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Anders Johansson - One of the best experts on this subject based on the ideXlab platform.
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the phylogeographic pattern of Francisella Tularensis in sweden indicates a scandinavian origin of eurosiberian tularaemia
Environmental Microbiology, 2013Co-Authors: Edvin Karlsson, Kerstin Svensson, Mats Forsman, Andreas Sjödin, Petter Lindgren, Mona Byström, Anders JohanssonAbstract:Previous studies of the causative agent of tularaemia, Francisella Tularensis have identified phylogeographic patterns suggestive of environmental maintenance reservoirs. To investigate the phyloge ...
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phylogeography of Francisella Tularensis subsp holarctica europe
Emerging Infectious Diseases, 2012Co-Authors: Miklos Gyuranecz, László Makrai, Dawn N Birdsell, Wolf D Splettstoesser, Erik Seibold, Stephen M Beckstromsternberg, Laszlo Fodor, Massimo Fabbi, Nadia Vicari, Anders JohanssonAbstract:Francisella Tularensis subsp. holarctica isolates from Austria, Germany, Hungary, Italy, and Romania were placed into an existing phylogeographic framework. Isolates from Italy were assigned to phy ...
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Phylogeography of Francisella Tularensis subsp. holarctica, Europe.
Emerging infectious diseases, 2012Co-Authors: Miklos Gyuranecz, László Makrai, Dawn N Birdsell, Wolf D Splettstoesser, Erik Seibold, Laszlo Fodor, Massimo Fabbi, Nadia Vicari, Stephen M. Beckstrom-sternberg, Anders JohanssonAbstract:Francisella Tularensis subsp. holarctica isolates from Austria, Germany, Hungary, Italy, and Romania were placed into an existing phylogeographic framework. Isolates from Italy were assigned to phylogenetic group B.FTNF002-00; the other isolates, to group B.13. Most F. Tularensis subsp. holarctica isolates from Europe belong to these 2 geographically segregated groups.
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Genotyping of Francisella Tularensis, the causative agent of tularemia.
Journal of AOAC International, 2010Co-Authors: Anders Johansson, Jeannine M. PetersenAbstract:Francisella Tularensis is a facultative, intracellular, zoonotic pathogen and the causative agent of tularemia. Historically, F. Tularensis has been subdivided into subspecies on the basis of pheno ...
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Molecular evolutionary consequences of niche restriction in Francisella Tularensis, a facultative intracellular pathogen
PLoS pathogens, 2009Co-Authors: Pär Larsson, Kerstin Svensson, Mats Forsman, Daniel Elfsmark, Per Wikström, Thomas Brettin, Paul Keim, Anders JohanssonAbstract:Francisella Tularensis is a potent mammalian pathogen well adapted to intracellular habitats, whereas F. novicida and F. philomiragia are less virulent in mammals and appear to have less specialize ...
Anders Sjostedt - One of the best experts on this subject based on the ideXlab platform.
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Roles of Reactive Oxygen Species-Degrading Enzymes of Francisella Tularensis SCHU S4
Infection and immunity, 2015Co-Authors: Johan Binesse, Helena Lindgren, Lena Lindgren, Wayne Conlan, Anders SjostedtAbstract:Francisella Tularensis is a facultative intracellular bacterium utilizing macrophages as its primary intracellular habitat and is therefore highly capable of resisting the effects of reactive oxyge ...
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A mutagenesisbased approach to map functional domain(s) within the N- terminus of Francisella Tularensis IglE
2015Co-Authors: Lena Meyer, Jeanette E. Bröms, Athar Alam, Anders SjostedtAbstract:A mutagenesisbased approach to map functional domain(s) within the N- terminus of Francisella Tularensis IglE
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Signatures of T cells as correlates of immunity to Francisella Tularensis.
PloS one, 2012Co-Authors: Kjell Eneslätt, Monica Normark, Rafael Björk, Cecilia Rietz, Carl Zingmark, Lawrence A. Wolfraim, Svenja Stöven, Anders SjostedtAbstract:Tularemia or vaccination with the live vaccine strain (LVS) of Francisella Tularensis confers long-lived cell-mediated immunity. We hypothesized that this immunity depends on polyfunctional memory ...
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Characterization of the spontaneous mutant FSC043 of Francisella Tularensis subspecies Tularensis
2011Co-Authors: Marie Lindgren, Linda Tancred, Igor Golovlev, Susan M. Twine, Anders SjostedtAbstract:Characterization of the spontaneous mutant FSC043 of Francisella Tularensis subspecies Tularensis
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A microarray analysis of the murine macrophage response to infection with Francisella Tularensis LVS.
Journal of Medical Microbiology, 2006Co-Authors: Henrik Andersson, Blanka Hartmanová, Patrik Rydén, Linda Näslund, Laila Noppa, Anders SjostedtAbstract:T A microarray analysis of the murine macrophage response to infection with Francisella Tularensis LVS
Mats Forsman - One of the best experts on this subject based on the ideXlab platform.
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Indigenous infection with Francisella Tularensis holarctica in The Netherlands
Case reports in infectious diseases, 2013Co-Authors: Boulos Maraha, Mats Forsman, Andreas Sjödin, Gerard F. Hajer, Ellen Verspui, Daan W. Notermans, Armand Paauw, Guus Roeselers, Ine H. M. E. Frenay, Maaike De VriesAbstract:We report here the first case of indigenous tularemia detected in The Netherlands, a nonendemic country, since 1953. Whole genome DNA sequence analysis assigned the isolate BD11-00177 to the genomic group B.FTNF002-00, which previously has been exclusively reported from Spain, France, Italy, Switzerland, and Germany. The patient had not been abroad for years, which implies that this is an indigenous infection. The current case might predict an upcoming distribution of Francisella Tularensis holarctica genomic group B.FTNF002-00 in Europe.
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Draft genome sequence of Francisella Tularensis subsp. holarctica BD11-00177
Standards in genomic sciences, 2013Co-Authors: Jordy P. M. Coolen, Mats Forsman, Andreas Sjödin, Boulos Maraha, Gerard F. Hajer, Ellen Verspui, Hendrina M. E. Frenay, Daan W. Notermans, Maaike De Vries, Frans A. G. ReubsaetAbstract:Francisella Tularensis is a facultative intracellular bacterium in the class Gammaproteobacteria. This strain is of interest because it is the etiologic agent of tularemia and a highly virulent category A biothreat agent. Here we describe the draft genome sequence and annotation of Francisella Tularensis subsp. holarctica BD11-00177, isolated from the first case of indigenous tularemia detected in The Netherlands since 1953. Whole genome DNA sequence analysis assigned this isolate to the genomic group B.FTNF002-00, which previously has been exclusively reported from Spain, France, Italy, Switzerland and Germany. Automatic annotation of the 1,813,372 bp draft genome revealed 2,103 protein-coding and 46 RNA genes.
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the phylogeographic pattern of Francisella Tularensis in sweden indicates a scandinavian origin of eurosiberian tularaemia
Environmental Microbiology, 2013Co-Authors: Edvin Karlsson, Kerstin Svensson, Mats Forsman, Andreas Sjödin, Petter Lindgren, Mona Byström, Anders JohanssonAbstract:Previous studies of the causative agent of tularaemia, Francisella Tularensis have identified phylogeographic patterns suggestive of environmental maintenance reservoirs. To investigate the phyloge ...
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Molecular evolutionary consequences of niche restriction in Francisella Tularensis, a facultative intracellular pathogen
PLoS pathogens, 2009Co-Authors: Pär Larsson, Kerstin Svensson, Mats Forsman, Daniel Elfsmark, Per Wikström, Thomas Brettin, Paul Keim, Anders JohanssonAbstract:Francisella Tularensis is a potent mammalian pathogen well adapted to intracellular habitats, whereas F. novicida and F. philomiragia are less virulent in mammals and appear to have less specialize ...
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Influence of nutrient status and microbial food web structure on the fate of Francisella Tularensis in lake water
2008Co-Authors: Johanna Thelaus, Anna-lena Forslund, Agneta Andersson, Peter Mathisen, Mats ForsmanAbstract:Influence of nutrient status and microbial food web structure on the fate of Francisella Tularensis in lake water
Wolf D Splettstoesser - One of the best experts on this subject based on the ideXlab platform.
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phylogeography of Francisella Tularensis subsp holarctica europe
Emerging Infectious Diseases, 2012Co-Authors: Miklos Gyuranecz, László Makrai, Dawn N Birdsell, Wolf D Splettstoesser, Erik Seibold, Stephen M Beckstromsternberg, Laszlo Fodor, Massimo Fabbi, Nadia Vicari, Anders JohanssonAbstract:Francisella Tularensis subsp. holarctica isolates from Austria, Germany, Hungary, Italy, and Romania were placed into an existing phylogeographic framework. Isolates from Italy were assigned to phy ...
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Phylogeography of Francisella Tularensis subsp. holarctica, Europe.
Emerging infectious diseases, 2012Co-Authors: Miklos Gyuranecz, László Makrai, Dawn N Birdsell, Wolf D Splettstoesser, Erik Seibold, Laszlo Fodor, Massimo Fabbi, Nadia Vicari, Stephen M. Beckstrom-sternberg, Anders JohanssonAbstract:Francisella Tularensis subsp. holarctica isolates from Austria, Germany, Hungary, Italy, and Romania were placed into an existing phylogeographic framework. Isolates from Italy were assigned to phylogenetic group B.FTNF002-00; the other isolates, to group B.13. Most F. Tularensis subsp. holarctica isolates from Europe belong to these 2 geographically segregated groups.
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identification of Francisella Tularensis by whole cell matrix assisted laser desorption ionization time of flight mass spectrometry fast reliable robust and cost effective differentiation on species and subspecies levels
Journal of Clinical Microbiology, 2010Co-Authors: Erik Seibold, Thomas Maier, Markus Kostrzewa, E Zeman, Wolf D SplettstoesserAbstract:Francisella Tularensis, the causative agent of tularemia, is a potential agent of bioterrorism. The phenotypic discrimination of closely related, but differently virulent, Francisella Tularensis subspecies with phenotyping methods is difficult and time-consuming, often producing ambiguous results. As a fast and simple alternative, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) was applied to 50 different strains of the genus Francisella to assess its ability to identify and discriminate between strains according to their designated species and subspecies. Reference spectra from five representative strains of Francisella philomiragia, Francisella Tularensis subsp. Tularensis, Francisella Tularensis subsp. holarctica, Francisella Tularensis subsp. mediasiatica, and Francisella Tularensis subsp. novicida were established and evaluated for their capability to correctly identify Francisella species and subspecies by matching a collection of spectra from 45 blind-coded Francisella strains against a database containing the five reference spectra and 3,287 spectra from other microorganisms. As a reference method for identification of strains from the genus Francisella, 23S rRNA gene sequencing was used. All strains were correctly identified, with both methods showing perfect agreement at the species level as well as at the subspecies level. The identification of Francisella strains by MALDI-TOF MS and subsequent database matching was reproducible using biological replicates, different culture media, different cultivation times, different serial in vitro passages of the same strain, different preparation protocols, and different mass spectrometers.
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Population structure of Francisella Tularensis.
Journal of bacteriology, 2006Co-Authors: Ulrich Nübel, Wolf D Splettstoesser, Rolf Reissbrodt, Annette Weller, Roland Grunow, Mustafa Porsch-Özcürümez, Herbert Tomaso, Erwin Hofer, Ernst-jürgen Finke, Helmut TschäpeAbstract:We have sequenced fragments of five metabolic housekeeping genes and two genes encoding outer membrane proteins from 81 isolates of Francisella Tularensis, representing all four subspecies. Phylogenetic clustering of gene sequences from F. Tularensis subsp. Tularensis and F. Tularensis subsp. holarctica aligned well with subspecies affiliations. In contrast, F. Tularensis subsp. novicida and F. Tularensis subsp. mediasiatica were indicated to be phylogenetically incoherent taxa. Incongruent gene trees and mosaic structures of housekeeping genes provided evidence for genetic recombination in F. Tularensis.
Dawn N Birdsell - One of the best experts on this subject based on the ideXlab platform.
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Water as Source of Francisella Tularensis Infection in Humans, Turkey.
Emerging infectious diseases, 2015Co-Authors: Selçuk Kiliç, Dawn N Birdsell, Alper Karagöz, Bekir Celebi, Zekiye Bakkaloglu, Muzaffer Arikan, Jason W. Sahl, Cedar L. Mitchell, Andrew Rivera, Sara MaltinskyAbstract:Francisella Tularensis DNA extractions and isolates from the environment and humans were genetically characterized to elucidate environmental sources that cause human tularemia in Turkey. Extensive genetic diversity consistent with genotypes from human outbreaks was identified in environmental samples and confirmed water as a source of human tularemia in Turkey.
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phylogeography of Francisella Tularensis subsp holarctica europe
Emerging Infectious Diseases, 2012Co-Authors: Miklos Gyuranecz, László Makrai, Dawn N Birdsell, Wolf D Splettstoesser, Erik Seibold, Stephen M Beckstromsternberg, Laszlo Fodor, Massimo Fabbi, Nadia Vicari, Anders JohanssonAbstract:Francisella Tularensis subsp. holarctica isolates from Austria, Germany, Hungary, Italy, and Romania were placed into an existing phylogeographic framework. Isolates from Italy were assigned to phy ...
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Phylogeography of Francisella Tularensis subsp. holarctica, Europe.
Emerging infectious diseases, 2012Co-Authors: Miklos Gyuranecz, László Makrai, Dawn N Birdsell, Wolf D Splettstoesser, Erik Seibold, Laszlo Fodor, Massimo Fabbi, Nadia Vicari, Stephen M. Beckstrom-sternberg, Anders JohanssonAbstract:Francisella Tularensis subsp. holarctica isolates from Austria, Germany, Hungary, Italy, and Romania were placed into an existing phylogeographic framework. Isolates from Italy were assigned to phylogenetic group B.FTNF002-00; the other isolates, to group B.13. Most F. Tularensis subsp. holarctica isolates from Europe belong to these 2 geographically segregated groups.
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Phylogeography of Francisella Tularensis : Global Expansion of a Highly Fit Clone
Journal of bacteriology, 2009Co-Authors: Amy J. Vogler, Dawn N Birdsell, Anders Johansson, Stephen M. Beckstrom-sternberg, Lance B. Price, Jolene Bowers, Raymond K. Auerbach, James S. Beckstrom-sternberg, Ashley Clare, Jordan L. BuchhagenAbstract:Francisella Tularensis contains several highly pathogenic subspecies, including Francisella Tularensis subsp. holarctica, whose distribution is circumpolar in the northern hemisphere. The phylogeography of these subspecies and their subclades was examined using whole-genome single nucleotide polymorphism (SNP) analysis, high-density microarray SNP genotyping, and real-time-PCR-based canonical SNP (canSNP) assays. Almost 30,000 SNPs were identified among 13 whole genomes for phylogenetic analysis. We selected 1,655 SNPs to genotype 95 isolates on a high-density microarray platform. Finally, 23 clade- and subclade-specific canSNPs were identified and used to genotype 496 isolates to establish global geographic genetic patterns. We confirm previous findings concerning the four subspecies and two Francisella Tularensis subsp. Tularensis subpopulations and identify additional structure within these groups. We identify 11 subclades within F. Tularensis subsp. holarctica, including a new, genetically distinct subclade that appears intermediate between Japanese F. Tularensis subsp. holarctica isolates and the common F. Tularensis subsp. holarctica isolates associated with the radiation event (the B radiation) wherein this subspecies spread throughout the northern hemisphere. Phylogenetic analyses suggest a North American origin for this B-radiation clade and multiple dispersal events between North America and Eurasia. These findings indicate a complex transmission history for F. Tularensis subsp. holarctica.
