The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform
Antonio Morelli - One of the best experts on this subject based on the ideXlab platform.
-
Effect of erythromycin on gastric and Gallbladder Emptying and gastrointestinal symptoms in scleroderma patients is maintained medium term.
The American journal of gastroenterology, 1994Co-Authors: Stefano Fiorucci, Eleonora Distrutti, Roberto Gerli, Antonio MorelliAbstract:OBJECTIVES Scleroderma patients frequently present esophageal and gastric Emptying abnormalities and small bowel dysfunction. Erythromycin, a macrolide antibiotic, has been found to accelerate gastric and Gallbladder Emptying in both healthy subjects and diabetic patients. Our objective was to investigate the effects of 4-wk oral erythromycin administration on the gastric and Gallbladder Emptying, gastrointestinal symptoms (early satiety, abdominal pain, nausea, bloating, vomiting, and constipation), and motilin plasma levels of patients with scleroderma. METHODS 12 scleroderma patients were investigated before and after 4-wk treatment with 250 mg oral erythromycin three times a day. The effect of a single i.v. dose of 2 mg/kg/h erythromycin on gastric and Gallbladder Emptying before starting the oral treatment was also evaluated. Gastric and Gallbladder Emptying after a solid meal were evaluated by sonography. RESULTS Single i.v. administration of erythromycin before the meal reduced gastric Emptying T1/2 from 121.3 +/- 14.0 to 45.5 +/- 7.3 min (p < 0.01) and accelerated Gallbladder Emptying without affecting the peak. Four-week oral administration of erythromycin reduced gastric Emptying T1/2 from 121.3 +/- 14.0 min to 46.5 +/- 8.3 min (p < 0.01). Peak Gallbladder Emptying was also significantly accelerated, while total Emptying remained unchanged (p < 0.01). Furthermore, 4-wk erythromycin administration reduced both motilin plasma levels (from 223.4 +/- 53.8 to 145.4 +/- 67.2 pmol/L, p < 0.01) and symptoms of nausea, vomiting, and abdominal pain (p < 0.01), and increased bowel movements in a subset of scleroderma patients with intestinal pseudo-obstruction. CONCLUSIONS Erythromycin stimulates gastrointestinal motility in patients with scleroderma. Administered medium-term, it accelerates gastric and Gallbladder Emptying and alleviates gastrointestinal symptoms.
-
5 hydroxytryptamine 3 receptor antagonist modulates Gallbladder Emptying and motilin release induced by erythromycin
Digestive Diseases and Sciences, 1993Co-Authors: Stefano Fiorucci, Luca Santucci, Antonio MorelliAbstract:In the present study we evaluated the effect of ondansetron (formerly indicated as GR38032F), a potent and selective type-3 5-hydroxytryptamine receptor antagonist, on erythromycin-induced Gallbladder Emptying and motilin release, as well as Gallbladder Emptying induced by a regular meal in healthy volunteers. Gallbladder Emptying was evaluated by sonography. Ondansetron, at the dose of 0.05 mg/kg, significantly reduced (P<0.001 by ANOVA) the Gallbladder Emptying induced by 2 mg/kg/hr erythromycin, but did not increase basal Gallbladder volume or inhibit Gallbladder Emptying induced by a regular meal. Ondansetron also inhibited the motilin release induced by erythromycin (P<0.001, by ANOVA). These results suggest that serotoninergic mechanisms modulate the effects of erythromycin on the gastrointestinal tract. The exact site of action of ondansetron remains to be identified.
-
5-hydroxytryptamine 3-receptor antagonist modulates Gallbladder Emptying and motilin release induced by erythromycin.
Digestive diseases and sciences, 1993Co-Authors: Stefano Fiorucci, Luca Santucci, Antonio MorelliAbstract:In the present study we evaluated the effect of ondansetron (formerly indicated as GR38032F), a potent and selective type-3 5-hydroxytryptamine receptor antagonist, on erythromycin-induced Gallbladder Emptying and motilin release, as well as Gallbladder Emptying induced by a regular meal in healthy volunteers. Gallbladder Emptying was evaluated by sonography. Ondansetron, at the dose of 0.05 mg/kg, significantly reduced (P
-
erythromycin stimulates Gallbladder Emptying and motilin release by atropine sensitive pathways
Digestive Diseases and Sciences, 1992Co-Authors: Stefano Fiorucci, Rachele Bosso, Antonio MorelliAbstract:The effect of administering different doses of erythromycin on Gallbladder Emptying and plasma concentrations of immunoreactive motilin was investigated in healthy volunteers. Erythromycin was infused for 30 min at four different doses: 20, 50, 100, and 1000 mg/hr. Gallbladder volume was determined by ultrasound scanning every 10 min for 60 min. All doses, except 20 mg/hr, provoked a significant reduction in Gallbladder volume (P<0.01). The Gallbladder Emptying peak occurred after 20 min infusion. It was approximately 40–45% of basal volume and 60–70% of the Emptying observed after a standard meal. At 100 mg/hr, erythromycin caused a 2.5-fold increase in plasma motilin concentration, which reached a peak after 30 min infusion. Plasma motilin peaked following maximum Gallbladder Emptying in all subjects. To evaluate whether cholinergic pathways were implicated in the action of erythromycin, 100 mg/hr erythromycin was infused together with 6 μg/kg/hr atropine. Atropine inhibited both Gallbladder Emptying and motilin release (P<0.001). Infusion of 1 μg/kg/hr somatostatin had the same inhibitory effects (P<0.001). Our results suggest that atropine acts by inhibiting an erythromycin-activated cholinergic neural mechanism. Somatostatin could exert its inhibitory effect by blocking the release of acetylcholine from neural terminations.
-
effect of erythromycin on Gallbladder Emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin
Digestive Diseases and Sciences, 1992Co-Authors: Stefano Fiorucci, Rachele Bosso, L Scionti, Antonio Desando, P Bottini, Cecilia Marino, Antonio MorelliAbstract:A reduction of Gallbladder Emptying in response to neural or hormonal stimulation has been reported in patients with diabetes mellitus. Decreased Gallbladder Emptying may be a key factor in the pathogenesis of Gallbladder stones. Few drugs, if any, are able to stimulate Gallbladder Emptying. However, in a previous study we demonstrated that erythromycin, a macrolide antibiotic, stimulates Gallbladder Emptying and motilin release in healthy human subjects by an atropine-sensitive pathway. Therefore, the present study was designed to evaluate the effect of erythromycin on Gallbladder Emptying and motilin release in diabetic patients with or without cardiac autonomic neuropathy (AN). Thirteen diabetic patients, six with AN, and 10 healthy subjects were enrolled in the study protocol. Gallbladder Emptying was determined by sonography after ingestion of a standard meal and during infusion of erythromycin alone or together with 6 μg/kg/hr atropine. We found that 100 mg/hr erythromycin caused a significant reduction in Gallbladder volume in both healthy subjects and diabetic patients. The ejection fraction (mean ±se) of 45.3±8.2% and 37.3±5.0% was similar. The presence of AN had no influence on Gallbladder Emptying induced by erythromycin. Basal motilin plasma levels were 111.5±14.5 pmol/liter in diabetic patients and 63.3 ±6.0 pmol/liter in healthy subjects (P<0.01). However, patients with AN had higher (130.0 ±11.9 pmol/liter) motilin plasma levels than patients without (74.0±9.4 pmol/liter,P<0.01). Erythromycin administration caused an approximately twofold increase in plasma motilin concentrations in healthy subject and patients withou AN, but did not stimulate motilin release in neuropathic patients. A negative correlation (r=−0.75,P<0.01) was found between basal plasma levels of motilin and peak of Gallbladder Emptying induced by erythromycin. Atropine completely inhibited the effects of erythromycin on Gallbladder Emptying and motilin release (P<0.001 by ANOVA). A negative correlation (r=−0.52,P<0.05) was also found between plasma glucose concentrations and peak of Gallbladder Emptying. Present results demonstrate that erythromycin could be used for treating alterations of Gallbladder Emptying in diabetic patients with or without AN.
Stefano Fiorucci - One of the best experts on this subject based on the ideXlab platform.
-
Effect of erythromycin on gastric and Gallbladder Emptying and gastrointestinal symptoms in scleroderma patients is maintained medium term.
The American journal of gastroenterology, 1994Co-Authors: Stefano Fiorucci, Eleonora Distrutti, Roberto Gerli, Antonio MorelliAbstract:OBJECTIVES Scleroderma patients frequently present esophageal and gastric Emptying abnormalities and small bowel dysfunction. Erythromycin, a macrolide antibiotic, has been found to accelerate gastric and Gallbladder Emptying in both healthy subjects and diabetic patients. Our objective was to investigate the effects of 4-wk oral erythromycin administration on the gastric and Gallbladder Emptying, gastrointestinal symptoms (early satiety, abdominal pain, nausea, bloating, vomiting, and constipation), and motilin plasma levels of patients with scleroderma. METHODS 12 scleroderma patients were investigated before and after 4-wk treatment with 250 mg oral erythromycin three times a day. The effect of a single i.v. dose of 2 mg/kg/h erythromycin on gastric and Gallbladder Emptying before starting the oral treatment was also evaluated. Gastric and Gallbladder Emptying after a solid meal were evaluated by sonography. RESULTS Single i.v. administration of erythromycin before the meal reduced gastric Emptying T1/2 from 121.3 +/- 14.0 to 45.5 +/- 7.3 min (p < 0.01) and accelerated Gallbladder Emptying without affecting the peak. Four-week oral administration of erythromycin reduced gastric Emptying T1/2 from 121.3 +/- 14.0 min to 46.5 +/- 8.3 min (p < 0.01). Peak Gallbladder Emptying was also significantly accelerated, while total Emptying remained unchanged (p < 0.01). Furthermore, 4-wk erythromycin administration reduced both motilin plasma levels (from 223.4 +/- 53.8 to 145.4 +/- 67.2 pmol/L, p < 0.01) and symptoms of nausea, vomiting, and abdominal pain (p < 0.01), and increased bowel movements in a subset of scleroderma patients with intestinal pseudo-obstruction. CONCLUSIONS Erythromycin stimulates gastrointestinal motility in patients with scleroderma. Administered medium-term, it accelerates gastric and Gallbladder Emptying and alleviates gastrointestinal symptoms.
-
5 hydroxytryptamine 3 receptor antagonist modulates Gallbladder Emptying and motilin release induced by erythromycin
Digestive Diseases and Sciences, 1993Co-Authors: Stefano Fiorucci, Luca Santucci, Antonio MorelliAbstract:In the present study we evaluated the effect of ondansetron (formerly indicated as GR38032F), a potent and selective type-3 5-hydroxytryptamine receptor antagonist, on erythromycin-induced Gallbladder Emptying and motilin release, as well as Gallbladder Emptying induced by a regular meal in healthy volunteers. Gallbladder Emptying was evaluated by sonography. Ondansetron, at the dose of 0.05 mg/kg, significantly reduced (P<0.001 by ANOVA) the Gallbladder Emptying induced by 2 mg/kg/hr erythromycin, but did not increase basal Gallbladder volume or inhibit Gallbladder Emptying induced by a regular meal. Ondansetron also inhibited the motilin release induced by erythromycin (P<0.001, by ANOVA). These results suggest that serotoninergic mechanisms modulate the effects of erythromycin on the gastrointestinal tract. The exact site of action of ondansetron remains to be identified.
-
5-hydroxytryptamine 3-receptor antagonist modulates Gallbladder Emptying and motilin release induced by erythromycin.
Digestive diseases and sciences, 1993Co-Authors: Stefano Fiorucci, Luca Santucci, Antonio MorelliAbstract:In the present study we evaluated the effect of ondansetron (formerly indicated as GR38032F), a potent and selective type-3 5-hydroxytryptamine receptor antagonist, on erythromycin-induced Gallbladder Emptying and motilin release, as well as Gallbladder Emptying induced by a regular meal in healthy volunteers. Gallbladder Emptying was evaluated by sonography. Ondansetron, at the dose of 0.05 mg/kg, significantly reduced (P
-
erythromycin stimulates Gallbladder Emptying and motilin release by atropine sensitive pathways
Digestive Diseases and Sciences, 1992Co-Authors: Stefano Fiorucci, Rachele Bosso, Antonio MorelliAbstract:The effect of administering different doses of erythromycin on Gallbladder Emptying and plasma concentrations of immunoreactive motilin was investigated in healthy volunteers. Erythromycin was infused for 30 min at four different doses: 20, 50, 100, and 1000 mg/hr. Gallbladder volume was determined by ultrasound scanning every 10 min for 60 min. All doses, except 20 mg/hr, provoked a significant reduction in Gallbladder volume (P<0.01). The Gallbladder Emptying peak occurred after 20 min infusion. It was approximately 40–45% of basal volume and 60–70% of the Emptying observed after a standard meal. At 100 mg/hr, erythromycin caused a 2.5-fold increase in plasma motilin concentration, which reached a peak after 30 min infusion. Plasma motilin peaked following maximum Gallbladder Emptying in all subjects. To evaluate whether cholinergic pathways were implicated in the action of erythromycin, 100 mg/hr erythromycin was infused together with 6 μg/kg/hr atropine. Atropine inhibited both Gallbladder Emptying and motilin release (P<0.001). Infusion of 1 μg/kg/hr somatostatin had the same inhibitory effects (P<0.001). Our results suggest that atropine acts by inhibiting an erythromycin-activated cholinergic neural mechanism. Somatostatin could exert its inhibitory effect by blocking the release of acetylcholine from neural terminations.
-
effect of erythromycin on Gallbladder Emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin
Digestive Diseases and Sciences, 1992Co-Authors: Stefano Fiorucci, Rachele Bosso, L Scionti, Antonio Desando, P Bottini, Cecilia Marino, Antonio MorelliAbstract:A reduction of Gallbladder Emptying in response to neural or hormonal stimulation has been reported in patients with diabetes mellitus. Decreased Gallbladder Emptying may be a key factor in the pathogenesis of Gallbladder stones. Few drugs, if any, are able to stimulate Gallbladder Emptying. However, in a previous study we demonstrated that erythromycin, a macrolide antibiotic, stimulates Gallbladder Emptying and motilin release in healthy human subjects by an atropine-sensitive pathway. Therefore, the present study was designed to evaluate the effect of erythromycin on Gallbladder Emptying and motilin release in diabetic patients with or without cardiac autonomic neuropathy (AN). Thirteen diabetic patients, six with AN, and 10 healthy subjects were enrolled in the study protocol. Gallbladder Emptying was determined by sonography after ingestion of a standard meal and during infusion of erythromycin alone or together with 6 μg/kg/hr atropine. We found that 100 mg/hr erythromycin caused a significant reduction in Gallbladder volume in both healthy subjects and diabetic patients. The ejection fraction (mean ±se) of 45.3±8.2% and 37.3±5.0% was similar. The presence of AN had no influence on Gallbladder Emptying induced by erythromycin. Basal motilin plasma levels were 111.5±14.5 pmol/liter in diabetic patients and 63.3 ±6.0 pmol/liter in healthy subjects (P<0.01). However, patients with AN had higher (130.0 ±11.9 pmol/liter) motilin plasma levels than patients without (74.0±9.4 pmol/liter,P<0.01). Erythromycin administration caused an approximately twofold increase in plasma motilin concentrations in healthy subject and patients withou AN, but did not stimulate motilin release in neuropathic patients. A negative correlation (r=−0.75,P<0.01) was found between basal plasma levels of motilin and peak of Gallbladder Emptying induced by erythromycin. Atropine completely inhibited the effects of erythromycin on Gallbladder Emptying and motilin release (P<0.001 by ANOVA). A negative correlation (r=−0.52,P<0.05) was also found between plasma glucose concentrations and peak of Gallbladder Emptying. Present results demonstrate that erythromycin could be used for treating alterations of Gallbladder Emptying in diabetic patients with or without AN.
Cornelius B H W Lamers - One of the best experts on this subject based on the ideXlab platform.
-
hyperglycemia reduces Gallbladder Emptying and plasma hormone secretion to modified sham feeding and regular feeding
Hepatology, 1993Co-Authors: Sybrand Y De Boer, Ad A.m. Masclee, Wai Fan Lam, J Schipper, Jan B M J Jansen, Cornelius B H W LamersAbstract:The purpose of this study was to investigate the effect of acute stable hyperglycemia on Gallbladder motility, plasma cholecystokinin level and pancreatic polypeptide secretion. Gallbladder Emptying in response to modified sham feeding and regular feeding was determined in six healthy subjects on two separate occasions during normoglycemia (serum glucose = 5 mmol/L) and during hyperglycemia (serum glucose = 15 mmol/L). Pancreatic polypeptide secretion was determined as an indirect measure of cholinergic tone. Gallbladder contraction in response to sham feeding during hyperglycemia (9% +/- 2%) was significantly (p < 0.05) reduced compared with that in normoglycemia (22% +/- 1%). During hyperglycemia, Gallbladder Emptying after meal ingestion (29% +/- 9%) was significantly (p < 0.05) less than that in normoglycemia (60% +/- 10%). Sham feeding did not affect plasma cholecystokinin levels. Regular feeding induced significant (p < 0.05) increases in plasma cholecystokinin levels in both experiments. However, integrated postprandial plasma cholecystokinin secretion was significantly (p < 0.05) reduced during hyperglycemia compared with that in normoglycemia (29 +/- 5 pmol.60 min vs. 58 +/- 10 pmol.60 min). Modified sham feeding-and feeding-stimulated pancreatic polypeptide secretion during hyperglycemia (235 +/- 95 pmol.90 min and 1,035 +/- 267 pmol.60 min, respectively) were significantly (p < 0.05) less than levels seen in normoglycemia (434 +/- 71 pmol.90 min and 1,961 +/- 219 pmol.60 min, respectively). This study indicates that Gallbladder Emptying and plasma hormone secretion in response to sham feeding and regular feeding are affected by blood glucose levels.
Sybrand Y De Boer - One of the best experts on this subject based on the ideXlab platform.
-
hyperglycemia reduces Gallbladder Emptying and plasma hormone secretion to modified sham feeding and regular feeding
Hepatology, 1993Co-Authors: Sybrand Y De Boer, Ad A.m. Masclee, Wai Fan Lam, J Schipper, Jan B M J Jansen, Cornelius B H W LamersAbstract:The purpose of this study was to investigate the effect of acute stable hyperglycemia on Gallbladder motility, plasma cholecystokinin level and pancreatic polypeptide secretion. Gallbladder Emptying in response to modified sham feeding and regular feeding was determined in six healthy subjects on two separate occasions during normoglycemia (serum glucose = 5 mmol/L) and during hyperglycemia (serum glucose = 15 mmol/L). Pancreatic polypeptide secretion was determined as an indirect measure of cholinergic tone. Gallbladder contraction in response to sham feeding during hyperglycemia (9% +/- 2%) was significantly (p < 0.05) reduced compared with that in normoglycemia (22% +/- 1%). During hyperglycemia, Gallbladder Emptying after meal ingestion (29% +/- 9%) was significantly (p < 0.05) less than that in normoglycemia (60% +/- 10%). Sham feeding did not affect plasma cholecystokinin levels. Regular feeding induced significant (p < 0.05) increases in plasma cholecystokinin levels in both experiments. However, integrated postprandial plasma cholecystokinin secretion was significantly (p < 0.05) reduced during hyperglycemia compared with that in normoglycemia (29 +/- 5 pmol.60 min vs. 58 +/- 10 pmol.60 min). Modified sham feeding-and feeding-stimulated pancreatic polypeptide secretion during hyperglycemia (235 +/- 95 pmol.90 min and 1,035 +/- 267 pmol.60 min, respectively) were significantly (p < 0.05) less than levels seen in normoglycemia (434 +/- 71 pmol.90 min and 1,961 +/- 219 pmol.60 min, respectively). This study indicates that Gallbladder Emptying and plasma hormone secretion in response to sham feeding and regular feeding are affected by blood glucose levels.
J B M J Jansen - One of the best experts on this subject based on the ideXlab platform.
-
Motor cycles with phase III in antrum are associated with high motilin levels and prolonged Gallbladder Emptying
2016Co-Authors: M. F. J. Stolk, J B M J Jansen, C B H W Lamers, K. J. Van Erpecum, A. J. P. M. Smout, L. M. A. Akkermans, T. L. Peeters, G. P. Vanberge-henegouwenAbstract:wen. Motor cycles with phase III in antrum are associated with high motilin levels and prolonged Gallbladder Emptying. Am. J. Physiol. 264 (Gastrointest. Liver Physiol. 27): G596-G600,1993.-We examined the relationship of interdigestive Gallbladder Emptying with the different phases of the migrating motor com-plex (MMC) and with plasma levels of cholecystokinin (CCK) and motilin. In 10 volunteers 20 cycles of the MMC were re-corded. In 11 cycles phase III occurred in antrum and duodenum (group 1). I n nine cycles phase III was observed only in duode-num (group 2). In group 1 Gallbladder Emptying started at 30% of total cycle length and continued until the end of the cycle. Maximal Gallbladder Emptying was 33.3 t 3.3 % (SE). In group 2 Gallbladder Emptying also started at 30 % of total cycle length but ended at 60%. Maximal Gallbladder Emptying in this group was 24.3,t 3.1 % (P < 0.05). Motilin levels were higher in group 1 than in group 2 during phase IIB (240.1 t 28.5 and 142.1
-
Effect of rectal distension on Gallbladder Emptying and circulating gut hormones
European journal of clinical investigation, 2000Co-Authors: F. Van Hoek, Wim P.m. Hopman, R. M. H. G. Mollen, Han C. Kuijpers, J B M J JansenAbstract:BACKGROUND Abnormalities of upper gut motility, including a delay of gastric Emptying and small bowel transit, found in patients with constipation may be secondary to factors originating in the colon or rectum as a result of faecal stasis. The aim was to determine if stimulation of mechanosensory function by rectal distension affects postprandial Gallbladder Emptying and release of gastrointestinal peptides participating in control of upper gut motility. MATERIALS AND METHODS Eight healthy volunteers were studied with an electronic barostat and a plastic bag positioned in the rectum. Intrabag pressure was maintained at minimal distension pressure + 2 mmHg on one occasion and on a pressure that induced a sensation of urge on the other. Gallbladder volume and plasma concentrations of cholecystokinin (CCK), pancreatic polypeptide (PP) and peptide YY (PYY) were measured before and after ingestion of a 450-kcal mixed liquid meal. RESULTS Rectal distension enhanced maximum Gallbladder Emptying from 66 +/- 7% to 78 +/- 5% (P < 0.05). Distension tended to increase integrated plasma PYY from 77 +/- 30 pM min to 128 +/- 40 pM min in the first hour after the meal (P = 0.08) and it suppressed integrated plasma PP from 1133 +/- 248 pM min to 269 +/- 284 pM min in the second hour (P < 0.05). Integrated plasma CCK concentrations were not significantly affected. CONCLUSION Mechanosensory stimulation of the rectum enhances postprandial Gallbladder Emptying and influences postprandial release of gut hormones involved in the regulation of gastrointestinal motility in healthy subjects. These mechanisms may play a role in the pathogenesis of the upper gastrointestinal motor abnormalities observed in constipated patients.
-
The nondigestible fat sucrose polyester does not stimulate Gallbladder Emptying in humans.
The American journal of clinical nutrition, 1998Co-Authors: M.i.m. Maas, Wim P.m. Hopman, Martijn B. Katan, J B M J JansenAbstract:Background: We determined the effect of oral ingestion of sucrose polyester, which was approved as a fat replacer in the United States, on Gallbladder motility and on the release of cholecystokinin, the hormone that mediates Gallbladder Emptying. Objective: Our objective was to measure effects of sucrose polyester on Gallbladder Emptying and cholecystokinin release. Design: Eight healthy volunteers (3 men and 5 women) drank 60 mL sucrose polyester, digestible fat, or saline solution in a balanced crossover design on 3 separate days. Results: Mean (∠ SEM) Gallbladder Emptying, when integrated over time, was low in response to both sucrose polyester (2150 ∠ 214 mL · 120 min) and saline solution (289 ∠ 123 mL · 120 min). In contrast, there was marked Emptying in response to digestible fat (1069 ∠ 253 mL · 120 min). Sucrose polyester did not affect plasma cholecystokinin concentrations (29.3 ∠ 15.0 pmol · 120 min/L), whereas digestible fat resulted in a significant increase (89.5 ∠ 44.8 pmol · 120 min/L, P = 0.014) compared with saline solution (23.0 ∠ 13.8 pmol · 120 min/L). Conclusions: Ingestion of sucrose polyester, in contrast with digestible fat, did not stimulate Gallbladder Emptying or release of cholecystokinin. Am J Clin Nutr 1998;68:1272‐5.
-
Motor cycles with phase III in antrum are associated with high motilin levels and prolonged Gallbladder Emptying
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1993Co-Authors: M. F. J. Stolk, J B M J Jansen, K. J. Van Erpecum, A. J. P. M. Smout, L. M. A. Akkermans, T. L. Peeters, Cornelis B.h.w. Lamers, Gerard P. Vanberge-henegouwenAbstract:We examined the relationship of interdigestive Gallbladder Emptying with the different phases of the migrating motor complex (MMC) and with plasma levels of cholecystokinin (CCK) and motilin. In 10 volunteers 20 cycles of the MMC were recorded. In 11 cycles phase III occurred in antrum and duodenum (group 1). In nine cycles phase III was observed only in duodenum (group 2). In group 1 Gallbladder Emptying started at 30% of total cycle length and continued until the end of the cycle. Maximal Gallbladder Emptying was 33.3 +/- 3.3% (SE). In group 2 Gallbladder Emptying also started at 30% of total cycle length but ended at 60%. Maximal Gallbladder Emptying in this group was 24.3 +/- 3.1% (P < 0.05). Motilin levels were higher in group 1 than in group 2 during phase IIB (240.1 +/- 28.5 and 142.1 +/- 30.9 pg/ml, respectively, P < 0.05) and during phase III (210.8 +/- 24.3 and 93.5 +/- 12.5 pg/ml, respectively, P < 0.05). We conclude that: 1) phase III activities starting in the antrum are preceded by greater and prolonged Gallbladder Emptying, higher motilin levels, and higher intraduodenal bile acid concentrations than phase III activities starting in the duodenum and 2) no relationship between interdigestive Gallbladder motility and CCK levels could be demonstrated.
-
Severely impaired postprandial Gallbladder Emptying despite unchanged cholecystokinin release in the early phase of biliary colic.
The Netherlands journal of medicine, 1991Co-Authors: K. J. Van Erpecum, J B M J Jansen, Wim P.m. Hopman, G. P. Van Berge Henegouwen, Cornelis B.h.w. LamersAbstract:In the present article we report transitory severely impaired postprandial Gallbladder Emptying preceding biliary colic in a cholesterol gallstone patient. Gallbladder Emptying 1 wk before and 3 wk after the biliary colic was normal. Treatment with ursodeoxycholic acid led to increased fasting Gallbladder volumes, but the postprandial residual volume did not change. Postprandial cholecystokinin release appeared not to change during ursodeoxycholic acid treatment or during biliary colic.
