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Hyon-jong Chung - One of the best experts on this subject based on the ideXlab platform.
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Flavonoids isolated from korea citrus aurantium l induce g2 m phase arrest and apoptosis in human gastric cancer ags cells
Evidence-based Complementary and Alternative Medicine, 2012Co-Authors: Do Hoon Lee, Jin-a Kim, Hyeon-soo Park, Sang-rim Kang, Kwang-il Park, Arulkumar Nagappan, Won Sup Lee, Eun Hee Kim, Young-sool Hah, Hyon-jong ChungAbstract:Aim of the Study. Citrus species is used in traditional medicine as medicinal herb in several Asian countries including Korea. Flavonioids became known as various properties, such as anti-oxidants, anti-inflammation and anti-cancer, and so forth. The present study, the anti-cancer effect of flavonioids isolated from Citrus aurantium L. in human gastric cancer AGS cells has been investigated. Materials and Methods. The anti-proliferative activity was assayed using MTT assay. Cell cycle analysis was done using flow cytometry and apoptosis detection was done using by hoechst fluorescent staining and Annexin V-propidium iodide double staining. Western blot was used to detect the expression of protein related with cell cycle and apoptosis. Results. Flavonoids isolated from Citrus aurantium L. have the effect of anti proliferation on AGS cells with IC50 value of 99 μg/mL. Flavonoids inhibited cell cycle progression in the G2/M phase and decrease expression level of cyclin B1, cdc 2, cdc 25c. Flavonoids induced apoptosis through activate caspase and inactivate PARP. Conclusions. Flavonoids isolated from Citrus aurantium L. induced G2/M phase arrest through the modulation of cell cycle related proteins and apoptosis through activation caspase. These finding suggest Flavonoids isolated from Citrus aurantium L. were useful agent for the chemoprevention of gastric cancer.
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Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells.
Evidence-based Complementary and Alternative Medicine, 2011Co-Authors: Hoon Lee, Jin-a Kim, Hyeon-soo Park, Sang-rim Kang, Kwang-il Park, Arulkumar Nagappan, Won Sup Lee, Eun Hee Kim, Young-sool Hah, Hyon-jong ChungAbstract:Aim of the Study. Citrus species is used in traditional medicine as medicinal herb in several Asian countries including Korea. Flavonioids became known as various properties, such as anti-oxidants, anti-inflammation and anti-cancer, and so forth. The present study, the anti-cancer effect of flavonioids isolated from Citrus aurantium L. in human gastric cancer AGS cells has been investigated. Materials and Methods. The anti-proliferative activity was assayed using MTT assay. Cell cycle analysis was done using flow cytometry and apoptosis detection was done using by hoechst fluorescent staining and Annexin V-propidium iodide double staining. Western blot was used to detect the expression of protein related with cell cycle and apoptosis. Results. Flavonoids isolated from Citrus aurantium L. have the effect of anti proliferation on AGS cells with IC50 value of 99 μg/mL. Flavonoids inhibited cell cycle progression in the G2/M phase and decrease expression level of cyclin B1, cdc 2, cdc 25c. Flavonoids induced apoptosis through activate caspase and inactivate PARP. Conclusions. Flavonoids isolated from Citrus aurantium L. induced G2/M phase arrest through the modulation of cell cycle related proteins and apoptosis through activation caspase. These finding suggest Flavonoids isolated from Citrus aurantium L. were useful agent for the chemoprevention of gastric cancer.
Chate Agama, Estrellita Briguitt Belen - One of the best experts on this subject based on the ideXlab platform.
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Loción floral de tropaeolum majus (mastuerzo) y efecto sobre tinea pedís en adultos del A.H. Nicolas de Pierola – Chosica
'Universidad Inca Garcilaso de la Vega', 2019Co-Authors: Chate Agama, Estrellita Briguitt BelenAbstract:La investigación realizada tuvo como objetivo general determinar si la loción a base de flores de Tropaeolum majus L. (Mastuerzo) produce efecto sobre Tinea pedis; a su vez, pretendió identificar metabolitos secundarios, determinar estructuras químicas mediante espectrofotómetro UV. Para ello se desarrolló el estudio fitoquímico, donde se encontraron compuestos fenólicos y flavonoides. También se realizaron lecturas en el espectrofotómetro UV y con ello se propusieron seis estructuras químicas de flavonoides. Después se realizó la evaluación diagnóstica de examen directo y cultivo de dermatofitos a los pacientes voluntarios; esto ocurrió previo al tratamiento con la loción a base de flores de Troapeolum majus L. (LBTM). El tratamiento se realizó con la LBTM.The general objective of the present investigation was to determine if the flower-based lotion of Tropaeolum majus L. (garden nasturtium) has an effect on Tinea pedis; at the same time, it aimed to identify secondary metabolites, determine chemical structures by UV spectrophotometer. For this, the phytochemical study was developed, where phenolic compounds and Flavonoids were found. Also readings were made in the UV spectrophotometer and with it six chemical structures were of Flavonoids proposed. After the diagnostic evaluation of direct examination and culture of dermatophytes to the voluntary patients; this occurred before the treatment with the lotion based on flowers of Troapeolum majus L. (LBTM)
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Loción floral de tropaeolum majus (mastuerzo) y efecto sobre tinea pedís en adultos del A.H. Nicolas de Pierola – Chosica
'Universidad Inca Garcilaso de la Vega', 2019Co-Authors: Chate Agama, Estrellita Briguitt BelenAbstract:TesisThe general objective of the present investigation was to determine if the flower-based lotion of Tropaeolum majus L. (garden nasturtium) has an effect on Tinea pedis; at the same time, it aimed to identify secondary metabolites, determine chemical structures by UV spectrophotometer. For this, the phytochemical study was developed, where phenolic compounds and Flavonoids were found. Also readings were made in the UV spectrophotometer and with it six chemical structures were of Flavonoids proposed. After the diagnostic evaluation of direct examination and culture of dermatophytes to the voluntary patients; this occurred before the treatment with the lotion based on flowers of Troapeolum majus L. (LBTM).La investigación realizada tuvo como objetivo general determinar si la loción a base de flores de Tropaeolum majus L. (Mastuerzo) produce efecto sobre Tinea pedis; a su vez, pretendió identificar metabolitos secundarios, determinar estructuras químicas mediante espectrofotómetro UV. Para ello se desarrolló el estudio fitoquímico, donde se encontraron compuestos fenólicos y flavonoides. También se realizaron lecturas en el espectrofotómetro UV y con ello se propusieron seis estructuras químicas de flavonoides. Después se realizó la evaluación diagnóstica de examen directo y cultivo de dermatofitos a los pacientes voluntarios; esto ocurrió previo al tratamiento con la loción a base de flores de Troapeolum majus L. (LBTM). El tratamiento se realizó con la LBTM
Do Hoon Lee - One of the best experts on this subject based on the ideXlab platform.
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Flavonoids isolated from korea citrus aurantium l induce g2 m phase arrest and apoptosis in human gastric cancer ags cells
Evidence-based Complementary and Alternative Medicine, 2012Co-Authors: Do Hoon Lee, Jin-a Kim, Hyeon-soo Park, Sang-rim Kang, Kwang-il Park, Arulkumar Nagappan, Won Sup Lee, Eun Hee Kim, Young-sool Hah, Hyon-jong ChungAbstract:Aim of the Study. Citrus species is used in traditional medicine as medicinal herb in several Asian countries including Korea. Flavonioids became known as various properties, such as anti-oxidants, anti-inflammation and anti-cancer, and so forth. The present study, the anti-cancer effect of flavonioids isolated from Citrus aurantium L. in human gastric cancer AGS cells has been investigated. Materials and Methods. The anti-proliferative activity was assayed using MTT assay. Cell cycle analysis was done using flow cytometry and apoptosis detection was done using by hoechst fluorescent staining and Annexin V-propidium iodide double staining. Western blot was used to detect the expression of protein related with cell cycle and apoptosis. Results. Flavonoids isolated from Citrus aurantium L. have the effect of anti proliferation on AGS cells with IC50 value of 99 μg/mL. Flavonoids inhibited cell cycle progression in the G2/M phase and decrease expression level of cyclin B1, cdc 2, cdc 25c. Flavonoids induced apoptosis through activate caspase and inactivate PARP. Conclusions. Flavonoids isolated from Citrus aurantium L. induced G2/M phase arrest through the modulation of cell cycle related proteins and apoptosis through activation caspase. These finding suggest Flavonoids isolated from Citrus aurantium L. were useful agent for the chemoprevention of gastric cancer.
Young-sool Hah - One of the best experts on this subject based on the ideXlab platform.
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Flavonoids isolated from korea citrus aurantium l induce g2 m phase arrest and apoptosis in human gastric cancer ags cells
Evidence-based Complementary and Alternative Medicine, 2012Co-Authors: Do Hoon Lee, Jin-a Kim, Hyeon-soo Park, Sang-rim Kang, Kwang-il Park, Arulkumar Nagappan, Won Sup Lee, Eun Hee Kim, Young-sool Hah, Hyon-jong ChungAbstract:Aim of the Study. Citrus species is used in traditional medicine as medicinal herb in several Asian countries including Korea. Flavonioids became known as various properties, such as anti-oxidants, anti-inflammation and anti-cancer, and so forth. The present study, the anti-cancer effect of flavonioids isolated from Citrus aurantium L. in human gastric cancer AGS cells has been investigated. Materials and Methods. The anti-proliferative activity was assayed using MTT assay. Cell cycle analysis was done using flow cytometry and apoptosis detection was done using by hoechst fluorescent staining and Annexin V-propidium iodide double staining. Western blot was used to detect the expression of protein related with cell cycle and apoptosis. Results. Flavonoids isolated from Citrus aurantium L. have the effect of anti proliferation on AGS cells with IC50 value of 99 μg/mL. Flavonoids inhibited cell cycle progression in the G2/M phase and decrease expression level of cyclin B1, cdc 2, cdc 25c. Flavonoids induced apoptosis through activate caspase and inactivate PARP. Conclusions. Flavonoids isolated from Citrus aurantium L. induced G2/M phase arrest through the modulation of cell cycle related proteins and apoptosis through activation caspase. These finding suggest Flavonoids isolated from Citrus aurantium L. were useful agent for the chemoprevention of gastric cancer.
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Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells.
Evidence-based Complementary and Alternative Medicine, 2011Co-Authors: Hoon Lee, Jin-a Kim, Hyeon-soo Park, Sang-rim Kang, Kwang-il Park, Arulkumar Nagappan, Won Sup Lee, Eun Hee Kim, Young-sool Hah, Hyon-jong ChungAbstract:Aim of the Study. Citrus species is used in traditional medicine as medicinal herb in several Asian countries including Korea. Flavonioids became known as various properties, such as anti-oxidants, anti-inflammation and anti-cancer, and so forth. The present study, the anti-cancer effect of flavonioids isolated from Citrus aurantium L. in human gastric cancer AGS cells has been investigated. Materials and Methods. The anti-proliferative activity was assayed using MTT assay. Cell cycle analysis was done using flow cytometry and apoptosis detection was done using by hoechst fluorescent staining and Annexin V-propidium iodide double staining. Western blot was used to detect the expression of protein related with cell cycle and apoptosis. Results. Flavonoids isolated from Citrus aurantium L. have the effect of anti proliferation on AGS cells with IC50 value of 99 μg/mL. Flavonoids inhibited cell cycle progression in the G2/M phase and decrease expression level of cyclin B1, cdc 2, cdc 25c. Flavonoids induced apoptosis through activate caspase and inactivate PARP. Conclusions. Flavonoids isolated from Citrus aurantium L. induced G2/M phase arrest through the modulation of cell cycle related proteins and apoptosis through activation caspase. These finding suggest Flavonoids isolated from Citrus aurantium L. were useful agent for the chemoprevention of gastric cancer.
Eun Hee Kim - One of the best experts on this subject based on the ideXlab platform.
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Flavonoids isolated from korea citrus aurantium l induce g2 m phase arrest and apoptosis in human gastric cancer ags cells
Evidence-based Complementary and Alternative Medicine, 2012Co-Authors: Do Hoon Lee, Jin-a Kim, Hyeon-soo Park, Sang-rim Kang, Kwang-il Park, Arulkumar Nagappan, Won Sup Lee, Eun Hee Kim, Young-sool Hah, Hyon-jong ChungAbstract:Aim of the Study. Citrus species is used in traditional medicine as medicinal herb in several Asian countries including Korea. Flavonioids became known as various properties, such as anti-oxidants, anti-inflammation and anti-cancer, and so forth. The present study, the anti-cancer effect of flavonioids isolated from Citrus aurantium L. in human gastric cancer AGS cells has been investigated. Materials and Methods. The anti-proliferative activity was assayed using MTT assay. Cell cycle analysis was done using flow cytometry and apoptosis detection was done using by hoechst fluorescent staining and Annexin V-propidium iodide double staining. Western blot was used to detect the expression of protein related with cell cycle and apoptosis. Results. Flavonoids isolated from Citrus aurantium L. have the effect of anti proliferation on AGS cells with IC50 value of 99 μg/mL. Flavonoids inhibited cell cycle progression in the G2/M phase and decrease expression level of cyclin B1, cdc 2, cdc 25c. Flavonoids induced apoptosis through activate caspase and inactivate PARP. Conclusions. Flavonoids isolated from Citrus aurantium L. induced G2/M phase arrest through the modulation of cell cycle related proteins and apoptosis through activation caspase. These finding suggest Flavonoids isolated from Citrus aurantium L. were useful agent for the chemoprevention of gastric cancer.
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Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells.
Evidence-based Complementary and Alternative Medicine, 2011Co-Authors: Hoon Lee, Jin-a Kim, Hyeon-soo Park, Sang-rim Kang, Kwang-il Park, Arulkumar Nagappan, Won Sup Lee, Eun Hee Kim, Young-sool Hah, Hyon-jong ChungAbstract:Aim of the Study. Citrus species is used in traditional medicine as medicinal herb in several Asian countries including Korea. Flavonioids became known as various properties, such as anti-oxidants, anti-inflammation and anti-cancer, and so forth. The present study, the anti-cancer effect of flavonioids isolated from Citrus aurantium L. in human gastric cancer AGS cells has been investigated. Materials and Methods. The anti-proliferative activity was assayed using MTT assay. Cell cycle analysis was done using flow cytometry and apoptosis detection was done using by hoechst fluorescent staining and Annexin V-propidium iodide double staining. Western blot was used to detect the expression of protein related with cell cycle and apoptosis. Results. Flavonoids isolated from Citrus aurantium L. have the effect of anti proliferation on AGS cells with IC50 value of 99 μg/mL. Flavonoids inhibited cell cycle progression in the G2/M phase and decrease expression level of cyclin B1, cdc 2, cdc 25c. Flavonoids induced apoptosis through activate caspase and inactivate PARP. Conclusions. Flavonoids isolated from Citrus aurantium L. induced G2/M phase arrest through the modulation of cell cycle related proteins and apoptosis through activation caspase. These finding suggest Flavonoids isolated from Citrus aurantium L. were useful agent for the chemoprevention of gastric cancer.
