The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Frédéric Relaix - One of the best experts on this subject based on the ideXlab platform.
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Genetic Regulation of skeletal muscle development.
Experimental Cell Research, 2010Co-Authors: Keren Bismuth, Frédéric RelaixAbstract:During development, skeletal muscles are established in a highly organized manner, which persists throughout life. Molecular and Genetic experiments over the last decades have identified many developmental control genes critical for skeletal muscle formation. Developmental studies have shown that skeletal muscles of the body, limb and head have distinct embryonic and cellular origin, and the Genetic Regulation at work in these domains and during adult myogenesis are starting to be identified. In this review we will summarize the current knowledge on the regulatory circuits that lead to the establishment of skeletal muscle in these different anatomical regions.
B.a. Kaminski - One of the best experts on this subject based on the ideXlab platform.
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Human Puberty: Physiology, Progression, and Genetic Regulation of Variation in Onset
Hormones Brain and Behavior, 2017Co-Authors: B.a. Kaminski, M.r. PalmertAbstract:Puberty is an important developmental process and life stage that leads to sexual maturation and reproductive capability. Although the physiology and progression of puberty is relatively common among individuals, the timing of puberty varies across the normal population and is affected by both Genetic and environmental influences. In this chapter, we present a discussion of the physiology and Regulation of pubertal development, with emphasis on the recent advances in Genetic Regulation of variation in pubertal timing. Changes in behavior that relate to puberty are also reviewed briefly.
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65 – Human Puberty: Physiology, Progression, and Genetic Regulation of Variation in Onset
Hormones Brain and Behavior, 2009Co-Authors: B.a. KaminskiAbstract:Puberty is an important developmental process and life stage that leads to sexual maturation and reproductive capability. Although the physiology and progression of puberty is relatively common among individuals, the timing of puberty varies across the normal population and is affected by both Genetic and environmental influences. In this chapter, we present a discussion of the physiology and Regulation of pubertal development, with emphasis on the recent advances in Genetic Regulation of variation in pubertal timing. Changes in behavior that relate to puberty are also reviewed briefly.
Keren Bismuth - One of the best experts on this subject based on the ideXlab platform.
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Genetic Regulation of skeletal muscle development.
Experimental Cell Research, 2010Co-Authors: Keren Bismuth, Frédéric RelaixAbstract:During development, skeletal muscles are established in a highly organized manner, which persists throughout life. Molecular and Genetic experiments over the last decades have identified many developmental control genes critical for skeletal muscle formation. Developmental studies have shown that skeletal muscles of the body, limb and head have distinct embryonic and cellular origin, and the Genetic Regulation at work in these domains and during adult myogenesis are starting to be identified. In this review we will summarize the current knowledge on the regulatory circuits that lead to the establishment of skeletal muscle in these different anatomical regions.
Eric E Allen - One of the best experts on this subject based on the ideXlab platform.
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Genetic Regulation of the bacterial omega 3 polyunsaturated fatty acid biosynthesis pathway
Journal of Bacteriology, 2020Co-Authors: Marco N Allemann, Eric E AllenAbstract:ABSTRACT A characteristic among many marine Gammaproteobacteria is the biosynthesis and incorporation of omega-3 polyunsaturated fatty acids into membrane phospholipids. The biosynthesis of eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is mediated by a polyketide/fatty acid synthase mechanism encoded by a set of five genes, pfaABCDE. This unique fatty acid synthesis pathway coexists with the principal type II dissociated fatty acid synthesis pathway, which is responsible for the biosynthesis of core saturated, monounsaturated, and hydroxylated fatty acids used in phospholipid and lipid A biosynthesis. In this work, a Genetic approach was undertaken to elucidate Genetic Regulation of the pfa genes in the model marine bacterium Photobacterium profundum SS9. Using a reporter gene fusion, we showed that expression of the pfa operon is downregulated in response to exogenous fatty acids, particularly long-chain monounsaturated fatty acids. This Regulation occurs independently of the canonical fatty acid regulators, FabR and FadR, present in P. profundum SS9. Transposon mutagenesis and screening of a library of mutants identified a novel transcriptional regulator, which we have designated pfaF, to be responsible for the observed Regulation of the pfa operon in P. profundum SS9. Gel mobility shift and DNase I footprinting assays confirmed that PfaF binds the pfaA promoter and identified the PfaF binding site. IMPORTANCE The production of long-chain omega-3 polyunsaturated fatty acids (PUFA) by marine Gammaproteobacteria, particularly those from deep-sea environments, has been known for decades. These unique fatty acids are produced by a polyketide-type mechanism and subsequently incorporated into the phospholipid membrane. While much research has focused on the biosynthesis genes, their products, and the phyloGenetic distribution of these gene clusters, no prior studies have detailed the Genetic Regulation of this pathway. This study describes how this pathway is regulated under various culture conditions and has identified and characterized a fatty acid-responsive transcriptional regulator specific to PUFA biosynthesis.
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Genetic Regulation of the bacterial omega 3 polyunsaturated fatty acid biosynthesis pathway
bioRxiv, 2020Co-Authors: Marco N Allemann, Eric E AllenAbstract:Abstract A characteristic among many marine Gammaproteobacteria is the biosynthesis and incorporation of omega-3 polyunsaturated fatty acids into membrane phospholipids. Biosynthesis of eicosapentaenoic (EPA) and/or docosahexaenoic (DHA) acids is accomplished using a polyketide/fatty acid synthase mechanism encoded by a set of five genes pfaABCDE. This unique fatty acid synthesis (FAS) pathway co-exists with the canonical Type II dissociated fatty acid synthesis pathway, which is responsible for the biosynthesis of saturated, monounsaturated, and hydroxylated fatty acids used in phospholipid and lipid A biosynthesis. In this work, a Genetic approach was undertaken to elucidate Genetic Regulation of the pfa genes in the model marine bacterium Photobacterium profundum SS9. Using a reporter gene fusion, we showed that expression of the pfa operon is down regulated in response to exogenous fatty acids, particularly long chain monounsaturated fatty acids. This Regulation occurs independently of the canonical fatty acid regulators, FabR and FadR, present in P. profundum SS9. Transposon mutagenesis and screening of a library of mutants identified a novel transcriptional regulator, which we have designated pfaF, to be responsible for the observed Regulation of the pfa operon in P. profundum SS9. Gel mobility shift and DNase I footprinting assays confirmed that PfaF binds the pfaA promoter and identified the PfaF binding site. Importance The production of polyunsaturated fatty acids (PUFA) by marine Gammaproteobacteria, particularly those from deep-sea environments, has been known for decades. These unique fatty acids are produced by a polyketide-type mechanism and subsequently incorporated into the phospholipid membrane. While much research has focused on the biosynthesis genes, their products and the phyloGenetic distribution of these gene clusters, no prior studies have detailed the Genetic Regulation of this pathway. This study describes how this pathway is regulated under various culture conditions and has identified and characterized a fatty acid responsive transcriptional regulator specific to the PUFA biosynthesis pathway.
M.r. Palmert - One of the best experts on this subject based on the ideXlab platform.
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Human Puberty: Physiology, Progression, and Genetic Regulation of Variation in Onset
Hormones Brain and Behavior, 2017Co-Authors: B.a. Kaminski, M.r. PalmertAbstract:Puberty is an important developmental process and life stage that leads to sexual maturation and reproductive capability. Although the physiology and progression of puberty is relatively common among individuals, the timing of puberty varies across the normal population and is affected by both Genetic and environmental influences. In this chapter, we present a discussion of the physiology and Regulation of pubertal development, with emphasis on the recent advances in Genetic Regulation of variation in pubertal timing. Changes in behavior that relate to puberty are also reviewed briefly.