The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Valerae O Lewis - One of the best experts on this subject based on the ideXlab platform.

David R Lucas - One of the best experts on this subject based on the ideXlab platform.

  • tenosynovial Giant Cell Tumor case report and review
    Archives of Pathology & Laboratory Medicine, 2012
    Co-Authors: David R Lucas
    Abstract:

    Tenosynovial Giant Cell Tumors are a group of generally benign intra-articular and soft tissue Tumors with common histologic features. They can be roughly divided into localized and diffuse types. Localized types include Giant Cell Tumors of tendon sheath and localized pigmented villonodular synovitis, whereas diffuse types encompass conventional pigmented villonodular synovitis and diffuse-type Giant Cell Tumor. Localized Tumors are generally indolent, whereas diffuse Tumors are locally aggressive. Recent developments indicate that tenosynovial Giant Cell Tumors are clonal neoplastic Tumors driven by overexpression of CSF1. Herein, I report a case of intra-articular, localized tenosynovial Giant Cell Tumor (or localized pigmented villonodular synovitis) and review the classification, histopathology, and recent developments regarding its pathogenesis.

S W Weiss - One of the best experts on this subject based on the ideXlab platform.

  • soft tissue Giant Cell Tumor of low malignant potential a proposal for the reclassification of malignant Giant Cell Tumor of soft parts
    Modern Pathology, 1999
    Co-Authors: Andrew L Folpe, R J Morris, S W Weiss
    Abstract:

    Although "Giant Cell Tumor of soft parts" has traditionally been considered a single entity as reflected in the original term "malignant Giant Cell Tumor of soft parts (MGCT)" and later by the term "malignant fibrous histiocytoma, Giant Cell type" the degree of atypia and mitotic activity varies in this group, suggesting biologic heterogeneity. The clinicopathologic features of 31 Tumors meeting the traditional criteria of MGCT but having only mild to moderate nuclear atypia are presented. Patients with these Tumors (19 females; 12 males) ranged in age from 14 to 84 years (mean, 40 years) and presented with masses of involving either superficial (n = 16) or deep (n = 13) soft tissue. Most occurred on the arm or hand (n = 16) and ranged in size from 0.7 to 6.5 cm (mean, 2.1 cm). The Tumors consisted of sheets and nodules of rounded mononuclear Cells that blended with spindled Cells and benign osteoclastic Giant Cells. Pleomorphic Giant Cells were absent. Osteoid was noted in 10 cases, but features typically associated with tenosynovial Giant Cell Tumors (such as dense stromal hyaline, siderophages, and xanthoma Cells) were nearly always absent. Mitotic figures ranged from 1-10/10 HPF (mean, 2-3/10 high-powered field), and angiolymphatic invasion was present in 10 cases. Necrosis was absent, however. The mononuclear Cells expressed CD68, tartrate-resistant acid phosphatase, and smooth muscle actin, but lacked CD45, S100 protein, desmin, and lysozyme, an immunophenotypic profile identical to that of Giant Cell Tumor of bone. Follow-up information in 19 patients (mean, 3 yrs; median, 1-7 yrs) indicated recurrences in four patients, but none developed metastasis. This behavior contrasts significantly with the high-grade behavior traditionally associated with MGCT of soft parts. These Giant Cell Tumors can be consistently recognized by the lack of cytologic atypia even in the face of mitotic activity and vascular invasion. Although their long term metastatic risk is not fully defined, we propose they be termed "Giant Cell Tumors of low malignant potential" and regarded as the soft tissue analogue of Giant Cell Tumor of bone. The term "malignant Giant Cell Tumor of soft parts" or Giant Cell malignant fibrous histiocytoma should be restricted to histologically high-grade lesions.

Vinod Ravi - One of the best experts on this subject based on the ideXlab platform.

C Lum - One of the best experts on this subject based on the ideXlab platform.

  • Giant Cell Tumor of the skull base
    Neuroradiology, 1999
    Co-Authors: Hueyjen Lee, C Lum
    Abstract:

    Giant Cell Tumors are uncommon primary bone Tumors. They primarily occur in the long bones. Giant Cell Tumors are extremely rare in the skull and head and neck. When it does occur, the maxilla and mandible are the common sites to be involved. We described two cases of Giant Cell Tumor in the temporal bone. In the non-contrast enhanced CT, the lesion presents as a soft tissue density mass with expansion of the bone. The bony cortex is usually intact. The adjacent soft tissues and cerebral parenchyma show no infiltration or edema. The post contrast scan reveals homogenous enhancement of the mass.