The Experts below are selected from a list of 7776 Experts worldwide ranked by ideXlab platform

Maie A St John - One of the best experts on this subject based on the ideXlab platform.

  • clinicopathologic characteristics and survival outcomes in Floor of Mouth squamous cell carcinoma a population based study
    Otolaryngology-Head and Neck Surgery, 2018
    Co-Authors: Satvir Saggi, Karam W Badran, Edward C Kuan, Maie A St John
    Abstract:

    ObjectiveTo describe the determinants of survival for patients with Floor of Mouth (FOM) squamous cell carcinoma (SCC) from 1973 to 2013 with the SEER database (Surveillance, Epidemiology, and End ...

  • clinicopathologic characteristics and survival outcomes in Floor of Mouth squamous cell carcinoma a population based study
    Otolaryngology-Head and Neck Surgery, 2018
    Co-Authors: Satvir Saggi, Karam W Badran, Edward C Kuan, Albert Y Han, Maie A St John
    Abstract:

    Objective To describe the determinants of survival for patients with Floor of Mouth (FOM) squamous cell carcinoma (SCC) from 1973 to 2013 with the SEER database (Surveillance, Epidemiology, and End Results). Study Design and Setting Retrospective cohort study with a national database. Subjects and Methods The SEER registry was utilized to calculate survival trends for patients with FOM SCC between 1973 and 2013. Patient data were analyzed with respect to age, sex, race, primary site, stage at presentation, tumor size, grade, and treatment modalities (surgery and radiotherapy). Overall survival (OS) and disease-specific survival (DSS) were calculated. Results A total of 14,010 FOM SCC cases were identified. The cohort was 69.5% male, and the median age at diagnosis was 62 years. Forty-six percent of cases were treated with surgery, while 14% received radiotherapy. Kaplan-Meier analysis demonstrated OS and DSS of 39% and 59% at 5 years, respectively. Multivariate analysis showed that age, grade, stage, size, and surgery were determinants for OS and DSS (all P < .05). For early- and advanced-stage cancers, age, grade, size, and surgery predicted OS and DSS, while radiotherapy was a predictor of OS and DSS in advanced-stage tumors only (all P < .05). Conclusion To our knowledge, this study is the largest to date investigating prognostic factors for survival of patients diagnosed with FOM SCC. Determinants of survival include age, grade, stage, size, and surgery. Surgery appears to play a critical role in the management of these tumors.

Yaohshiang Lin - One of the best experts on this subject based on the ideXlab platform.

  • medial sural artery perforator flap for tongue and Floor of Mouth reconstruction
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2008
    Co-Authors: Shaoliang Chen, Niann Tzyy Dai, Timmo Chen, Yijan Hsia, Yaohshiang Lin
    Abstract:

    Background. The radial forearm flap is frequently considered the first choice for tongue reconstruction, but the disadvantages of donor site morbidity are well known. The search for another thin skin flap as an alternative has led to the application of the medial sural artery perforator flap. Methods. We used 12 medial sural artery perforator flaps to reconstruct tongue and Floor of Mouth following cancer ablation. We paid attention to the major perforator (vein ≥ 1 mm) as the vascular relay. Results. Most flaps were raised with a single perforator. The size of the skin paddle varied from 9 cm × 5 cm to 14 cm × 12 cm. The mean thickness of the flap was 5.2 mm. We reexplored 1 patient for venous insufficiency and could not salvage the flap. Conclusions. The thin medial sural artery perforator flap permits high accuracy of tongue restoration and reduces the morbidity at the donor site. © 2007 Wiley Periodicals, Inc. Head Neck, 2008

Anthony Bared - One of the best experts on this subject based on the ideXlab platform.

  • sentinel node biopsy in oral squamous cell carcinoma
    Journal of Surgical Oncology, 2007
    Co-Authors: Francisco Civantos, Robert P Zitsch, Anthony Bared
    Abstract:

    The clinical utility of sentinel node biopsy techniques for cutaneous melanoma has led multiple investigators to study the applicability of this approach to other solid tumors, including cancers of the upper aerodigestive tract, and especially the oral cavity. Preliminary data indicate that it may be useful for early oral cancers, with the exception of Floor of Mouth tumors, where technical challenges related to the proximity of the lymphatic basin remain a problem. A multi-institutional pathologic validation trial, involving sentinel node biopsy followed by completion selective neck dissection, has completed accrual. While central step sectioning and immunohistochemistry remain to be completed and analyzed, routine pathologic techniques provided negative predictive values of 96% for oral cancer excluding Floor of Mouth lesions. Subsequent trials need to involve clinical follow-up and evaluation for recurrence in the neck. We believe this technique may ultimately play a role in the management of early oral cancer. J. Surg. Oncol. 2007;96:330–336. © 2007 Wiley-Liss, Inc.

Robin L Wagner - One of the best experts on this subject based on the ideXlab platform.

  • Floor of Mouth carcinoma the management of the clinically negative neck
    Archives of Otolaryngology-head & Neck Surgery, 1995
    Co-Authors: William F. Mcguirt, Robert E. Rothfield, Jonas T Johnson, Eugene N Myers, Robin L Wagner
    Abstract:

    Objectives: Examine the management of the clinically negative neck and evaluate the role of elective neck dissection in patients with squamous carcinoma of the Floor of the Mouth. Design: Retrospective analysis of a cohort of patients with squamous carcinoma of the Floor of the Mouth and NO stage disease of the neck who were treated between 1973 and 1992. The mean follow-up was 6 years. Patients: The cohort consisted of 129 patients. Excluded from analysis were patients without evidence of disease but less than 3 years of follow-up and those with uncertain resection margins. Intervention: Resection of the Floor of the Mouth lesion with or without marginal mandibulectomy. Elective lymphadenectomy was performed in 26 (23%) of the 129 patients. Outcome Measure: Estimates were obtained of survival according to mode of therapy, classification of treatment modality, determinate cure, locoregional failure, salvage, and occult disease by clinical stage. Results: Occult disease was detected in 23% of the patients who underwent elective neck dissection. Recurrence in the neck occurred in 36% of 103 patients who received follow-up but did not undergo elective neck dissection. The determinate survival at 3 years was 100% for patients with occult disease who underwent elective neck dissection. Overall, 96% of the patients who were treated with elective neck dissection were cured; 85% of the patients who received no initial treatment of the neck were cured; and 59% of the patients with failure in the neck were salvaged. Conclusions: A more aggressive approach to the neck with NO disease may be warranted. Selective neck dissection allows early removal of occult metastases with acceptable morbidity. In elective dissection for clinically and histologically negative necks, the high rate of survival may result from the removal of metastatic carcinoma that was missed in the histopathologic sampling process. (Arch Otolaryngol Head Neck Surg. 1995;121:278-282)

Rodney R Million - One of the best experts on this subject based on the ideXlab platform.

  • management of squamous cell carcinoma of the Floor of Mouth
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 1993
    Co-Authors: Lawrence W Rodgers, William M Mendenhall, Scott P Stringer, James T Parsons, Nicholas J Cassisi, Rodney R Million
    Abstract:

    : Between 1964 and 1987, 194 patients with previously untreated squamous cell carcinoma of the Floor of Mouth were managed at the University of Florida. A retrospective analysis was undertaken in order to evaluate the treatment results and associated complication rates. Surgery or irradiation alone was found to result in similar local control rates for stage I and II lesions, whereas more advanced tumors had better local control rates with a combination of surgery and irradiation. Radiotherapy had a higher incidence of minor and moderate complications, whereas a greater number of severe complications occurred after surgery. We recommend surgery for early lesions due to the lower overall incidence of associated complications. Despite a higher risk of severe complications, combination therapy is recommended for more advanced lesions due to improved local control as compared to single modality therapy.