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Christof Roosli - One of the best experts on this subject based on the ideXlab platform.

  • english translation and validation of the zurich chronic middle ear inventory zcmei 21 e assessing quality of life in chronic otitis media a prospective international multicentre study
    Clinical Otolaryngology, 2019
    Co-Authors: Michail Chatzimichalis, Lorenz Epprecht, Stefan Weder, Chanan Shaul, Kristi Engle J Folchert, Maria C Machala, Madeline M Goosmann, Marc Naville, Angela Zhu, Christof Roosli
    Abstract:

    OBJECTIVES To translate and validate the Zurich Chronic Middle Ear Inventory (ZCMEI-21) for the English language in order to provide an English instrument to assess health-related quality of life in chronic otitis media (COM). DESIGN Pilot translation study including cognitive debriefings, prospective multicenter cross-sectional psychometric validation study. SETTING Four tertiary referral centers in three different English-speaking countries (United Kingdom, United States of America and Australia). PARTICIPANTS Adult patients suffering from COM. MAIN OUTCOME MeasureS The English translation of the ZCMEI-21 (ZCMEI-21-E) and the five-level version of the EQ-5D questionnaire. The EQ-5D, which constitutes a Generic Measure of health-related quality of life, consists of a descriptive system score and a visual analogue scale. Statistical outcomes included single item descriptive statistics, internal consistency (Cronbach's α) as an indicator of reliability, as well as construct validity. RESULTS A total of 124 patients suffering from COM were included. The mean age was 50.1 years (SD 16.9 years) and 72 (58.1%) were males. The Cronbach's α of the ZCMEI-21-E was 0.91, suggesting an excellent internal consistency. The Spearman's correlation coefficient of the ZCMEI-21-E total score was 0.55 (p < 0.0001) for convergent construct validity with EQ-5D descriptive system score and 0.57 (p < 0.0001) with the EQ-5D visual analogue scale. CONCLUSIONS The ZCMEI-21-E is a new validated questionnaire that provides clinicians with a short, comprehensive and reliable instrument to quantify health-related quality of life in patients suffering from COM. The ZCMEI-21-E may be of use in clinical routine as well as in outcome research and monitoring. This article is protected by copyright. All rights reserved.

  • development and validation of the zurich chronic middle ear inventory zcmei 21 an electronic questionnaire for assessing quality of life in patients with chronic otitis media
    European Archives of Oto-rhino-laryngology, 2016
    Co-Authors: David Bachinger, Christof Roosli, Beate Ditzen, Alexander M Huber
    Abstract:

    Because existing patient-reported outcome Measures (PROMs) specific for chronic otitis media (COM) are lacking certain relevant symptoms and dimensions of health-related quality of life (HRQoL), we aimed to develop and validate a new questionnaire for comprehensively measuring HRQoL in adult patients with COM. An expert panel and patients were involved in developing the first version of the Zurich chronic middle ear inventory, containing 33 items (ZCMEI-33). An electronic application was chosen not only to provide maximal data quality, but also to facilitate and accelerate data analysis. Item reduction was performed by testing the questionnaire in a first cohort (n = 85). Using sequential statistical analysis, the ZCMEI-33 was reduced to 21 items (ZCMEI-21). Subsequently, the ZCMEI-21 was validated in a second cohort (n = 76). Validation revealed a Cronbach’s α of 0.91, indicating excellent internal consistency. Moreover, the ZCMEI-21 was able to discriminate between patients with COM and healthy participants (p < 0.0001), thus possessing good discrimination validity. Assessing criterion validity, the ZCMEI-21 total score was compared to a question directly addressing HRQoL and the EQ-5D descriptive system score, a Generic Measure of HRQoL. Whereas the ZCMEI-21 total score and the EQ-5D descriptive system score were only moderately correlated (r = 0.60, p < 0.0001), the ZCMEI-21 total score and the question directly addressing HRQoL showed a strong correlation (r = 0.74, p < 0.0001). In conclusion, sufficient information on reliability and validity was obtained to propagate the application of the ZCMEI-21 to quantify HRQoL in patients with COM.

John Brazier - One of the best experts on this subject based on the ideXlab platform.

  • preparatory study for the revaluation of the eq 5d tariff methodology report
    Health Technology Assessment, 2014
    Co-Authors: Brendan Mulhern, Nancy Devlin, John Brazier, Nick Bansback, Ken Buckingham, John Cairns, Paul Dolan, Arne Risa Hole, Georgios Kavetsos, Louise Longworth
    Abstract:

    BACKGROUND: EQ-5D is a widely used Generic Measure of health with a 'tariff', or preference weights, obtained from the general population, using time trade-off (TTO). PRET (Preparatory study for the Re-valuation of the EQ-5D Tariff project) contributes towards the methodology for its revaluation. METHODS: Stage 1 examined key assumptions typically involved in health-state valuations through a series of binary choice exercises, namely that health-state preferences are independent of (1) duration of the state; (2) whose health it is (i.e. perspective); (3) length of 'lead time' (a mechanism to value all states on the same scale, including those who are worse than being dead); (4) when health events take place (time preference); and (5) satisfaction associated with the state. Further topics addressed were (6) exhaustion of lead time in the worst state; (7) health-state valuation using discrete choice experiments (DCEs) with a duration attribute; and (8) binary choice administration of lead time - time trade-off (LT-TTO). Stage 1 consisted of an online survey with 6000 respondents. Stage 2 compared the results above to those of an identical survey conducted in 200 face-to-face computer-assisted personal interviews (CAPIs), covering topics (1) to (7). Stages 3 and 4 examined - in more detail and depth - issues taken from stage 1. Stage 3 consisted of CAPI surveys of a representative UK sample of 300, using examples of TTO, LT-TTO, and DCE with duration, each followed by extensive feedback questions. Stage 4 was a more intensive exercise involving a qualitative analysis of people's thought processes during both binary choice and iterative health-state valuation exercises. Data were collected through 'think-aloud' methods in 30 interviews of a convenience sample. RESULTS: Stage 1 found that health-state values are not independent of (1) duration of the state but there is no clear pattern; (2) whose health it is; (3) the duration of 'lead time' but there was no clear pattern; (4) when health events take place; or (5) satisfaction associated with the state. Furthermore, (6) exhaustion of lead time in the worst state was subject to substantial framing effects; (7) the five-level version of the EQ-5D (EQ-5D-5L) can be valued using DCE with duration as an attribute; and (8) binary choice LT-TTO can be administered in an online environment. Stage 2 found that although online surveys and CAPI surveys resulted in different compositions of respondents, at the aggregate, their responses to the experimental questions covering (1) to (7) above were not statistically significantly different from each other. Stages 3 and 4 found that TTO and LT-TTO were easier than DCE with duration; respondents did not necessarily trade across all attributes of EQ-5D; some respondents found it difficult to distinguish between the two worst levels of EQ-5D-5L, and some respondents may be thinking about the impact of their ill health on their family. CONCLUSIONS: In order for the National Institute for Health and Care Excellence to make the most appropriate decisions, the EQ-5D tariff needs to incorporate the latest understanding of health-state preferences. PRET contributed to the knowledge base on the conduct of health-state valuation studies. FUNDING: The Medical Research Council (MRC)-National Institute for Health Research (NIHR) Methodology Research Programme funded the PRET project (MRC ref. G0901500), and the EuroQol Group funded the PRET-AS project (Preparatory study for the Re-valuation of the EQ-5D Tariff project - Additional Sample) as an extension to the PRET project with formal agreement from the MRC.

  • using the health assessment questionnaire to estimate preference based single indices in patients with rheumatoid arthritis
    Arthritis & Rheumatism, 2007
    Co-Authors: Nick Bansback, Carlo A Marra, Aki Tsuchiya, Aslam H Anis, Daphne Guh, Tony Hammond, John Brazier
    Abstract:

    Objective To estimate the relationship between preference-based Measures, EuroQol (EQ-5D) and SF-6D, and the Health Assessment Questionnaire (HAQ) disability index (DI) in patients with rheumatoid arthritis (RA), and to characterize components that are predictors of health utility. Methods Patients with RA participating in 2 studies in the UK (n = 151) and Canada (n = 319) completed the HAQ, EQ-5D, and Short Form 36 (SF-36). The SF-36, a Generic Measure of quality of life, was converted into the preference-based SF-6D. From these results we developed models of the relationship between the HAQ and SF-6D and EQ-5D using various regression analyses. Results The optimal model developed for the EQ-5D entered levels for each item as independent variables (model 5). A root mean square error (RMSE) of 0.18 suggested relatively good predictive ability. For the SF-6D, RMSEs were lower (0.09), suggesting better predictions than for the EQ-5D, but models with more explanatory variables did not improve results (model 2 or 4 optimal). The models were able to predict actual SF-6D and EQ-5D across the range of the HAQ DI. Conclusion Our approach enabled calculations of quality-adjusted life years from existing trials where only the HAQ was Measured. All aspects of the HAQ may not be reflected in the preference-based Measures, and this method is suboptimal to direct Measurement of health state utility in clinical trials. Given this limitation, our approach provides an alternative for researchers who need health-state utility values, but had not included a preference-based Measure in their clinical study because of resource constraints or a desire to limit patient burden.

  • estimating a preference based single index for the impact of weight on quality of life lite iwqol lite instrument from the sf 6d
    Value in Health, 2004
    Co-Authors: John Brazier, Ronette L Kolotkin, Ross D Crosby, Rhys G Williams
    Abstract:

    Abstract Objective To facilitate economic evaluations of interventions for treating obesity, we estimated a preference-based single index for the Impact of Weight on Quality of Life-Lite (IWQOL-lite) instrument by mapping it onto the SF-6D preference-based index. Methods A heterogeneous sample of 1972 individuals, composed of community volunteers and participants in weight loss programs, clinical trials, and gastric bypass studies, completed the IWQOL-lite, an obesity-specific Measure of health-related quality of life (HRQOL), and the SF-36, a Generic Measure of HRQOL converted into the preference-based SF-6D. Models of the relationship between the IWQOL-lite and SF-6D of increasing complexity were estimated by regression analyses. Results The best fitting model for predicting SF-6D index scores entered levels for each item as independent variables ( R 2 = 0.530 in the cross-validation sample, with a mean absolute error of 0.0976). This model (1) makes fewer assumptions than those using total score, dimension scores or item scores as dependent variables and (2) provides a robust unbiased estimate of a preference-based index from IWQOL-Lite data where a preference-based Measure was not used. The addition of age and body mass index (BMI) led to a slight improvement in the model. Conclusions It is possible to facilitate economic evaluations using results obtained from disease-specific instruments using this approach. A weakness of this approach is that there may be aspects of the condition that have not been properly reflected in the SF-6D index. It is, however, useful when a preference-based Measure has not been administered and when it would be impractical to conduct a full valuation survey.

Michail Chatzimichalis - One of the best experts on this subject based on the ideXlab platform.

  • english translation and validation of the zurich chronic middle ear inventory zcmei 21 e assessing quality of life in chronic otitis media a prospective international multicentre study
    Clinical Otolaryngology, 2019
    Co-Authors: Michail Chatzimichalis, Lorenz Epprecht, Stefan Weder, Chanan Shaul, Kristi Engle J Folchert, Maria C Machala, Madeline M Goosmann, Marc Naville, Angela Zhu, Christof Roosli
    Abstract:

    OBJECTIVES To translate and validate the Zurich Chronic Middle Ear Inventory (ZCMEI-21) for the English language in order to provide an English instrument to assess health-related quality of life in chronic otitis media (COM). DESIGN Pilot translation study including cognitive debriefings, prospective multicenter cross-sectional psychometric validation study. SETTING Four tertiary referral centers in three different English-speaking countries (United Kingdom, United States of America and Australia). PARTICIPANTS Adult patients suffering from COM. MAIN OUTCOME MeasureS The English translation of the ZCMEI-21 (ZCMEI-21-E) and the five-level version of the EQ-5D questionnaire. The EQ-5D, which constitutes a Generic Measure of health-related quality of life, consists of a descriptive system score and a visual analogue scale. Statistical outcomes included single item descriptive statistics, internal consistency (Cronbach's α) as an indicator of reliability, as well as construct validity. RESULTS A total of 124 patients suffering from COM were included. The mean age was 50.1 years (SD 16.9 years) and 72 (58.1%) were males. The Cronbach's α of the ZCMEI-21-E was 0.91, suggesting an excellent internal consistency. The Spearman's correlation coefficient of the ZCMEI-21-E total score was 0.55 (p < 0.0001) for convergent construct validity with EQ-5D descriptive system score and 0.57 (p < 0.0001) with the EQ-5D visual analogue scale. CONCLUSIONS The ZCMEI-21-E is a new validated questionnaire that provides clinicians with a short, comprehensive and reliable instrument to quantify health-related quality of life in patients suffering from COM. The ZCMEI-21-E may be of use in clinical routine as well as in outcome research and monitoring. This article is protected by copyright. All rights reserved.

John E. Ware - One of the best experts on this subject based on the ideXlab platform.

Crispin Jenkinson - One of the best experts on this subject based on the ideXlab platform.

  • perspectives from health social care and policy stakeholders on the value of a single self report outcome Measure across long term conditions a qualitative study
    BMJ Open, 2015
    Co-Authors: Cheryl Hunter, Crispin Jenkinson, Ray Fitzpatrick, Annesophie E Darlington, Angela Coulter, Julien E Forder, Michele Peters
    Abstract:

    Objectives: To explore the views of a range of stakeholders regarding whether patient-reported outcome Measures (PROMs) can be developed to Measure key attributes of long-term conditions (LTCs) care in England, and the potential value of a single Generic Measure. Design: Qualitative semistructured interview study, analysed using a framework approach. Participants and setting: Interviews with 31 stakeholders from primary care, secondary care, social care, policy and patient-focused voluntary organisations in England. Results: There was broad support for a single PROM that could be used to Measure outcomes for patients with any LTCs in any health or social care setting. Interviewees identified three desired uses for a PROM: to improve the quality of individual care; to increase people’s engagement in their own care; and to monitor the performance of services. Interviewees felt that a PROM for LTCs should incorporate a mixture of traditional and non-traditional domains, such as functioning, empowerment and social participation, and be codesigned with patients and professional endusers. Stakeholders emphasised the need for a PROM to be feasible for practical implementation at the individual clinical level as a first priority. A number of concerns and potential problems were identified in relation to the application and interpretation of an LTC PROM. Conclusions: This study has demonstrated support for a single self-report outcome Measure that reflects the priorities of people with LTCs, if such a Measure can be shown to be meaningful and useful at the individual level. People with LTCs and professional end-users in health and social care should be involved in the development and evaluation of such a Measure.

  • evaluation of index and profile Measures of health status in a randomized controlled trial comparison of the medical outcomes study 36 item short form health survey euroqol and disease specific Measures
    Medical Care, 1997
    Co-Authors: Crispin Jenkinson, Alastair Gray, Helen Doll, Kate Lawrence, Stephen Keoghane, Richard Layte
    Abstract:

    thral resection of the prostate with laser vaporization prostatectomy for benign prostatic hypertrophy. METHODS. Patients entered into the trial completed the following questionnaires prior to treatment and at follow-up at 3 months and 1 year. The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) is a Generic Measure that produces an eight-dimension profile as well as two summary Measures of health status (the physical component score and the mental component score). The EuroQol provides two single index Measures of health status; one intended to convey the utility (or lack of) that an individual derives from his or her own health state compared with alternative states and a second simple visual analog scale "thermometer" of health status. The American Urological Association symptom score and the Bothersome index are disease-specific indices of health status for use specifically with benign prostatic hypertrophy patients. RESULTS. The EuroQol indicates no statistically significant improvements with time for either arm of the trial. The SF-36 physical and general health perceptions domains indicates statistically significant improvements for the transurethral resection of the prostate arm alone at 3 months and 1 year, as do the physical summary score at the 3-month follow-up visit. The effect sizes of these improvements, however, are small, using standard criteria. In contrast, statistically significant differences are found with time for both transurethral resection of the prostate and laser prostatectomy on both disease-specific Measures, which also indicate statistically significant superior outcome for the transurethral resection of the prostate arm compared with the laser arm.

  • self reported functioning and well being in patients with parkinson s disease comparison of the short form health survey sf 36 and the parkinson s disease questionnaire pdq 39
    Age and Ageing, 1995
    Co-Authors: Crispin Jenkinson, Viv Peto, Ray Fitzpatrick, R Greenhall, Neil Hyman
    Abstract:

    The purpose of this paper was to document the impact of Parkinson's disease (PD) upon patients using both a Generic health status Measure (the Short-form 36 health survey questionnaire, SF-36) and a disease-specific Measure (the 39-item Parkinson's Disease Questionnaire, PDQ-39). Comparing the results of the SF-36 in this population with a similar aged group selected randomly from two general practices it was evident that the disease has considerable impact on general levels of functioning and well-being. Furthermore, other areas not contained on the SF-36 were found to be relevant to PD patients. It is suggested that the disease-specific Measure will be of value, ideally alongside a Generic Measure, in studies aimed at determining the impact of a treatment regimen upon PD patients, or to monitor the long-term progress of cohorts of patients with PD. The paper highlights the need for careful consideration of Measures for evaluation.