The Experts below are selected from a list of 165 Experts worldwide ranked by ideXlab platform
David R Jacobs - One of the best experts on this subject based on the ideXlab platform.
-
association between serum Gamma Glutamyltransferase and c reactive protein
Atherosclerosis, 2005Co-Authors: David R JacobsAbstract:Abstract A series of epidemiological studies have suggested serum Gamma Glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation. Therefore, we examined the cross-sectional association between deciles of serum GGT and concentrations of serum C-reactive protein (CRP), a marker of chronic inflammation, among 12,110 adult participants in the third U.S. National Health and Nutrition Examination Survey. After adjustment for race, sex, age, cigarette smoking, alcohol intake, and body mass index (BMI), serum concentration of GGT across all deciles was positively associated with serum concentrations of CRP ( P for trend P for trend
-
Gamma Glutamyltransferase an effect modifier in the association between age and hypertension in a 4 year follow up study
Journal of Human Hypertension, 2004Co-Authors: Myunghwa Ha, David R JacobsAbstract:Gamma-Glutamyltransferase: an effect modifier in the association between age and hypertension in a 4-year follow-up study
Setor K. Kunutsor - One of the best experts on this subject based on the ideXlab platform.
-
Gamma-Glutamyltransferase and Future Risk of Pneumonia: A Long-Term Prospective Cohort Study
Lung, 2017Co-Authors: Setor K. Kunutsor, Jari A. LaukkanenAbstract:Serum Gamma-Glutamyltransferase (GGT) has been linked with the risk of adverse health outcomes. We aimed to assess the prospective association of GGT activity with pneumonia risk. Serum GGT was measured at baseline in 2400 middle-aged men. Within-person variability in GGT values was corrected for using data from repeat measurements. During a median follow-up of 25.3 years, 409 pneumonia cases were recorded. The age-adjusted regression dilution ratio of GGT was 0.68 (95% CI 0.63–0.73). Gamma-Glutamyltransferase was approximately log-linearly associated with pneumonia risk. In analysis adjusted for several major pneumonia risk factors, the hazard ratio (95% CI) for pneumonia per 1 standard deviation increase in GGT was 1.14 (1.02–1.28). The association was however attenuated on additional adjustment for high-sensitivity C-reactive protein (hsCRP) 1.08 (0.96–1.22). There is an approximately log-linear positive association between GGT activity and future risk of pneumonia in a middle-aged male population, which is partly dependent on hsCRP.
-
Gamma Glutamyltransferase and risk of chronic kidney disease a prospective cohort study
Clinica Chimica Acta, 2017Co-Authors: Setor K. Kunutsor, Jari A. LaukkanenAbstract:Abstract Background Elevated serum Gamma-Glutamyltransferase (GGT) activity has been linked with an increased risk of chronic kidney disease (CKD) in Asian populations. We aimed to assess the prospective association of serum GGT with risk of CKD in a Caucasian population. Materials and methods We related GGT activity to the incidence of CKD in 2338 men aged 42–61 years of the Kuopio Ischemic Heart Disease study with normal kidney function at baseline. Repeat measurements of GGT were used to correct for within-person variability. Results During a median follow-up of 25.6 years, 221 men developed new-onset CKD. The age-adjusted regression dilution ratio of loge GGT was 0.70 (95% CI: 0.64–0.75). Gamma-Glutamyltransferase was log-linearly associated with risk of CKD in age-adjusted analysis. In Cox regression analysis adjusted for age, the hazard ratio (95% CIs) for CKD per standard deviation increase in loge baseline GGT was 1.25 (1.09–1.43) which was attenuated to 1.01 (0.86–1.19) on further adjustment for several confounders. Conclusion Contrary to previous evidence of an independent association between elevated GGT and increased risk of CKD in Asian populations, initial evidence of an association between GGT and CKD in Caucasian men was confounded by body mass index, lifestyle factors, and lipids.
-
Gamma Glutamyltransferase friend or foe within
Liver International, 2016Co-Authors: Setor K. KunutsorAbstract:Gamma-Glutamyltransferase, is a liver enzyme which is located on the plasma membranes of most cells and organ tissues, but more commonly in hepatocytes and is routinely used in clinical practice to help indicate liver injury and as a marker of excessive alcohol consumption. Among the liver enzymes, important advances have especially been made in understanding the physiological functions of GGT. The primary role of GGT is the extracellular catabolism of glutathione, the major thiol antioxidant in mammalian cells, which plays a relevant role in protecting cells against oxidants produced during normal metabolism; GGT, therefore plays an important role in cellular defence. Beyond its physiological functions, circulating serum GGT has been linked to a remarkable array of chronic conditions and diseases, which include nonalcoholic fatty liver disease, vascular and non-vascular diseases, as well as mortality outcomes. This review summarizes the available epidemiological and genetic evidence for the associations between GGT and these adverse outcomes; the postulated biologic mechanisms underlying these associations; outlines areas of outstanding uncertainty; and the implications for clinical practice. This article is protected by copyright. All rights reserved.
Jari A. Laukkanen - One of the best experts on this subject based on the ideXlab platform.
-
Gamma-Glutamyltransferase and Future Risk of Pneumonia: A Long-Term Prospective Cohort Study
Lung, 2017Co-Authors: Setor K. Kunutsor, Jari A. LaukkanenAbstract:Serum Gamma-Glutamyltransferase (GGT) has been linked with the risk of adverse health outcomes. We aimed to assess the prospective association of GGT activity with pneumonia risk. Serum GGT was measured at baseline in 2400 middle-aged men. Within-person variability in GGT values was corrected for using data from repeat measurements. During a median follow-up of 25.3 years, 409 pneumonia cases were recorded. The age-adjusted regression dilution ratio of GGT was 0.68 (95% CI 0.63–0.73). Gamma-Glutamyltransferase was approximately log-linearly associated with pneumonia risk. In analysis adjusted for several major pneumonia risk factors, the hazard ratio (95% CI) for pneumonia per 1 standard deviation increase in GGT was 1.14 (1.02–1.28). The association was however attenuated on additional adjustment for high-sensitivity C-reactive protein (hsCRP) 1.08 (0.96–1.22). There is an approximately log-linear positive association between GGT activity and future risk of pneumonia in a middle-aged male population, which is partly dependent on hsCRP.
-
Gamma Glutamyltransferase and risk of chronic kidney disease a prospective cohort study
Clinica Chimica Acta, 2017Co-Authors: Setor K. Kunutsor, Jari A. LaukkanenAbstract:Abstract Background Elevated serum Gamma-Glutamyltransferase (GGT) activity has been linked with an increased risk of chronic kidney disease (CKD) in Asian populations. We aimed to assess the prospective association of serum GGT with risk of CKD in a Caucasian population. Materials and methods We related GGT activity to the incidence of CKD in 2338 men aged 42–61 years of the Kuopio Ischemic Heart Disease study with normal kidney function at baseline. Repeat measurements of GGT were used to correct for within-person variability. Results During a median follow-up of 25.6 years, 221 men developed new-onset CKD. The age-adjusted regression dilution ratio of loge GGT was 0.70 (95% CI: 0.64–0.75). Gamma-Glutamyltransferase was log-linearly associated with risk of CKD in age-adjusted analysis. In Cox regression analysis adjusted for age, the hazard ratio (95% CIs) for CKD per standard deviation increase in loge baseline GGT was 1.25 (1.09–1.43) which was attenuated to 1.01 (0.86–1.19) on further adjustment for several confounders. Conclusion Contrary to previous evidence of an independent association between elevated GGT and increased risk of CKD in Asian populations, initial evidence of an association between GGT and CKD in Caucasian men was confounded by body mass index, lifestyle factors, and lipids.
Fumio Nomura - One of the best experts on this subject based on the ideXlab platform.
-
fractionation of Gamma Glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease
World Journal of Hepatology, 2016Co-Authors: Shigeo Sueyoshi, Setsu Sawai, Mamoru Satoh, Masanori Seimiya, Kazuyuki Sogawa, Atsushi Fukumura, Mikihiro Tsutsumi, Fumio NomuraAbstract:Fractionation of Gamma-Glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease
Hayato Nakagawa - One of the best experts on this subject based on the ideXlab platform.
-
serum Gamma Glutamyltransferase level is associated with serum superoxide dismutase activity and metabolic syndrome in a japanese population
Journal of Gastroenterology, 2012Co-Authors: Hayato Nakagawa, Akihiro Isogawa, Ryosuke Tateishi, Mizuki Tani, Haruhiko Yoshida, Minoru Yamakado, Kazuhiko KoikeAbstract:Background Serum Gamma-Glutamyltransferase level has attracted considerable attention as a predictor of various conditions, such as cardiovascular disease and cancer. Although the mechanism that links the serum Gamma-Glutamyltransferase level to these diseases is not fully understood, one explanation is that Gamma-Glutamyltransferase may be closely related to oxidative stress. We conducted a large cross-sectional study to evaluate the relationship between serum Gamma-Glutamyltransferase and oxidative stress.
