The Experts below are selected from a list of 12459 Experts worldwide ranked by ideXlab platform
Zhao-xu Wang - One of the best experts on this subject based on the ideXlab platform.
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synthesis and Fungicidal Activity of novel 2 aryl 3 1 3 4 thiadiazolyl 6 8 methyl 1 3 benzoxazines
ChemInform, 2015Co-Authors: Zilong Tang, Shuhong Chang, Zhao-xu WangAbstract:Among the tested compounds, derivative (IIIc) shows up to 98% Fungicidal Activity against S.
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Synthesis and Fungicidal Activity of Novel 2‐Aryl‐3‐(1,3,4‐thiadiazolyl)‐6(8)‐methyl‐1,3‐benzoxazines.
ChemInform, 2015Co-Authors: Zilong Tang, Shuhong Chang, Zhao-xu WangAbstract:Among the tested compounds, derivative (IIIc) shows up to 98% Fungicidal Activity against S.
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synthesis and Fungicidal Activity of novel 2 aryl 3 1 3 4 thiadiazolyl 6 8 methyl 1 3 benzoxazines
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Zilong Tang, Shuhong Chang, Zhao-xu WangAbstract:Abstract A class of novel 2-aryl-3-(1,3,4-thiadiazolyl)-6(8)-methyl-1,3-benzoxazines was prepared by reactions of 2-methyl-6-((1,3,4-thiadiazolylamino)methyl)phenols or 4-methyl-2-((1,3,4-thiadiazolylamino)methyl)phenols and 2- or 4-nitrobenzaldehyde in the presence of TMSCl in refluxing toluene. The electron-donating methyl group on the benzene ring played an essential role on the reActivity of the substituted phenols, which was proved by DFT calculation. The Fungicidal Activity of the resultant products were also preliminarily evaluated, most of which displayed moderate to good Fungicidal Activity. Especially, compound 6f showed 98.0% Activity against Sclerotonia sclerotiorum and Botrytis cinerea at concentration of 25 μg/mL.
Zilong Tang - One of the best experts on this subject based on the ideXlab platform.
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synthesis and Fungicidal Activity of novel 2 aryl 3 1 3 4 thiadiazolyl 6 8 methyl 1 3 benzoxazines
ChemInform, 2015Co-Authors: Zilong Tang, Shuhong Chang, Zhao-xu WangAbstract:Among the tested compounds, derivative (IIIc) shows up to 98% Fungicidal Activity against S.
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Synthesis and Fungicidal Activity of Novel 2‐Aryl‐3‐(1,3,4‐thiadiazolyl)‐6(8)‐methyl‐1,3‐benzoxazines.
ChemInform, 2015Co-Authors: Zilong Tang, Shuhong Chang, Zhao-xu WangAbstract:Among the tested compounds, derivative (IIIc) shows up to 98% Fungicidal Activity against S.
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synthesis and Fungicidal Activity of novel 2 aryl 3 1 3 4 thiadiazolyl 6 8 methyl 1 3 benzoxazines
Bioorganic & Medicinal Chemistry Letters, 2015Co-Authors: Zilong Tang, Shuhong Chang, Zhao-xu WangAbstract:Abstract A class of novel 2-aryl-3-(1,3,4-thiadiazolyl)-6(8)-methyl-1,3-benzoxazines was prepared by reactions of 2-methyl-6-((1,3,4-thiadiazolylamino)methyl)phenols or 4-methyl-2-((1,3,4-thiadiazolylamino)methyl)phenols and 2- or 4-nitrobenzaldehyde in the presence of TMSCl in refluxing toluene. The electron-donating methyl group on the benzene ring played an essential role on the reActivity of the substituted phenols, which was proved by DFT calculation. The Fungicidal Activity of the resultant products were also preliminarily evaluated, most of which displayed moderate to good Fungicidal Activity. Especially, compound 6f showed 98.0% Activity against Sclerotonia sclerotiorum and Botrytis cinerea at concentration of 25 μg/mL.
Jose Mauricio Sforcin - One of the best experts on this subject based on the ideXlab platform.
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the immunomodulatory effect of propolis on receptors expression cytokine production and Fungicidal Activity of human monocytes
Journal of Pharmacy and Pharmacology, 2014Co-Authors: Michelle Cristiane Bufalo, Ana Paula Bordongraciani, Bruno Jose Conti, Marjorie De Assis Golim, Jose Mauricio SforcinAbstract:Objectives Propolis is a beehive product and its immunomodulatory action has been documented; however, little is known concerning its mechanisms of action on human cells. Propolis influence on the initial events of the immune response was assessed, evaluating cell markers, cytokine production and the Fungicidal Activity of human monocytes. Methods Toll-like receptor (TLR)-2, TLR-4, human leukocyte antigen-DR and cluster of differentiation (CD)80 expression by human monocytes was assessed using a FACSCalibur flow cytometer, cytokine production (tumour necrosis factor (TNF)-α and interleukin (IL)-10) was determined by ELISA and the candidacidal Activity was investigated after monocytes incubation with propolis and challenged with Candida albicans. The role of TLR-2 and TLR-4 on propolis action was assessed as well. Key findings Propolis upregulated TLR-4 and CD80 expression and affected TNF-α and IL-10 production, depending on concentration. Propolis also increased the Fungicidal Activity of monocytes. Cytokine production was decreased by blocking TLR-4, whereas the Fungicidal Activity was affected by blocking TLR-2. Conclusions Propolis exerted an immunomodulatory action on cell receptors, cytokine production and Fungicidal Activity of human monocytes without affecting cell viability and depending on concentration. TLR-2 and TLR-4 may be involved in its mechanism of action.
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effects of propolis from brazil and bulgaria on Fungicidal Activity of macrophages against paracoccidioides brasiliensis
Web Science, 2002Co-Authors: Joana M Murad, Sueli Aparecida Calvi, A. M. V. C. Soares, Vassya Bankova, Jose Mauricio SforcinAbstract:Paracoccidioidomycosis is the most important systemic mycosis in Latin America. Its etiological agent, Paracoccidoides brasiliensis, affects individuals living in endemic areas through inhalation of airborne conidia or mycelial fragments. The disease may affect different organs and systems, with multiple clinical features, with cell-mediated immunity playing a significant role in host defence. Peritoneal macrophages from BALB/c mice were stimulated with Brazilian or Bulgarian propolis and subsequently challenged with P. brasiliensis. Data suggest an increase in the Fungicidal Activity of macrophages by propolis stimulation, independently from its geographic origin.
Guangfu Yang - One of the best experts on this subject based on the ideXlab platform.
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design synthesis and Fungicidal Activity of novel sclerotiorin derivatives
Chemical Biology & Drug Design, 2012Co-Authors: Nick Mulholland, Shaowei Huang, David Beattie, Dianne Irwin, Yucheng Gu, John Martin Clough, Qiongyou Wu, Guangfu YangAbstract:Sclerotiorin, a chlorine-containing azaphilone-type natural product, was first isolated from Penicillium sclerotiorum and has been reported to exhibit weak Fungicidal Activity. Optimization of the substituents at the 3- and 5-positions of the sclerotiorin framework was investigated with the aim of discovering novel fungicides with improved Activity. The design of sclerotiorin analogues involved replacing the diene side chain with a phenyl group or an aromatic- or heteroaromatic-containing aliphatic side chain. The designed compounds were synthesized by cycloisomerization and subsequent oxidation of suitable 2-alkynylbenzaldehydes, in which a variety of substituents were introduced using a Sonogashira coupling reaction. The structures of these newly prepared compounds were confirmed by 1H and 13C NMR spectroscopy, HRMS and single-crystal X-ray analysis. The antifungal Activity of the synthesized compounds was evaluated against seven phytopathogenic species. Compounds 3, 9g and 9h were found to have a broad spectrum of Fungicidal Activity, and these structurally simpler products can be recognized as lead compounds for further optimization.
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synthesis and Fungicidal Activity of novel pimprinine analogues
European Journal of Medicinal Chemistry, 2012Co-Authors: Mingzhi Zhang, Nick Mulholland, David Beattie, Dianne Irwin, Yucheng Gu, Guangfu Yang, Qiong Chen, John Martin CloughAbstract:Abstract A simple and efficient synthetic protocol for 5-(3-indolyl)-oxazoles has been developed and further used to synthesize a series of novel analogues of natural product pimprinine. All new compounds were identified by 1H NMR, high resolution mass spectrometry, and the structures of 10 and 18o were further confirmed by X-ray crystallographic diffraction analysis. Bioassay conducted at Syngenta showed that several of the synthesized compounds exhibited Fungicidal Activity. Compounds 10, 17, 18h, 18o, 19h, 19i and 19l all showed effective control of three out of the seven tested phytopathogenic fungi at the highest rate screened. Compounds 17 and 19h in particular showed Activity against the four pathogens screened in artificial media; Pythium dissimile, Alternaria solani, Botryotinia fuckeliana and Gibberella zeae.
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microwave assisted one pot syntheses and Fungicidal Activity of polyfluorinated 2 benzylthiobenzothiazoles
Bioorganic & Medicinal Chemistry, 2006Co-Authors: Wei Huang, Guangfu YangAbstract:Abstract Polyfluorinated 2-benzylthiobenzothiazoles 3a – l are prepared via a microwave-assisted, one-pot procedure. The advantages, such as good to excellent yields, shorter reaction time (14–21 min), readily available starting material, and simple purification procedure, distinguish the present protocol from other existing methods used for the synthesis of 2-benzylthiobenzothiazoles. Bioassay indicated that most of the compounds showed significant Fungicidal Activity against Rhizoctonia solani , Botrytis cinereapers , and Dothiorella gregaria at a dosage of 50 μg/mL. Interestingly, compared to the control of commercial fungicide, triadimefon, compound 3c exhibited much higher activities against R. solani , B. cinereapers , and D. gregaria , which showed that the polyfluorinated 2-benzylthiobenzothiazoles can be used as lead compound for developing novel fungicides.
M T Saleh - One of the best experts on this subject based on the ideXlab platform.
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synthesis characterization and Fungicidal Activity of zinc diethyldithiocarbamate and phosphate
Journal of Thermal Analysis and Calorimetry, 2007Co-Authors: H. S. Rathore, G. Varshney, S C Mojumdar, M T SalehAbstract:Zinc diethyldithiocarbamate, zinc diethyldithiocarbamate-phosphate and zinc phosphate have been synthesized. They have been characterized using DTA-TG, IR spectra and X-ray. The dithiocarbamate and phosphate contents have been determined spectrophotometrically and volumetrically, respectively. Fungicidal Activity of the compounds has been tested by well diffusion method using fungi Fusarium sp.
