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Charlotte Cunningham-rundles - One of the best experts on this subject based on the ideXlab platform.

  • Common variable Immunodeficiency.
    Current allergy and asthma reports, 2001
    Co-Authors: Charlotte Cunningham-rundles
    Abstract:

    Common variable Immunodeficiency (CVID) is a common primary immnodeficiency disease, the hallmark of which is hypogammaglobulinemia. Due to the lack of antibodies, patients usually have recurrent bacterial infections, but there are a number of other puzzling manifestations, including inflammatory conditions, autoimmune disease, and the development of lymphomas. Most patients are diagnosed as adults, and delay in the recognition of the antibody defect is common. A number of defects of T cell function and deficits in the memory B cell pool have been identified, but the underlying cause of this defect remains unknown.

  • New Insights into Common Variable Immunodeficiency
    Annals of internal medicine, 1993
    Co-Authors: M C Sneller, Warren Strober, Eli M. Eisenstein, Jonathan S. Jaffe, Charlotte Cunningham-rundles
    Abstract:

    Common variable Immunodeficiency (CVI) is a heterogenous Immunodeficiency syndrome characterized by hypogammaglobulinemia, recurrent bacterial infections, and various immunologic abnormalities. In ...

Thierry Lamy - One of the best experts on this subject based on the ideXlab platform.

  • Two cases of disseminated Mycobacterium avium infection associated with a new Immunodeficiency syndrome related to CXCR4 dysfunctions.
    Clinical Microbiology and Infection, 2011
    Co-Authors: Anne-violaine Doncker, Karl Balabanian, Francoise Bachelerie, Christine Bellanné-chantelot, Sophie De Guibert, Matthieu Revest, Thierry Lamy
    Abstract:

    Disseminated Mycobacterium avium complex (MAC) infection is a rare but severe disease mostly seen in patients with AIDS. It has been previously described in patients suffering from other kinds of Immunodeficiency (e.g. primary Immunodeficiency diseases in children or hairy cell leukaemia). We report two cases of disseminated MAC disease in young women with extended granulomatosis that revealed a new form of severe Immunodeficiency syndrome. Both clinical observations initially appeared to be very similar to WHIM syndrome (Warts, Hypogammaglobulinemia, Infection, Myelokathexis), a rare Immunodeficiency disease correlated with CXC chemokine receptor 4 (CXCR4) mutation leading to an impaired internalization of the receptor upon its ligand CXCL12. We investigated the CXCR4 status of the lymphocytes in both patients and found a severe defect in CXCL12-promoted internalization but no mutation of its gene. Moreover, myelokathexis was not noted in bone marrow biopsies and therefore a diagnosis of WHIM syndrome could not be assessed. This Immunodeficiency syndrome associated with CXCR4 dysfunction was responsible for severe MAC infection in our patients, with a fatal outcome in one case. It may be possible that these patients would have benefited from early antimycobacterial infection or azythromycin prophylaxis.

Carlos Avilafigueroa - One of the best experts on this subject based on the ideXlab platform.

  • a controlled study of funding for human Immunodeficiency virus acquired Immunodeficiency syndrome as resource capacity building in the health system in rwanda
    American Journal of Tropical Medicine and Hygiene, 2012
    Co-Authors: Donald S Shepard, Wu Zeng, Peter Amico, Angelique K Rwiyereka, Carlos Avilafigueroa
    Abstract:

    Because human inmmunodeficiency virus/acquired Immunodeficiency syndrome (HIV/AIDS) receives more donor funding globally than that for all other diseases combined, some critics allege this support undermines general health care. This empirical study evaluates the impact of HIV/AIDS funding on the primary health care system in Rwanda. Using a quasi-experimental design, we randomly selected 25 rural health centers (HCs) that started comprehensive HIV/AIDS services from 2002 through 2006 as the intervention group. Matched HCs with no HIV/AIDS services formed the control group. The analysis compared growth in inputs and services between intervention and control HCs with a difference-in-difference analysis in a random-effects model. Intervention HCs performed better than control HCs in most services (seven of nine), although only one of these improvements (Bacille Calmette-Guerin vaccination) reached or approached statistical significance. In conclusion, this six-year controlled study found no adverse effects of the expansion of HIV/AIDS services on non-HIV services among rural health centers in Rwanda.

William S Dynan - One of the best experts on this subject based on the ideXlab platform.

  • incidence of bk virus and jc virus viruria in human Immunodeficiency virus infected and uninfected subjects
    The Journal of Infectious Diseases, 1993
    Co-Authors: Rheabeth Markowitz, Harry C Thompson, Jane F Mueller, Jeffrey A Cohen, William S Dynan
    Abstract:

    BK virus (BKV) and JC virus (JCV) are present within the renal system of most adults. Reactivation may be linked to Immunodeficiency, since many of the extant virus strains have been isolated from urine or kidney tissue of patients who were receiving immunosuppressive therapy or who had disorders of the immune system. To more critically evaluate the relationship between Immunodeficiency and viruria, urine samples from individuals infected with human Immunodeficiency virus (HIV) with various degrees of Immunodeficiency were screened for the presence of viral DNA. JCV viruria occurred in 24%-27% of immunocompetent control subjects and was not increased with Immunodeficiency. By contrast, there were both qualitative and quantitative changes in BKV viruria in immunodeficient subjects. The incidence of BKV viruria was increased, and some immunodeficient subjects shed BKV at levels up to 3000 times greater than levels shed by any of the nonimmunodeficient controls. DNA sequence rearrangements in the viral regulatory region did not appear to be required for shedding of virus, although they were present in approximately 20% of samples.

Maria Isabel Veiga - One of the best experts on this subject based on the ideXlab platform.