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Lale Kostakoglu - One of the best experts on this subject based on the ideXlab platform.
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positron emission tomography in lymphoma comparison with computed tomography and Gallium 67 single photon emission computed tomography
Clinical Lymphoma Myeloma & Leukemia, 2000Co-Authors: Lale Kostakoglu, Stanley J GoldsmithAbstract:Abstract With the advent of positron emission tomography (PET), metabolic imaging has become a reality for tumor staging and monitoring response to therapy in lymphoma. Increased Fluorine-18 fluorodeoxyglucose ([ 18 F]FDG) uptake in lymphomas has been well documented in the literature; it is based upon elevated glycolysis and longer residence time of FDG in malignant cells compared to most normal tissues. This suggests that in tumor staging, FDG-PET may be more sensitive and specific than the anatomic imaging modalities. Computed tomography (CT) is the standard imaging modality for the staging and restaging of lymphoma, and Gallium-67 ( 67 Ga) scintigraphy has played an important role in monitoring response to therapy and follow-up of patients. Published results suggest that FDG-PET is superior to 67 Ga imaging and may be equal or superior to CT for the detection of nodal as well as extranodal involvement in lymphoma.
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simultaneous Gallium 67 citrate and technetium 99m sestamibi spet in a case of myocardial lymphoma comparison with echocardiography before and after chemotherapy
European Journal of Nuclear Medicine and Molecular Imaging, 1994Co-Authors: Lale Kostakoglu, Steven M Larson, Nancy Roistacher, Hovanes Kalaigian, Hussein M AbdeldayemAbstract:A patient with diffuse large cell lymphoma involving the interventricular septum and the inferior ventricular wall was imaged with a simultaneous dual-isotope single-photon emission tomography (SPET) acquisition technique, using the radiotracers technetium-99m hexakis 2-methoxyisobutylisonitrile (sestamibi) and Gallium-67 citrate, in conjunction with echocardiography, prior to and following the first course of chemotherapy. Simultaneous acquisition — with the advantage of displaying corresponding sets of SPET slices without any need for position correction - , supplemented by echocardiography, increased the accuracy of evaluation of the extent of disease and response to treatment.
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validation of Gallium 67 citrate single photon emission computed tomography in biopsy confirmed residual hodgkin s disease in the mediastinum
The Journal of Nuclear Medicine, 1992Co-Authors: Lale Kostakoglu, Samuel D J Yeh, Carol S Portlock, Robert T Heelan, Tzyjyun Yao, Donna Niedzwiecki, Steven M LarsonAbstract:In a retrospective study of a series of 30 adult patients during restaging of Hodgkin's disease after therapy, computed tomography (CT) and biopsy results were correlated with 67Ga SPECT in order to determine the value of SPECT imaging in monitoring recurrent mediastinal Hodgkin's disease. SPECT had an overall accuracy of 93% (28/30) and correctly identified active disease in 24 of 25, 96% of histopathologically proven recurrent Hodgkin's disease. Thus in this post-therapy setting, we have confirmed the high sensitivity of 67GA SPECT scans in patients selected for biopsy. Gallium-67 may prove particularly useful in detecting residual disease activity in patients in whom biopsy was positive but the interpretations of the CT scans were uncertain in regard to presence of tumors [8/30 (27%)]. In this group of patients, we found SPECT particularly helpful. A larger prospective series is under way to assess this possibility.
Steven M Larson - One of the best experts on this subject based on the ideXlab platform.
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simultaneous Gallium 67 citrate and technetium 99m sestamibi spet in a case of myocardial lymphoma comparison with echocardiography before and after chemotherapy
European Journal of Nuclear Medicine and Molecular Imaging, 1994Co-Authors: Lale Kostakoglu, Steven M Larson, Nancy Roistacher, Hovanes Kalaigian, Hussein M AbdeldayemAbstract:A patient with diffuse large cell lymphoma involving the interventricular septum and the inferior ventricular wall was imaged with a simultaneous dual-isotope single-photon emission tomography (SPET) acquisition technique, using the radiotracers technetium-99m hexakis 2-methoxyisobutylisonitrile (sestamibi) and Gallium-67 citrate, in conjunction with echocardiography, prior to and following the first course of chemotherapy. Simultaneous acquisition — with the advantage of displaying corresponding sets of SPET slices without any need for position correction - , supplemented by echocardiography, increased the accuracy of evaluation of the extent of disease and response to treatment.
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Gallium 67 citrate imaging in nuclear oncology
Nuclear Medicine and Biology, 1994Co-Authors: Homer A Macapinlac, Andrew M Scott, Steven M Larson, Chaitanya R Divgi, Samuel D J Yeh, Stanley J GoldsmithAbstract:Gallium-67-citrate is one of the most useful radiopharmaceuticals to detect tumors, stage extent of the disease, monitor response to treatment and distinguish recurrent disease from post-treatment changes. Gallium is likewise very sensitive to detect and locate infections and inflammatory foci. This application is extremely important in the management of immunocompromised cancer patients. Image interpretation should be tempered with full knowledge of the patients clinical condition, anatomic alterations due to prior surgery and correct timing of image acquisition. Early imaging at 4-6 h is useful to detect gastrointestinal infections, whereas 24 h imaging is used to evaluate chest infections. Although Gallium-67 is a non-specific agent, the identification of the etiology of the inflammation may be improved by adequate clinical and laboratory information as well as correlation with other imaging modalities such as sonography and computerized x-ray tomography (CT). High dose (10 mCi) Gallium-67 single photon emission computed tomography (SPECT) imaging with image co-registration is important for accurate uptake localization.
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validation of Gallium 67 citrate single photon emission computed tomography in biopsy confirmed residual hodgkin s disease in the mediastinum
The Journal of Nuclear Medicine, 1992Co-Authors: Lale Kostakoglu, Samuel D J Yeh, Carol S Portlock, Robert T Heelan, Tzyjyun Yao, Donna Niedzwiecki, Steven M LarsonAbstract:In a retrospective study of a series of 30 adult patients during restaging of Hodgkin's disease after therapy, computed tomography (CT) and biopsy results were correlated with 67Ga SPECT in order to determine the value of SPECT imaging in monitoring recurrent mediastinal Hodgkin's disease. SPECT had an overall accuracy of 93% (28/30) and correctly identified active disease in 24 of 25, 96% of histopathologically proven recurrent Hodgkin's disease. Thus in this post-therapy setting, we have confirmed the high sensitivity of 67GA SPECT scans in patients selected for biopsy. Gallium-67 may prove particularly useful in detecting residual disease activity in patients in whom biopsy was positive but the interpretations of the CT scans were uncertain in regard to presence of tumors [8/30 (27%)]. In this group of patients, we found SPECT particularly helpful. A larger prospective series is under way to assess this possibility.
Stanley J Goldsmith - One of the best experts on this subject based on the ideXlab platform.
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positron emission tomography in lymphoma comparison with computed tomography and Gallium 67 single photon emission computed tomography
Clinical Lymphoma Myeloma & Leukemia, 2000Co-Authors: Lale Kostakoglu, Stanley J GoldsmithAbstract:Abstract With the advent of positron emission tomography (PET), metabolic imaging has become a reality for tumor staging and monitoring response to therapy in lymphoma. Increased Fluorine-18 fluorodeoxyglucose ([ 18 F]FDG) uptake in lymphomas has been well documented in the literature; it is based upon elevated glycolysis and longer residence time of FDG in malignant cells compared to most normal tissues. This suggests that in tumor staging, FDG-PET may be more sensitive and specific than the anatomic imaging modalities. Computed tomography (CT) is the standard imaging modality for the staging and restaging of lymphoma, and Gallium-67 ( 67 Ga) scintigraphy has played an important role in monitoring response to therapy and follow-up of patients. Published results suggest that FDG-PET is superior to 67 Ga imaging and may be equal or superior to CT for the detection of nodal as well as extranodal involvement in lymphoma.
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Gallium 67 citrate imaging in nuclear oncology
Nuclear Medicine and Biology, 1994Co-Authors: Homer A Macapinlac, Andrew M Scott, Steven M Larson, Chaitanya R Divgi, Samuel D J Yeh, Stanley J GoldsmithAbstract:Gallium-67-citrate is one of the most useful radiopharmaceuticals to detect tumors, stage extent of the disease, monitor response to treatment and distinguish recurrent disease from post-treatment changes. Gallium is likewise very sensitive to detect and locate infections and inflammatory foci. This application is extremely important in the management of immunocompromised cancer patients. Image interpretation should be tempered with full knowledge of the patients clinical condition, anatomic alterations due to prior surgery and correct timing of image acquisition. Early imaging at 4-6 h is useful to detect gastrointestinal infections, whereas 24 h imaging is used to evaluate chest infections. Although Gallium-67 is a non-specific agent, the identification of the etiology of the inflammation may be improved by adequate clinical and laboratory information as well as correlation with other imaging modalities such as sonography and computerized x-ray tomography (CT). High dose (10 mCi) Gallium-67 single photon emission computed tomography (SPECT) imaging with image co-registration is important for accurate uptake localization.
Chiahung Kao - One of the best experts on this subject based on the ideXlab platform.
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condyloma mistaken for stool contamination in a human immunodeficiency virus patient by Gallium 67 scintigraphy
The American Journal of the Medical Sciences, 2010Co-Authors: Kuoyang Yen, Chihhsius Wnag, Yuyi Lin, Techun Hsieh, Shungshung Sun, Chiahung KaoAbstract:We demonstrated a unique image finding related to condyloma in a patient infected with human immunodeficiency virus. It is worth noting that a thorough literature search of the available databases to date failed to retrieve any case reports of condyloma with representative Gallium-67 scintigraphic images.
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comparison of Gallium 67 citrate and technetium 99m tetrofosmin scan to detect hodgkin s disease
Annals of Nuclear Medicine, 2003Co-Authors: Feng Yuan Liu, Ruohfang Yen, Yuchien Shiau, Jhijoung Wang, Chiahung KaoAbstract:Objective: The purpose of this study was to compare the usefulness of Gallium-67 citrate (67Ga) and technetium-99m tetrofosmin (Tc-TF) scan to detect Hodgkin’s disease (HD).Methods: In this study, 24 patients with HD underwent67Ga and Tc-TF scan before receiving any therapy.Results:67Ga scan could detect HD in all 24 (100%) patients. Tc-TF scan could detect HD in 22/24 (91.6%) patients, but it was false-negative in one case of infradiaphragmatic HD and in another, case with chemotherapy resistance. There was no significant difference in detection sensitivity between67Ga and Tc-TF scan.Conclusions: We conclude that Tc-TF scan can not replace conventional67Ga scan to detect HD.
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comparison of technetium 99m tetrofosmin and Gallium 67 citrate scintigraphy for detecting malignant lymphoma
Anticancer Research, 2001Co-Authors: Ching Chiang Yang, Shungshung Sun, Chiahung Kao, Chengchieh Lin, Chengchun LeeAbstract:The aim of this study was to compare the value of technetium-99m tetrofosmin (Tc-TF) scintigraphy with that of Gallium-67 citrate (Ga-67) scintigraphy for detecting malignant lymphoma. In this study, 50 patients with malignant lymphoma underwent Tc-TF and Ga-67 scintigraphy before receiving any therapy. Tc-TF scintigraphy detected malignant lymphoma in 44 (88%) patients, but was false-negative in 4 cases of infradiaphragmatic malignant lymphoma and in 2 cases of malignant lymphoma with chemotherapy resistance, Ga-67 scintigraphy detected malignant lymphoma in 45 (90%) patients, but was false-negative in 3 cases of low-grade non-Hodgkin's 's lymphoma and in 2 cases of malignant lymphoma with hone marrow involvement. There was no significant difference in sensitivity between Tc-TF and Ga scintigraphy. However, a combination of Tc-TF and Ga-67 scintigraphy detected malignant lymphoma in all 50 patients (100%). We conclude that it is necessary to combine Tc-TF and Ga-67 scintigraphy to accurately detect malignant lymphoma.
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usefulness of Gallium 67 citrate scans in patients with acute disseminated tuberculosis and comparison with chest x rays
The Journal of Nuclear Medicine, 1993Co-Authors: Chiahung Kao, Wanyu Lin, Shyhjen Wang, Shuquinn Liao, Chungyuan HsuAbstract:Sixteen patients (4 females, 12 males; ages: 15-80 yr) were admitted to our hospital and diagnosed as having acute disseminated tuberculosis (TB). Gallium-67-citrate scans and chest x-rays were used to localize the TB. The results revealed that: (1) most patients had an underlying disease (malignancy or immunocompromise); (2) Gallium lung scans demonstrated multiple patterns from a negative picture to greater than liver uptake (localized or diffuse); (3) the extrapulmonary TB focus could be clearly visualized by whole-body Gallium scans; (4) most chest x-rays had a miliary pattern and few cases were negative or localized. A combination examination, including Gallium scans and chest x-rays, is needed to avoid missing early diagnosis of acute disseminated tuberculosis, especially in high risk group patients.
Yoshiya Tanaka - One of the best experts on this subject based on the ideXlab platform.
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relapsing polychondritis diagnosed by fusion images of Gallium 67 uptake on computed tomography and single photon emission computed tomography
Arthritis & Rheumatism, 2017Co-Authors: Kazuhisa Nakano, Takafumi Aritomi, Naoaki Ohkubo, Yoshiya TanakaAbstract:A 64-year-old man has revealed dry cough and severe pain of ear, nose and throat for several weeks. After visiting clinics and hospitals, he was introduced to our hospital and was diagnosed as relapsing polychondritis (RP) based on McAdam's criteria. The involvement in auricular, nasal and tracheal cartilage was clearly shown by fusion images of Gallium-67 on single photon emission computed tomography and computed tomography (SPECT/CT) (A, B). High-dose glucocorticoid (GC) therapy markedly improved relevant signs, symptoms and inflammatory reactions as well as Gallium uptake in cartilage detected by Gallium-SPECT/CT (C). This article is protected by copyright. All rights reserved.
