The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Matthew L Costa - One of the best experts on this subject based on the ideXlab platform.
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randomised controlled feasibility Trial of standard wound management versus negative pressure wound therapy in the treatment of adult patients having surgical incisions for hip fractures
BMJ Open, 2018Co-Authors: Masters Jpm, Juul Achten, Jonathan Cook, Melina Dritsaki, Lucy Sansom, Matthew L CostaAbstract:Introduction Deep wound infection is a catastrophic complication after hip fracture surgery. However, current understanding of infection rates in this population is limited. Many technologies such as incisional negative-pressure wound therapy (NPWT) show promise in reducing the rate of infection. This Trial is a feasibility study looking to establish a value estimated with a greater precision of the rate of deep infection after hip fracture treatment in patients treated with NPWT versus standard dressing following hip fracture surgery. Methods and analysis A randomised controlled Trial of 464 patients will be run across multiple centres. It is embedded in the World Hip Trauma Evaluation cohort study. Any patient over the age of 65 years having surgery for hip fracture is eligible unless they are being treated with percutaneous screw fixation. A web-based randomisation sequence will stratify patients by centre. Patients will be allocated to either NPWT or standard care on a 1:1 basis. The primary outcome measure is the Centre for Disease Control definition of deep infection at 30 days. Follow-up at 4 months will also assess deep infection and the core outcome dataset for hip fractures. This includes health-related quality of life (EQ-5D-5L), mobility, mortality and late complications such as further surgery. The primary analysis will be intention to treat. Ethics and dissemination Oxford C Research Ethics Committee granted ethical approval on 28/04/2017, 17/SC/0207. The results of this study will be reported in a peer-reviewed publication and inform the design of a future Full-Scale Trial. Trial registration number ISRCTN55305726.
Paton Graeme - One of the best experts on this subject based on the ideXlab platform.
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When is a soil remediated? Comparison of biopiled and windrowed soils contaminated with bunker-fuel in a Full-Scale Trial
'Elsevier BV', 2010Co-Authors: Coulon Frederic, Al, Awadi M., Cowie W., Mardlin D., Pollard, Simon J. T., Cunningham C., Risdon G., Arthur P., Semple, Kirk T., Paton GraemeAbstract:A six month field Scale study was carried out to compare windrow turning and biopile techniques for the remediation of soil contaminated with bunker C fuel oil. End-point clean-up targets were defined by human risk assessment and ecotoxicological hazard assessment approaches. Replicate windrows and biopiles were amended with either nutrients and inocula, nutrients alone or no amendment. In addition to fractionated hydrocarbon analysis, culturable microbial characterisation and soil ecotoxicological assays were performed. This particular soil, heavy in texture and historically contaminated with bunker fuel was more effectively remediated by windrowing, but coarser textures may be more amendable to biopiling. This Trial reveals the benefit of developing risk and hazard based approaches in defining end-point bioremediation of heavy hydrocarbons when engineered biopile or windrow are proposed as treatment option. (c) 2010 Elsevier Ltd. All rights reserved
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When is a soil remediated? Comparison of biopiled and windrowed soils contaminated with bunker-fuel in a Full-Scale Trial
'Elsevier BV', 2010Co-Authors: Coulon Frederic, Semple, Kirk T., Al Awadi Mohammed, Cowie William, Mardlin David, Pollard Simon, Cunningham Colin, Risdon Graeme, Arthur Paul, Paton GraemeAbstract:A six month field Scale study was carried out to compare windrow turning and biopile techniques for the remediation of soil contaminated with bunker C fuel oil. End-point clean-up targets were defined by human risk assessment and ecotoxicological hazard assessment approaches. Replicate windrows and biopiles were amended with either nutrients and inocula, nutrients alone or no amendment. In addition to fractionated hydrocarbon analysis, culturable microbial characterisation and soil ecotoxicological assays were performed. This particular soil, heavy in texture and historically contaminated with bunker fuel was more effectively remediated by windrowing, but coarser textures may be more amendable to biopiling. This Trial reveals the benefit of developing risk and hazard based approaches in defining end-point bioremediation of heavy hydrocarbons when engineered biopile or windrow are proposed as treatment option. (c) 2010 Elsevier Ltd. All rights reserved
A M Heagerty - One of the best experts on this subject based on the ideXlab platform.
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establishing the feasibility of group metacognitive therapy for anxiety and depression in cardiac rehabilitation a single blind randomized pilot study
Frontiers in Psychiatry, 2020Co-Authors: Adrian Wells, David Reeves, Calvin Heal, Peter Fisher, Linda Davies, A M Heagerty, Patrick Doherty, Lora CapobiancoAbstract:Background Anxiety and depression are common in cardiac rehabilitation (CR) patients. However, CR programs which incorporate psychological techniques achieve modest reductions in emotional distress. More efficacious interventions that can be easily integrated within services are required. A promising alternative to current psychological interventions is metacognitive therapy (MCT). The aim was to evaluate the acceptability and feasibility of delivering Group-MCT to CR patients experiencing symptoms of anxiety and depression. Method and Results Fifty-two CR patients with elevated anxiety and/or depression were recruited to a single-blind randomized feasibility Trial across three UK National Health Service Trusts and randomized to usual CR or usual CR plus six weekly sessions of group-MCT. Acceptability and feasibility of adding group-MCT to CR was based on recruitment rates, withdrawal, and drop-out by the primary end-point of 4 months; number of MCT and CR sessions attended; completion of follow-up questionnaires; and ability of the outcome measures to discriminate between patients. The study was also used to re-estimate the required sample size for a Full-Scale Trial. We also examined the extent by which non-specialists adhered to the Group-MCT protocol. Group-MCT was found to be feasible and acceptable for CR patients with anxiety and depression. Recruitment and retention of participants was high, and attendance rates at CR were similar for both groups. Conclusion The results suggest the addition of MCT to CR did not have a negative impact on retention and support a Full-Scale Trial of Group-MCT for cardiac patients.
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Metacognitive therapy home-based self-help for cardiac rehabilitation patients experiencing anxiety and depressive symptoms: study protocol for a feasibility randomised controlled Trial (PATHWAY Home-MCT)
Trials, 2018Co-Authors: Adrian Wells, David Reeves, Linda Davies, A M Heagerty, Patrick Doherty, Kirsten Mcnicol, Peter Salmon, Rebecca Mcphillips, Rebecca Anderson, Cintia FaijaAbstract:Background Anxiety and depression are common among patients attending cardiac rehabilitation services. Currently available pharmacological and psychological interventions have limited effectiveness in this population. There are presently no psychological interventions for anxiety and depression integrated into cardiac rehabilitation services despite emphasis in key UK National Health Service policy. A new treatment, metacognitive therapy, is highly effective at reducing anxiety and depression in mental health settings. The principal aims of the current study are (1) to evaluate the acceptability of delivering metacognitive therapy in a home-based self-help format (Home-MCT) to cardiac rehabilitation patients experiencing anxiety and depressive symptoms and conduct a feasibility Trial of Home-MCT plus usual cardiac rehabilitation compared to usual cardiac rehabilitation; and (2) to inform the design and sample size for a Full-Scale Trial. Methods The PATHWAY Home-MCT Trial is a single-blind feasibility randomised controlled Trial comparing usual cardiac rehabilitation (control) versus usual cardiac rehabilitation plus home-based self-help metacognitive therapy (intervention). Economic and qualitative evaluations will be embedded within the Trial. Participants will be assessed at baseline and followed-up at 4 and 12 months. Patients who have been referred to cardiac rehabilitation programmes and have a score of ≥ 8 on the anxiety and/or depression subScales of the Hospital Anxiety and Depression Scale will be invited to take part in the study and written informed consent will be obtained. Participants will be recruited from the National Health Service in the UK. A minimum of 108 participants will be randomised to the intervention and control arms in a 1:1 ratio. Discussion The Home-MCT feasibility randomised controlled Trial will provide evidence on the acceptability of delivering metacognitive therapy in a home-based self-help format for cardiac rehabilitation patients experiencing symptoms of anxiety and/or depression and on the feasibility and design of a Full-Scale Trial. In addition, it will provide provisional point estimates, with appropriately wide measures of uncertainty, relating to the effectiveness and cost-effectiveness of the intervention. Trial registration ClinicalTrials.gov, NCT03129282 , Submitted to Registry: 11 April 2017.
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metacognitive therapy home based self help for cardiac rehabilitation patients experiencing anxiety and depressive symptoms study protocol for a feasibility randomised controlled Trial pathway home mct
Trials, 2018Co-Authors: Adrian Wells, David Reeves, Linda Davies, A M Heagerty, Kirsten Mcnicol, Peter Salmon, Patrick DohertyAbstract:Background Anxiety and depression are common among patients attending cardiac rehabilitation services. Currently available pharmacological and psychological interventions have limited effectiveness in this population. There are presently no psychological interventions for anxiety and depression integrated into cardiac rehabilitation services despite emphasis in key UK National Health Service policy. A new treatment, metacognitive therapy, is highly effective at reducing anxiety and depression in mental health settings. The principal aims of the current study are (1) to evaluate the acceptability of delivering metacognitive therapy in a home-based self-help format (Home-MCT) to cardiac rehabilitation patients experiencing anxiety and depressive symptoms and conduct a feasibility Trial of Home-MCT plus usual cardiac rehabilitation compared to usual cardiac rehabilitation; and (2) to inform the design and sample size for a Full-Scale Trial.
Adrian Wells - One of the best experts on this subject based on the ideXlab platform.
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establishing the feasibility of group metacognitive therapy for anxiety and depression in cardiac rehabilitation a single blind randomized pilot study
Frontiers in Psychiatry, 2020Co-Authors: Adrian Wells, David Reeves, Calvin Heal, Peter Fisher, Linda Davies, A M Heagerty, Patrick Doherty, Lora CapobiancoAbstract:Background Anxiety and depression are common in cardiac rehabilitation (CR) patients. However, CR programs which incorporate psychological techniques achieve modest reductions in emotional distress. More efficacious interventions that can be easily integrated within services are required. A promising alternative to current psychological interventions is metacognitive therapy (MCT). The aim was to evaluate the acceptability and feasibility of delivering Group-MCT to CR patients experiencing symptoms of anxiety and depression. Method and Results Fifty-two CR patients with elevated anxiety and/or depression were recruited to a single-blind randomized feasibility Trial across three UK National Health Service Trusts and randomized to usual CR or usual CR plus six weekly sessions of group-MCT. Acceptability and feasibility of adding group-MCT to CR was based on recruitment rates, withdrawal, and drop-out by the primary end-point of 4 months; number of MCT and CR sessions attended; completion of follow-up questionnaires; and ability of the outcome measures to discriminate between patients. The study was also used to re-estimate the required sample size for a Full-Scale Trial. We also examined the extent by which non-specialists adhered to the Group-MCT protocol. Group-MCT was found to be feasible and acceptable for CR patients with anxiety and depression. Recruitment and retention of participants was high, and attendance rates at CR were similar for both groups. Conclusion The results suggest the addition of MCT to CR did not have a negative impact on retention and support a Full-Scale Trial of Group-MCT for cardiac patients.
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Metacognitive therapy home-based self-help for cardiac rehabilitation patients experiencing anxiety and depressive symptoms: study protocol for a feasibility randomised controlled Trial (PATHWAY Home-MCT)
Trials, 2018Co-Authors: Adrian Wells, David Reeves, Linda Davies, A M Heagerty, Patrick Doherty, Kirsten Mcnicol, Peter Salmon, Rebecca Mcphillips, Rebecca Anderson, Cintia FaijaAbstract:Background Anxiety and depression are common among patients attending cardiac rehabilitation services. Currently available pharmacological and psychological interventions have limited effectiveness in this population. There are presently no psychological interventions for anxiety and depression integrated into cardiac rehabilitation services despite emphasis in key UK National Health Service policy. A new treatment, metacognitive therapy, is highly effective at reducing anxiety and depression in mental health settings. The principal aims of the current study are (1) to evaluate the acceptability of delivering metacognitive therapy in a home-based self-help format (Home-MCT) to cardiac rehabilitation patients experiencing anxiety and depressive symptoms and conduct a feasibility Trial of Home-MCT plus usual cardiac rehabilitation compared to usual cardiac rehabilitation; and (2) to inform the design and sample size for a Full-Scale Trial. Methods The PATHWAY Home-MCT Trial is a single-blind feasibility randomised controlled Trial comparing usual cardiac rehabilitation (control) versus usual cardiac rehabilitation plus home-based self-help metacognitive therapy (intervention). Economic and qualitative evaluations will be embedded within the Trial. Participants will be assessed at baseline and followed-up at 4 and 12 months. Patients who have been referred to cardiac rehabilitation programmes and have a score of ≥ 8 on the anxiety and/or depression subScales of the Hospital Anxiety and Depression Scale will be invited to take part in the study and written informed consent will be obtained. Participants will be recruited from the National Health Service in the UK. A minimum of 108 participants will be randomised to the intervention and control arms in a 1:1 ratio. Discussion The Home-MCT feasibility randomised controlled Trial will provide evidence on the acceptability of delivering metacognitive therapy in a home-based self-help format for cardiac rehabilitation patients experiencing symptoms of anxiety and/or depression and on the feasibility and design of a Full-Scale Trial. In addition, it will provide provisional point estimates, with appropriately wide measures of uncertainty, relating to the effectiveness and cost-effectiveness of the intervention. Trial registration ClinicalTrials.gov, NCT03129282 , Submitted to Registry: 11 April 2017.
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metacognitive therapy home based self help for cardiac rehabilitation patients experiencing anxiety and depressive symptoms study protocol for a feasibility randomised controlled Trial pathway home mct
Trials, 2018Co-Authors: Adrian Wells, David Reeves, Linda Davies, A M Heagerty, Kirsten Mcnicol, Peter Salmon, Patrick DohertyAbstract:Background Anxiety and depression are common among patients attending cardiac rehabilitation services. Currently available pharmacological and psychological interventions have limited effectiveness in this population. There are presently no psychological interventions for anxiety and depression integrated into cardiac rehabilitation services despite emphasis in key UK National Health Service policy. A new treatment, metacognitive therapy, is highly effective at reducing anxiety and depression in mental health settings. The principal aims of the current study are (1) to evaluate the acceptability of delivering metacognitive therapy in a home-based self-help format (Home-MCT) to cardiac rehabilitation patients experiencing anxiety and depressive symptoms and conduct a feasibility Trial of Home-MCT plus usual cardiac rehabilitation compared to usual cardiac rehabilitation; and (2) to inform the design and sample size for a Full-Scale Trial.
Masters Jpm - One of the best experts on this subject based on the ideXlab platform.
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randomised controlled feasibility Trial of standard wound management versus negative pressure wound therapy in the treatment of adult patients having surgical incisions for hip fractures
BMJ Open, 2018Co-Authors: Masters Jpm, Juul Achten, Jonathan Cook, Melina Dritsaki, Lucy Sansom, Matthew L CostaAbstract:Introduction Deep wound infection is a catastrophic complication after hip fracture surgery. However, current understanding of infection rates in this population is limited. Many technologies such as incisional negative-pressure wound therapy (NPWT) show promise in reducing the rate of infection. This Trial is a feasibility study looking to establish a value estimated with a greater precision of the rate of deep infection after hip fracture treatment in patients treated with NPWT versus standard dressing following hip fracture surgery. Methods and analysis A randomised controlled Trial of 464 patients will be run across multiple centres. It is embedded in the World Hip Trauma Evaluation cohort study. Any patient over the age of 65 years having surgery for hip fracture is eligible unless they are being treated with percutaneous screw fixation. A web-based randomisation sequence will stratify patients by centre. Patients will be allocated to either NPWT or standard care on a 1:1 basis. The primary outcome measure is the Centre for Disease Control definition of deep infection at 30 days. Follow-up at 4 months will also assess deep infection and the core outcome dataset for hip fractures. This includes health-related quality of life (EQ-5D-5L), mobility, mortality and late complications such as further surgery. The primary analysis will be intention to treat. Ethics and dissemination Oxford C Research Ethics Committee granted ethical approval on 28/04/2017, 17/SC/0207. The results of this study will be reported in a peer-reviewed publication and inform the design of a future Full-Scale Trial. Trial registration number ISRCTN55305726.
