The Experts below are selected from a list of 118794 Experts worldwide ranked by ideXlab platform
Sajid Siddiq - One of the best experts on this subject based on the ideXlab platform.
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Functional Brain Imaging alterations in acne patients treated with isotretinoin
American Journal of Psychiatry, 2005Co-Authors: Douglas J Bremner, Negar Fani, Ali Ashraf, John R Votaw, Marijn E Brummer, Thomas Cummins, Viola L Vaccarino, Mark M Goodman, Lai Reed, Sajid SiddiqAbstract:Objective: Although there have been case reports suggesting a relationship between treatment with the acne medication isotretinoin and the development of depression and suicide, this topic remains controversial. In order for isotretinoin to cause depression, it must have an effect on the Brain; however, the effects of isotretinoin on Brain functioning in acne patients have not been established. The purpose of this study was to assess the effects of isotretinoin on Brain functioning in acne patients. Method: Brain functioning in adults was measured with [ 18 F]fluorodeoxyglucose positron emission tomography before and after 4 months of treatment with isotretinoin (N=13) or an antibiotic (N=15). Results: Isotretinoin but not antibiotic treatment was associated with decreased Brain metabolism in the orbitofrontal cortex (–21% change versus 2% change for antibiotic), a Brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment. Conclusions: This study suggests that isotretinoin treatment is associated with changes in Brain functioning.
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Functional Brain Imaging alterations in acne patients treated with isotretinoin
American Journal of Psychiatry, 2005Co-Authors: Douglas J Bremner, Negar Fani, Ali Ashraf, John R Votaw, Marijn E Brummer, Thomas Cummins, Viola L Vaccarino, Mark M Goodman, Lai Reed, Sajid SiddiqAbstract:OBJECTIVE: Although there have been case reports suggesting a relationship between treatment with the acne medication isotretinoin and the development of depression and suicide, this topic remains controversial. In order for isotretinoin to cause depression, it must have an effect on the Brain; however, the effects of isotretinoin on Brain functioning in acne patients have not been established. The purpose of this study was to assess the effects of isotretinoin on Brain functioning in acne patients. METHOD: Brain functioning in adults was measured with [18F]fluorodeoxyglucose positron emission tomography before and after 4 months of treatment with isotretinoin (N=13) or an antibiotic (N=15). RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased Brain metabolism in the orbitofrontal cortex (–21% change versus 2% change for antibiotic), a Brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin an...
Peter D D Schwindt - One of the best experts on this subject based on the ideXlab platform.
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non invasive Functional Brain Imaging with an opm based magnetoencephalography system
PLOS ONE, 2020Co-Authors: Amir Borna, T R Carter, Anthony P Colombo, Julia M Stephen, Samu Taulu, James R Mckay, Michael Patrick Weisend, Peter D D SchwindtAbstract:A non-invasive Functional-Brain-Imaging system based on optically-pumped-magnetometers (OPM) is presented. The OPM-based magnetoencephalography (MEG) system features 20 OPM channels conforming to the subject’s scalp. We have conducted two MEG experiments on three subjects: assessment of somatosensory evoked magnetic field (SEF) and auditory evoked magnetic field (AEF) using our OPM-based MEG system and a commercial MEG system based on superconducting quantum interference devices (SQUIDs). We cross validated the robustness of our system by calculating the distance between the location of the equivalent current dipole (ECD) yielded by our OPM-based MEG system and the ECD location calculated by the commercial SQUID-based MEG system. We achieved sub-centimeter accuracy for both SEF and AEF responses in all three subjects. Due to the proximity (12 mm) of the OPM channels to the scalp, it is anticipated that future OPM-based MEG systems will offer enhanced spatial resolution as they will capture finer spatial features compared to traditional MEG systems employing SQUIDs.
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non invasive Functional Brain Imaging with a novel magnetoencephalography system
arXiv: Medical Physics, 2018Co-Authors: Amir Borna, T R Carter, Anthony P Colombo, Jim Mckay, Julia M Stephen, Samu Taulu, Michael Patrick Weisend, Peter D D SchwindtAbstract:A non-invasive Functional-Brain-Imaging system based on optically-pumped-magnetometers (OPM) is presented. The OPM-based magnetoencephalography (MEG) system features 20 OPM channels conforming to the subject's scalp. Due to proximity (12 mm) of the OPM channels to the Brain, it is anticipated that this MEG system offers an enhanced spatial resolution as it can capture finer spatial features compared to traditional MEG systems employing superconducting quantum interference device (SQUID). We have conducted two MEG experiments on three subjects: somatosensory evoked magnetic field (SEF) and auditory evoked magnetic field (AEF) using our OPM-based MEG system and a commercial SQUID-based MEG system. We have cross validated the robustness of our system by calculating the distance between the location of the equivalent current dipole (ECD) yielded by our OPM-based MEG system and the ECD location calculated by the commercial SQUID-based MEG system. We achieved sub-centimeter accuracy for both SEF and AEF responses in all three subjects.
Douglas J Bremner - One of the best experts on this subject based on the ideXlab platform.
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Functional Brain Imaging alterations in acne patients treated with isotretinoin
American Journal of Psychiatry, 2005Co-Authors: Douglas J Bremner, Negar Fani, Ali Ashraf, John R Votaw, Marijn E Brummer, Thomas Cummins, Viola L Vaccarino, Mark M Goodman, Lai Reed, Sajid SiddiqAbstract:Objective: Although there have been case reports suggesting a relationship between treatment with the acne medication isotretinoin and the development of depression and suicide, this topic remains controversial. In order for isotretinoin to cause depression, it must have an effect on the Brain; however, the effects of isotretinoin on Brain functioning in acne patients have not been established. The purpose of this study was to assess the effects of isotretinoin on Brain functioning in acne patients. Method: Brain functioning in adults was measured with [ 18 F]fluorodeoxyglucose positron emission tomography before and after 4 months of treatment with isotretinoin (N=13) or an antibiotic (N=15). Results: Isotretinoin but not antibiotic treatment was associated with decreased Brain metabolism in the orbitofrontal cortex (–21% change versus 2% change for antibiotic), a Brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment. Conclusions: This study suggests that isotretinoin treatment is associated with changes in Brain functioning.
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Functional Brain Imaging alterations in acne patients treated with isotretinoin
American Journal of Psychiatry, 2005Co-Authors: Douglas J Bremner, Negar Fani, Ali Ashraf, John R Votaw, Marijn E Brummer, Thomas Cummins, Viola L Vaccarino, Mark M Goodman, Lai Reed, Sajid SiddiqAbstract:OBJECTIVE: Although there have been case reports suggesting a relationship between treatment with the acne medication isotretinoin and the development of depression and suicide, this topic remains controversial. In order for isotretinoin to cause depression, it must have an effect on the Brain; however, the effects of isotretinoin on Brain functioning in acne patients have not been established. The purpose of this study was to assess the effects of isotretinoin on Brain functioning in acne patients. METHOD: Brain functioning in adults was measured with [18F]fluorodeoxyglucose positron emission tomography before and after 4 months of treatment with isotretinoin (N=13) or an antibiotic (N=15). RESULTS: Isotretinoin but not antibiotic treatment was associated with decreased Brain metabolism in the orbitofrontal cortex (–21% change versus 2% change for antibiotic), a Brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin an...
Amir Borna - One of the best experts on this subject based on the ideXlab platform.
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non invasive Functional Brain Imaging with an opm based magnetoencephalography system
PLOS ONE, 2020Co-Authors: Amir Borna, T R Carter, Anthony P Colombo, Julia M Stephen, Samu Taulu, James R Mckay, Michael Patrick Weisend, Peter D D SchwindtAbstract:A non-invasive Functional-Brain-Imaging system based on optically-pumped-magnetometers (OPM) is presented. The OPM-based magnetoencephalography (MEG) system features 20 OPM channels conforming to the subject’s scalp. We have conducted two MEG experiments on three subjects: assessment of somatosensory evoked magnetic field (SEF) and auditory evoked magnetic field (AEF) using our OPM-based MEG system and a commercial MEG system based on superconducting quantum interference devices (SQUIDs). We cross validated the robustness of our system by calculating the distance between the location of the equivalent current dipole (ECD) yielded by our OPM-based MEG system and the ECD location calculated by the commercial SQUID-based MEG system. We achieved sub-centimeter accuracy for both SEF and AEF responses in all three subjects. Due to the proximity (12 mm) of the OPM channels to the scalp, it is anticipated that future OPM-based MEG systems will offer enhanced spatial resolution as they will capture finer spatial features compared to traditional MEG systems employing SQUIDs.
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non invasive Functional Brain Imaging with a novel magnetoencephalography system
arXiv: Medical Physics, 2018Co-Authors: Amir Borna, T R Carter, Anthony P Colombo, Jim Mckay, Julia M Stephen, Samu Taulu, Michael Patrick Weisend, Peter D D SchwindtAbstract:A non-invasive Functional-Brain-Imaging system based on optically-pumped-magnetometers (OPM) is presented. The OPM-based magnetoencephalography (MEG) system features 20 OPM channels conforming to the subject's scalp. Due to proximity (12 mm) of the OPM channels to the Brain, it is anticipated that this MEG system offers an enhanced spatial resolution as it can capture finer spatial features compared to traditional MEG systems employing superconducting quantum interference device (SQUID). We have conducted two MEG experiments on three subjects: somatosensory evoked magnetic field (SEF) and auditory evoked magnetic field (AEF) using our OPM-based MEG system and a commercial SQUID-based MEG system. We have cross validated the robustness of our system by calculating the distance between the location of the equivalent current dipole (ECD) yielded by our OPM-based MEG system and the ECD location calculated by the commercial SQUID-based MEG system. We achieved sub-centimeter accuracy for both SEF and AEF responses in all three subjects.
Theodore J Huppert - One of the best experts on this subject based on the ideXlab platform.
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Functional near infrared spectroscopy enabling routine Functional Brain Imaging
Current Opinion in Biomedical Engineering, 2017Co-Authors: Meryem A. Yücel, Maria Angela Franceschini, David A Boas, Theodore J Huppert, Juliette SelbAbstract:Functional Near-Infrared Spectroscopy (fNIRS) maps human Brain function by measuring and Imaging local changes in hemoglobin concentrations in the Brain that arise from the modulation of cerebral blood flow and oxygen metabolism by neural activity. Since its advent over 20 years ago, researchers have exploited and continuously advanced the ability of near infrared light to penetrate through the scalp and skull in order to non-invasively monitor changes in cerebral hemoglobin concentrations that reflect Brain activity. We review recent advances in signal processing and hardware that significantly improve the capabilities of fNIRS by reducing the impact of confounding signals to improve statistical robustness of the Brain signals and by enhancing the density, spatial coverage, and wearability of measuring devices respectively. We then summarize the application areas that are experiencing rapid growth as fNIRS begins to enable routine Functional Brain Imaging.
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Functional Brain Imaging of multi sensory vestibular processing during computerized dynamic posturography using near infrared spectroscopy
NeuroImage, 2013Co-Authors: Helmet T Karim, Susan I Fuhrman, Patrick J Sparto, Joseph M Furman, Theodore J HuppertAbstract:Abstract Functional near-infrared spectroscopy (fNIRS) is a non-invasive Brain Imaging method that uses light to record regional changes in cerebral blood flow in the cortex during activation. fNIRS uses portable wearable sensors to allow measurements of Brain activation during tasking. In this study, fNIRS was used to investigate how the Brain processes information from multiple sensory modalities during dynamic posturography. Fifteen healthy volunteers (9M/6F; ages 28 +/− 9 yrs) participated in the posturography study while undergoing fNIRS Brain Imaging. Four standard conditions from the sensory organization test (SOT) were performed and a bilateral fNIRS probe was used to examine the cortical Brain responses from the frontal, temporal, and parietal Brain regions. We found that there was bilateral activation in the temporal–parietal areas (superior temporal gyrus, STG, and supramarginal gyrus, SMG) when both vision and proprioceptive information were degraded; forcing reliance on primarily vestibular information in the control of balance. This is consistent with previous reports of the role of these regions in vestibular control and demonstrates the potential utility of fNIRS in the study of cortical control of vestibular function during standing balance tasks.
