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Jiaxing Huang - One of the best experts on this subject based on the ideXlab platform.
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synthesis of graphene based noble metal composites for Glucose Biosensor
Materials Letters, 2013Co-Authors: Hee Dong Jang, Sun Kyung Kim, Hankwon Chang, Jeong-woo Choi, Jiaxing HuangAbstract:Abstract Graphene (GR) based noble metal composites such as Pt–GR and Au–GR were synthesized for sensitive Glucose Biosensors. Aerosol spray pyrolysis (ASP) was employed to synthesize the noble metal nanoparticles–GR composites using a colloidal mixture of GO and noble metal precursor (H 2 PtCl 6 ·6H 2 O and AuCl 4 ·3H 2 O). The morphology of noble metal–GR composites was generally the shape of a crumpled paper ball, and the average composite size was about 1 µm. Crystalline Pt and Au nanoparticles less than 5 nm in diameter were uniformly deposited on the crumpled GR sheets, respectively. The charateristics of the as-prepared Biosensors were tested through cyclic voltammetry measurements. All the Biosensors based on the noble metal–crumpled GR composite exhibited a higher current flow as well as clear redox peaks, which resulted in a superior ability of the catalyst in terms of an electrochemical reaction. The amperometric response of the Glucose Biosensor based on the Pt–crumpled GR composite indicated the highest sensitivity as 62 µA/mM cm 2 .
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a Glucose Biosensor based on tio2 graphene composite
Biosensors and Bioelectronics, 2012Co-Authors: Hee Dong Jang, Sun Kyung Kim, Hankwon Chang, Ki Min Roh, Jeong-woo Choi, Jiaxing HuangAbstract:Abstract A novel Glucose Biosensor was developed based on the adsorption of Glucose oxidase at a TiO 2 –Graphene (GR) nanocomposite electrode. A TiO 2 –GR composite was synthesized from a colloidal mixture of TiO 2 nanparticles and graphene oxide (GO) nanosheets by an aerosol assisted self-assembly (AASA). The particle morphology of all TiO 2 –GR composites was spherical in shape. It was observed that micron-sized TiO 2 particles were encapsulated by GR nanosheets and that the degree of encapsulation was proportional to the ratio of GO/TiO 2 . The amperometric response of the Glucose Biosensor fabricated by the TiO 2 –GR composite was linear against a concentration of Glucose ranging from 0 to 8 mM at −0.6 V. The highest sensitivity was noted at about 6.2 μA/mM cm 2 . The as prepared Glucose Biosensor based on the TiO 2 –GR composite showed higher catalytic performance for Glucose redox than a pure TiO 2 and GR Biosensor.
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A Glucose Biosensor based on TiO2–Graphene composite
Biosensors & bioelectronics, 2012Co-Authors: Hee Dong Jang, Sun Kyung Kim, Hankwon Chang, Ki Min Roh, Jeong-woo Choi, Jiaxing HuangAbstract:Abstract A novel Glucose Biosensor was developed based on the adsorption of Glucose oxidase at a TiO 2 –Graphene (GR) nanocomposite electrode. A TiO 2 –GR composite was synthesized from a colloidal mixture of TiO 2 nanparticles and graphene oxide (GO) nanosheets by an aerosol assisted self-assembly (AASA). The particle morphology of all TiO 2 –GR composites was spherical in shape. It was observed that micron-sized TiO 2 particles were encapsulated by GR nanosheets and that the degree of encapsulation was proportional to the ratio of GO/TiO 2 . The amperometric response of the Glucose Biosensor fabricated by the TiO 2 –GR composite was linear against a concentration of Glucose ranging from 0 to 8 mM at −0.6 V. The highest sensitivity was noted at about 6.2 μA/mM cm 2 . The as prepared Glucose Biosensor based on the TiO 2 –GR composite showed higher catalytic performance for Glucose redox than a pure TiO 2 and GR Biosensor.
Jung-chuan Chou - One of the best experts on this subject based on the ideXlab platform.
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Potentiometric Non-Enzymatic Glucose Biosensor Modified with Silver Nanowires
2020 IEEE Eurasia Conference on IOT Communication and Engineering (ECICE), 2020Co-Authors: Yu-hao Huang, Jung-chuan Chou, Chih-hsien Lai, Tsu-yang Lai, Po-yu Kuo, Yu-hsun Nien, Zhe-xin Dong, Yung-yu Chen, Zhi-xuan KangAbstract:In recent years, Glucose Biosensors play an important role in diabetes detection. This paper describes a potentiometric non-enzymatic Glucose Biosensor. The sensor is modified by silver nanowires (Ag NWs) which are fabricated by the polyol method. Using the voltage-time (V-T) system and electrochemical impedance spectroscopy (EIS), the sensing characteristics of the sensor are analyzed and the impact of silver nanowires (Ag NWs) on the performance of the sensor are investigated.
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A Facile Fabrication of a Potentiometric Arrayed Glucose Biosensor Based on Nafion-GOx/GO/AZO.
Sensors (Basel Switzerland), 2020Co-Authors: Jung-chuan Chou, Chih-hsien Lai, Si-hong Lin, Tsu-yang Lai, Po-yu Kuo, Yu-hsun NienAbstract:In this study, the potentiometric arrayed Glucose Biosensors, which were based on zinc oxide (ZnO) or aluminum-doped zinc oxide (AZO) sensing membranes, were fabricated by using screen-printing technology and a sputtering system, and graphene oxide (GO) and Nafion-Glucose oxidase (GOx) were used to modify sensing membranes by using the drop-coating method. Next, the material properties were characterized by using a Raman spectrometer, a field-emission scanning electron microscope (FE-SEM), and a scanning probe microscope (SPM). The sensing characteristics of the Glucose Biosensors were measured by using the voltage-time (V-T) measurement system. Finally, electrochemical impedance spectroscopy (EIS) was conducted to analyze their charge transfer abilities. The results indicated that the average sensitivity of the Glucose Biosensor based on Nafion-GOx/GO/AZO was apparently higher than that of the Glucose Biosensor based on Nafion-GOx/GO/ZnO. In addition, the Glucose Biosensor based on Nafion-GOx/GO/AZO exhibited an excellent average sensitivity of 15.44 mV/mM and linearity of 0.997 over a narrow range of Glucose concentration range, a response time of 26 s, a limit of detection (LOD) of 1.89 mM, and good reproducibility. In terms of the reversibility and stability, the hysteresis voltages (VH) were 3.96 mV and 2.42 mV. Additionally, the Glucose Biosensor also showed good anti-inference ability and reproducibility. According to these results, it is demonstrated that AZO is a promising material, which could be used to develop a reliable, simple, and low-cost potentiometric Glucose Biosensor.
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Fabrication and Characteristic Analysis for Enzymatic Glucose Biosensor Modified by Graphene Oxide and Magnetic Beads Based on Microfluidic Framework
IEEE Sensors Journal, 2017Co-Authors: Jung-chuan Chou, Yi-hung Liao, Jian-syun Chen, Chih-hsien Lai, Siao-jie Yan, Min-siang HuangAbstract:The indium gallium zinc oxide (IGZO) was adopted as enzymatic Glucose sensing membrane and a screen-printed technology was used to complete fabrication of sensor in this paper. There are some drawbacks for most of the enzymatic Glucose Biosensors, such as insufficient sensing area and weak immobilization strength, formed between Glucose oxidase (GOx) and support materials. For improving drawbacks of enzymatic Glucose Biosensor, graphene oxide (GO) was directly dropped on the IGZO sensing membrane to improve sensing area and magnetic beads (MBs) were combined with GOx by covalent bonding to enhance immobilization strength for GOx. In addition, the enzymatic Glucose Biosensor modified by GO and MBs was integrated with microfluidic framework in order to investigate sensing characteristics under the dynamic conditions. According to the experimental results, the optimal average sensitivity and linearity of the enzymatic Glucose Biosensor were 12.383 mV/mM and 0.999 at 25- $\mu \text{L}$ /min flow rate, respectively.
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The Characteristic Analysis of IGZO/Al pH Sensor and Glucose Biosensor in Static and Dynamic Measurements
IEEE Sensors Journal, 2016Co-Authors: Jung-chuan Chou, Yi-hung Liao, Min-siang Huang, Jian-syun Chen, Chih-hsien Lai, Siao-jie YanAbstract:In this paper, the pH sensor and Glucose Biosensor were integrated with microfluidic framework, and the sensing characteristics under the dynamic conditions, i.e., solution under flowing condition, were investigated. The indium-gallium–zinc oxide (IGZO), as a sensing membrane, was deposited on aluminum electrodes/polyethylene terephthalate substrate. Then, the screen-printed technology was used to accomplish the encapsulation of sensor. The Glucose Biosensor based on enzyme needed an extra Glucose sensing membrane, which was composed of Glucose oxidase (GO x ) and nafion. The Glucose sensing membrane was dropped on the IGZO/Al sensing membrane. According to the experimental results, the optimal sensing characteristics of pH sensor and Glucose Biosensor under the dynamic conditions were better than those under the static condition (solution without flowing). The optimal average sensitivity and linearity were 56.857 mV/pH and 0.997 at $25~\mu \text{L}$ /min flow rate, respectively (in pH sensor), and 7.255 mV/mM and 0.994 at $20~\mu \text{L}$ /min flow rate, respectively (in Glucose Biosensor). Furthermore, the hysteresis effect and drift effect were researched for pH sensor, and the electrochemical impedance spectroscopy was used to demonstrate whether the IGZO/Al sensing membrane had been modified by GO x and nafion and it was found that the additions of GO x and nafion had increased the electron transfer resistance ( $\text{R}_{\mathrm {et}})$ .
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Effect of different contents of magnetic beads on enzymatic IGZO Glucose Biosensor
Materials Letters, 2016Co-Authors: Jung-chuan Chou, Yi-hung Liao, Hsueh-tao Chou, Min-siang Huang, Jian-syun Chen, Chih-hsien Lai, Bo-yang Zhuang, Siao-jie Yan, Chih-chieh HsuAbstract:Abstract In this letter, the Glucose Biosensor was based on Glucose oxidase (GOx) to catalyze the oxidation of Glucose. The weak immobilization strength of GOx would lead to the poor sensing characteristics. In order to enhance immobilization strength of GOx, the magnetic beads (MBs) combined with GOx to form the Nafion-MBs-GOx /indium gallium zinc oxide (IGZO) Glucose Biosensor. Besides, the Glucose Biosensor modified by different contents of MBs solution was investigated to obtain optimal content of MBs. The Nafion-MBs-GOx /IGZO Glucose Biosensor with 1.00 ml MBs solution had the optimal average sensitivity and linearity which were 7.390 mV/mM and 0.994, respectively.
Hee Dong Jang - One of the best experts on this subject based on the ideXlab platform.
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synthesis of graphene based noble metal composites for Glucose Biosensor
Materials Letters, 2013Co-Authors: Hee Dong Jang, Sun Kyung Kim, Hankwon Chang, Jeong-woo Choi, Jiaxing HuangAbstract:Abstract Graphene (GR) based noble metal composites such as Pt–GR and Au–GR were synthesized for sensitive Glucose Biosensors. Aerosol spray pyrolysis (ASP) was employed to synthesize the noble metal nanoparticles–GR composites using a colloidal mixture of GO and noble metal precursor (H 2 PtCl 6 ·6H 2 O and AuCl 4 ·3H 2 O). The morphology of noble metal–GR composites was generally the shape of a crumpled paper ball, and the average composite size was about 1 µm. Crystalline Pt and Au nanoparticles less than 5 nm in diameter were uniformly deposited on the crumpled GR sheets, respectively. The charateristics of the as-prepared Biosensors were tested through cyclic voltammetry measurements. All the Biosensors based on the noble metal–crumpled GR composite exhibited a higher current flow as well as clear redox peaks, which resulted in a superior ability of the catalyst in terms of an electrochemical reaction. The amperometric response of the Glucose Biosensor based on the Pt–crumpled GR composite indicated the highest sensitivity as 62 µA/mM cm 2 .
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a Glucose Biosensor based on tio2 graphene composite
Biosensors and Bioelectronics, 2012Co-Authors: Hee Dong Jang, Sun Kyung Kim, Hankwon Chang, Ki Min Roh, Jeong-woo Choi, Jiaxing HuangAbstract:Abstract A novel Glucose Biosensor was developed based on the adsorption of Glucose oxidase at a TiO 2 –Graphene (GR) nanocomposite electrode. A TiO 2 –GR composite was synthesized from a colloidal mixture of TiO 2 nanparticles and graphene oxide (GO) nanosheets by an aerosol assisted self-assembly (AASA). The particle morphology of all TiO 2 –GR composites was spherical in shape. It was observed that micron-sized TiO 2 particles were encapsulated by GR nanosheets and that the degree of encapsulation was proportional to the ratio of GO/TiO 2 . The amperometric response of the Glucose Biosensor fabricated by the TiO 2 –GR composite was linear against a concentration of Glucose ranging from 0 to 8 mM at −0.6 V. The highest sensitivity was noted at about 6.2 μA/mM cm 2 . The as prepared Glucose Biosensor based on the TiO 2 –GR composite showed higher catalytic performance for Glucose redox than a pure TiO 2 and GR Biosensor.
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A Glucose Biosensor based on TiO2–Graphene composite
Biosensors & bioelectronics, 2012Co-Authors: Hee Dong Jang, Sun Kyung Kim, Hankwon Chang, Ki Min Roh, Jeong-woo Choi, Jiaxing HuangAbstract:Abstract A novel Glucose Biosensor was developed based on the adsorption of Glucose oxidase at a TiO 2 –Graphene (GR) nanocomposite electrode. A TiO 2 –GR composite was synthesized from a colloidal mixture of TiO 2 nanparticles and graphene oxide (GO) nanosheets by an aerosol assisted self-assembly (AASA). The particle morphology of all TiO 2 –GR composites was spherical in shape. It was observed that micron-sized TiO 2 particles were encapsulated by GR nanosheets and that the degree of encapsulation was proportional to the ratio of GO/TiO 2 . The amperometric response of the Glucose Biosensor fabricated by the TiO 2 –GR composite was linear against a concentration of Glucose ranging from 0 to 8 mM at −0.6 V. The highest sensitivity was noted at about 6.2 μA/mM cm 2 . The as prepared Glucose Biosensor based on the TiO 2 –GR composite showed higher catalytic performance for Glucose redox than a pure TiO 2 and GR Biosensor.
Tp Sun - One of the best experts on this subject based on the ideXlab platform.
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Investigation of the Amperometric/Potentiometric Dual Mode Glucose Biosensor
AMER SCIENTIFIC PUBLISHERS, 2020Co-Authors: Tp SunAbstract:[[abstract]]In this study, a dual mode Glucose Biosensor based on the amperometric and potentiometric techniques is proposed. The amperometric and potentiometric circuit modes are linked in one system by a 9-pin switch to construct a dual mode circuit. Moreover, the homemade dual mode circuit is designed for detecting amperometric and potentiometric signals to realize the small dimension and low cost advantages for portable and home-care purposes. According to the experiment results, the merit for the tin oxide (SnO(2)) amperometric Glucose Biosensor is rapid detection. Conversely, the SnO(2) potentiometric Glucose Biosensor can be operated under a simple circuit. Accordingly, these two different Biosensors combined in one system provide users a versatile option.[[note]]SC
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Study on the amperometric Glucose Biosensor based on tin oxide electrode
NORTHWEST INST NONFERROUS METAL RESEARCH, 2020Co-Authors: Tp SunAbstract:[[abstract]]An amperometric Glucose Biosensor based on a tin oxide (SnO2) electrode has been developed. The SnO2 electrode is prepared by depositing the SnO2 thin film onto a carbon electrode. To fabricate the SnO2 amperometric Glucose Biosensor, the Glucose oxidase and electron transfer mediator (ferrocenecarboxylic acid, FcA) are coimmobilized on the SnO2 electrode using polyacrylamide. The detection range is up to Glucose concentration of 520 mg/dl as the applied potential is set at 300 mV. Moreover, the most merit for the SnO2 electrode as the base electrode of the SnO2 amperometric Glucose Biosensor is that it can be operated at 150 mV constant applied potential. The interference reduction, detection range, sensitivity and linearity are improved as the SnO2 thin film is deposited onto a carbon electrode. Furthermore, due to the low cost substrate and simple fabrication characteristics, a disposable amperometric Glucose Biosensor based on the SnO2 electrode has been realized in this study.[[note]]SC
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STUDY ON THE POTENTIOMETRIC Glucose Biosensor BASED ON THE SnO2/ITO/PET
WORLD SCIENTIFIC PUBL CO PTE LTD, 2020Co-Authors: Tp SunAbstract:[[abstract]]A potentiometric Glucose Biosensor based on a SnO2/ITO/PET substrate is presented in this study. The sensing membrane of SnO2 is coated on ITO/PET substrate by utilized radio frequency (RF)-sputtering method of semiconductor fabrication. The potentiometric Glucose Biosensor is established on an FET-type pH sensor. Therein, the Glucose oxidase (GOD) and chitosan/multi-wall carbon nano-tubes (chitosan/MWCNTs) are immobilized by 3-glycidoxypropyl trimethoxysilane (3-GPTS). Finally, the drift characteristic and calibration curve of the potentiometric pH sensor and potentiometric Glucose Biosensor is discussed in the following article. We find the nonideal effect of device reduced significantly, due to the coating of SnO2 thin film.[[note]]SC
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Preliminary investigations on a Glucose Biosensor based on the potentiometric principle
ELSEVIER SCIENCE SA, 2020Co-Authors: Tp SunAbstract:[[abstract]]In this study, an electron mediator and a simple immobilization process are adopted to fabricate a potentiometric Glucose Biosensor. The enzyme and the electron mediator are immobilized on the surface of tin oxide (SnO2)/indium tin oxide (ITO) glass using a covalent bond method to develop a disposable potentiometric Glucose Biosensor. The SnO2/ITO glass is a pH sensor fabricated by depositing SnO2 thin films onto an ITO glass. The Glucose oxidase (GOD) and the electron mediator (ferrocenecarboxylic acid, FcA) are co-immobilized on the SnO2/ITO glass using 3-glycidyl oxypropyl tri methoxysi lane (GPTS). This work investigates the coimmobilization of GOD and FcA as a useful approach for enlarging the dynamic range to a Glucose concentration of 360 mg/dl, and for improving linearity and sensitivity of the fabricated Glucose Biosensor. The experimental results indicate that the optimal weight ratio of GOD to FcA is 1: 1. The output signal is associated with the pH of the measurement environment and the optimal pH value is pH 7.5. (C) 2006 Elsevier B.V. All rights reserved.[[note]]SC
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Effects of tin oxide sputtered on a carbon electrode for fabricating Glucose Biosensor
ELECTROCHEMICAL SOC INC, 2020Co-Authors: Tp SunAbstract:[[abstract]]Tin oxide (SnO(2)) thin films are sputtered onto a commercial carbon electrode to develop a SnO(2) electrode. A mediator (ferrocene-carboxylic acid) and an enzyme (Glucose oxidase) are coimmobilized by polyvinylalcohol bearing styrylpyridinium groups on the surface of the carbon and SnO(2) electrodes, to fabricate carbon and SnO(2) amperometric Glucose Biosensors. Following electrode modification, the applied potential is reduced from 452 to 236 mV and the current response increases from 320 to 508 mu A cm(-2) as the carbon and SnO(2) amperometric Glucose Biosensors are immersed in 360 mg/dL Glucose solution. The detection limit of the carbon amperometric Glucose Biosensor is 360 mg/dL under an applied potential of 452 mV. Furthermore, when the applied potential is set to 236 mV, the detection limit of the SnO2 amperometric Glucose Biosensor reaches 600 mg/dL. No significant interference is observed when the applied potential is set at 236 mV. Furthermore, the Glucose concentration determined by the Glucose presence in the serum sample agrees closely with that in the buffer solution. The merits of reducing the applied potential and increasing current response enable a highly accurate SnO2 amperometric Glucose Biosensor based on a low-cost substrate to be developed in this study. (C) 2008 The Electrochemical Society.[[note]]SC
Suresha K. Mahadeva - One of the best experts on this subject based on the ideXlab platform.
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Titanium dioxide-cellulose hybrid nanocomposite based conductometric Glucose Biosensor
Nanosensors Biosensors and Info-Tech Sensors and Systems 2012, 2012Co-Authors: Mohammad Maniruzzaman, Suresha K. Mahadeva, Abu Hasan Khondoker, Jaehwan KimAbstract:This paper investigates the feasibility of conductometric Glucose Biosensor based on Glucose oxidase (GOx) immobilized TiO2-cellulose hybrid nanocomposite. TiO2 nanoparticles were blended with cellulose solution prepared by dissolving cotton pulp with lithium chloride/N, N-dimethylacetamide solvent to fabricate TiO2-cellulose hybrid nanocomposite. The enzyme (GOx) was immobilized into this hybrid material by physical adsorption method. The successful immobilization of GOx into TiO2-cellulose hybrid nanocomposite via covalent bonding between TiO2 and GOx was confirmed by X-ray photoelectron analysis. The linear response of our propose Glucose Biosensor is obtained in the range of 1-10mM with correlation coefficient of 0.93. Our study demonstrates TiO2-cellulose hybrid material as a potential candidate for an inexpensive, flexible and disposable Glucose Biosensor.
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Conductometric Glucose Biosensor made with cellulose and tin oxide hybrid nanocomposite
Sensors and Actuators B-chemical, 2011Co-Authors: Suresha K. MahadevaAbstract:Abstract This paper reports the feasibility study of Glucose oxidase (GOx) immobilized cellulose–tin oxide (SnO2) hybrid nanocomposite as a Glucose Biosensor. Porous SnO2 layer was grown on regenerated cellulose films via liquid phase deposition technique with varying deposition time. Tin oxide was crystallized in the solution and formed nanocrystal coatings on the cellulose films. Enzyme (GOx) was immobilized into cellulose–SnO2 hybrid nanocomposite by physical absorption method. X-ray photoelectron spectroscopy analysis revealed the successful immobilization of GOx into the cellulose–SnO2 hybrid nanocomposite via covalent bonding between GOx and SnO2. The Glucose Biosensor under study is displayed linear response in the range of 0.5–12 mM with correlation coefficient of 0.96, which can cover the clinical region of Glucose concentration. These results indicate that the cellulose–SnO2 hybrid nanocomposite can be an inexpensive, flexible and disposable Glucose Biosensor.