The Experts below are selected from a list of 162 Experts worldwide ranked by ideXlab platform
Yi-chen Chen - One of the best experts on this subject based on the ideXlab platform.
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ameliorative effects of d Glucuronolactone on oxidative stress and inflammatory fibrogenic responses in livers of thioacetamide treated rats
Journal of Functional Foods, 2015Co-Authors: Po-ju Chen, Chih-hsien Chiu, Jung-kai Tseng, Kou-tai Yang, Yi-chen ChenAbstract:D-Glucuronolactone (C6H8O6, lactone), naturally found in plant gums, is commercially acclaimed for its hepatoprotective effects. This study was to investigate whether lactone can attenuate thioacetamide (TAA)-induced liver fibrosis in a rat model. Results showed that lactone supplementation (75 mg kg−1 bw Glucuronolactone) alleviated AST values in TAA-intraperitoneally-injected rats (100 mg kg−1 bw TAA) and increased antioxidant capacity of liver via elevations of antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GPx)], glutathione (GSH) and trolox equivalent antioxidative capacity (TEAC) levels (p < 0.05). Down-regulated (p < 0.05) expression of inflammation including interleukin-6 (IL-6), nuclear factor-kappa B (NF-κB), activator protein 1 (AP-1), kruppel-like factor 6 (KLF-6), and fibrosis related fibrotic factors, i.e., alpha smooth muscle actin (α-SMA), and collagen alpha1 (I) (COLα1) through lactone supplementation underlay the lower collagen contents and less severe liver damage on histopathology observations. Therefore, hepatoprotection of lactone against TAA-induced liver fibrosis can be attributed to the amelioration of oxidative stress and inflammation.
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Ameliorative effects of D-Glucuronolactone on oxidative stress and inflammatory/fibrogenic responses in livers of thioacetamide-treated rats
Journal of Functional Foods, 2015Co-Authors: Po-ju Chen, Chih-hsien Chiu, Jung-kai Tseng, Kou-tai Yang, Yi-chen ChenAbstract:D-Glucuronolactone (C6H8O6, lactone), naturally found in plant gums, is commercially acclaimed for its hepatoprotective effects. This study was to investigate whether lactone can attenuate thioacetamide (TAA)-induced liver fibrosis in a rat model. Results showed that lactone supplementation (75 mg kg−1 bw Glucuronolactone) alleviated AST values in TAA-intraperitoneally-injected rats (100 mg kg−1 bw TAA) and increased antioxidant capacity of liver via elevations of antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GPx)], glutathione (GSH) and trolox equivalent antioxidative capacity (TEAC) levels (p
Hidemi Yoda - One of the best experts on this subject based on the ideXlab platform.
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First total synthesis and absolute stereochemical assignment of vittarilide-A, an antioxidant extractive component isolated from Vittaria anguste-elongata Hayata
Tetrahedron, 2012Co-Authors: Masaki Takahashi, Yusuke Murata, Yuki Hakamata, Kohei Suzuki, Tetsuya Sengoku, Hidemi YodaAbstract:The first stereocontrolled synthesis of vittarilide-A and its C5-epimer was completed from d-Glucuronolactone. Comparison with the spectroscopic properties reported for authentic material has given a clear indication as to the absolute stereochemistry of the natural vittarilide-A.
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Stereodivergent synthesis of new amino sugars, furanodictines A and B, starting from d-Glucuronolactone
Tetrahedron, 2008Co-Authors: Daisuke Matsuura, Masaki Takahashi, Tetsuya Sengoku, Takeshi Mitsui, Hidemi YodaAbstract:Abstract An efficient and divergent strategy for the total synthesis of the first 3,6-dihydroaminosugars, furanodictines A (2-acetamido-3,6-anhydro-2-deoxy-5-O-isovaleryl- d -glucofuranose) and B (2-acetamido-3,6-anhydro-2-deoxy-5-O-isovaleryl- d -mannofuranose), has been developed. The synthetic process is featured by readily accessible and stereodefined manipulation of highly functionalized bicyclic tetrahydrofuran derivatives incorporating the Glucuronolactone (common starting material)-derived skeleton.
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Novel and stereocontrolled asymmetric synthesis of a new naturally occurring styryllactone, (+)-cardiobutanolide
Tetrahedron Letters, 2006Co-Authors: Daisuke Matsuura, Kunihiko Takabe, Hidemi YodaAbstract:An efficient and stereodefined strategy is described for the asymmetric synthesis of a new styryllactone from the stem bark of Goniothalamus cardiopetalus, cardiobutanolide. The synthetic process is based on requisite manipulation of the functionalized bicyclic lactol–lactone intermediate incorporating the Glucuronolactone-derived skeleton in a complete stereoselective manner.
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An Efficient and Straightforward Synthetic Process to an Amino Sugar Analogue, Furanodictine B
Synlett, 2005Co-Authors: Daisuke Matsuura, Kunihiko Takabe, Tomoko Nojiri, Yuji Suzuki, Hidemi YodaAbstract:A convenient and practical strategy for the construction of a natural amino sugar analogue, furanodictine B, isolated from the multicellular fruit body has been developed in an optically active form. The synthetic process is based on readily accessible and stereodefined manipulation of the highly functionalized bicyclic derivative incorporating the Glucuronolactone-derived skeleton.
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First Practical Asymmetric Synthesis of a New TetrasubstitutedTetrahydrofuran, (-)-Goniothalesdiol
Synlett, 2002Co-Authors: Hidemi Yoda, Yuka Nakaseko, Kunihiko TakabeAbstract:An efficient and practical strategy has been developed for the construction of the antipode of 3,4-dihydroxy-2,5-disubstituted tetrahydrofuran, goniothalesdiol, isolated from the bark of the Malaysian tree. The synthetic process is based on the convenient manipulation via Lewis acid-induced deoxygenation of the highly functionalized lactone derived from d-Glucuronolactone.
Po-ju Chen - One of the best experts on this subject based on the ideXlab platform.
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ameliorative effects of d Glucuronolactone on oxidative stress and inflammatory fibrogenic responses in livers of thioacetamide treated rats
Journal of Functional Foods, 2015Co-Authors: Po-ju Chen, Chih-hsien Chiu, Jung-kai Tseng, Kou-tai Yang, Yi-chen ChenAbstract:D-Glucuronolactone (C6H8O6, lactone), naturally found in plant gums, is commercially acclaimed for its hepatoprotective effects. This study was to investigate whether lactone can attenuate thioacetamide (TAA)-induced liver fibrosis in a rat model. Results showed that lactone supplementation (75 mg kg−1 bw Glucuronolactone) alleviated AST values in TAA-intraperitoneally-injected rats (100 mg kg−1 bw TAA) and increased antioxidant capacity of liver via elevations of antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GPx)], glutathione (GSH) and trolox equivalent antioxidative capacity (TEAC) levels (p < 0.05). Down-regulated (p < 0.05) expression of inflammation including interleukin-6 (IL-6), nuclear factor-kappa B (NF-κB), activator protein 1 (AP-1), kruppel-like factor 6 (KLF-6), and fibrosis related fibrotic factors, i.e., alpha smooth muscle actin (α-SMA), and collagen alpha1 (I) (COLα1) through lactone supplementation underlay the lower collagen contents and less severe liver damage on histopathology observations. Therefore, hepatoprotection of lactone against TAA-induced liver fibrosis can be attributed to the amelioration of oxidative stress and inflammation.
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Ameliorative effects of D-Glucuronolactone on oxidative stress and inflammatory/fibrogenic responses in livers of thioacetamide-treated rats
Journal of Functional Foods, 2015Co-Authors: Po-ju Chen, Chih-hsien Chiu, Jung-kai Tseng, Kou-tai Yang, Yi-chen ChenAbstract:D-Glucuronolactone (C6H8O6, lactone), naturally found in plant gums, is commercially acclaimed for its hepatoprotective effects. This study was to investigate whether lactone can attenuate thioacetamide (TAA)-induced liver fibrosis in a rat model. Results showed that lactone supplementation (75 mg kg−1 bw Glucuronolactone) alleviated AST values in TAA-intraperitoneally-injected rats (100 mg kg−1 bw TAA) and increased antioxidant capacity of liver via elevations of antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GPx)], glutathione (GSH) and trolox equivalent antioxidative capacity (TEAC) levels (p
George W. J. Fleet - One of the best experts on this subject based on the ideXlab platform.
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(1R,2R,3S,6aS,7R,8R,9S,12aS)-1,2,3,7,8,9-Hexahydroxyperhydrodipyrido[1,2-a:1′,2′-d]pyrazine-6,12-dione
Acta Crystallographica Section E Structure Reports Online, 2010Co-Authors: Sarah F. Jenkinson, Daniel Best, George W. J. Fleet, Francis Wilson, David J. WatkinAbstract:The crystal structure of the title compound, C12H18N2O8, exists as O—H⋯O hydrogen-bonded layers of molecules running parallel to the ab plane. Each molecule is a donor and acceptor for six hydrogen bonds. The absolute stereochemistry was determined by the use of d-Glucuronolactone as the starting material.
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Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-Glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-Glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases wher
Tetrahedron: Asymmetry, 2010Co-Authors: Daniel Best, Alexander C. Weymouth-wilson, Robert Clarkson, Chen Wang, Francis Wilson, Robert J. Nash, Saori Miyauchi, Atsushi Kato, George W. J. FleetAbstract:Abstract A convenient large-scale synthesis of 1-deoxynojirimyin (DNJ) from d -Glucuronolactone involves introduction of azide at C-5 with retention of configuration to give 5-azido-5-deoxy-1,2- O -isopropylidene-α- d -glucofuranose as a key intermediate in an overall yield of up to 72%; the same intermediate can be transformed into DMDP [(2 R, 3 R, 4 R, 5 R )-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol] and (3 R )-3-hydroxy- l -bulgecinine [(2 S, 3 R, 4 R, 5 R )-3,4-dihydroxy-5-hydroxymethyl- l -proline]. l -Glucuronolactone, a readily available l -sugar chiron, may similarly be used to access the enantiomers l -DNJ, l -DMDP, and (3 S )-3-hydroxy- d -bulgecinine. A comparison of glycosidase inhibition by DMDP (an inhibitor of β-glucosidases and β-galactosidases) and l -DMDP (a potent and specific α-glucosidase inhibitor) with the corresponding enantiomeric hydroxybulgecinines is reported; DMDP and (3 R )-3-hydroxy- l -bulgecinine show weak inhibition of glycogen phosphorylase.
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(1R,2R,3S,6aS,7R,8R,9S,12aS)-1,2,3,7,8,9-Hexahydroxyperhydrodipyrido[1,2-a:1′,2′-d]pyrazine-6,12-dione
International Union of Crystallography, 2010Co-Authors: Sarah F. Jenkinson, Daniel Best, George W. J. Fleet, Fx Wilson, David J. WatkinAbstract:The crystal structure of the title compound, C12H18N2O8, exists as O—H...O hydrogen-bonded layers of molecules running parallel to the ab plane. Each molecule is a donor and acceptor for six hydrogen bonds. The absolute stereochemistry was determined by the use of d-Glucuronolactone as the starting material
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(2S,3R,4R,5R)-3,4-Dihydr-oxy-5-(hydroxy-meth-yl)pyrrolidine-2-carboxylic acid [(2S,3R,4R,5R)-3,4-dihydr-oxy-5-(hydroxy-meth-yl)proline].
Acta Crystallographica Section E Structure Reports Online, 2009Co-Authors: Daniel Best, Sarah F. Jenkinson, David J. Watkin, Francis Wilson, Robert J. Nash, Amber L. Thompson, George W. J. FleetAbstract:The crystal structure of the title compound, C6H11NO5, establishes the relative configuration at the four stereogenic centres; the absolute configuration is determined by the use of d-Glucuronolactone as the starting material for the synthesis. Molecules are linked by intermolecular O—H⋯O and N—H⋯O hydrogen bonds into a three-dimensional network, with each molecule acting as a donor and acceptor for five hydrogen bonds.
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(1S)-1,2-O-Benzyl-idene-α-d-glucurono-6,3-lactone.
Acta Crystallographica Section E Structure Reports Online, 2009Co-Authors: Sarah F. Jenkinson, Daniel Best, Alexander C. Weymouth-wilson, Robert Clarkson, George W. J. Fleet, David J. WatkinAbstract:X-ray crystallographic analysis has established that the major product from the protection of d-glucoronolactone with benzaldehyde is (1S)-1,2-O-benzylidene-α-d-glucurono-6,3-lactone, C13H12O6, rather than the R epimer. The crystal structure exists as O—H⋯O hydrogen-bonded chains of molecules lying parallel to the a axis. The absolute configuration was determined by the use of d-Glucuronolactone as the starting material.
Kou-tai Yang - One of the best experts on this subject based on the ideXlab platform.
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ameliorative effects of d Glucuronolactone on oxidative stress and inflammatory fibrogenic responses in livers of thioacetamide treated rats
Journal of Functional Foods, 2015Co-Authors: Po-ju Chen, Chih-hsien Chiu, Jung-kai Tseng, Kou-tai Yang, Yi-chen ChenAbstract:D-Glucuronolactone (C6H8O6, lactone), naturally found in plant gums, is commercially acclaimed for its hepatoprotective effects. This study was to investigate whether lactone can attenuate thioacetamide (TAA)-induced liver fibrosis in a rat model. Results showed that lactone supplementation (75 mg kg−1 bw Glucuronolactone) alleviated AST values in TAA-intraperitoneally-injected rats (100 mg kg−1 bw TAA) and increased antioxidant capacity of liver via elevations of antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GPx)], glutathione (GSH) and trolox equivalent antioxidative capacity (TEAC) levels (p < 0.05). Down-regulated (p < 0.05) expression of inflammation including interleukin-6 (IL-6), nuclear factor-kappa B (NF-κB), activator protein 1 (AP-1), kruppel-like factor 6 (KLF-6), and fibrosis related fibrotic factors, i.e., alpha smooth muscle actin (α-SMA), and collagen alpha1 (I) (COLα1) through lactone supplementation underlay the lower collagen contents and less severe liver damage on histopathology observations. Therefore, hepatoprotection of lactone against TAA-induced liver fibrosis can be attributed to the amelioration of oxidative stress and inflammation.
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Ameliorative effects of D-Glucuronolactone on oxidative stress and inflammatory/fibrogenic responses in livers of thioacetamide-treated rats
Journal of Functional Foods, 2015Co-Authors: Po-ju Chen, Chih-hsien Chiu, Jung-kai Tseng, Kou-tai Yang, Yi-chen ChenAbstract:D-Glucuronolactone (C6H8O6, lactone), naturally found in plant gums, is commercially acclaimed for its hepatoprotective effects. This study was to investigate whether lactone can attenuate thioacetamide (TAA)-induced liver fibrosis in a rat model. Results showed that lactone supplementation (75 mg kg−1 bw Glucuronolactone) alleviated AST values in TAA-intraperitoneally-injected rats (100 mg kg−1 bw TAA) and increased antioxidant capacity of liver via elevations of antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GPx)], glutathione (GSH) and trolox equivalent antioxidative capacity (TEAC) levels (p