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Sarvesh Paliwal - One of the best experts on this subject based on the ideXlab platform.
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analgesic and anti pyretic activity of ethanolic and aqueous extracts of Ficus Benghalensis
2014Co-Authors: Vipin Kumar Garg, Sarvesh PaliwalAbstract:Objective: Ficus Benghalensis Linn. (Family: Moraceae) is a reputed plant in ayurvedic medicine and commonly known as "banayan tree" in ayurvedic literature. Traditionally, Ficus Benghalensis is used for pain and fever. Since no detailed scientific data is available regarding the analgesic and antipyretic activities of Ficus Benghalensis, the present study was designed to explore the same. Methods: In the present study, analgesic and anti-pyretic activities of ethanolic and aqueous extracts of Ficus Benghalensis at dose levels of 100 mg/kg, 200mg/kg and 400 mg/kg was studied using hot plate, acetic acid induced writhing and yeast induced hyperthermia method. Student’s t test was used to analyze the results obtained from the present study and p<0.05 was considered significant. Results: Ficus Benghalensis showed significant analgesic and anti-pyretic activities in all models studied. Results support the traditional use of the plant in the treatment of pain and fever. Conclusion: The present study has demonstrated the analgesic and antipyretic potential of the ethanolic and aqueous extracts of Ficus Benghalensis. Therefore the present study had verified the traditional use of Ficus Benghalensis in pain and fever. As the phytochemical screening has shown the presence of flavonoids and glycosides in both ethanolic and aqueous extracts, the potent activity may be attributed to the presence of these phytoconstituents.
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Wound-healing activity of ethanolic and aqueous extracts of Ficus Benghalensis.
Journal of advanced pharmaceutical technology & research, 2011Co-Authors: Vipin Kumar Garg, Sarvesh PaliwalAbstract:Wound healing is the process of repair that follows injury to the skin and other soft tissues. Following injury, an inflammatory response occurs and the cells below the dermis (the deepest skin layer) begin to increase collagen (connective tissue) production. Later, the epithelial tissue (the outer skin) is regenerated. There are three stages to the process of wound healing: inflammation, proliferation, and remodeling. Traditionally, Ficus Benghalensis is used for wound healing. Since no detailed scientific data are available regarding the wound-healing activity of F. Benghalensis, the present study was designed to explore the same. The wound-healing efficacy of ethanolic and aqueous extracts of F. Benghalensis was evaluated in excision and incision wound models. The parameters studied include rate of wound contraction, period of complete epithelialization, and tensile strength of incision wound. Student's t test was used to analyze the results obtained from the present study and P
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wound healing activity of ethanolic and aqueous extracts of Ficus Benghalensis
Journal of advanced pharmaceutical technology & research, 2011Co-Authors: Vipin Kumar Garg, Sarvesh PaliwalAbstract:Wound healing is the process of repair that follows injury to the skin and other soft tissues. Following injury, an inflammatory response occurs and the cells below the dermis (the deepest skin layer) begin to increase collagen (connective tissue) production. Later, the epithelial tissue (the outer skin) is regenerated. There are three stages to the process of wound healing: inflammation, proliferation, and remodeling. Traditionally, Ficus Benghalensis is used for wound healing. Since no detailed scientific data are available regarding the wound-healing activity of F. Benghalensis , the present study was designed to explore the same. The wound-healing efficacy of ethanolic and aqueous extracts of F. Benghalensis was evaluated in excision and incision wound models. The parameters studied include rate of wound contraction, period of complete epithelialization, and tensile strength of incision wound. Student's t test was used to analyze the results obtained from the present study and P F. Benghalensis were found to possess significant wound-healing activity, which was evidenced by decrease in the period of epithelialization, increase in the rate of wound contraction and skin-breaking strength. The present study has demonstrated that the ethanolic and aqueous extracts of F. Benghalensis have properties that render them capable of promoting accelerated wound-healing activity compared with placebo control.
Priti Singh - One of the best experts on this subject based on the ideXlab platform.
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green synthesis of silver nanoparticles using aqueous solution of Ficus Benghalensis leaf extract and characterization of their antibacterial activity
Materials Letters, 2012Co-Authors: Antariksh Saxena, R M Tripathi, Fahmina Zafar, Priti SinghAbstract:Abstract The present study reports an environmentally friendly and rapid method for synthesis of silver nanoparticles. Although several articles have been reported for the synthesis of silver nanoparticles from plant extract, here we have developed a green synthetic method for silver nanoparticles using Ficus Benghalensis leaf extract which acts as a reducing and capping agent. It was observed that use of Ficus Benghalensis leaf extract makes a fast and convenient method for the synthesis of silver nanoparticles and can reduce silver ions into silver nanoparticles within 5 min of reaction time without using any harsh conditions. Silver nanoparticles so prepared were characterized by using UV–visible spectroscopy, transmission electron microscope-energy dispersive spectra (TEM-EDS) and X-ray diffraction (XRD). Further, these nanoparticles show effective antibacterial activity toward E.coli MTCC1302 due to high surface to volume ratio.
Vipin Kumar Garg - One of the best experts on this subject based on the ideXlab platform.
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analgesic and anti pyretic activity of ethanolic and aqueous extracts of Ficus Benghalensis
2014Co-Authors: Vipin Kumar Garg, Sarvesh PaliwalAbstract:Objective: Ficus Benghalensis Linn. (Family: Moraceae) is a reputed plant in ayurvedic medicine and commonly known as "banayan tree" in ayurvedic literature. Traditionally, Ficus Benghalensis is used for pain and fever. Since no detailed scientific data is available regarding the analgesic and antipyretic activities of Ficus Benghalensis, the present study was designed to explore the same. Methods: In the present study, analgesic and anti-pyretic activities of ethanolic and aqueous extracts of Ficus Benghalensis at dose levels of 100 mg/kg, 200mg/kg and 400 mg/kg was studied using hot plate, acetic acid induced writhing and yeast induced hyperthermia method. Student’s t test was used to analyze the results obtained from the present study and p<0.05 was considered significant. Results: Ficus Benghalensis showed significant analgesic and anti-pyretic activities in all models studied. Results support the traditional use of the plant in the treatment of pain and fever. Conclusion: The present study has demonstrated the analgesic and antipyretic potential of the ethanolic and aqueous extracts of Ficus Benghalensis. Therefore the present study had verified the traditional use of Ficus Benghalensis in pain and fever. As the phytochemical screening has shown the presence of flavonoids and glycosides in both ethanolic and aqueous extracts, the potent activity may be attributed to the presence of these phytoconstituents.
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Wound-healing activity of ethanolic and aqueous extracts of Ficus Benghalensis.
Journal of advanced pharmaceutical technology & research, 2011Co-Authors: Vipin Kumar Garg, Sarvesh PaliwalAbstract:Wound healing is the process of repair that follows injury to the skin and other soft tissues. Following injury, an inflammatory response occurs and the cells below the dermis (the deepest skin layer) begin to increase collagen (connective tissue) production. Later, the epithelial tissue (the outer skin) is regenerated. There are three stages to the process of wound healing: inflammation, proliferation, and remodeling. Traditionally, Ficus Benghalensis is used for wound healing. Since no detailed scientific data are available regarding the wound-healing activity of F. Benghalensis, the present study was designed to explore the same. The wound-healing efficacy of ethanolic and aqueous extracts of F. Benghalensis was evaluated in excision and incision wound models. The parameters studied include rate of wound contraction, period of complete epithelialization, and tensile strength of incision wound. Student's t test was used to analyze the results obtained from the present study and P
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wound healing activity of ethanolic and aqueous extracts of Ficus Benghalensis
Journal of advanced pharmaceutical technology & research, 2011Co-Authors: Vipin Kumar Garg, Sarvesh PaliwalAbstract:Wound healing is the process of repair that follows injury to the skin and other soft tissues. Following injury, an inflammatory response occurs and the cells below the dermis (the deepest skin layer) begin to increase collagen (connective tissue) production. Later, the epithelial tissue (the outer skin) is regenerated. There are three stages to the process of wound healing: inflammation, proliferation, and remodeling. Traditionally, Ficus Benghalensis is used for wound healing. Since no detailed scientific data are available regarding the wound-healing activity of F. Benghalensis , the present study was designed to explore the same. The wound-healing efficacy of ethanolic and aqueous extracts of F. Benghalensis was evaluated in excision and incision wound models. The parameters studied include rate of wound contraction, period of complete epithelialization, and tensile strength of incision wound. Student's t test was used to analyze the results obtained from the present study and P F. Benghalensis were found to possess significant wound-healing activity, which was evidenced by decrease in the period of epithelialization, increase in the rate of wound contraction and skin-breaking strength. The present study has demonstrated that the ethanolic and aqueous extracts of F. Benghalensis have properties that render them capable of promoting accelerated wound-healing activity compared with placebo control.
Hunseung Kang - One of the best experts on this subject based on the ideXlab platform.
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the micromorphology and protein characterization of rubber particles in Ficus carica Ficus Benghalensis and hevea brasiliensis
Journal of Experimental Botany, 2003Co-Authors: Adya P Singh, Gap Chae Chung, Seung Gon Wi, Hunseung KangAbstract:Rubber biosynthesis takes place on the surface of rubber particles. These particles are surrounded by a monolayer membrane in which the rubber transferase is anchored. In order to gain better insight into whether rubber particles from different plant species share common structural characteristics, the micro morphology of rubber particles from Ficus carica, Ficus Benghalensis, and Hevea brasiliensis was examined by electron microscopy. Rubber particles of ail three species were spherical in shape, and the size of rubber particles of H. brasiliensis was much smaller than those of F. carica and F. Benghalensis. In addition, investigations were undertaken to com pare the cross-reactivity of the antibody raised against either the H. brasiliensis small rubber particle protein (SRPP) which is suggested to be involved in rubber biosynthesis, or the c/s-prenyltransferase (CPT) which has an activity similar to rubber transfer ase. Both western analysis and TEM-immunogold labelling studies showed that rubber particles of F. carica and F. Benghalensis do not contain the SRPP. None of the rubber particles in F. carica, F. bengha lensis and H. brasiliensis contained the CPT, sug gesting that the CPT itself could not catalyse the formation of high molecular weight rubber. These results indicate that rubber particles in the three dif ferent plant species investigated share some degree of similarity in architecture, and that the SRPP and CPT themselves are not the core proteins necessary for rubber biosynthesis.
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characterization of natural rubber biosynthesisin Ficus Benghalensis
Plant Physiology and Biochemistry, 2000Co-Authors: Hunseung Kang, Gap Chae ChungAbstract:Abstract Natural rubber was identified for the first time in the latex of Ficus Benghalensis, and the rubber biosynthetic activity in latex and rubber particles was investigated. 13C NMR analysis of samples prepared by successive extractions with acetone and benzene confirmed that the benzene-soluble residues were natural rubber, cis-1,4-polyisoprene. The rubber content in the latex of F. Benghalensis was approximately 17 %. Gel permeation chromatography revealed that the molecular mass of the natural rubber from F. Benghalensis was approximately 1 500 kDa. The high rubber content and large molecular size suggest that F. Benghalensis is a good candidate for an alternative rubber source. Examination of latex serum from F. Benghalensis by SDS-polyacrylamide gel electrophoresis revealed a small number of proteins with major proteins of 31 and 55 kDa in size. The 31-kDa protein was predominant in catalytically-active rubber particles. Determination of metal ion concentration in latex and a comparison of the effect of ethylenediamine-tetraacetic acid on in vitro rubber biosynthesis in F. Benghalensis, F. carica and Hevea brasiliensis suggest that the divalent metal ion present in latex serum is an important physiological factor controlling the rubber biosynthetic activities in these plant species. Microscopic examination revealed that the rubber in F. Benghalensis occurred in a series of laticifer cells located in concentric zones in the inner bark of stems and branches.
Upendra Kumar - One of the best experts on this subject based on the ideXlab platform.
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formulation and evaluation of Ficus Benghalensis and Ficus racemosa aquoues extracts
American Journal of Biochemistry and Biotechnology, 2013Co-Authors: Krishna Murti, Upendra Kumar, Divya Kiran, Manish KaushikAbstract:We intended to develop a desired ointment for treat ment of wound. Main objective of this study was to formulate the ointment with different ointment base s having good consistency, better diffusion and antiseptic properties. To assess the efficacy of un iformity, viscosity, diffusivity, rheology, stabili ty, spreadability, permeability and other physical char acteristics were evaluated. Two Formulations, formulation A (Aq. extract of Ficus racemosa ) and B (Aqueous extract of Ficus Benghalensis ) were prepared with same bases. Both the Formulation A and B contains hard paraffin, cetostearyl alcohol, Li ght liquid paraffin and microcrystalline wax. Formulati on B was found better than formulation A in all asp ects like spreadability, viscosity, consistency, stabili ty, diffusibility. In conclusion, it was clearly observed that Formulation B was better than formulation A.
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preliminary phytochemical investigation of roots of Ficus Benghalensis
亚洲传统医药, 2012Co-Authors: Krishna Murti, Upendra Kumar, Manish Kaushik, Aditi KaushikAbstract:Micromorphological characters for Ficus Benghalensis are not reported. It is used in Ayurveda for the treatment of Diarrhea, Dysentery and piles, Rheumatism, skin disorders like sores, teeth disorders, to boost immune system, as a hypoglycemic. Literature reports the number of uses like anthelmentic, astringent, antidiabetic, dermatitis, and anti-inflammatory activity of this plant. The main constituents in the plant are carbohydrates, glycosides, tannins, steroids and gums and mucilage, lupeol, ceryl behenate, lupeol acetate, α-amyrin acetate, leucoantho cyanidin, and leucoanthocyanin. It is characterized by the presence of thick walled cork, several layered regularly arranged. Epidermis is thin walled and single layered, cortex and hypodermis is distinct, fibres and vessels are lignified, medullary rays are thick walled and lignified. Centre is occupied by the pith which is thin walled and has parenchymatous cells. Phytochemical investigation of root shows total ash (3.5% w/w), acid insoluble ash (4.0% w/w), and water soluble ash (5.0% w/w). Loss on drying is 4.6% w/w. Alcohol soluble extractive value (3.8% w/w), water soluble extractive value (10.5% w/w), chloroform soluble extractive value (10.4% w/w) and ether soluble extractive value (7.2% w/w). In alcoholic extract and aqueous extract, tannins and saponins are present in in major amount. Other constituents include carbohydrate, glycosides, phenolic compounds and gums and mucilage were present.
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antimicrobial activity of Ficus Benghalensis and Ficus racemosa roots l
Current Research in Microbiology, 2012Co-Authors: Krishna Murti, Upendra KumarAbstract:Problems statement: To evaluate the antimicrobial activity of aqueous and ethanolic extracts of Ficus Benghalensis and Ficus racemosa against three bacterial strains that is Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumonia. Approach: The different concentrations viz. 25, 50 and 75 mg mL-1 of aqueous as well as ethanolic extract solutions of roots of Ficus Benghalensis and Ficus racemosa were tested against above three bacterial strains. The effects were compared with that of a standard antibiotic-loaded disc, ampicillin (10 mcg/disc) of Himedia Labs. Finally, the plates were incubated with lids closed at 37°C for 24 h. Discs were observed for zones of inhibition by measuring the Diameter of Inhibition Zone (DIZ) using a ruler. Results: Ficus racemosa ethanolic extract showed maximum inhibition against Staphylococcus aureus when compared with Ficus Benghalensis ethanolic extract. However standard drug ampicillin showed maximum antimicrobial activity compared with both the plants. Conclusion: In conclusion, it was clearly observed that ethanolic extract of both the plants were having good antimicrobial activity towards Staphylococcus aureus.
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healing promoting potentials of roots of Ficus Benghalensis l in albino rats
Asian Pacific Journal of Tropical Medicine, 2011Co-Authors: Krishna Murti, Upendra Kumar, Mayank PanchalAbstract:Objective To screen the wound healing activity of aqueous and ethanolic extract of roots of Ficus Benghalensis . Methods Both the extracts were evaluated for wound healing by three modelsie. incision, excision and dead space wound. In incision and dead space the extracts were applied daily topically till the 10 th post wounding days while in excision model it was till the complete epithelialization process. Standard group were administered Povidone iodine ointment topically daily. The breaking strength, percentage of wound contraction, period of epithelialization, dry granulation weight and hydroxyproline content were observed. Results The result of the present study showed that both extracts were able to increase the breaking strength (incision model), decrease period of epithelialization, increase percentage wound contraction (excision model), increase hydroxyproline content (Dead space wound model) significantly compared with control group ( P Conclusions Based on result we conclude that aqueous extract is more effective than ethanolic extract. However, it is needed more research to be carried out especially on toxicity studies of ethanolic extract.
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reversal of dexamethasone depressant action in wound healing by Ficus Benghalensis l roots
American Journal of Pharmacology and Toxicology, 2011Co-Authors: Krishna Murti, Upendra KumarAbstract:Problem statement: Ficus Benghalensis is widely used plant world wide traditionally as well as scientifically. It has a wide uses in various medical ailments. As a part of pharmacological evaluations, we have carried out wound healing activity specially in dexamethasone depressed healing conditions. Approach: Wound healing activity was established by two medels namely incision and excision. Results: The roots of Ficus Benghalensis clearly reverted the antihealing in presence of dexamethasone treated animals. It happened through increase in breaking strength in incision model and increase in percentage wound contraction and reduction in period of epithelialization. Conclusion: Presence of various chemical constituents in the roots of Ficus Benghalensis specially saponins, flavanoids, taannins and alkaloids were responsible for antagonizing the antihealing effect of dexamethasone treated animals.