The Experts below are selected from a list of 11508 Experts worldwide ranked by ideXlab platform
Hidetake Matsuyoshi - One of the best experts on this subject based on the ideXlab platform.
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Vestibular Function in superficial siderosis
BMC Ear Nose and Throat Disorders, 2013Co-Authors: Toru Miwa, Ryosei Minoda, Hidetake MatsuyoshiAbstract:Background Superficial siderosis (SS) is caused by repeated or continuous bleeding into the subarachnoid space that results in iron from hemoglobin (hemosiderin) being deposited on the surface of the brain. Clinically, the condition is characterized by sensorineural deafness, ataxia, and pyramidal signs. However the mechanism of peripheral Vestibular disturbance was not revealed. We show the Vestibular Function of SS patients, and shed light on saccule-inferior Vestibular nerve. Methods Over the past 9 years, 5 patients were definitively diagnosed with SS by MRI in our department. These patients were subjected to balance testing. Results Vestibular evoked myogenic potential (VEMP) was observed in patients who had suffered from SS for a short period but tended to be diminished or absent in patients who had suffered from the condition for a longer period. Conclusions These findings in SS patients suggest that saccule-inferior Vestibular Function is maintained at early stages of the disorder. Our study may help to clarify the mechanism of SS.
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Vestibular Function in superficial siderosis
BMC ear nose and throat disorders, 2013Co-Authors: Toru Miwa, Ryosei Minoda, Hidetake MatsuyoshiAbstract:Superficial siderosis (SS) is caused by repeated or continuous bleeding into the subarachnoid space that results in iron from hemoglobin (hemosiderin) being deposited on the surface of the brain. Clinically, the condition is characterized by sensorineural deafness, ataxia, and pyramidal signs. However the mechanism of peripheral Vestibular disturbance was not revealed. We show the Vestibular Function of SS patients, and shed light on saccule-inferior Vestibular nerve. Over the past 9 years, 5 patients were definitively diagnosed with SS by MRI in our department. These patients were subjected to balance testing. Vestibular evoked myogenic potential (VEMP) was observed in patients who had suffered from SS for a short period but tended to be diminished or absent in patients who had suffered from the condition for a longer period. These findings in SS patients suggest that saccule-inferior Vestibular Function is maintained at early stages of the disorder. Our study may help to clarify the mechanism of SS.
Shinichi Iwasaki - One of the best experts on this subject based on the ideXlab platform.
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postural stability in Vestibular neuritis age disease duration and residual Vestibular Function
Laryngoscope, 2014Co-Authors: Chisato Fujimoto, Naoya Egami, Makoto Kinoshita, Keiko Sugasawa, Tatsuya Yamasoba, Shinichi IwasakiAbstract:Objectives/Hypothesis To assess the influence of factors that can affect postural instability in Vestibular neuritis (VN). Study Design Retrospective data collection study. Methods Foam posturography was performed in 58 VN patients. We examined six variables: the velocity of movement of the center of pressure and the envelopment area in eyes closed/foam rubber condition, Romberg's ratios of velocity and area with foam rubber, and the foam ratios of velocity and area with eyes closed. Multiple regression analyses were performed to explore the relationship between these variables and the following independent variables: gender, age, canal paresis (CP) percentage, and disease duration. Results All six variables were positively associated with age, CP percentage, and a disease duration of 10 days or less (P .05). Conclusions VN patients show poor postural performance, which is affected by age, residual Vestibular Function, and disease duration. Once a VN patient passes the acute phase of the vertigo attack, it is likely that age and residual Vestibular Function make a greater contribution to postural control. Level of Evidence 3b. Laryngoscope, 124:974–979, 2014
Yuri Agrawal - One of the best experts on this subject based on the ideXlab platform.
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Vestibular Function and cortical and sub-cortical alterations in an aging population
Heliyon, 2020Co-Authors: Athira Jacob, Daniel Tward, Susan Resnick, Paul Smith, Christophe Lopez, Elliott Rebello, Eric Wei, J Tilak Ratnanather, Yuri AgrawalAbstract:While it is well known that the Vestibular system is responsible for maintaining balance, posture and coordination, there is increasing evidence that it also plays an important role in cognition. Moreover, a growing number of epidemiological studies are demonstrating a link between Vestibular dysFunction and cognitive deficits in older adults; however, the exact pathways through which Vestibular loss may affect cognition are unknown. In this cross-sectional study, we sought to identify relationships between Vestibular Function and variation in morphometry in brain structures from structural neuroimaging. We used a subset of 80 participants from the Baltimore Longitudinal Study of Aging, who had both brain MRI and Vestibular physiological data acquired during the same visit. Vestibular Function was evaluated through the cervical Vestibular-evoked myogenic potential (cVEMP). The brain structures of interest that we analyzed were the hippocampus, amygdala, thalamus, caudate nucleus, putamen, insula, entorhinal cortex (ERC), trans-entorhinal cortex (TEC) and perirhinal cortex, as these structures comprise or are connected with the putative "Vestibular cortex." We modeled the volume and shape of these structures as a Function of the presence/absence of cVEMP and the cVEMP amplitude, adjusting for age and sex. We observed reduced overall volumes of the hippocampus and the ERC associated with poorer Vestibular Function. In addition, we also found significant relationships between the shape of the hippocampus (p ¼ 0.0008), amygdala (p ¼ 0.01), thalamus (p ¼ 0.008), caudate nucleus (p ¼ 0.002), putamen (p ¼ 0.02), and ERC-TEC complex (p ¼ 0.008) and Vestibular Function. These findings provide novel insight into the multiple pathways through which Vestibular loss may impact brain structures that are critically involved in spatial memory, navigation and orientation.
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Vestibular Function and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging.
Frontiers in aging neuroscience, 2018Co-Authors: Rebecca J. Kamil, Susan M. Resnick, Murat Bilgel, Dean F. Wong, Yuri AgrawalAbstract:Beta-amyloid (Aβ) plaque deposition is a key feature of Alzheimer’s disease (AD), and occurs years before the onset of symptoms. (Aβ) plaque deposition has been shown to be present in ~30% of cognitively normal older adults using amyloid C-11 labeled Pittsburgh Compound B (11C-PiB) Positron Emission Tomography (PET) imaging. Prior studies have reported a link between reduced Vestibular Function and poorer cognition in healthy older adults. It is unknown whether Vestibular impairment occurs in association with AD pathology among individuals in the preclinical phase of AD, which could contribute to the observed association between Vestibular and cognitive Function in healthy older adults. Using the Baltimore Longitudinal Study of Aging (BLSA), we analyzed the association between a comprehensive set of Vestibular Function measures and PiB status in 98 healthy participants with a mean age of 77.3 (±8.26). We did not observe a significant relationship between any Vestibular Function measure and PiB status in cognitively-intact older adults in the BLSA. This finding suggests that Aβ deposition does not explain the observed association between reduced Vestibular Function and poorer cognition in healthy older adults.
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Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging.
Journal of the American Geriatrics Society, 2015Co-Authors: Robin T. Bigelow, Yevgeniy R. Semenov, Carolina Trevino, Luigi Ferrucci, Susan M. Resnick, Eleanor M. Simonsick, Qian Li Xue, Yuri AgrawalAbstract:Numerous lines of evidence— epidemiological, physiological, histopathological— have shown that Vestibular Function declines with age.1–4 The Vestibular system is known for its role in maintaining balance and postural control, and several studies have noted associations between Vestibular loss and balance impairment and falls in older individuals.5–7 Increasing evidence demonstrates important connections between the Vestibular system and various domains of cognitive Function, most notably visuospatial ability, but also memory, executive Function, and attention.8–11 Studies in animals and individuals with unilateral or bilateral Vestibular loss suggest that the Vestibular system provides critical information about spatial orientation, spatial memory, and spatial navigation.10–13 Visuospatial ability deteriorates with age. Studies have shown that older individuals have greater difficulty with navigation in real-world and virtual environments. Older adults make more errors in returning to their starting locations and have greater difficulty remembering locations of previously observed targets.14–17 In addition, perception of subjective visual vertical also appears to degrade with age, with greater deviations from true vertical observed in healthy older than younger adults.18 It is unknown whether Vestibular loss associated with age plays a role in the degradation of these critical spatial cognitive Functions in elderly adults. This link may be important to establish, given that declines in spatial orientation and navigation may mediate the association between age-related Vestibular loss and falls. The current study used data from the Baltimore Longitudinal Study of Aging (BLSA) to evaluate the cross-sectional association between Vestibular Function and selected domains of cognitive Function, including visuospatial ability, memory, executive Function, and attention. The Function of the saccule, the Vestibular end organ responsible for measuring changes in spatial orientation with respect to gravity, was specifically considered. Based on the existing literature, it was hypothesized that Vestibular Function would have the strongest association with visuospatial ability. A series of structural equation models was developed to evaluate the extent to which Vestibular Function may mediate age-related changes in cognition. These analyses offer insight into the mechanisms by which peripheral Vestibular sensitivity may be associated with specific cognitive Functions and may inform future research on preventive and treatment strategies for age-related cognitive decline.
Toru Miwa - One of the best experts on this subject based on the ideXlab platform.
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Vestibular Function in superficial siderosis
BMC Ear Nose and Throat Disorders, 2013Co-Authors: Toru Miwa, Ryosei Minoda, Hidetake MatsuyoshiAbstract:Background Superficial siderosis (SS) is caused by repeated or continuous bleeding into the subarachnoid space that results in iron from hemoglobin (hemosiderin) being deposited on the surface of the brain. Clinically, the condition is characterized by sensorineural deafness, ataxia, and pyramidal signs. However the mechanism of peripheral Vestibular disturbance was not revealed. We show the Vestibular Function of SS patients, and shed light on saccule-inferior Vestibular nerve. Methods Over the past 9 years, 5 patients were definitively diagnosed with SS by MRI in our department. These patients were subjected to balance testing. Results Vestibular evoked myogenic potential (VEMP) was observed in patients who had suffered from SS for a short period but tended to be diminished or absent in patients who had suffered from the condition for a longer period. Conclusions These findings in SS patients suggest that saccule-inferior Vestibular Function is maintained at early stages of the disorder. Our study may help to clarify the mechanism of SS.
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Vestibular Function in superficial siderosis
BMC ear nose and throat disorders, 2013Co-Authors: Toru Miwa, Ryosei Minoda, Hidetake MatsuyoshiAbstract:Superficial siderosis (SS) is caused by repeated or continuous bleeding into the subarachnoid space that results in iron from hemoglobin (hemosiderin) being deposited on the surface of the brain. Clinically, the condition is characterized by sensorineural deafness, ataxia, and pyramidal signs. However the mechanism of peripheral Vestibular disturbance was not revealed. We show the Vestibular Function of SS patients, and shed light on saccule-inferior Vestibular nerve. Over the past 9 years, 5 patients were definitively diagnosed with SS by MRI in our department. These patients were subjected to balance testing. Vestibular evoked myogenic potential (VEMP) was observed in patients who had suffered from SS for a short period but tended to be diminished or absent in patients who had suffered from the condition for a longer period. These findings in SS patients suggest that saccule-inferior Vestibular Function is maintained at early stages of the disorder. Our study may help to clarify the mechanism of SS.
Chisato Fujimoto - One of the best experts on this subject based on the ideXlab platform.
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postural stability in Vestibular neuritis age disease duration and residual Vestibular Function
Laryngoscope, 2014Co-Authors: Chisato Fujimoto, Naoya Egami, Makoto Kinoshita, Keiko Sugasawa, Tatsuya Yamasoba, Shinichi IwasakiAbstract:Objectives/Hypothesis To assess the influence of factors that can affect postural instability in Vestibular neuritis (VN). Study Design Retrospective data collection study. Methods Foam posturography was performed in 58 VN patients. We examined six variables: the velocity of movement of the center of pressure and the envelopment area in eyes closed/foam rubber condition, Romberg's ratios of velocity and area with foam rubber, and the foam ratios of velocity and area with eyes closed. Multiple regression analyses were performed to explore the relationship between these variables and the following independent variables: gender, age, canal paresis (CP) percentage, and disease duration. Results All six variables were positively associated with age, CP percentage, and a disease duration of 10 days or less (P .05). Conclusions VN patients show poor postural performance, which is affected by age, residual Vestibular Function, and disease duration. Once a VN patient passes the acute phase of the vertigo attack, it is likely that age and residual Vestibular Function make a greater contribution to postural control. Level of Evidence 3b. Laryngoscope, 124:974–979, 2014
