The Experts below are selected from a list of 540 Experts worldwide ranked by ideXlab platform

Yuri Volkov - One of the best experts on this subject based on the ideXlab platform.

  • length dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity
    Nanotoxicology, 2012
    Co-Authors: Craig A Poland, Fiona Byrne, Adriele Prinamello, Fiona A Murphy, Gemmalouise Davies, J M D Coey, Yurii Gounko, Rodger Duffin, Yuri Volkov, Ken Donaldson
    Abstract:

    The use of fibre-shaped Nanomaterials in commercial applications has met with concern that they could cause health effects similar to those seen with pathogenic fibres such as certain forms of asbestos. Of the attributes which form the fibre pathogenicity paradigm, fibre length is thought to be a critical factor in determining fibre toxicity. We have previously shown that carbon nanotubes display such length-dependent pathogenicity but it remains unclear if other forms of Fibrous Nanomaterials conform to the fibre pathogenicity paradigm. As such, our aim is to determine the generality of this hypothesis by asking whether a radically different form of Fibrous nanomaterial, nickel nanowires, show length-dependent pathogenicity. Our results indicate that nickel nanowires synthesised to be predominantly long (>20 mm) show the ability to elicit strong inflammation in the mouse peritoneal model in a dose-dependent manner; inflammation or fibrosis was not seen with the short (<5 mm) nanowires. This length-dependent response was also seen after lung aspiration and within a macrophage in vitro model adding further weight to the contention that fibre length is an important driver of hazard potential. This may have important implications when considering the hazard posed by Fibrous Nanomaterials and their regulation in workplaces.

  • Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity
    Nanotoxicology, 2011
    Co-Authors: Craig A Poland, Fiona Byrne, Fiona A Murphy, Gemmalouise Davies, J M D Coey, Yurii Gounko, Rodger Duffin, Adriele Prina-mello, Yuri Volkov
    Abstract:

    The use of fibre-shaped Nanomaterials in commercial applications has met with concern that they could cause health effects similar to those seen with pathogenic fibres such as certain forms of asbestos. Of the attributes which form the fibre pathogenicity paradigm, fibre length is thought to be a critical factor in determining fibre toxicity. We have previously shown that carbon nanotubes display such length-dependent pathogenicity but it remains unclear if other forms of Fibrous Nanomaterials conform to the fibre pathogenicity paradigm. As such, our aim is to determine the generality of this hypothesis by asking whether a radically different form of Fibrous nanomaterial, nickel nanowires, show length-dependent pathogenicity. Our results indicate that nickel nanowires synthesised to be predominantly long (>20 mm) show the ability to elicit strong inflammation in the mouse peritoneal model in a dose-dependent manner; inflammation or fibrosis was not seen with the short (

Craig A Poland - One of the best experts on this subject based on the ideXlab platform.

  • length dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity
    Nanotoxicology, 2012
    Co-Authors: Craig A Poland, Fiona Byrne, Adriele Prinamello, Fiona A Murphy, Gemmalouise Davies, J M D Coey, Yurii Gounko, Rodger Duffin, Yuri Volkov, Ken Donaldson
    Abstract:

    The use of fibre-shaped Nanomaterials in commercial applications has met with concern that they could cause health effects similar to those seen with pathogenic fibres such as certain forms of asbestos. Of the attributes which form the fibre pathogenicity paradigm, fibre length is thought to be a critical factor in determining fibre toxicity. We have previously shown that carbon nanotubes display such length-dependent pathogenicity but it remains unclear if other forms of Fibrous Nanomaterials conform to the fibre pathogenicity paradigm. As such, our aim is to determine the generality of this hypothesis by asking whether a radically different form of Fibrous nanomaterial, nickel nanowires, show length-dependent pathogenicity. Our results indicate that nickel nanowires synthesised to be predominantly long (>20 mm) show the ability to elicit strong inflammation in the mouse peritoneal model in a dose-dependent manner; inflammation or fibrosis was not seen with the short (<5 mm) nanowires. This length-dependent response was also seen after lung aspiration and within a macrophage in vitro model adding further weight to the contention that fibre length is an important driver of hazard potential. This may have important implications when considering the hazard posed by Fibrous Nanomaterials and their regulation in workplaces.

  • Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity
    Nanotoxicology, 2011
    Co-Authors: Craig A Poland, Fiona Byrne, Fiona A Murphy, Gemmalouise Davies, J M D Coey, Yurii Gounko, Rodger Duffin, Adriele Prina-mello, Yuri Volkov
    Abstract:

    The use of fibre-shaped Nanomaterials in commercial applications has met with concern that they could cause health effects similar to those seen with pathogenic fibres such as certain forms of asbestos. Of the attributes which form the fibre pathogenicity paradigm, fibre length is thought to be a critical factor in determining fibre toxicity. We have previously shown that carbon nanotubes display such length-dependent pathogenicity but it remains unclear if other forms of Fibrous Nanomaterials conform to the fibre pathogenicity paradigm. As such, our aim is to determine the generality of this hypothesis by asking whether a radically different form of Fibrous nanomaterial, nickel nanowires, show length-dependent pathogenicity. Our results indicate that nickel nanowires synthesised to be predominantly long (>20 mm) show the ability to elicit strong inflammation in the mouse peritoneal model in a dose-dependent manner; inflammation or fibrosis was not seen with the short (

Liyang Yu - One of the best experts on this subject based on the ideXlab platform.

  • emulsion electrospinning of polytetrafluoroethylene ptfe nanoFibrous membranes for high performance triboelectric nanogenerators
    ACS Applied Materials & Interfaces, 2018
    Co-Authors: Pengfei Zhao, Navneet Soin, K Prashanthi, Jinkai Chen, Shurong Dong, Erping Zhou, Anand Arcot Narasimulu, Carlo Montemagno, Liyang Yu
    Abstract:

    Electrospinning is a simple, versatile technique for fabricating Fibrous Nanomaterials with the desirable features of extremely high porosities and large surface areas. Using emulsion electrospinning, polytetrafluoroethylene/polyethene oxide (PTFE/PEO) membranes were fabricated, followed by a sintering process to obtain pure PTFE Fibrous membranes, which were further utilized against a polyamide 6 (PA6) membrane for vertical contact-mode triboelectric nanogenerators (TENGs). Electrostatic force microscopy (EFM) measurements of the sintered electrospun PTFE membranes revealed the presence of both positive and negative surface charges owing to the transfer of positive charge from PEO which was further corroborated by FTIR measurements. To enhance the ensuing triboelectric surface charge, a facile negative charge-injection process was carried out onto the electrospun (ES) PTFE subsequently. The fabricated TENG gave a stabilized peak-to-peak open-circuit voltage (Voc) of up to ∼900 V, a short-circuit current ...

Anna Luisa Costa - One of the best experts on this subject based on the ideXlab platform.

Agnes B. Kane - One of the best experts on this subject based on the ideXlab platform.

  • The asbestos-carbon nanotube analogy: An update.
    Toxicology and applied pharmacology, 2018
    Co-Authors: Agnes B. Kane, Robert H. Hurt, Huajian Gao
    Abstract:

    Abstract Nanotechnology is an emerging industry based on commercialization of materials with one or more dimensions of 100 nm or less. Engineered Nanomaterials are currently incorporated into thin films, porous materials, liquid suspensions, or filler/matrix nanocomposites with future applications predicted in energy and catalysis, microelectronics, environmental sensing and remediation, and nanomedicine. Carbon nanotubes are one-dimensional Fibrous Nanomaterials that physically resemble asbestos fibers. Toxicologic studies in rodents demonstrated that some types of carbon nanotubes can induce mesothelioma, and the World Health Organization evaluated long, rigid multiwall carbon nanotubes as possibly carcinogenic for humans in 2014. This review summarizes key physicochemical similarities and differences between asbestos fibers and carbon nanotubes. The “fiber pathogenicity paradigm” has been extended to include carbon nanotubes as well as other high-aspect-ratio Fibrous Nanomaterials including metallic nanowires. This paradigm identifies width, length, and biopersistence of high-aspect-ratio Fibrous Nanomaterials as critical determinants of lung disease, including mesothelioma, following inhalation. Based on recent theoretical modeling studies, a fourth factor, mechanical bending stiffness, will be considered as predictive of potential carcinogenicity. Novel three-dimensional lung tissue platforms provide an opportunity for in vitro screening of a wide range of high aspect ratio Fibrous Nanomaterials for potential lung toxicity prior to commercialization.

  • Biopersistence and potential adverse health impacts of Fibrous Nanomaterials: what have we learned from asbestos?
    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2009
    Co-Authors: Vanesa C. Sanchez, Jodie R. Pietruska, Nathan R. Miselis, Robert H. Hurt, Agnes B. Kane
    Abstract:

    Human diseases associated with exposure to asbestos fibers include pleural fibrosis and plaques, pulmonary fibrosis (asbestosis), lung cancer, and diffuse malignant mesothelioma. The critical determinants of fiber bioactivity and toxicity include not only fiber dimensions, but also shape, surface reactivity, crystallinity, chemical composition, and presence of transition metals. Depending on their size and dimensions, inhaled fibers can penetrate the respiratory tract to the distal airways and into the alveolar spaces. Fibers can be cleared by several mechanisms, including the mucociliary escalator, engulfment, and removal by macrophages, or through splitting and chemical modification. Biopersistence of long asbestos fibers can lead to inflammation, granuloma formation, fibrosis, and cancer. Exposure to synthetic carbon Nanomaterials, including carbon nanofibers and carbon nanotubes (CNTs), is considered a potential health hazard because of their physical similarities with asbestos fibers. Respiratory exposure to CNTs can produce an inflammatory response, diffuse interstitial fibrosis, and formation of fibrotic granulomas similar to that observed in asbestos-exposed animals and humans. Given the known cytotoxic and carcinogenic properties of asbestos fibers, toxicity of Fibrous Nanomaterials is a topic of intense study. The mechanisms of nanomaterial toxicity remain to be fully elucidated, but recent evidence suggests points of similarity with asbestos fibers, including a role for generation of reactive oxygen species, oxidative stress, and genotoxicity. Considering the rapid increase in production and use of Fibrous Nanomaterials, it is imperative to gain a thorough understanding of their biologic activity to avoid the human health catastrophe that has resulted from widespread use of asbestos fibers.