The Experts below are selected from a list of 4632 Experts worldwide ranked by ideXlab platform
Bert F. Sels - One of the best experts on this subject based on the ideXlab platform.
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Sulfonated mesoporous carbon and silica-carbon nanocomposites for biomass conversion
Applied Catalysis B: Environmental, 2018Co-Authors: Ruyi Zhong, Bert F. SelsAbstract:Abstract Sulfonated mesoporous carbon or silica-carbon nanocomposite materials possess a large amount of accessible SO3H acid groups, which may have versatile applications as solid acid catalysts in biomass conversion. The mesopores can facilitate the transportation of the large biomass substrates and the targeted products. The hydrophobicity of carbon ensures the hydrothermal stability of the materials, which is essential since biomass conversion usually occurs in polar circumstances (e.g., in water), and it can facilitate the adsorption of reactants and the desorption of formed H2O during the conversion simultaneously. The other weak acid groups of carbon, like phenolic OH and COOH groups may help the adsorption of reactants or even exert a synergistic catalytic function. With the co-existence of silica phase, the mesopores can be maintained under harsh conditions, e.g., during the sulfonation synthesis step in concentrated H2SO4 at a high temperature. Furthermore, the hybrid silica-carbon surface can provide specific polarity from the synergy of both kinds of components and offer potentiality for multi-functionalization. Herein, the synthesis and fabrication of such sulfonated mesoporous carbon and silica-carbon nanocomposite wherein C SO3H is confined in mesoporous channels is reviewed. Their state-of-the-art use in catalytic biomass-related conversion such as fatty acids esterification, carbohydrates conversion and Furan-Derivative condensation, are discussed in detail. The stability issues of the sulfonated carbon or silica-carbon nanocomposites for the specific catalytic reactions are specifically addressed. Finally, a general conclusion is drawn from the above and a future outlook for this class of upcoming materials in terms of synthetic challenges and catalytic application is presented.
Ruyi Zhong - One of the best experts on this subject based on the ideXlab platform.
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Sulfonated mesoporous carbon and silica-carbon nanocomposites for biomass conversion
Applied Catalysis B: Environmental, 2018Co-Authors: Ruyi Zhong, Bert F. SelsAbstract:Abstract Sulfonated mesoporous carbon or silica-carbon nanocomposite materials possess a large amount of accessible SO3H acid groups, which may have versatile applications as solid acid catalysts in biomass conversion. The mesopores can facilitate the transportation of the large biomass substrates and the targeted products. The hydrophobicity of carbon ensures the hydrothermal stability of the materials, which is essential since biomass conversion usually occurs in polar circumstances (e.g., in water), and it can facilitate the adsorption of reactants and the desorption of formed H2O during the conversion simultaneously. The other weak acid groups of carbon, like phenolic OH and COOH groups may help the adsorption of reactants or even exert a synergistic catalytic function. With the co-existence of silica phase, the mesopores can be maintained under harsh conditions, e.g., during the sulfonation synthesis step in concentrated H2SO4 at a high temperature. Furthermore, the hybrid silica-carbon surface can provide specific polarity from the synergy of both kinds of components and offer potentiality for multi-functionalization. Herein, the synthesis and fabrication of such sulfonated mesoporous carbon and silica-carbon nanocomposite wherein C SO3H is confined in mesoporous channels is reviewed. Their state-of-the-art use in catalytic biomass-related conversion such as fatty acids esterification, carbohydrates conversion and Furan-Derivative condensation, are discussed in detail. The stability issues of the sulfonated carbon or silica-carbon nanocomposites for the specific catalytic reactions are specifically addressed. Finally, a general conclusion is drawn from the above and a future outlook for this class of upcoming materials in terms of synthetic challenges and catalytic application is presented.
Jong Hwan Kwak - One of the best experts on this subject based on the ideXlab platform.
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A Furan Derivative fromCornus officinalis
Archives of Pharmacal Research, 1998Co-Authors: Jong Hwan KwakAbstract:DimethyltetrahydroFuran cis -2,5-dicarboxylate a Furan Derivative has been isolated from the fruits of Cornus officinalis , and it was isolated for the first time in the nature. The structure was elucidated by NMR spectroscopic techniques.
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a Furan Derivative from cornus officinalis
Archives of Pharmacal Research, 1998Co-Authors: Jong Hwan KwakAbstract:DimethyltetrahydroFurancis-2,5-dicarboxylate a Furan Derivative has been isolated from the fruits ofCornus officinalis, and it was isolated for the first time in the nature. The structure was elucidated by NMR spectroscopic techniques.
Jonggab Jun - One of the best experts on this subject based on the ideXlab platform.
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xh 14 a novel danshen methoxybenzo b Furan Derivative exhibits anti inflammatory properties in lipopolysaccharide treated raw 264 7 cells
Journal of Inflammation, 2013Co-Authors: Geun-mook Park, Jonggab Jun, Jin-kyung KimAbstract:Background XH-14 isolated from Salvia miltiorrhiza is a bioactive component and adenosine antagonist. In the present study, we evaluated anti-inflammatory properties of XH-14 in murine macrophages.
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XH-14, a novel danshen methoxybenzo[b]Furan Derivative, exhibits anti-inflammatory properties in lipopolysaccharide-treated RAW 264.7 cells
Journal of Inflammation, 2013Co-Authors: Geun-mook Park, Jonggab Jun, Jin-kyung KimAbstract:Background XH-14 isolated from Salvia miltiorrhiza is a bioactive component and adenosine antagonist. In the present study, we evaluated anti-inflammatory properties of XH-14 in murine macrophages. Methods RAW 264.7 murine macrophage cell line was cultured with various concentrations of XH-14 in the absence or presence of lipopolysaccharide (LPS). LPS-induced release and mRNA expression of inflammatory mediators were examined by ELISA and real-time PCR. The modification of signal pathways involved in inflammatory reactions was determined by Western blotting analysis. Results XH-14 suppressed the generation of nitric oxide (NO) and prostaglandin E_2, and the expression of inducible NO synthase and cyclooxygenase-2 induced by LPS. Similarly, XH-14 inhibited the release of pro-inflammatory cytokines induced by LPS in RAW 264.7 cells. The underlying mechanism of XH-14 on anti-inflammatory action was correlated with down-regulation of mitogen-activated protein kinase and activator protein-1 activation. Conclusions XH-14 inhibits the production of several inflammatory mediators and so might be useful for the treatment of various inflammatory diseases.
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novel danshen methoxybenzo b Furan Derivative antagonizing adipogenic differentiation and production of inflammatory adipokines
Chemico-Biological Interactions, 2010Co-Authors: Hyeyoung Sung, Jonggab Jun, Sangwook Kang, Hyunsung Kim, Daekeun Shin, Iljun Kang, Younghee KangAbstract:Many benzo[b]Furan lignans are known to be biologically active in nature. 2-(3'-Methoxy-4'-hydroxy-phenyl)-5-(3-hydroxypropyl)-7-methoxy-benzo[b]Furan-3-carbaldehyde (XH-14) is found as a bioactive component isolated from the plant Salvia miltiorrhiza, commonly known as Danshen, which is a traditional Chinese medicine that is used as a cardiovascular medication. This study examined whether 3 different XH-14 Derivatives can inhibit adipocyte differentiation and induction of the adipokines visfatin and resistin in 3T3-L1 adipocytes. Adipocytes were cultured and differentiated in Dulbecco's modified Eagle medium containing fetal bovine serum, 3-isobytyl-1-methylxanthine, dexamethasone, and insulin for 6-8d in the absence and presence of 1-25μM XH-14-derived benzo[b]Furan Derivatives. Nontoxic 2-(3'-methoxy-4'-hydroxy-phenyl)-6-(3-hydroxypropyl)-5-methoxy-benzo[b]Furan (5-MBF) at ≥5μM attenuated cellular lipid accumulation and down-regulated induction of peroxisome proliferator activated receptors γ (PPARγ) and CCAAT enhancer binding protein α (C/EBPα) in a dose-dependent manner, as evidenced by Oil Red O staining and Western blot analysis. Such inhibition of PPAR( and C/EBP( by 5-MBF was achieved at transcriptional mRNA levels. However, 2-(3'-methoxy-4'-hydroxy-phenyl)-5-(3-hydroxypropyl)-7-methoxy-benzo[b]Furan (7-MBF) and 2-(3'-methoxy-4'-hydroxy-phenyl)-5-(3-hydroxypropyl)-7-methoxy-benzo[b]Furan (6-MBF) had minimal effects on adipogenic differentiation, suggesting a structure-activity relationship of methoxybenzo[b]Furan Derivatives as an inhibitor of adipogenic differentiation. Furthermore, ≥5μM 5-MBF retarded protein and mRNA expression of proinflammatory and insulin resistance-enhancing adipokines of visfatin and resistin in differentiated adipocytes. Induction of visfatin and resistin was, at least in part, mediated via adipocyte differentiation-associated activation of PPARγ signal targeting adipocyte protein 2 and stearoyl-CoA desaturase. These results demonstrate that the 2-(3'-methoxy-4'-hydroxy-phenyl)-3-hydroxypropyl benzo[b]Furan lignan, with a methoxy group at the 5-position on the benzene ring, may be a promising agent for disturbance of adipogenic differentiation and for blockage of obesity-associated inflammatory and metabolic diseases.
Younghee Kang - One of the best experts on this subject based on the ideXlab platform.
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novel danshen methoxybenzo b Furan Derivative antagonizing adipogenic differentiation and production of inflammatory adipokines
Chemico-Biological Interactions, 2010Co-Authors: Hyeyoung Sung, Jonggab Jun, Sangwook Kang, Hyunsung Kim, Daekeun Shin, Iljun Kang, Younghee KangAbstract:Many benzo[b]Furan lignans are known to be biologically active in nature. 2-(3'-Methoxy-4'-hydroxy-phenyl)-5-(3-hydroxypropyl)-7-methoxy-benzo[b]Furan-3-carbaldehyde (XH-14) is found as a bioactive component isolated from the plant Salvia miltiorrhiza, commonly known as Danshen, which is a traditional Chinese medicine that is used as a cardiovascular medication. This study examined whether 3 different XH-14 Derivatives can inhibit adipocyte differentiation and induction of the adipokines visfatin and resistin in 3T3-L1 adipocytes. Adipocytes were cultured and differentiated in Dulbecco's modified Eagle medium containing fetal bovine serum, 3-isobytyl-1-methylxanthine, dexamethasone, and insulin for 6-8d in the absence and presence of 1-25μM XH-14-derived benzo[b]Furan Derivatives. Nontoxic 2-(3'-methoxy-4'-hydroxy-phenyl)-6-(3-hydroxypropyl)-5-methoxy-benzo[b]Furan (5-MBF) at ≥5μM attenuated cellular lipid accumulation and down-regulated induction of peroxisome proliferator activated receptors γ (PPARγ) and CCAAT enhancer binding protein α (C/EBPα) in a dose-dependent manner, as evidenced by Oil Red O staining and Western blot analysis. Such inhibition of PPAR( and C/EBP( by 5-MBF was achieved at transcriptional mRNA levels. However, 2-(3'-methoxy-4'-hydroxy-phenyl)-5-(3-hydroxypropyl)-7-methoxy-benzo[b]Furan (7-MBF) and 2-(3'-methoxy-4'-hydroxy-phenyl)-5-(3-hydroxypropyl)-7-methoxy-benzo[b]Furan (6-MBF) had minimal effects on adipogenic differentiation, suggesting a structure-activity relationship of methoxybenzo[b]Furan Derivatives as an inhibitor of adipogenic differentiation. Furthermore, ≥5μM 5-MBF retarded protein and mRNA expression of proinflammatory and insulin resistance-enhancing adipokines of visfatin and resistin in differentiated adipocytes. Induction of visfatin and resistin was, at least in part, mediated via adipocyte differentiation-associated activation of PPARγ signal targeting adipocyte protein 2 and stearoyl-CoA desaturase. These results demonstrate that the 2-(3'-methoxy-4'-hydroxy-phenyl)-3-hydroxypropyl benzo[b]Furan lignan, with a methoxy group at the 5-position on the benzene ring, may be a promising agent for disturbance of adipogenic differentiation and for blockage of obesity-associated inflammatory and metabolic diseases.
