture with both multiple regression and BKMR, we observed positive associations of butylparaben (e.g comparing the 4th and 1st quartiles) with glucose levels, for both the 1st trimester (adjusted difference=12.5 mg/dL; 95% CI: 0.9, 24.2) and 2nd trimester (adjusted difference=11.2 mg/dL; 95% CI: 0.2, 22.3), and a negative association between 1st trimester propylparaben and glucose (adjusted difference=−22.3 mg/dL; 95% CI: −43.2, −1.4). Conclusions We found 1st trimester butylparaben and propylparaben urinary concentrations to be associated with glucose levels in a pregnancy cohort of women at high risk of GDM, even after adjusting for potential confounders. Because exposure to parabens is widespread, these findings may suggest further investigating the effects of this chemical class on pregnancy health.

Jennifer B Ford - One of the best experts on this subject based on the ideXlab platform.

  • dietary patterns and ovarian reserve among women attending a Fertility Clinic
    Fertility and Sterility, 2020
    Co-Authors: Lidia Minguezalarcon, Paige L Williams, Audrey J. Gaskins, Ana B Maldonadocarceles, Irene Souter, Mariel Arvizu, Jennifer B Ford
    Abstract:

    Objective To investigate the associations between dietary patterns and antral follicle count (AFC), a marker of ovarian reserve. Design Prospective cohort study. Setting Fertility center at an academic hospital. Patient(s) A total of 363 women seeking preconception evaluation and inFertility care at the Massachusetts General Hospital who participated in the Environment and Reproductive Health Study. Intervention(s) None. At enrollment, women reported diet through a food frequency questionnaire, from which we computed three dietary pattern adherence scores: the Mediterranean diet, the Fertility diet, and the ProFertility diet. Main Outcome Measure(s) The AFC was assessed with a transvaginal ultrasound performed on the third day of an unstimulated menstrual cycle or on the third day of a P withdrawal bleed. Result(s) Higher adherence to the three dietary patterns examined were unrelated to AFC. The multivariable adjusted AFC means and 95% confidence intervals for women in the highest compared with the lowest quartile of adherence score were 13.9 (13.0–14.9) and 13.5 (12.6–14.4) for the Mediterranean diet, 14.0 (13.2–14.9) and 13.5 (12.7–14.3) for the Fertility diet, and 12.5 (11.6–13.5) and 13.3 (12.5–14.2) for the ProFertility diet. Conclusion(s) Dietary patterns were unrelated to AFC among a cohort of women presenting at a Fertility center. Due to the limited and heterogeneous current evidence, it is important to evaluate this association in further studies, and in particular among women from the general population.

  • Perinatal urinary benzophenone-3 concentrations and glucose levels among women from a Fertility Clinic
    Environmental health : a global access science source, 2020
    Co-Authors: Zifan Wang, Andrea Bellavia, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Russ Hauser, Antonia M. Calafat, Lidia Mínguez-alarcón, Tamarra James-todd
    Abstract:

    Subfertile women have higher risk of glucose intolerance during pregnancy. Studies suggest associations between several endocrine disrupting chemicals (EDCs) and pregnancy glucose levels. However, the association between benzophenone-3 (BP-3), an EDC widely found in sunscreen, and pregnancy glucose levels remains unclear. We aimed to assess the association between perinatal exposures to BP-3 and pregnancy glucose levels in subfertile women. We evaluated 217 women from a prospective cohort based at a Fertility Clinic who had urinary BP-3 concentrations measured during 3-month preconception, first and/or second trimesters, and blood glucose measured at glucose load tests (GLTs) during late pregnancy. Multivariable linear and logistic regression models were used to assess associations between time-specific BP-3 in quartiles (Q1 – Q4) and mean glucose levels, as well as odds of abnormal GLT (glucose level ≥ 140 mg/dL), adjusting for potential confounders. Effect modification was assessed by age, season, BMI, inFertility diagnosis, sex of fetus (es) and physical activity. Women with higher first trimester BP-3 concentrations had lower mean glucose levels [mean glucose (95% CI) for Q4 vs Q1 = 103.4 (95.0, 112.5) vs. 114.6 (105.8, 124.2) mg/dL]. Women with higher second trimester BP-3 concentrations had lower odds of abnormal GLT [OR (95% CI) for Q3 vs. Q1 = 0.12 (0.01, 0.94)]. The associations between BP-3 and glucose levels were modified by several factors: women with female-factor inFertility, urine collected during summer, older age, lower BMI, or carried female fetus (es) had the strongest inverse associations between BP-3 and glucose levels, while no associations were observed in the remaining subgroups. Time-specific inverse associations between BP-3 and pregnancy glucose levels existed in subfertile women, and especially among certain subgroups of this high-risk-population.

  • association of self reported personal care product use with blood glucose levels measured during pregnancy among women from a Fertility Clinic
    Science of The Total Environment, 2019
    Co-Authors: Andrea Bellavia, Lidia Minguezalarcon, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Russ Hauser, Tamarra Jamestodd
    Abstract:

    Abstract Background Personal care products (PCPs), known sources of endocrine disrupting chemicals (EDCs) such as phthalates and parabens, are widely used among women of reproductive age. EDCs have been linked to pregnancy complications such as gestational diabetes (GDM), and PCP use could represent a modifiable source of exposure in this sensitive time window. Yet, to our knowledge, no study has directly evaluated the association between pregnancy use of PCP and late pregnancy glucose levels, established risk factors for complications such as GDM. Methods A total of 233 women from the Environment and Reproductive Health (EARTH) Study had data available on 1st and/or 2nd trimester PCP use, assessed through self-reported use over the previous 24 h, and blood glucose levels after the glucose loading test (GLT), taken at late 2nd trimester. Associations between each individual PCP and total PCP with glucose levels were evaluated in multivariable adjusted linear regression models. Results Both positive and negative differences in glucose levels were observed when comparing users vs. non-users of several PCPs including 2nd trimester use of deodorant (adjusted mean difference: 12.2 mg/dL, 95% CI: −0.6, 24.9); bar soap (6.9 mg/dL, 95% CI: −0.9, 14.7 mg/dL); and liquid soap (−13.3, 95% CI: −26.8, 0.1 mg/dL), and 1st trimester use of sunscreen (−14.6 mg/dL, 95% CI: −27.8, −1.5 mg/dL). Total number of PCPs used in the 2nd trimester was also associated with higher glucose levels, with the largest difference of 20 mg/dL when comparing individuals who used eight vs none PCPs (95% CI: 3–37). Conclusions In a pregnancy cohort of women seeking care at a Fertility Clinic, we found the use of several PCPs to be positively or negatively associated with glucose levels in the late second trimester, which may reflect increased risk of GDM and subsequent perinatal outcomes. These results strengthen the role of product use as a potentially modifiable source of EDCs that may impact glucose levels.

  • urinary triclosan concentrations and semen quality among men from a Fertility Clinic
    Environmental Research, 2019
    Co-Authors: Feiby L. Nassan, Lidia Minguezalarcon, Jennifer B Ford, John C. Petrozza, Paige L Williams, Antonia M. Calafat, Ramace Dadd, Russ Hauser
    Abstract:

    Abstract Background Triclosan, a widely-used antimicrobial in personal care products, has shown endocrine disrupting activity in experimental studies. However, there is limited evidence from epidemiologic studies on health effects. Objective To examine the association between urinary triclosan concentrations and semen quality. Methods A total of 262 men enrolled in the Environmental and Reproductive Health (EARTH) Study provided 581 paired urine and semen samples (2009–2017). Urinary triclosan concentrations were quantified and semen analysis was evaluated according to WHO guidelines. We used linear mixed regression models to estimate the associations between specific gravity-adjusted urinary triclosan concentrations with semen parameters, with a random intercept to account for multiple samples per man and adjusting for age, body mass index (BMI), smoking, physical activity, sexual abstinence time, and season and year of samples’ collection. Results Men had a mean (standard deviation) age of 36.6 (5.24) years and BMI of 27.9 (5.94) kg/m2. Seventy four percent of the samples had detectable (>2.3 μg/L) concentrations. We did not observe significant dose response trends between SG-adjusted urinary triclosan concentrations and semen parameters. However, in the adjusted analysis, compared to men with non-detectable triclosan concentrations in the lowest quartile, those in the second, third, and fourth quartiles had −1.32% (95%CI: –2.04, −0.59), −0.91% (95%CI: –1.63, –0.18), and −0.46% (95%CI: –1.25, 0.33) lower percent morphologically normal sperm, respectively. Similarly, a lower percentage of morphologically normal sperm was found among men with detectable triclosan concentrations, compared to men with non-detectable triclosan [–0.96% (95% CI: –1.57, −0.35)]. In sensitivity analyses, there was stronger negative associations on the percent morphologically normal sperm in the earlier time period due to the significant negative trend in detectable triclosan concentrations over time. Conclusion Despite the lack of observed dose response relationship, we found consistent patterns of lower percent morphologically normal sperm for men with urinary triclosan in the 2nd or 3rd quartile compared to undetectable concentrations.This association was stronger for samples obtained prior to 2013 when triclosan was more often detectable in urine.

  • urinary concentrations of parabens mixture and pregnancy glucose levels among women from a Fertility Clinic
    Environmental Research, 2019
    Co-Authors: Andrea Bellavia, Lidia Minguezalarcon, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Antonia M. Calafat, Yu-han Chiu, Florence M Brown, Russ Hauser
    Abstract:

    Abstract Background A number of endocrine disrupting chemicals (EDC) have been associated with gestational diabetes (GDM) risk factors. However, no human study has investigated the association between pregnancy exposure to parabens, a class of EDCs, and pregnancy glucose levels, a risk factor for GDM. Furthermore, little is known about this association in subfertile women—a group at high risk of GDM. Methods A total of 241 women from the Environment and Reproductive Health Study had data available on 1st and/or 2nd trimester urinary methylparaben, propylparaben, and butylparaben concentrations, and blood glucose levels after the glucose loading test (GLT), a non-fasting 50 g glucose loading test taken at late 2nd trimester. Trimester-specific associations between specific gravity adjusted methylparaben, butylparaben, and propylparaben with adjusted mean of pregnancy glucose levels were evaluated in linear regression models, using quartiles of each paraben's distribution, and as a paraben mixture, using mutual adjustment and Bayesian kernel machine regression (BKMR), a recently proposed method for investigating chemical mixtures that flexibly models the joint effect of chemicals. Results Investigating parabens one at the time did not provide any significant results. When investigating parabens as a chemical mixture with both multiple regression and BKMR, we observed positive associations of butylparaben (e.g comparing the 4th and 1st quartiles) with glucose levels, for both the 1st trimester (adjusted difference=12.5 mg/dL; 95% CI: 0.9, 24.2) and 2nd trimester (adjusted difference=11.2 mg/dL; 95% CI: 0.2, 22.3), and a negative association between 1st trimester propylparaben and glucose (adjusted difference=−22.3 mg/dL; 95% CI: −43.2, −1.4). Conclusions We found 1st trimester butylparaben and propylparaben urinary concentrations to be associated with glucose levels in a pregnancy cohort of women at high risk of GDM, even after adjusting for potential confounders. Because exposure to parabens is widespread, these findings may suggest further investigating the effects of this chemical class on pregnancy health.

Jorge E. Chavarro - One of the best experts on this subject based on the ideXlab platform.

  • exposure to fine particulate matter and ovarian reserve among women from a Fertility Clinic
    Epidemiology, 2019
    Co-Authors: Audrey J. Gaskins, Lidia Minguezalarcon, Jorge E. Chavarro, Irene Souter, Kelvin C Fong, Sarah Abdelmessih, Brent A Coull, Joel Schwartz, Itai Kloog, Russ Hauser
    Abstract:

    Background:An increasing number of studies have linked air pollution to decreased Fertility. Whether this is due to an effect on ovarian reserve is unknown.Method:Our study included 632 women attending the Massachusetts General Hospital Fertility Center (2004–2015) who had a measured antral follicle

  • Residential distance to major roadways and semen quality, sperm DNA integrity, chromosomal disomy, and serum reproductive hormones among men attending a Fertility Clinic.
    International journal of hygiene and environmental health, 2018
    Co-Authors: Feiby L. Nassan, Jennifer B Ford, Paige L Williams, Russ Hauser, Lidia Mínguez-alarcón, Cigdem Tanrikut, Jorge E. Chavarro, Ramace Dadd, Melissa J. Perry, Audrey J. Gaskins
    Abstract:

    Abstract Objective We examined associations of residential distance to major roadways, as a proxy for traffic-related air pollution exposures, with sperm characteristics and male reproductive hormones. Design The cohort included 797 men recruited from Massachusetts General Hospital Fertility Center between 2000 and 2015 to participate in Fertility research studies. Materials and methods Men reported their residential addresses at enrollment and provided 1–6 semen samples and a blood sample during follow-up. We estimated the Euclidean distance to major roadways (e.g. interstates and highways: limited access highways, multi–lane highways (not limited access), other numbered routes, and major roads) using information from the Massachusetts Department of Geographic Information Systems. Semen parameters (1238 semen samples), sperm DNA integrity (389 semen samples), chromosomal disomy (101 semen samples), and serum reproductive hormones (405 serum samples) were assessed following standard procedures. Results Men in this cohort were primarily Caucasian (86%), not current smokers (92%), with a college or higher education (88%), and had an average age of 36 years and BMI of 27.7 kg/m2. The median (interquartile range) residential distance to a major roadway was 111 (37, 248) meters. Residential proximity to major roadways was not associated with semen parameters, sperm DNA integrity, chromosomal disomy, or serum reproductive hormone concentrations. The adjusted percent change (95% CI) in semen quality parameters associated with a 500 m increase in residential distance to a major roadway was –1.0% (–6.3, 4.5) for semen volume, 4.3% (–5.8, 15.7) for sperm concentration, 3.1% (–7.2, 14.5) for sperm count, 1.1% (–1.2, 3.4) for % total motile sperm, and 0.1% (–0.3, 0.5) for % morphologically normal sperm. Results were consistent when we modeled the semen parameters dichotomized according to WHO 2010 reference values. Conclusion Residential distance to major roadways, as a proxy for traffic-related air pollution exposure, was not related to sperm characteristics or serum reproductive hormones among men attending a Fertility Clinic in Massachusetts.

  • dairy intake in relation to in vitro fertilization outcomes among women from a Fertility Clinic
    Human Reproduction, 2016
    Co-Authors: Myriam C. Afeiche, Paige L Williams, Russ Hauser, Audrey J. Gaskins, Jorge E. Chavarro, Yu-han Chiu, Irene Souter, Diane L Wright
    Abstract:

    STUDY QUESTION Is dairy food consumption associated with live birth among women undergoing inFertility treatment? SUMMARY ANSWER There was a positive association between total dairy food consumption and live birth among women ≥35 years of age. WHAT IS KNOWN ALREADY Dairy food intake has been previously related to inFertility risk and measures of Fertility potential but its relation to inFertility treatment outcomes are unknown. STUDY DESIGN, SIZE, DURATION Our study population comprised a total of 232 women undergoing 353 in vitro fertilization (IVF) treatment cycles between February 2007 and May 2013, from the Environment and Reproductive Health study, an ongoing prospective cohort. PARTICIPANTS/MATERIALS, SETTING, METHODS Diet was assessed before assisted reproductive technology (ART) treatment using a validated food frequency questionnaire. Study outcomes included ovarian stimulation outcomes (endometrial thickness, estradiol levels and oocyte yield), fertilization rates, embryo quality measures and Clinical outcomes (implantation, Clinical pregnancy and live birth rates). We used generalized linear mixed models with random intercepts to account for multiple ART cycles per woman while simultaneously adjusting for age, caloric intake, BMI, race, smoking status, inFertility diagnosis, protocol type, alcohol intake and dietary patterns. MAIN RESULTS AND THE ROLE OF CHANCE The age- and calorie-adjusted difference in live birth between women in the highest (>3.0 servings/day) and lowest (<1.34 servings/day) quartile of dairy intake was 21% (P = 0.02). However, after adjusting for additional covariates, this association was observed only among women ≥35 years (P, interaction = 0.04). The multivariable-adjusted live birth (95% CI) in increasing quartiles of total dairy intake was 23% (11, 42%), 39% (24, 56%), 29% (17, 47%) and 55% (39, 69%) (P, trend = 0.02) among women ≥35 years old, and ranged from 46 to 54% among women <35 years old (P, trend = 0.69). There was no association between dairy intake and any of the intermediate outcomes. LIMITATIONS, REASONS FOR CAUTION The lack of a known biological mechanism linking dairy intake to inFertility treatment outcomes calls for caution when interpreting these results and for additional work to corroborate or refute them. WIDER IMPLICATIONS OF THE FINDINGS Dairy intake does not appear to harm IVF outcomes and, if anything, is associated with higher chances of live birth. STUDY FUNDING/COMPETING INTERESTS This work was supported by NIH grants R01-ES009718 and R01ES000002 from NIEHS, P30 DK046200 from NIDDK and T32HD060454 from NICHD. M.C.A. was supported by a Ruth L. Kirschstein National Research Service Award T32 DK 007703-16 from NIDDK. She is currently employed at the Nestle Research Center, Switzerland and completed this work while at the Harvard School of Public Health. The other authors declare no conflicts of interest.

  • urinary bisphenol a concentrations and association with in vitro fertilization outcomes among women from a Fertility Clinic
    Human Reproduction, 2015
    Co-Authors: Lidia Minguezalarcon, Jennifer B Ford, John C. Petrozza, Paige L Williams, Audrey J. Gaskins, Jorge E. Chavarro, Yu-han Chiu, Shelley Ehrlich, Antonia M. Calafat
    Abstract:

    STUDY QUESTION Are urinary BPA concentrations associated with in vitro fertilization (IVF) outcomes among women attending an academic Fertility center? SUMMARY ANSWER Urinary BPA concentrations were not associated with adverse reproductive and pregnancy outcomes among women from a Fertility Clinic. WHAT IS KNOWN ALREADY Bisphenol A (BPA), an endocrine disruptor, is detected in the urine of most Americans. Although animal studies have demonstrated that BPA reduces female Fertility through effects on the ovarian follicle and uterus, data from human populations are scarce and equivocal. STUDY DESIGN, SIZE AND DURATION This prospective cohort study between 2004 and 2012 at the Massachusetts General Hospital Fertility Center included 256 women (n = 375 IVF cycles) who provided up to two urine samples prior to oocyte retrieval (total N = 673). PARTICIPANTS/MATERIALS, SETTINGS, METHODS Study participants were women enrolled in the Environment and Reproductive Health (EARTH) Study. Intermediate and Clinical end-points of IVF treatments were abstracted from electronic medical records. We used generalized linear mixed models with random intercepts to evaluate the association between urinary BPA concentrations and IVF outcomes adjusted by age, race, body mass index, smoking status and inFertility diagnosis. MAIN RESULTS AND THE ROLE OF CHANCE The specific gravity-adjusted geometric mean of BPA was 1.87 µg/l, which is comparable to that for female participants in the National Health and Nutrition Examination Survey, 2011-2012. Urinary BPA concentrations were not associated with endometrial wall thickness, peak estradiol levels, proportion of high quality embryos or fertilization rates. Furthermore, there were no associations between urinary BPA concentrations and implantation, Clinical pregnancy or live birth rates per initiated cycle or per embryo transfer. Although we did not find any associations between urinary BPA concentrations and IVF outcomes, the relation between BPA and endometrial wall thickness was modified by age. Younger women (<37 years old) had thicker endometrial thickness across increasing quartiles of urinary BPA concentrations, while older women (≥37 years old) had thinner endometrial thickness across increasing quartiles of urinary BPA concentrations. LIMITATIONS, REASONS FOR CAUTION Limitations to this study include a possible misclassification of BPA exposure and difficulties in extrapolating the findings to the general population. WIDER IMPLICATIONS OF THE FINDINGS Data on the relation between urinary BPA concentrations and reproductive outcomes remain scarce and additional research is needed to clarify its role in human reproduction. STUDY FUNDING/COMPETING INTERESTS This work was supported by NIH grants R01ES022955, R01ES009718 and R01ES000002 from the National Institute of Environmental Health Sciences (NIEHS) and grant T32DK00770316 from the National Institute of Child Health and Human Development (NICHD). None of the authors has any conflicts of interest to declare. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

  • Urinary bisphenol A concentrations and association with in vitro fertilization outcomes among women from a Fertility Clinic
    Human reproduction (Oxford England), 2015
    Co-Authors: Lidia Mínguez-alarcón, Jennifer B Ford, John C. Petrozza, Paige L Williams, Antonia M. Calafat, Audrey J. Gaskins, Jorge E. Chavarro, Yu-han Chiu, Shelley Ehrlich, Russ Hauser
    Abstract:

    STUDY QUESTION Are urinary BPA concentrations associated with in vitro fertilization (IVF) outcomes among women attending an academic Fertility center? SUMMARY ANSWER Urinary BPA concentrations were not associated with adverse reproductive and pregnancy outcomes among women from a Fertility Clinic. WHAT IS KNOWN ALREADY Bisphenol A (BPA), an endocrine disruptor, is detected in the urine of most Americans. Although animal studies have demonstrated that BPA reduces female Fertility through effects on the ovarian follicle and uterus, data from human populations are scarce and equivocal. STUDY DESIGN, SIZE AND DURATION This prospective cohort study between 2004 and 2012 at the Massachusetts General Hospital Fertility Center included 256 women (n = 375 IVF cycles) who provided up to two urine samples prior to oocyte retrieval (total N = 673). PARTICIPANTS/MATERIALS, SETTINGS, METHODS Study participants were women enrolled in the Environment and Reproductive Health (EARTH) Study. Intermediate and Clinical end-points of IVF treatments were abstracted from electronic medical records. We used generalized linear mixed models with random intercepts to evaluate the association between urinary BPA concentrations and IVF outcomes adjusted by age, race, body mass index, smoking status and inFertility diagnosis. MAIN RESULTS AND THE ROLE OF CHANCE The specific gravity-adjusted geometric mean of BPA was 1.87 µg/l, which is comparable to that for female participants in the National Health and Nutrition Examination Survey, 2011-2012. Urinary BPA concentrations were not associated with endometrial wall thickness, peak estradiol levels, proportion of high quality embryos or fertilization rates. Furthermore, there were no associations between urinary BPA concentrations and implantation, Clinical pregnancy or live birth rates per initiated cycle or per embryo transfer. Although we did not find any associations between urinary BPA concentrations and IVF outcomes, the relation between BPA and endometrial wall thickness was modified by age. Younger women (

Antonia M. Calafat - One of the best experts on this subject based on the ideXlab platform.

  • Perinatal urinary benzophenone-3 concentrations and glucose levels among women from a Fertility Clinic
    Environmental health : a global access science source, 2020
    Co-Authors: Zifan Wang, Andrea Bellavia, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Russ Hauser, Antonia M. Calafat, Lidia Mínguez-alarcón, Tamarra James-todd
    Abstract:

    Subfertile women have higher risk of glucose intolerance during pregnancy. Studies suggest associations between several endocrine disrupting chemicals (EDCs) and pregnancy glucose levels. However, the association between benzophenone-3 (BP-3), an EDC widely found in sunscreen, and pregnancy glucose levels remains unclear. We aimed to assess the association between perinatal exposures to BP-3 and pregnancy glucose levels in subfertile women. We evaluated 217 women from a prospective cohort based at a Fertility Clinic who had urinary BP-3 concentrations measured during 3-month preconception, first and/or second trimesters, and blood glucose measured at glucose load tests (GLTs) during late pregnancy. Multivariable linear and logistic regression models were used to assess associations between time-specific BP-3 in quartiles (Q1 – Q4) and mean glucose levels, as well as odds of abnormal GLT (glucose level ≥ 140 mg/dL), adjusting for potential confounders. Effect modification was assessed by age, season, BMI, inFertility diagnosis, sex of fetus (es) and physical activity. Women with higher first trimester BP-3 concentrations had lower mean glucose levels [mean glucose (95% CI) for Q4 vs Q1 = 103.4 (95.0, 112.5) vs. 114.6 (105.8, 124.2) mg/dL]. Women with higher second trimester BP-3 concentrations had lower odds of abnormal GLT [OR (95% CI) for Q3 vs. Q1 = 0.12 (0.01, 0.94)]. The associations between BP-3 and glucose levels were modified by several factors: women with female-factor inFertility, urine collected during summer, older age, lower BMI, or carried female fetus (es) had the strongest inverse associations between BP-3 and glucose levels, while no associations were observed in the remaining subgroups. Time-specific inverse associations between BP-3 and pregnancy glucose levels existed in subfertile women, and especially among certain subgroups of this high-risk-population.

  • urinary triclosan concentrations and semen quality among men from a Fertility Clinic
    Environmental Research, 2019
    Co-Authors: Feiby L. Nassan, Lidia Minguezalarcon, Jennifer B Ford, John C. Petrozza, Paige L Williams, Antonia M. Calafat, Ramace Dadd, Russ Hauser
    Abstract:

    Abstract Background Triclosan, a widely-used antimicrobial in personal care products, has shown endocrine disrupting activity in experimental studies. However, there is limited evidence from epidemiologic studies on health effects. Objective To examine the association between urinary triclosan concentrations and semen quality. Methods A total of 262 men enrolled in the Environmental and Reproductive Health (EARTH) Study provided 581 paired urine and semen samples (2009–2017). Urinary triclosan concentrations were quantified and semen analysis was evaluated according to WHO guidelines. We used linear mixed regression models to estimate the associations between specific gravity-adjusted urinary triclosan concentrations with semen parameters, with a random intercept to account for multiple samples per man and adjusting for age, body mass index (BMI), smoking, physical activity, sexual abstinence time, and season and year of samples’ collection. Results Men had a mean (standard deviation) age of 36.6 (5.24) years and BMI of 27.9 (5.94) kg/m2. Seventy four percent of the samples had detectable (>2.3 μg/L) concentrations. We did not observe significant dose response trends between SG-adjusted urinary triclosan concentrations and semen parameters. However, in the adjusted analysis, compared to men with non-detectable triclosan concentrations in the lowest quartile, those in the second, third, and fourth quartiles had −1.32% (95%CI: –2.04, −0.59), −0.91% (95%CI: –1.63, –0.18), and −0.46% (95%CI: –1.25, 0.33) lower percent morphologically normal sperm, respectively. Similarly, a lower percentage of morphologically normal sperm was found among men with detectable triclosan concentrations, compared to men with non-detectable triclosan [–0.96% (95% CI: –1.57, −0.35)]. In sensitivity analyses, there was stronger negative associations on the percent morphologically normal sperm in the earlier time period due to the significant negative trend in detectable triclosan concentrations over time. Conclusion Despite the lack of observed dose response relationship, we found consistent patterns of lower percent morphologically normal sperm for men with urinary triclosan in the 2nd or 3rd quartile compared to undetectable concentrations.This association was stronger for samples obtained prior to 2013 when triclosan was more often detectable in urine.

  • urinary concentrations of parabens mixture and pregnancy glucose levels among women from a Fertility Clinic
    Environmental Research, 2019
    Co-Authors: Andrea Bellavia, Lidia Minguezalarcon, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Antonia M. Calafat, Yu-han Chiu, Florence M Brown, Russ Hauser
    Abstract:

    Abstract Background A number of endocrine disrupting chemicals (EDC) have been associated with gestational diabetes (GDM) risk factors. However, no human study has investigated the association between pregnancy exposure to parabens, a class of EDCs, and pregnancy glucose levels, a risk factor for GDM. Furthermore, little is known about this association in subfertile women—a group at high risk of GDM. Methods A total of 241 women from the Environment and Reproductive Health Study had data available on 1st and/or 2nd trimester urinary methylparaben, propylparaben, and butylparaben concentrations, and blood glucose levels after the glucose loading test (GLT), a non-fasting 50 g glucose loading test taken at late 2nd trimester. Trimester-specific associations between specific gravity adjusted methylparaben, butylparaben, and propylparaben with adjusted mean of pregnancy glucose levels were evaluated in linear regression models, using quartiles of each paraben's distribution, and as a paraben mixture, using mutual adjustment and Bayesian kernel machine regression (BKMR), a recently proposed method for investigating chemical mixtures that flexibly models the joint effect of chemicals. Results Investigating parabens one at the time did not provide any significant results. When investigating parabens as a chemical mixture with both multiple regression and BKMR, we observed positive associations of butylparaben (e.g comparing the 4th and 1st quartiles) with glucose levels, for both the 1st trimester (adjusted difference=12.5 mg/dL; 95% CI: 0.9, 24.2) and 2nd trimester (adjusted difference=11.2 mg/dL; 95% CI: 0.2, 22.3), and a negative association between 1st trimester propylparaben and glucose (adjusted difference=−22.3 mg/dL; 95% CI: −43.2, −1.4). Conclusions We found 1st trimester butylparaben and propylparaben urinary concentrations to be associated with glucose levels in a pregnancy cohort of women at high risk of GDM, even after adjusting for potential confounders. Because exposure to parabens is widespread, these findings may suggest further investigating the effects of this chemical class on pregnancy health.

  • Trimester-specific phthalate concentrations and glucose levels among women from a Fertility Clinic.
    Environmental health : a global access science source, 2018
    Co-Authors: Tamarra James-todd, Jennifer B Ford, Myra Keller, John C. Petrozza, Paige L Williams, Lidia Mínguez-alarcón, Yu-han Chiu, Carmen Messerlian, Antonia M. Calafat
    Abstract:

    Subfertile women are at increased risk of glucose intolerance in pregnancy. Based on epidemiologic studies, exposure to certain phthalates is associated with diabetes, elevated glucose, and increased insulin resistance. To evaluate the association between urinary phthalate metabolites and pregnancy glucose levels in women seeking medically assisted reproduction. We evaluated 245 women participating in a prospective cohort study based at a large Fertility Clinic who delivered live births and had data on pregnancy urinary phthalate metabolite concentrations and blood glucose levels. Urinary phthalate metabolite concentrations were from single spot urine samples collected in 1st and 2nd trimesters. Blood glucose data was abstracted from medical records for non-fasting 50-g glucose challenge tests at 24–28 weeks gestation. Multivariable linear regression models were used to evaluate associations between 7 urinary phthalate metabolites in quartiles and mean glucose adjusted for potential confounders. Eighteen percent of women had glucose levels ≥ 140 mg/dL. Second trimester monoethyl phthalate (MEP) concentrations were positively associated with glucose levels, with adjusted mean (95%CI) glucose levels of 121 mg/dl (114, 128) vs. 109 mg/dL (103, 116) for women in highest and lowest quartiles, respectively. Women in the highest quartile of second trimester mono-isobutyl phthalate (MiBP) concentrations had a mean glucose level 14 mg/dL lower compared to women in the lowest quartile. No other urinary phthalate metabolites were associated with glucose levels. MEP and MiBP—metabolites of diethyl phthalate and dibutyl phthalate, respectively—were associated with higher pregnancy glucose in subfertile women—a population at high risk of glucose intolerance in pregnancy.

  • urinary triclosan concentrations and diminished ovarian reserve among women from a Fertility Clinic
    ISEE Conference Abstracts, 2018
    Co-Authors: Lidia Minguezalarcon, Jennifer B Ford, Paige L Williams, Antonia M. Calafat, Carmen Messerlian, Courtney C. Carignan, Irene Souter, Georgios A Christou, Russ Hauser
    Abstract:

    Background/Aim: Triclosan, an endocrine disrupting chemical used as an antibacterial in personal care and consumer products, has shown estrogenic activity in experimental studies. There are limited...