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Sunit Suksamrarn - One of the best experts on this subject based on the ideXlab platform.
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Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G
BMC complementary and alternative medicine, 2013Co-Authors: Weeranuch Seesom, Sunit Suksamrarn, Piniti Ratananukul, Amornmart Jaratrungtawee, Chantana Mekseepralard, Wasana SukhumsirichartAbstract:Background Leptospirosis, one of the most widespread zoonotic infectious diseases worldwide, is caused by spirochetes bacteria of the genus Leptospira. The present study examined inhibitory activity of purified xanthones and crude extracts from Garcinia mangostana against both non-pathogenic and pathogenic leptospira. Synergy between γ-mangostin and penicillin G against leptospires was also determined.
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microbial metabolism of α mangostin isolated from Garcinia mangostana l
Phytochemistry, 2011Co-Authors: Panarat Arunrattiyakorn, Sunit Suksamrarn, Nuttika Suwannasai, Hiroshi KanzakiAbstract:α-Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively. Incubation of 1 with C. gloeosporioides (EYL131) gave four metabolites which were identified as mangostin 3-sulfate (2), mangostanin 6-sulfate (3), 17,18-dihydroxymangostanin 6-sulfate (4)and isomangostanin 3-sulfate (5). Compound 2 was also formed by incubation with N. spathulata (EYR042). The structures of the isolated compounds were elucidated by spectroscopic data analysis. Of the isolated metabolites, 2 exhibited significant anti-mycobacterial activity against Mycobacterium tuberculosis.
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Prenylated xanthone composition of Garcinia mangostana (mangosteen) fruit hull.
Chromatographia, 2008Co-Authors: Apinya Chaivisuthangkura, Piniti Ratananukul, Yaowaluk Malaikaew, Arusa Chaovanalikit, Amornmart Jaratrungtawee, Panomwan Panseeta, Sunit SuksamrarnAbstract:Fourteen prenylated xanthones found in mangosteen fruit, Garcinia mangostana L., have been simultaneously separated by reversed-phase high-performance liquid chromatography with water–acetonitrile gradient elution and diode-array detection. The separated xanthones were detected at 254 nm. This new method was developed to establish a chemical fingerprint of the major constituents of mangosteen. It was also used for quantitative analysis of the two major xanthones in crude extracts of mangosteen fruit hull. This chemical fingerprint of G. mangostana extract can be used for comprehensive quality-control of mangosteen extract.
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Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana
Chemical & pharmaceutical bulletin, 2003Co-Authors: Sunit Suksamrarn, Piniti Ratananukul, Narisara Suwannapoch, Wong Phakhodee, Janthana Thanuhiranlert, Nitirat Chimnoi, Apichart SuksamrarnAbstract:Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.
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xanthones from the green fruit hulls of Garcinia mangostana
Journal of Natural Products, 2002Co-Authors: Sunit Suksamrarn, Piniti Ratananukul, Narisara Suwannapoch, Nantana Aroonlerk, Apichart SuksamrarnAbstract:Three new xanthones, mangostenol (1), mangostenone A (2), and mangostenone B (3), were isolated from the green fruit hulls of Garcinia mangostana, along with the known xanthones, trapezifolixanthone, tovophyllin B (4), α- and β-mangostins, garcinone B, mangostinone, mangostanol, and the flavonoid epicatechin. The structures of the new xanthones were elucidated by analysis of their spectroscopic data.
Riri Nofrianti - One of the best experts on this subject based on the ideXlab platform.
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Physicochemical Study of Mangosteen (Garcinia mangostana L.) peel Extract as Coloring Agent in Tablet Formulation
Journal of Pharmaceutical And Sciences, 2020Co-Authors: Ridho Asra, Rusdi Rusdi, Riri NofriantiAbstract:The mangosteen peel (Garcinia mangostana L.) contains anthocyanin pigments, which has an important role in coloring. This study aims to determine the physicochemical properties of mangosteen peel extract (Garcinia mangostana L.) with two methods, which is an examination with UV-Vis and FTIR spectrophotometry. Then the extract was characterized, identified, and analyzed for its stability against temperature, pH, and applied as a coloring agent in the formulation of pharmaceutical preparations (tablets). The results showed that the yield of mangosteen peel extract obtained 13.0975 %, drying losses 5.2822 %, total ash content 14.488 %, acid insoluble ash content 0.684 %, water-soluble extract content 29.58 %, extract content dissolved in ethanol 37.78 %, total anthocyanin content with λmax = 367 nm which is = 9.58 mg / 100 g and with λmax = 289 nm which is = 52.43 mg / 100 g. In this study, the anthocyanin pigment content in mangosteen peel extract cannot be used as an alternative to natural dyes for pharmaceutical preparations (tablets).
Tomihisa Ohta - One of the best experts on this subject based on the ideXlab platform.
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mangostanol a prenyl xanthone from Garcinia mangostana
Phytochemistry, 1996Co-Authors: Nattaya Chairungsrilerd, Shigeo Nozoe, Yasushi Ohizumi, Kazuya Takeuchi, Tomihisa OhtaAbstract:Abstract During studies for identification of biologically active components from natural sources, a new polyoxygenated xanthone mangostanol was isolated from the fruit hull of Garcinia mangostana , along with known xanthones, α-mangostin, γ-mangostin, gartanin, 8-deoxygartnin, 5,9-dihydroxy-2,2-dimethyl-8-methoxy-7-(3-methylbut-2-enyl)-2 H ,6 H -pyrano[3,2- b ]xanthen-6-one, garcinone E and 2-(γ,γ-dimethylallyl)-1,7-dihydroxy-3-methoxyxanthone and epicatechin. Spectroscopic analysis mainly by 1D and 2D NMR spectroscopy, established the structure of mangostanol {3,5,9-trihydroxy-2,2-dimethyl-8-methoxy-7-(3-methylbut-2-enyl)-2 H ,6 H -3,4-dihydropyrano[3,2- b ]xanthen-6-one} Mangostanol, and α- and γ-mangostin show moderate inhibitory effects on cAMP phosphodiesterase.
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histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana
Planta Medica, 1996Co-Authors: Nattaya Chairungsrilerd, Kenichi Furukawa, Tomihisa Ohta, Shigeo Nozoe, Yasushi OhizumiAbstract:: A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mangostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin. The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give alpha- and gamma-mangostin. On the basis of pharmacological data, it is suggested that alpha-mangostin and gamma-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.
Nattaya Chairungsrilerd - One of the best experts on this subject based on the ideXlab platform.
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mangostanol a prenyl xanthone from Garcinia mangostana
Phytochemistry, 1996Co-Authors: Nattaya Chairungsrilerd, Shigeo Nozoe, Yasushi Ohizumi, Kazuya Takeuchi, Tomihisa OhtaAbstract:Abstract During studies for identification of biologically active components from natural sources, a new polyoxygenated xanthone mangostanol was isolated from the fruit hull of Garcinia mangostana , along with known xanthones, α-mangostin, γ-mangostin, gartanin, 8-deoxygartnin, 5,9-dihydroxy-2,2-dimethyl-8-methoxy-7-(3-methylbut-2-enyl)-2 H ,6 H -pyrano[3,2- b ]xanthen-6-one, garcinone E and 2-(γ,γ-dimethylallyl)-1,7-dihydroxy-3-methoxyxanthone and epicatechin. Spectroscopic analysis mainly by 1D and 2D NMR spectroscopy, established the structure of mangostanol {3,5,9-trihydroxy-2,2-dimethyl-8-methoxy-7-(3-methylbut-2-enyl)-2 H ,6 H -3,4-dihydropyrano[3,2- b ]xanthen-6-one} Mangostanol, and α- and γ-mangostin show moderate inhibitory effects on cAMP phosphodiesterase.
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histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana
Planta Medica, 1996Co-Authors: Nattaya Chairungsrilerd, Kenichi Furukawa, Tomihisa Ohta, Shigeo Nozoe, Yasushi OhizumiAbstract:: A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mangostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin. The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give alpha- and gamma-mangostin. On the basis of pharmacological data, it is suggested that alpha-mangostin and gamma-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.
Yasushi Ohizumi - One of the best experts on this subject based on the ideXlab platform.
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mangostanol a prenyl xanthone from Garcinia mangostana
Phytochemistry, 1996Co-Authors: Nattaya Chairungsrilerd, Shigeo Nozoe, Yasushi Ohizumi, Kazuya Takeuchi, Tomihisa OhtaAbstract:Abstract During studies for identification of biologically active components from natural sources, a new polyoxygenated xanthone mangostanol was isolated from the fruit hull of Garcinia mangostana , along with known xanthones, α-mangostin, γ-mangostin, gartanin, 8-deoxygartnin, 5,9-dihydroxy-2,2-dimethyl-8-methoxy-7-(3-methylbut-2-enyl)-2 H ,6 H -pyrano[3,2- b ]xanthen-6-one, garcinone E and 2-(γ,γ-dimethylallyl)-1,7-dihydroxy-3-methoxyxanthone and epicatechin. Spectroscopic analysis mainly by 1D and 2D NMR spectroscopy, established the structure of mangostanol {3,5,9-trihydroxy-2,2-dimethyl-8-methoxy-7-(3-methylbut-2-enyl)-2 H ,6 H -3,4-dihydropyrano[3,2- b ]xanthen-6-one} Mangostanol, and α- and γ-mangostin show moderate inhibitory effects on cAMP phosphodiesterase.
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histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana
Planta Medica, 1996Co-Authors: Nattaya Chairungsrilerd, Kenichi Furukawa, Tomihisa Ohta, Shigeo Nozoe, Yasushi OhizumiAbstract:: A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mangostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin. The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give alpha- and gamma-mangostin. On the basis of pharmacological data, it is suggested that alpha-mangostin and gamma-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.
