The Experts below are selected from a list of 4398 Experts worldwide ranked by ideXlab platform
Fang Gao - One of the best experts on this subject based on the ideXlab platform.
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Plasma levels of monokine induced by interferon-Gamma/Chemokine (C-X-X motif) ligand 9, thymus and activation-regulated Chemokine/Chemokine (C-C motif) ligand 17 in children with Kawasaki disease.
BMC pediatrics, 2015Co-Authors: Siqi Feng, Shiv Kumar Yadav, Fang GaoAbstract:Background Monokines induced by interferon-Gamma/Chemokine (C-X-C motif) ligand 9 (MIG/CXCL9), thymus and activation-regulated Chemokine/Chemokine (C-C motif) ligand 17 (TARC/CCL17) are chemotactic factors that specifically collect and activate leukocytes, which are considered as chemoattractants of T helper cells. In the present study, we have investigated the effects of T helper type-1 (Th1) cells and T helper type-2 (Th2) cells in Kawasaki disease (KD) by determining plasma levels of MIG/CXCL9 and TARC/CCL17 and exploring the relationship between MIG/CXCL9, TARC/CCL17 levels and coronary artery lesions (CAL).
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plasma levels of monokine induced by interferon Gamma Chemokine c x x motif ligand 9 thymus and activation regulated Chemokine Chemokine c c motif ligand 17 in children with kawasaki disease
BMC Pediatrics, 2015Co-Authors: Siqi Feng, Shiv Kumar Yadav, Fang GaoAbstract:Background Monokines induced by interferon-Gamma/Chemokine (C-X-C motif) ligand 9 (MIG/CXCL9), thymus and activation-regulated Chemokine/Chemokine (C-C motif) ligand 17 (TARC/CCL17) are chemotactic factors that specifically collect and activate leukocytes, which are considered as chemoattractants of T helper cells. In the present study, we have investigated the effects of T helper type-1 (Th1) cells and T helper type-2 (Th2) cells in Kawasaki disease (KD) by determining plasma levels of MIG/CXCL9 and TARC/CCL17 and exploring the relationship between MIG/CXCL9, TARC/CCL17 levels and coronary artery lesions (CAL).
Siqi Feng - One of the best experts on this subject based on the ideXlab platform.
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Plasma levels of monokine induced by interferon-Gamma/Chemokine (C-X-X motif) ligand 9, thymus and activation-regulated Chemokine/Chemokine (C-C motif) ligand 17 in children with Kawasaki disease.
BMC pediatrics, 2015Co-Authors: Siqi Feng, Shiv Kumar Yadav, Fang GaoAbstract:Background Monokines induced by interferon-Gamma/Chemokine (C-X-C motif) ligand 9 (MIG/CXCL9), thymus and activation-regulated Chemokine/Chemokine (C-C motif) ligand 17 (TARC/CCL17) are chemotactic factors that specifically collect and activate leukocytes, which are considered as chemoattractants of T helper cells. In the present study, we have investigated the effects of T helper type-1 (Th1) cells and T helper type-2 (Th2) cells in Kawasaki disease (KD) by determining plasma levels of MIG/CXCL9 and TARC/CCL17 and exploring the relationship between MIG/CXCL9, TARC/CCL17 levels and coronary artery lesions (CAL).
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plasma levels of monokine induced by interferon Gamma Chemokine c x x motif ligand 9 thymus and activation regulated Chemokine Chemokine c c motif ligand 17 in children with kawasaki disease
BMC Pediatrics, 2015Co-Authors: Siqi Feng, Shiv Kumar Yadav, Fang GaoAbstract:Background Monokines induced by interferon-Gamma/Chemokine (C-X-C motif) ligand 9 (MIG/CXCL9), thymus and activation-regulated Chemokine/Chemokine (C-C motif) ligand 17 (TARC/CCL17) are chemotactic factors that specifically collect and activate leukocytes, which are considered as chemoattractants of T helper cells. In the present study, we have investigated the effects of T helper type-1 (Th1) cells and T helper type-2 (Th2) cells in Kawasaki disease (KD) by determining plasma levels of MIG/CXCL9 and TARC/CCL17 and exploring the relationship between MIG/CXCL9, TARC/CCL17 levels and coronary artery lesions (CAL).
Shiv Kumar Yadav - One of the best experts on this subject based on the ideXlab platform.
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Plasma levels of monokine induced by interferon-Gamma/Chemokine (C-X-X motif) ligand 9, thymus and activation-regulated Chemokine/Chemokine (C-C motif) ligand 17 in children with Kawasaki disease.
BMC pediatrics, 2015Co-Authors: Siqi Feng, Shiv Kumar Yadav, Fang GaoAbstract:Background Monokines induced by interferon-Gamma/Chemokine (C-X-C motif) ligand 9 (MIG/CXCL9), thymus and activation-regulated Chemokine/Chemokine (C-C motif) ligand 17 (TARC/CCL17) are chemotactic factors that specifically collect and activate leukocytes, which are considered as chemoattractants of T helper cells. In the present study, we have investigated the effects of T helper type-1 (Th1) cells and T helper type-2 (Th2) cells in Kawasaki disease (KD) by determining plasma levels of MIG/CXCL9 and TARC/CCL17 and exploring the relationship between MIG/CXCL9, TARC/CCL17 levels and coronary artery lesions (CAL).
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plasma levels of monokine induced by interferon Gamma Chemokine c x x motif ligand 9 thymus and activation regulated Chemokine Chemokine c c motif ligand 17 in children with kawasaki disease
BMC Pediatrics, 2015Co-Authors: Siqi Feng, Shiv Kumar Yadav, Fang GaoAbstract:Background Monokines induced by interferon-Gamma/Chemokine (C-X-C motif) ligand 9 (MIG/CXCL9), thymus and activation-regulated Chemokine/Chemokine (C-C motif) ligand 17 (TARC/CCL17) are chemotactic factors that specifically collect and activate leukocytes, which are considered as chemoattractants of T helper cells. In the present study, we have investigated the effects of T helper type-1 (Th1) cells and T helper type-2 (Th2) cells in Kawasaki disease (KD) by determining plasma levels of MIG/CXCL9 and TARC/CCL17 and exploring the relationship between MIG/CXCL9, TARC/CCL17 levels and coronary artery lesions (CAL).
Luiz G.s. Branco - One of the best experts on this subject based on the ideXlab platform.
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Central fractalkine stimulates central prostaglandin E2 production and induces systemic inflammatory responses.
Brain research bulletin, 2018Co-Authors: Clarissa M.d. Mota, José Antunes-rodrigues, Luiz G.s. BrancoAbstract:Abstract Fractalkine (FKN; CX3CL1) belongs to Gamma-Chemokine family and binds to CX3CR1 receptors. Currently, the mechanisms involving FKN-induced inflammatory mediators are research targets in an attempt to study immune diseases mechanisms. Besides, FKN seems to modulate inflammation in the nervous system by inducing the secretion of pro-inflammatory mediators such as prostaglandin E2 (PGE2). PGE2 is a classic and important mediator of fever that activates warm-responsive neurons in the anteroventral preoptic region of the hypothalamus (AVPO). Here, we tested the hypothesis that central FKN modulates febrigenic signaling both centrally and peripherally. We performed intracerebroventricular (icv) microinjections of saline (1 μL) or FKN (doses of 5, 50, 500 pg/μL) in rats and measured body temperature (Tb) besides assessing tail skin temperature (Tsk) as a thermoeffector indicator used to calculate the heat loss index (HLI). We also measured the time course changes in AVPO PGE2, besides plasma corticosterone (CORT) and interleukin-6 (IL-6) levels. FKN induced a long lasting febrile response in which the highest dose (500 pg/μL) induced a marked rise on Tb that was accompanied by a reduced Tsk and HLI, consequently. FKN increased AVPO PGE2 production in a time-dependent manner besides increasing plasma CORT and IL-6 levels. Our data consistently indicate that FKN increases AVPO PGE2 production and Tb, accompanied by raised plasma IL-6 levels and activation of the hypothalamus-pituitary-adrenal axis.
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Central Fractalkine Induces Systemic Inflammation Independently of Hypothalamic Prostaglandin E2
The FASEB Journal, 2018Co-Authors: Clarissa M.d. Mota, Maria José Alves Da Rocha, José Antunes-rodrigues, Luiz G.s. BrancoAbstract:Fractalkine (FKN; CX3CL1) belongs to the Gamma-Chemokine family and binds to CX3CR1 receptors. Currently, the mechanisms involving FKN-induced inflammatory mediators are research targets in an atte...
Clarissa M.d. Mota - One of the best experts on this subject based on the ideXlab platform.
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Central fractalkine stimulates central prostaglandin E2 production and induces systemic inflammatory responses.
Brain research bulletin, 2018Co-Authors: Clarissa M.d. Mota, José Antunes-rodrigues, Luiz G.s. BrancoAbstract:Abstract Fractalkine (FKN; CX3CL1) belongs to Gamma-Chemokine family and binds to CX3CR1 receptors. Currently, the mechanisms involving FKN-induced inflammatory mediators are research targets in an attempt to study immune diseases mechanisms. Besides, FKN seems to modulate inflammation in the nervous system by inducing the secretion of pro-inflammatory mediators such as prostaglandin E2 (PGE2). PGE2 is a classic and important mediator of fever that activates warm-responsive neurons in the anteroventral preoptic region of the hypothalamus (AVPO). Here, we tested the hypothesis that central FKN modulates febrigenic signaling both centrally and peripherally. We performed intracerebroventricular (icv) microinjections of saline (1 μL) or FKN (doses of 5, 50, 500 pg/μL) in rats and measured body temperature (Tb) besides assessing tail skin temperature (Tsk) as a thermoeffector indicator used to calculate the heat loss index (HLI). We also measured the time course changes in AVPO PGE2, besides plasma corticosterone (CORT) and interleukin-6 (IL-6) levels. FKN induced a long lasting febrile response in which the highest dose (500 pg/μL) induced a marked rise on Tb that was accompanied by a reduced Tsk and HLI, consequently. FKN increased AVPO PGE2 production in a time-dependent manner besides increasing plasma CORT and IL-6 levels. Our data consistently indicate that FKN increases AVPO PGE2 production and Tb, accompanied by raised plasma IL-6 levels and activation of the hypothalamus-pituitary-adrenal axis.
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Central Fractalkine Induces Systemic Inflammation Independently of Hypothalamic Prostaglandin E2
The FASEB Journal, 2018Co-Authors: Clarissa M.d. Mota, Maria José Alves Da Rocha, José Antunes-rodrigues, Luiz G.s. BrancoAbstract:Fractalkine (FKN; CX3CL1) belongs to the Gamma-Chemokine family and binds to CX3CR1 receptors. Currently, the mechanisms involving FKN-induced inflammatory mediators are research targets in an atte...
