The Experts below are selected from a list of 23232 Experts worldwide ranked by ideXlab platform
Yoshikazu Kinoshita - One of the best experts on this subject based on the ideXlab platform.
-
Original Article Effects of Rikkunshito (TJ-43) on Esophageal Motor Function and Gastroesophageal Reflux
2013Co-Authors: Terumi Morita, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Kenji Koshino, Takashi Tanimura, Tomochika Uemura, Yoshikazu KinoshitaAbstract:Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve Gastroesophageal Reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and Gastroesophageal Reflux. Methods The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial Gastroesophageal Reflux was also determined using a multi-channel impedance pH dual monitor. Results TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial Gastroesophageal acid, non-acid Reflux events or accelerate esophageal clearance time. Conclusions TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or Gastroesophageal Reflux in healthy adults. (J Neurogastroenterol Motil 2012;18:181-186
-
effects of rikkunshito tj 43 on esophageal motor function and Gastroesophageal Reflux
Journal of Neurogastroenterology and Motility, 2012Co-Authors: Terumi Morita, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Kenji Koshino, Takashi Tanimura, Tomochika Uemura, Kohji Naora, Yoshikazu KinoshitaAbstract:BACKGROUND/AIMS: Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve Gastroesophageal Reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and Gastroesophageal Reflux. METHODS: The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial Gastroesophageal Reflux was also determined using a multi-channel impedance pH dual monitor. RESULTS: TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial Gastroesophageal acid, non-acid Reflux events or accelerate esophageal clearance time. CONCLUSIONS: TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or Gastroesophageal Reflux in healthy adults.
-
tolerance to h2 receptor antagonist correlates well with the decline in efficacy against Gastroesophageal Reflux in patients with Gastroesophageal Reflux disease
Journal of Gastroenterology and Hepatology, 2006Co-Authors: Kenji Furuta, Kyoichi Adachi, Masaharu Miki, Yoshinori Komazawa, Takafumi Mihara, Takane Azumi, Tomoo Fujisawa, Tomoko Katsube, Yoshikazu KinoshitaAbstract:Background and Aim: The attenuated antisecretory activity of H2 receptor antagonists (H2RA) during continuous administration is known as the tolerance phenomenon. The authors recently clarified that presence or absence of Helicobacter pylori infection influences the occurrence of the tolerance phenomenon. The aim of this study was to clarify whether tolerance to H2RA is correlated with attenuation of the inhibitory effect against Gastroesophageal acid Reflux in patients with Gastroesophageal Reflux disease (GERD). Methods: Ten male patients with GERD symptoms and abnormal Gastroesophageal Reflux were investigated by pH monitoring on days 1 and 15 of continuous oral famotidine administration at 20 mg twice daily, and H. pylori infection was examined using the urea breath test. Results: Intragastric and intraesophageal acidity were significantly decreased on the first day of famotidine administration, but then increased during the 15-day administration period in seven patients who were negative for H. pylori. In contrast, the efficacy of famotidine against gastric acid secretion and Gastroesophageal acid Reflux was not attenuated in three H. pylori-positive patients. The changes in GERD symptoms were correlated with the change in the degree of Gastroesophageal Reflux. Conclusion: The presence or absence of tolerance to H2RA during 15-day administration is correlated with the efficacy for inhibition of Gastroesophageal acid Reflux.
Kenji Furuta - One of the best experts on this subject based on the ideXlab platform.
-
Original Article Effects of Rikkunshito (TJ-43) on Esophageal Motor Function and Gastroesophageal Reflux
2013Co-Authors: Terumi Morita, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Kenji Koshino, Takashi Tanimura, Tomochika Uemura, Yoshikazu KinoshitaAbstract:Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve Gastroesophageal Reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and Gastroesophageal Reflux. Methods The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial Gastroesophageal Reflux was also determined using a multi-channel impedance pH dual monitor. Results TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial Gastroesophageal acid, non-acid Reflux events or accelerate esophageal clearance time. Conclusions TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or Gastroesophageal Reflux in healthy adults. (J Neurogastroenterol Motil 2012;18:181-186
-
effects of rikkunshito tj 43 on esophageal motor function and Gastroesophageal Reflux
Journal of Neurogastroenterology and Motility, 2012Co-Authors: Terumi Morita, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Kenji Koshino, Takashi Tanimura, Tomochika Uemura, Kohji Naora, Yoshikazu KinoshitaAbstract:BACKGROUND/AIMS: Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve Gastroesophageal Reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and Gastroesophageal Reflux. METHODS: The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial Gastroesophageal Reflux was also determined using a multi-channel impedance pH dual monitor. RESULTS: TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial Gastroesophageal acid, non-acid Reflux events or accelerate esophageal clearance time. CONCLUSIONS: TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or Gastroesophageal Reflux in healthy adults.
-
effects of mosapride on esophageal functions and Gastroesophageal Reflux
Journal of Gastroenterology and Hepatology, 2010Co-Authors: Kenji Koshino, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Terumi Morita, Shuji Nakata, Takashi Tanimura, Masaharu MikiAbstract:Background and Aim: A substantial number of patients with Gastroesophageal Reflux disease show symptomatic resistance to high-dose proton pump inhibitors. In those cases, prokinetics are possible candidates for treatment. The aim of the present study was to determine whether mosapride, a prokinetic agent, stimulates esophageal functions, and prevents acidic and non-acidic Gastroesophageal Reflux. Methods: Normal volunteers (nine and 13 for two experiments, respectively) were enrolled. Salivary secretion, esophageal peristaltic contractions, and resting lower esophageal sphincter pressure with and without mosapride administration were recorded using a cross-over protocol. Post-prandial acidic and non-acidic Reflux levels were also recorded. Results: Mosapride at a standard dose of 15 mg/day did not stimulate salivary secretion or any esophageal motor functions. It also failed to prevent acidic and non-acidic post-prandial Gastroesophageal Reflux. Conclusions: Mosapride at 15 mg/day, a standard dose in Japan, did not change the esophageal motility and salivary secretion in healthy volunteers. Future study on a larger number of individuals with higher dose of mosapride is worthwhile.
-
tolerance to h2 receptor antagonist correlates well with the decline in efficacy against Gastroesophageal Reflux in patients with Gastroesophageal Reflux disease
Journal of Gastroenterology and Hepatology, 2006Co-Authors: Kenji Furuta, Kyoichi Adachi, Masaharu Miki, Yoshinori Komazawa, Takafumi Mihara, Takane Azumi, Tomoo Fujisawa, Tomoko Katsube, Yoshikazu KinoshitaAbstract:Background and Aim: The attenuated antisecretory activity of H2 receptor antagonists (H2RA) during continuous administration is known as the tolerance phenomenon. The authors recently clarified that presence or absence of Helicobacter pylori infection influences the occurrence of the tolerance phenomenon. The aim of this study was to clarify whether tolerance to H2RA is correlated with attenuation of the inhibitory effect against Gastroesophageal acid Reflux in patients with Gastroesophageal Reflux disease (GERD). Methods: Ten male patients with GERD symptoms and abnormal Gastroesophageal Reflux were investigated by pH monitoring on days 1 and 15 of continuous oral famotidine administration at 20 mg twice daily, and H. pylori infection was examined using the urea breath test. Results: Intragastric and intraesophageal acidity were significantly decreased on the first day of famotidine administration, but then increased during the 15-day administration period in seven patients who were negative for H. pylori. In contrast, the efficacy of famotidine against gastric acid secretion and Gastroesophageal acid Reflux was not attenuated in three H. pylori-positive patients. The changes in GERD symptoms were correlated with the change in the degree of Gastroesophageal Reflux. Conclusion: The presence or absence of tolerance to H2RA during 15-day administration is correlated with the efficacy for inhibition of Gastroesophageal acid Reflux.
Kyoichi Adachi - One of the best experts on this subject based on the ideXlab platform.
-
Original Article Effects of Rikkunshito (TJ-43) on Esophageal Motor Function and Gastroesophageal Reflux
2013Co-Authors: Terumi Morita, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Kenji Koshino, Takashi Tanimura, Tomochika Uemura, Yoshikazu KinoshitaAbstract:Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve Gastroesophageal Reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and Gastroesophageal Reflux. Methods The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial Gastroesophageal Reflux was also determined using a multi-channel impedance pH dual monitor. Results TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial Gastroesophageal acid, non-acid Reflux events or accelerate esophageal clearance time. Conclusions TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or Gastroesophageal Reflux in healthy adults. (J Neurogastroenterol Motil 2012;18:181-186
-
effects of rikkunshito tj 43 on esophageal motor function and Gastroesophageal Reflux
Journal of Neurogastroenterology and Motility, 2012Co-Authors: Terumi Morita, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Kenji Koshino, Takashi Tanimura, Tomochika Uemura, Kohji Naora, Yoshikazu KinoshitaAbstract:BACKGROUND/AIMS: Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve Gastroesophageal Reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and Gastroesophageal Reflux. METHODS: The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial Gastroesophageal Reflux was also determined using a multi-channel impedance pH dual monitor. RESULTS: TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial Gastroesophageal acid, non-acid Reflux events or accelerate esophageal clearance time. CONCLUSIONS: TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or Gastroesophageal Reflux in healthy adults.
-
effects of mosapride on esophageal functions and Gastroesophageal Reflux
Journal of Gastroenterology and Hepatology, 2010Co-Authors: Kenji Koshino, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Terumi Morita, Shuji Nakata, Takashi Tanimura, Masaharu MikiAbstract:Background and Aim: A substantial number of patients with Gastroesophageal Reflux disease show symptomatic resistance to high-dose proton pump inhibitors. In those cases, prokinetics are possible candidates for treatment. The aim of the present study was to determine whether mosapride, a prokinetic agent, stimulates esophageal functions, and prevents acidic and non-acidic Gastroesophageal Reflux. Methods: Normal volunteers (nine and 13 for two experiments, respectively) were enrolled. Salivary secretion, esophageal peristaltic contractions, and resting lower esophageal sphincter pressure with and without mosapride administration were recorded using a cross-over protocol. Post-prandial acidic and non-acidic Reflux levels were also recorded. Results: Mosapride at a standard dose of 15 mg/day did not stimulate salivary secretion or any esophageal motor functions. It also failed to prevent acidic and non-acidic post-prandial Gastroesophageal Reflux. Conclusions: Mosapride at 15 mg/day, a standard dose in Japan, did not change the esophageal motility and salivary secretion in healthy volunteers. Future study on a larger number of individuals with higher dose of mosapride is worthwhile.
-
tolerance to h2 receptor antagonist correlates well with the decline in efficacy against Gastroesophageal Reflux in patients with Gastroesophageal Reflux disease
Journal of Gastroenterology and Hepatology, 2006Co-Authors: Kenji Furuta, Kyoichi Adachi, Masaharu Miki, Yoshinori Komazawa, Takafumi Mihara, Takane Azumi, Tomoo Fujisawa, Tomoko Katsube, Yoshikazu KinoshitaAbstract:Background and Aim: The attenuated antisecretory activity of H2 receptor antagonists (H2RA) during continuous administration is known as the tolerance phenomenon. The authors recently clarified that presence or absence of Helicobacter pylori infection influences the occurrence of the tolerance phenomenon. The aim of this study was to clarify whether tolerance to H2RA is correlated with attenuation of the inhibitory effect against Gastroesophageal acid Reflux in patients with Gastroesophageal Reflux disease (GERD). Methods: Ten male patients with GERD symptoms and abnormal Gastroesophageal Reflux were investigated by pH monitoring on days 1 and 15 of continuous oral famotidine administration at 20 mg twice daily, and H. pylori infection was examined using the urea breath test. Results: Intragastric and intraesophageal acidity were significantly decreased on the first day of famotidine administration, but then increased during the 15-day administration period in seven patients who were negative for H. pylori. In contrast, the efficacy of famotidine against gastric acid secretion and Gastroesophageal acid Reflux was not attenuated in three H. pylori-positive patients. The changes in GERD symptoms were correlated with the change in the degree of Gastroesophageal Reflux. Conclusion: The presence or absence of tolerance to H2RA during 15-day administration is correlated with the efficacy for inhibition of Gastroesophageal acid Reflux.
Terumi Morita - One of the best experts on this subject based on the ideXlab platform.
-
Original Article Effects of Rikkunshito (TJ-43) on Esophageal Motor Function and Gastroesophageal Reflux
2013Co-Authors: Terumi Morita, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Kenji Koshino, Takashi Tanimura, Tomochika Uemura, Yoshikazu KinoshitaAbstract:Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve Gastroesophageal Reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and Gastroesophageal Reflux. Methods The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial Gastroesophageal Reflux was also determined using a multi-channel impedance pH dual monitor. Results TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial Gastroesophageal acid, non-acid Reflux events or accelerate esophageal clearance time. Conclusions TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or Gastroesophageal Reflux in healthy adults. (J Neurogastroenterol Motil 2012;18:181-186
-
effects of rikkunshito tj 43 on esophageal motor function and Gastroesophageal Reflux
Journal of Neurogastroenterology and Motility, 2012Co-Authors: Terumi Morita, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Kenji Koshino, Takashi Tanimura, Tomochika Uemura, Kohji Naora, Yoshikazu KinoshitaAbstract:BACKGROUND/AIMS: Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve Gastroesophageal Reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and Gastroesophageal Reflux. METHODS: The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial Gastroesophageal Reflux was also determined using a multi-channel impedance pH dual monitor. RESULTS: TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial Gastroesophageal acid, non-acid Reflux events or accelerate esophageal clearance time. CONCLUSIONS: TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or Gastroesophageal Reflux in healthy adults.
-
effects of mosapride on esophageal functions and Gastroesophageal Reflux
Journal of Gastroenterology and Hepatology, 2010Co-Authors: Kenji Koshino, Kenji Furuta, Kyoichi Adachi, Shunji Ohara, Terumi Morita, Shuji Nakata, Takashi Tanimura, Masaharu MikiAbstract:Background and Aim: A substantial number of patients with Gastroesophageal Reflux disease show symptomatic resistance to high-dose proton pump inhibitors. In those cases, prokinetics are possible candidates for treatment. The aim of the present study was to determine whether mosapride, a prokinetic agent, stimulates esophageal functions, and prevents acidic and non-acidic Gastroesophageal Reflux. Methods: Normal volunteers (nine and 13 for two experiments, respectively) were enrolled. Salivary secretion, esophageal peristaltic contractions, and resting lower esophageal sphincter pressure with and without mosapride administration were recorded using a cross-over protocol. Post-prandial acidic and non-acidic Reflux levels were also recorded. Results: Mosapride at a standard dose of 15 mg/day did not stimulate salivary secretion or any esophageal motor functions. It also failed to prevent acidic and non-acidic post-prandial Gastroesophageal Reflux. Conclusions: Mosapride at 15 mg/day, a standard dose in Japan, did not change the esophageal motility and salivary secretion in healthy volunteers. Future study on a larger number of individuals with higher dose of mosapride is worthwhile.
Joel H Rubenstein - One of the best experts on this subject based on the ideXlab platform.
-
presentation and epidemiology of Gastroesophageal Reflux disease
Gastroenterology, 2018Co-Authors: Joel E. Richter, Joel H RubensteinAbstract:Gastroesophageal Reflux disease (GERD) is the most prevalent gastrointestinal disorder in the United States, and leads to substantial morbidity, though associated mortality is rare. The prevalence of GERD symptoms appeared to increase until 1999. Risk factors for complications of GERD include advanced age, male sex, white race, abdominal obesity, and tobacco use. Most patients with GERD present with heartburn and effortless regurgitation. Coexistent dysphagia is considered an alarm symptom, prompting evaluation. There is substantial overlap between symptoms of GERD and those of eosinophilic esophagitis, functional dyspepsia, and gastroparesis, posing a challenge for patient management.
-
epidemiology of Gastroesophageal Reflux disease
Gastroenterology Clinics of North America, 2014Co-Authors: Joel H Rubenstein, Joan W ChenAbstract:The prevalence of Gastroesophageal Reflux disease (GERD) symptoms increased approximately 50% until the mid-1990s, when it plateaued. The incidence of complications related to GERD including hospitalization, esophageal strictures, esophageal adenocarcinoma, and mortality also increased during that time period, but the increase in esophageal adenocarcinoma has since slowed, and the incidence of strictures has decreased since the mid-1990s. GERD is responsible for the greatest direct costs in the United States of any gastrointestinal disease, and most of those expenditures are for pharmacotherapy. Risk factors for GERD include obesity, poor diet, lack of physical activity, consumption of tobacco and alcohol, and respiratory diseases.
-
esophageal adenocarcinoma incidence in individuals with Gastroesophageal Reflux synthesis and estimates from population studies
The American Journal of Gastroenterology, 2011Co-Authors: Joel H Rubenstein, James M Scheiman, Shahram Sadeghi, David C Whiteman, John M InadomiAbstract:Esophageal Adenocarcinoma Incidence in Individuals With Gastroesophageal Reflux: Synthesis and Estimates From Population Studies
