The Experts below are selected from a list of 1458 Experts worldwide ranked by ideXlab platform
Michael M. Alper - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of pregnancy rates following Gamete Intrafallopian Transfer (GIFT) under general anesthesia with thiopental sodium or propofol.
Journal of clinical anesthesia, 1992Co-Authors: Eric T Pierce, Michael M. Alper, Michael Smalky, Jennifer A Hunter, Robert L Amrhein, Ellison C PierceAbstract:Abstract Study Objective: To determine whether the pregnancy rate for Gamete Intrafallopian Transfer (GIFT) patients who received thiopental sodium was different from the pregnancy rate for patients who received propofol for the induction o f general anesthesia. Design: Retrospective review of clinical records. Setting: Private outpatient infertility clinic. Patients: Two hundred eighty-two consecutive GIFT procedures performed on 230 patients with infertility. Intervention: Patients undergoing GIFT were divided into two groups on the basis of whether they received thiopental or propofol for induction of anesthesia. Measurements and Main Results: Clinical pregnancy following each GIFT procedure was assessed by multiple-serum beta human chorionie gonadotropin and ultrasound determinations. The pregnancy rates of 24.6% and 25.8% for the thiopental and propofol groups, respectively, were not significantly different. Conclusions: The pregnancy rate following GIFT for patients given propofol for induction of general anesthesia did not differ from that for patients given thiopental.
-
Comparison of unilateral and bilateral tubal Transfer in Gamete Intrafallopian Transfer (GIFT).
Journal of in vitro fertilization and embryo transfer : IVF, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Merle J. Berger, Irwin E. ThompsonAbstract:Gamete Intrafallopian, Transfer (GIFT) is traditionally performed by delivering Gametes into the ampullary region of either one or two fallopian tubes. The choice is made by the surgeon at the time of laparoscopy based upon the patient's anatomy, the number of oocytes available, and clinical judgment. In this nonrandomized, retrospective review, 399 tubal Gamete Transfers were performed over a period of 18 months, 133 to a single tube and 266 to both tubes. A clinical pregnancy rate of approximately 24% was observed in each modality. The multiple pregnancy rate of 31.3% for one tube was not significantly different from the 25% seen for two tubes. Unilateral tubal Transfer offers the distinct advantages of less Gamete and tissue handling. This, along with the apparent same outcome parameters, makes unilateral tubal Transfer the preferred method of returing Gametes at GIFT.
-
Gamete Intrafallopian Transfer: assessment of the optimal number of oocytes to Transfer.
Fertility and sterility, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Merle J. Berger, Irwin E. ThompsonAbstract:The optimum number of oocytes that should be Transferred at the time of Gamete Intrafallopian Transfer (GIFT) is important information. Nonessential oocytes can be inseminated and frozen for later use or the extra oocytes can be donated to another woman. In this preliminary study, the results of 399 consecutive GIFT procedures were evaluated retrospectively as a function of the number of oocytes Transferred. Women who received four or more oocytes were three times more likely to achieve a clinical pregnancy than those who received three or less. There was no statistically significant difference in pregnancy rates between patients who received five, six, seven, or eight oocytes. Oocytes in excess of five may be more effectively used if they are fertilized and frozen as embryos for later Transfer rather than replacing them all at the time of GIFT.
-
Successful use of Gamete Intrafallopian Transfer does not reverse the decline in fertility in women over 40 years of age.
Obstetrics and gynecology, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Irwin E. Thompson, Merle J. BergerAbstract:To assess the impact of assisted reproductive technologies on the potential fertility of older women, we report our experience with Gamete Intrafallopian Transfer (GIFT) in a large number of women 40 years of age and older. One hundred twenty-two GIFT cycles were initiated in 59 women over 18 months. Seventy-three tubal Transfers were performed, resulting in seven clinical pregnancies, a rate of 9.6% per Transfer. This contrasts with a 27.3% clinical pregnancy rate per Transfer in women under 40. Thus, older patients require thorough counseling regarding the decreased likelihood of success despite the use of assisted reproductive technologies.
Irwin E. Thompson - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of unilateral and bilateral tubal Transfer in Gamete Intrafallopian Transfer (GIFT).
Journal of in vitro fertilization and embryo transfer : IVF, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Merle J. Berger, Irwin E. ThompsonAbstract:Gamete Intrafallopian, Transfer (GIFT) is traditionally performed by delivering Gametes into the ampullary region of either one or two fallopian tubes. The choice is made by the surgeon at the time of laparoscopy based upon the patient's anatomy, the number of oocytes available, and clinical judgment. In this nonrandomized, retrospective review, 399 tubal Gamete Transfers were performed over a period of 18 months, 133 to a single tube and 266 to both tubes. A clinical pregnancy rate of approximately 24% was observed in each modality. The multiple pregnancy rate of 31.3% for one tube was not significantly different from the 25% seen for two tubes. Unilateral tubal Transfer offers the distinct advantages of less Gamete and tissue handling. This, along with the apparent same outcome parameters, makes unilateral tubal Transfer the preferred method of returing Gametes at GIFT.
-
Gamete Intrafallopian Transfer: assessment of the optimal number of oocytes to Transfer.
Fertility and sterility, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Merle J. Berger, Irwin E. ThompsonAbstract:The optimum number of oocytes that should be Transferred at the time of Gamete Intrafallopian Transfer (GIFT) is important information. Nonessential oocytes can be inseminated and frozen for later use or the extra oocytes can be donated to another woman. In this preliminary study, the results of 399 consecutive GIFT procedures were evaluated retrospectively as a function of the number of oocytes Transferred. Women who received four or more oocytes were three times more likely to achieve a clinical pregnancy than those who received three or less. There was no statistically significant difference in pregnancy rates between patients who received five, six, seven, or eight oocytes. Oocytes in excess of five may be more effectively used if they are fertilized and frozen as embryos for later Transfer rather than replacing them all at the time of GIFT.
-
Successful use of Gamete Intrafallopian Transfer does not reverse the decline in fertility in women over 40 years of age.
Obstetrics and gynecology, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Irwin E. Thompson, Merle J. BergerAbstract:To assess the impact of assisted reproductive technologies on the potential fertility of older women, we report our experience with Gamete Intrafallopian Transfer (GIFT) in a large number of women 40 years of age and older. One hundred twenty-two GIFT cycles were initiated in 59 women over 18 months. Seventy-three tubal Transfers were performed, resulting in seven clinical pregnancies, a rate of 9.6% per Transfer. This contrasts with a 27.3% clinical pregnancy rate per Transfer in women under 40. Thus, older patients require thorough counseling regarding the decreased likelihood of success despite the use of assisted reproductive technologies.
J. P. Van Der Merwe - One of the best experts on this subject based on the ideXlab platform.
-
Surgical treatment of endometriosis before Gamete Intrafallopian Transfer (GIFT)
South African Medical Journal, 2007Co-Authors: J. P. Van Der Merwe, T. F. Kruger, Carl J. LombardAbstract:Objective. To determine whether active pelvic endometriosis impairs the efficacy of GIFT (Gamete Intrafallopian Transfer) and whether prior surgical treatment of endometriosis improves the efficacy of GIFT. Design. Matched controlled retrospective study. Setting. University-based assisted reproduction programme. Patients. Patients who had GIFT between 1990 and 1997 were included in the study. Female patients were laparoscopically diagnosed as having endometriosis. Patients who did not have surgical treatment for endometriosis before GIFT were staged for endometriosis during the GIFT laparoscopy. Two patients, with no signs of endometriosis, were matched for every endometriosis case, and served as controls. Patients were matched for age, number of eggs Transferred and percentage of normal sperm morphology. Intervention. Patients in 80 cycles had surgical treatment for endometriosis and 128 patients had GIFT procedures as treatment for endometriosis-related infertility. Main outcome measures. Ongoing pregnancies and deliveries. Statistical analysis. A Mantel-Haenszel approach was used to estimate relative risk of pregnancy outcome in the endometriosis groups versus controls. Results. There was a 22.9% pregnancy rate (11/48) among patients with active endometriosis who had GIFT procedures, versus a 37.0% pregnancy rate (37/100) for the controls, giving a relative risk of 0.62 (95% confidence interval (CI): 0.35 - 1.10, p = 0.082). There was a 36.3% pregnancy rate (29/80) among patients who had surgical treatment for endometriosis before GIFT, versus a 33.3% pregnancy rate (53/159) for the controls, giving a relative risk of 1.07 (95% CI: 0.75 - 1.54, p = 0.647). Conclusion. There is an indication that GIFT pregnancy rates are impared in patients suffering from active endometriosis, while prior surgery may alleviate the impairment. South African Journal of Obstetrics and Gynaecology Vol. 13 (2) 2007: pp.42-45
-
Factors affecting pregnancy outcome in a Gamete Intrafallopian Transfer (GIFT) programme.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2003Co-Authors: J M De Bruijn, T. F. Kruger, J. P. Van Der Merwe, F. S. H. Stander, Carl J. LombardAbstract:Objective . To identify the factors that most significantly affected pregnancy rates in a Gamete Intrafallopian Transfer (GIFT) programme. Methods . A total of 863 GIFT cycles were analysed retrospectively. The variables found to be associated significantly with pregnancy were then used to obtain multivariate analysis using logistical regression. Results . Overall and ongoing pregnancy rates were significantly better in patients ≤ 38 years than in patients > 38 years (37.3% and 28.4% v. 23.7% and 11.0% respectively), and age was positively associated with success after GIFT (odds ratio (OR) 1.87, 95% confidence interval (CI): 1.22- 2.85). Metaphase I (MI) oocytes were negatively associated with pregnancy (OR 1.54, 95% CI: 0.28 - 1.04). The highest pregnancy rates occurred when 3 metaphase II (MII) oocytes were Transferred (39.8%, OR 7.51, 95% CI: 1.74 - 32.42). With regard to sperm morphology, overall pregnancy rates of 25.5% (≤ 4% normal forms) and 37.2% (> 4% normal forms) were obtained. Morphology of > 4% normal forms was positively associated with pregnancy (OR 1.58, 95% CI: 1.04 - 2.42). Conclusion . The results of this study suggest that the most important factors influencing pregnancy rates in a GIFT programme are the woman's age and those factors pertaining to the characteristics of the Gametes. Considering the emotional and financial costs it is important to relate this information to all prospective participants in a GIFT programme.
-
Comparison between swim-up and glass wool column filtration of human semen in a Gamete Intrafallopian Transfer program.
Archives of andrology, 1996Co-Authors: C. A. Sanchez Sarmiento, Kevin Coetzee, T. F. Kruger, J. P. Van Der Merwe, F. S. H. Stander, Ralf Henkel, Carl LombardAbstract:This study compared swim-up and glass wool filtration in both pregnancy outcome and fertilization of excess oocytes in patients undergoing Gamete Intrafallopian Transfer. Gamete Intrafallopian Transfer patients were retrospectively included in the study group (n = 52). The criteria for inclusion were as follows: Semen had to have been prepared by means of glass wool filtration and at least 2 metaphase II oocytes had to have been Transferred. Each patient from this group was then carefully matched with another patient according to specific criteria (number of metaphase II oocytes aspirated and Transferred, normal sperm morphology, wife's age, the absence of anti-sperm antibodies, semen preparation by means of the swim-up procedure). Fourteen patients were matched with themselves (groups Al and A2) and 38 patients were matched with another patient (groups B and C). The results indicate that there was no significant difference in the fertilization and pregnancy probabilities of sperm prepared by means of gla...
-
Effect of semen characteristics on pregnancy rate in a Gamete Intrafallopian Transfer program.
Archives of andrology, 1993Co-Authors: Thinus F. Kruger, Daniel R. Franken, E. Stander, Y. Swart, J. P. Van Der MerweAbstract:The aim of this study was to evaluate the influence of sperm morphology, swim-up concentration, and insemination volume on pregnancy outcome in patients undergoing Gamete Intrafallopian Transfer (GIFT) treatment in whom the male partner had a morphology of less than 14%. Only patients who received four oocytes were entered into this study (n = 103). In all cases the swim-up procedure time was standardized to 1 h and the insemination concentration was standardized to 500,000 per oviduct. There was no significant difference in pregnancy rate when normal morphology, swim-up concentration, or insemination volume were used as predictors. In the P pattern group ( 0.05; not significant). The fertilization rate among excess oocytes in the P pattern group was 18% but was 39% (p
-
Comparative trial of clomiphene citrate/human menopausal gonadotropin and the contraceptive pill, followed by clomiphene citrate/human menopausal gonadotropin, in a Gamete Intrafallopian Transfer program
Journal of assisted reproduction and genetics, 1993Co-Authors: Thinus F. Kruger, J. P. Van Der Merwe, Y. Swart, A. Fisher, K. SmithAbstract:It may sometimes be necessary to regulate cycles in assisted reproduction. Cycles can be regulated with gonadotropin releasing hormone (GnRHa) agonist but other methods can also be used. The aim of this study was to compare the pregnancy rate in a Gamete Intrafallopian Transfer (GIFT) program in patients receiving a contraceptive pill/Clomid/human menopausal gonadotropin (hMG) regimen (study group), with the standard Clomid/hMG regime (control group). Fifty one patients in the study group were carefully matched for patient age, infertility diagnosis (female), semen parameters, number of follicles, and number of oocytes Transferred into consideration with a control group.
Alan S. Penzias - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of unilateral and bilateral tubal Transfer in Gamete Intrafallopian Transfer (GIFT).
Journal of in vitro fertilization and embryo transfer : IVF, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Merle J. Berger, Irwin E. ThompsonAbstract:Gamete Intrafallopian, Transfer (GIFT) is traditionally performed by delivering Gametes into the ampullary region of either one or two fallopian tubes. The choice is made by the surgeon at the time of laparoscopy based upon the patient's anatomy, the number of oocytes available, and clinical judgment. In this nonrandomized, retrospective review, 399 tubal Gamete Transfers were performed over a period of 18 months, 133 to a single tube and 266 to both tubes. A clinical pregnancy rate of approximately 24% was observed in each modality. The multiple pregnancy rate of 31.3% for one tube was not significantly different from the 25% seen for two tubes. Unilateral tubal Transfer offers the distinct advantages of less Gamete and tissue handling. This, along with the apparent same outcome parameters, makes unilateral tubal Transfer the preferred method of returing Gametes at GIFT.
-
Gamete Intrafallopian Transfer: assessment of the optimal number of oocytes to Transfer.
Fertility and sterility, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Merle J. Berger, Irwin E. ThompsonAbstract:The optimum number of oocytes that should be Transferred at the time of Gamete Intrafallopian Transfer (GIFT) is important information. Nonessential oocytes can be inseminated and frozen for later use or the extra oocytes can be donated to another woman. In this preliminary study, the results of 399 consecutive GIFT procedures were evaluated retrospectively as a function of the number of oocytes Transferred. Women who received four or more oocytes were three times more likely to achieve a clinical pregnancy than those who received three or less. There was no statistically significant difference in pregnancy rates between patients who received five, six, seven, or eight oocytes. Oocytes in excess of five may be more effectively used if they are fertilized and frozen as embryos for later Transfer rather than replacing them all at the time of GIFT.
-
Successful use of Gamete Intrafallopian Transfer does not reverse the decline in fertility in women over 40 years of age.
Obstetrics and gynecology, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Irwin E. Thompson, Merle J. BergerAbstract:To assess the impact of assisted reproductive technologies on the potential fertility of older women, we report our experience with Gamete Intrafallopian Transfer (GIFT) in a large number of women 40 years of age and older. One hundred twenty-two GIFT cycles were initiated in 59 women over 18 months. Seventy-three tubal Transfers were performed, resulting in seven clinical pregnancies, a rate of 9.6% per Transfer. This contrasts with a 27.3% clinical pregnancy rate per Transfer in women under 40. Thus, older patients require thorough counseling regarding the decreased likelihood of success despite the use of assisted reproductive technologies.
Merle J. Berger - One of the best experts on this subject based on the ideXlab platform.
-
Comparison of unilateral and bilateral tubal Transfer in Gamete Intrafallopian Transfer (GIFT).
Journal of in vitro fertilization and embryo transfer : IVF, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Merle J. Berger, Irwin E. ThompsonAbstract:Gamete Intrafallopian, Transfer (GIFT) is traditionally performed by delivering Gametes into the ampullary region of either one or two fallopian tubes. The choice is made by the surgeon at the time of laparoscopy based upon the patient's anatomy, the number of oocytes available, and clinical judgment. In this nonrandomized, retrospective review, 399 tubal Gamete Transfers were performed over a period of 18 months, 133 to a single tube and 266 to both tubes. A clinical pregnancy rate of approximately 24% was observed in each modality. The multiple pregnancy rate of 31.3% for one tube was not significantly different from the 25% seen for two tubes. Unilateral tubal Transfer offers the distinct advantages of less Gamete and tissue handling. This, along with the apparent same outcome parameters, makes unilateral tubal Transfer the preferred method of returing Gametes at GIFT.
-
Gamete Intrafallopian Transfer: assessment of the optimal number of oocytes to Transfer.
Fertility and sterility, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Merle J. Berger, Irwin E. ThompsonAbstract:The optimum number of oocytes that should be Transferred at the time of Gamete Intrafallopian Transfer (GIFT) is important information. Nonessential oocytes can be inseminated and frozen for later use or the extra oocytes can be donated to another woman. In this preliminary study, the results of 399 consecutive GIFT procedures were evaluated retrospectively as a function of the number of oocytes Transferred. Women who received four or more oocytes were three times more likely to achieve a clinical pregnancy than those who received three or less. There was no statistically significant difference in pregnancy rates between patients who received five, six, seven, or eight oocytes. Oocytes in excess of five may be more effectively used if they are fertilized and frozen as embryos for later Transfer rather than replacing them all at the time of GIFT.
-
Successful use of Gamete Intrafallopian Transfer does not reverse the decline in fertility in women over 40 years of age.
Obstetrics and gynecology, 1991Co-Authors: Alan S. Penzias, Michael M. Alper, Selwyn P. Oskowitz, Irwin E. Thompson, Merle J. BergerAbstract:To assess the impact of assisted reproductive technologies on the potential fertility of older women, we report our experience with Gamete Intrafallopian Transfer (GIFT) in a large number of women 40 years of age and older. One hundred twenty-two GIFT cycles were initiated in 59 women over 18 months. Seventy-three tubal Transfers were performed, resulting in seven clinical pregnancies, a rate of 9.6% per Transfer. This contrasts with a 27.3% clinical pregnancy rate per Transfer in women under 40. Thus, older patients require thorough counseling regarding the decreased likelihood of success despite the use of assisted reproductive technologies.
