The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform
Horacio Jinich - One of the best experts on this subject based on the ideXlab platform.
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human gallbladder morphology after Gallstone Dissolution with methyl tert butyl ether
Gastroenterology, 1991Co-Authors: Alan F. Hofmann, Salam Zakko, E Vansonnenberg, Horacio B Dagostino, Horacio JinichAbstract:The effects of methyl tert-butyl ether exposure on the human gallbladder in five patients who were treated for Gallstones by contact Dissolution is described. Two patients underwent cholecystectomy within 1 week of methyl tert-butyl ether treatment, one patient 2 weeks after, another 10 weeks after, and one 12 weeks after. Indications for cholecystectomy were bilirubinate stones (resistant to methyl tert-butyl ether), catheter dislodgement, bile leakage, and Gallstone recurrence (2 patients). Gallstones were dissolved completely in three patients, there was approximately 50% stone reduction in one patient, and no Dissolution occurred in the fifth patient. Each gallbladder was examined grossly and histologically. Electron microscopic evaluation was performed in one cases. Typical inflammatory findings of chronic cholecystitis were observed in each gallbladder and were most conspicuous in the submucosa; the mucosal and serosal surfaces were intact. Mild acute inflammatory changes were noted in the submucosa in the two patients with the shortest interval between methyl tert-butyl ether administration and cholecystectomy. There were no ulcerations in the mucosa and no unusual wall thickening or fibrosis in any patient. These observations support the safety of methyl tert-butyl ether perfusion in the human gallbladder; the mild acute changes may be a transient and reversible phenomenon.
Salam Zakko - One of the best experts on this subject based on the ideXlab platform.
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Ethyl propionate is more effective and less cytotoxic than methyl tert- butyl ether for topical Gallstone Dissolution
Gastroenterology, 1997Co-Authors: Salam Zakko, Jc Scirica, Mc Guttermuth, J Dodge, Jj HajjarAbstract:Abstract BACKGROUND & AIMS: Ethyl propionate and isopropyl acetate were identified as Gallstone solvents with more favorable physicochemical properties than the currently used solvent methyl tert-butyl ether (MTBE). In this study, their efficacy and toxicity were compared. METHODS: To compare efficacy, matched stones from 33 patients were subjected to Dissolution with each solvent. To evaluate cytotoxicity, jejunal segments of the anesthetized rat were exposed to each solvent or saline; the segments were then perfused with markers for active absorption and passive permeability. RESULTS: For 23 Gallstone sets that dissolved completely with all three solvents, the average Dissolution time was shorter with ethyl propionate (38 +/- 8 minutes) than with MTBE (60 +/- 13 minutes) (P = 0.03) or isopropyl acetate (55 +/- 12 minutes) (P CONCLUSIONS: Ethyl propionate and isopropyl acetate are less toxic to the intestinal mucosa than MTBE, and ethyl propionate is more effective for Gallstone Dissolution. (Gastroenterology 1997 Jul;113(1):232-7)
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human gallbladder morphology after Gallstone Dissolution with methyl tert butyl ether
Gastroenterology, 1991Co-Authors: Alan F. Hofmann, Salam Zakko, E Vansonnenberg, Horacio B Dagostino, Horacio JinichAbstract:The effects of methyl tert-butyl ether exposure on the human gallbladder in five patients who were treated for Gallstones by contact Dissolution is described. Two patients underwent cholecystectomy within 1 week of methyl tert-butyl ether treatment, one patient 2 weeks after, another 10 weeks after, and one 12 weeks after. Indications for cholecystectomy were bilirubinate stones (resistant to methyl tert-butyl ether), catheter dislodgement, bile leakage, and Gallstone recurrence (2 patients). Gallstones were dissolved completely in three patients, there was approximately 50% stone reduction in one patient, and no Dissolution occurred in the fifth patient. Each gallbladder was examined grossly and histologically. Electron microscopic evaluation was performed in one cases. Typical inflammatory findings of chronic cholecystitis were observed in each gallbladder and were most conspicuous in the submucosa; the mucosal and serosal surfaces were intact. Mild acute inflammatory changes were noted in the submucosa in the two patients with the shortest interval between methyl tert-butyl ether administration and cholecystectomy. There were no ulcerations in the mucosa and no unusual wall thickening or fibrosis in any patient. These observations support the safety of methyl tert-butyl ether perfusion in the human gallbladder; the mild acute changes may be a transient and reversible phenomenon.
Tae Ho Hong - One of the best experts on this subject based on the ideXlab platform.
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Efficacy and safety of a novel topical agent for Gallstone Dissolution: 2-methoxy-6-methylpyridine
Journal of translational medicine, 2019Co-Authors: Ho Joong Choi, Suk Joon Cho, Ok-hee Kim, Jin Sook Song, Ha-eun Hong, Sang Chul Lee, Kee-hwan Kim, Sang Kuon Lee, Young Kyoung You, Tae Ho HongAbstract:Although methyl-tertiary butyl ether (MTBE) is the only clinical topical agent for Gallstone Dissolution, its use is limited by its side effects mostly arising from a relatively low boiling point (55 °C). In this study, we developed the Gallstone-dissolving compound containing an aromatic moiety, named 2-methoxy-6-methylpyridine (MMP) with higher boiling point (156 °C), and compared its effectiveness and toxicities with MTBE. The dissolubility of MTBE and MMP in vitro was determined by placing human Gallstones in glass containers with either solvent and, then, measuring their dry weights. Their dissolubility in vivo was determined by comparing the weights of solvent-treated Gallstones and control (dimethyl sulfoxide)-treated Gallstones, after directly injecting each solvent into the gallbladder in hamster models with cholesterol and pigmented Gallstones. In the in vitro Dissolution test, MMP demonstrated statistically higher dissolubility than did MTBE for cholesterol and pigmented Gallstones (88.2% vs. 65.7%, 50.8% vs. 29.0%, respectively; P
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efficacy and safety of a novel topical agent for Gallstone Dissolution 2 methoxy 6 methylpyridine
Journal of Translational Medicine, 2019Co-Authors: Ho Joong Choi, Suk Joon Cho, Ok-hee Kim, Jin Sook Song, Ha-eun Hong, Sang Chul Lee, Kee-hwan Kim, Sang Kuon Lee, Young Kyoung You, Tae Ho HongAbstract:Although methyl-tertiary butyl ether (MTBE) is the only clinical topical agent for Gallstone Dissolution, its use is limited by its side effects mostly arising from a relatively low boiling point (55 °C). In this study, we developed the Gallstone-dissolving compound containing an aromatic moiety, named 2-methoxy-6-methylpyridine (MMP) with higher boiling point (156 °C), and compared its effectiveness and toxicities with MTBE. The dissolubility of MTBE and MMP in vitro was determined by placing human Gallstones in glass containers with either solvent and, then, measuring their dry weights. Their dissolubility in vivo was determined by comparing the weights of solvent-treated Gallstones and control (dimethyl sulfoxide)-treated Gallstones, after directly injecting each solvent into the gallbladder in hamster models with cholesterol and pigmented Gallstones. In the in vitro Dissolution test, MMP demonstrated statistically higher dissolubility than did MTBE for cholesterol and pigmented Gallstones (88.2% vs. 65.7%, 50.8% vs. 29.0%, respectively; P < 0.05). In the in vivo experiments, MMP exhibited 59.0% and 54.3% dissolubility for cholesterol and pigmented Gallstones, respectively, which were significantly higher than those of MTBE (50.0% and 32.0%, respectively; P < 0.05). The immunohistochemical stains of gallbladder specimens obtained from the MMP-treated hamsters demonstrated that MMP did not significantly increase the expression of cleaved caspase 9 or significantly decrease the expression of proliferation cell nuclear antigen. This study demonstrated that MMP has better potential than does MTBE in dissolving Gallstones, especially pigmented Gallstones, while resulting in lesser toxicities.
Alan F. Hofmann - One of the best experts on this subject based on the ideXlab platform.
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human gallbladder morphology after Gallstone Dissolution with methyl tert butyl ether
Gastroenterology, 1991Co-Authors: Alan F. Hofmann, Salam Zakko, E Vansonnenberg, Horacio B Dagostino, Horacio JinichAbstract:The effects of methyl tert-butyl ether exposure on the human gallbladder in five patients who were treated for Gallstones by contact Dissolution is described. Two patients underwent cholecystectomy within 1 week of methyl tert-butyl ether treatment, one patient 2 weeks after, another 10 weeks after, and one 12 weeks after. Indications for cholecystectomy were bilirubinate stones (resistant to methyl tert-butyl ether), catheter dislodgement, bile leakage, and Gallstone recurrence (2 patients). Gallstones were dissolved completely in three patients, there was approximately 50% stone reduction in one patient, and no Dissolution occurred in the fifth patient. Each gallbladder was examined grossly and histologically. Electron microscopic evaluation was performed in one cases. Typical inflammatory findings of chronic cholecystitis were observed in each gallbladder and were most conspicuous in the submucosa; the mucosal and serosal surfaces were intact. Mild acute inflammatory changes were noted in the submucosa in the two patients with the shortest interval between methyl tert-butyl ether administration and cholecystectomy. There were no ulcerations in the mucosa and no unusual wall thickening or fibrosis in any patient. These observations support the safety of methyl tert-butyl ether perfusion in the human gallbladder; the mild acute changes may be a transient and reversible phenomenon.
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Thin-layer chromatography to monitor cholesterol Gallstone Dissolution by methyl tert-butyl ether.
AJR. American journal of roentgenology, 1991Co-Authors: H B D'agostino, Alan F. Hofmann, Eric Vansonnenberg, C D Schteingart, Giovanna Casola, J. R. M. MathiesonAbstract:We describe a simple and inexpensive method of monitoring methyl tert-butyl ether (MTBE) Dissolution of cholesterol Gallstones with thin-layer chromatography (TLC) in 10 patients. TLC is a routine semiquantitative laboratory method that can be used to measure the cholesterol concentration present in the MTBE and bile mixture aspirated through the cholecystostomy catheter during Gallstone Dissolution. TLC is practical in the clinical setting because it can be used to determine if Gallstone Dissolution is occurring and when MTBE lavage is no longer effective. TLC is performed in the laboratory with routine material and is completed in 15 min. Each TLC measurement costs about $1. The procedure provides objective and specific chemical information on effectiveness and progression of Gallstone Dissolution, apart from the radiologic and sonographic studies. In our study, TLC signaled effective Dissolution in the initial phase of Gallstone Dissolution by detecting large amounts of cholesterol in the MTBE and bile...
E Vansonnenberg - One of the best experts on this subject based on the ideXlab platform.
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human gallbladder morphology after Gallstone Dissolution with methyl tert butyl ether
Gastroenterology, 1991Co-Authors: Alan F. Hofmann, Salam Zakko, E Vansonnenberg, Horacio B Dagostino, Horacio JinichAbstract:The effects of methyl tert-butyl ether exposure on the human gallbladder in five patients who were treated for Gallstones by contact Dissolution is described. Two patients underwent cholecystectomy within 1 week of methyl tert-butyl ether treatment, one patient 2 weeks after, another 10 weeks after, and one 12 weeks after. Indications for cholecystectomy were bilirubinate stones (resistant to methyl tert-butyl ether), catheter dislodgement, bile leakage, and Gallstone recurrence (2 patients). Gallstones were dissolved completely in three patients, there was approximately 50% stone reduction in one patient, and no Dissolution occurred in the fifth patient. Each gallbladder was examined grossly and histologically. Electron microscopic evaluation was performed in one cases. Typical inflammatory findings of chronic cholecystitis were observed in each gallbladder and were most conspicuous in the submucosa; the mucosal and serosal surfaces were intact. Mild acute inflammatory changes were noted in the submucosa in the two patients with the shortest interval between methyl tert-butyl ether administration and cholecystectomy. There were no ulcerations in the mucosa and no unusual wall thickening or fibrosis in any patient. These observations support the safety of methyl tert-butyl ether perfusion in the human gallbladder; the mild acute changes may be a transient and reversible phenomenon.
