The Experts below are selected from a list of 122409 Experts worldwide ranked by ideXlab platform
Christopher Yheulon - One of the best experts on this subject based on the ideXlab platform.
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Fibrin versus cyanoacrylate Glue for fixation in laparoscopic inguinal hernia repair: a network meta-analysis and indirect comparison
Hernia, 2019Co-Authors: Kelli Tavares, John Mayo, Kenneth Bogenberger, S. Scott Davis, Christopher YheulonAbstract:Introduction Evidence has demonstrated that biosynthetic Glue for laparoscopic inguinal hernia repair results in decreased pain. However, the two Glue sub-types (biologic—fibrin based; synthetic—cyanoacrylate based) have never been compared. This study aims to assess the outcomes of those subtypes. Method and procedures A systematic review of the MEDLINE database was undertaken. Randomized trials assessing the outcomes of laparoscopic inguinal hernia repair with penetrating and Glue fixation methods were considered for inclusion and data analysis. Thirteen trials involving 1947 laparoscopic inguinal hernia repairs were identified with eight trials utilizing fibrin and five trials utilizing cyanoacrylate. Results There were no differences in recurrence or wound infection between the Glue subtypes when compared individually to penetrating fixation alone or indirectly to each other. There were non-significant trends in reduction of hematoma and seroma for both Glue subtypes when compared to penetrating fixation (OR 0.73, 95% CI 0.39–1.40). There was a significant reduction in urinary retention with Glue fixation (pooled results of both sub-types) when compared to penetrating fixation (OR 0.33, 95% CI 0.13–0.83). Conclusions Glue fixation in laparoscopic inguinal hernia repair reduces the incidence of urinary retention and may reduce the rate of hematoma or seroma formation. As there are no differences in outcomes when comparing fibrin or cyanoacrylate Glue, surgeons should choose the Glue that is available at the lowest cost at their respective institutions.
Kelli Tavares - One of the best experts on this subject based on the ideXlab platform.
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Fibrin versus cyanoacrylate Glue for fixation in laparoscopic inguinal hernia repair: a network meta-analysis and indirect comparison
Hernia, 2019Co-Authors: Kelli Tavares, John Mayo, Kenneth Bogenberger, S. Scott Davis, Christopher YheulonAbstract:Introduction Evidence has demonstrated that biosynthetic Glue for laparoscopic inguinal hernia repair results in decreased pain. However, the two Glue sub-types (biologic—fibrin based; synthetic—cyanoacrylate based) have never been compared. This study aims to assess the outcomes of those subtypes. Method and procedures A systematic review of the MEDLINE database was undertaken. Randomized trials assessing the outcomes of laparoscopic inguinal hernia repair with penetrating and Glue fixation methods were considered for inclusion and data analysis. Thirteen trials involving 1947 laparoscopic inguinal hernia repairs were identified with eight trials utilizing fibrin and five trials utilizing cyanoacrylate. Results There were no differences in recurrence or wound infection between the Glue subtypes when compared individually to penetrating fixation alone or indirectly to each other. There were non-significant trends in reduction of hematoma and seroma for both Glue subtypes when compared to penetrating fixation (OR 0.73, 95% CI 0.39–1.40). There was a significant reduction in urinary retention with Glue fixation (pooled results of both sub-types) when compared to penetrating fixation (OR 0.33, 95% CI 0.13–0.83). Conclusions Glue fixation in laparoscopic inguinal hernia repair reduces the incidence of urinary retention and may reduce the rate of hematoma or seroma formation. As there are no differences in outcomes when comparing fibrin or cyanoacrylate Glue, surgeons should choose the Glue that is available at the lowest cost at their respective institutions.
M Weber - One of the best experts on this subject based on the ideXlab platform.
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Efficiency and safety of mesh fixation in laparoscopic inguinal hernia repair using n-butyl cyanoacrylate: Long-term biocompatibility in over 1, 300 mesh fixations
Hernia, 2012Co-Authors: J. F. Kukleta, Claudia Freytag, M WeberAbstract:INTRODUCTION: In adult patients, most inguinal hernias are treated by implanting a prosthetic mesh. To prevent mesh dislocation and thus recurrence, different types of fixation have been proposed. In contrast to penetrating fixation known to cause acute chronic pain, adhesive fixation is becoming increasingly popular as it reduces markedly the risk of injury and chronic pain. Apart from the biological sealants (e.g., fibrin Glue), surgical adhesives include a group of synthetic Glues and genetically engineered protein Glues. For example, cyanoacrylate is used in various medical and veterinary indications due to its fast action, excellent bonding strength and low price.\n\nOBJECTIVE: The main objective of this paper was to communicate positive results obtained using n-butyl-cyanoacrylate Glue to fix prosthetic meshes in over 1,300 TAPP repairs of primary and recurrent inguinal hernias. The secondary objective was to highlight the rationale (e.g., safety) for using non-fibrin based Glue in this type of procedure.\n\nMETHOD: We present the in vitro and in vivo data necessary for the approval of n-butyl cyanoacrylate Histoacryl(®) Glue. We use an equivalent Glue, Glubran-2(®), to fix prosthetic meshes in 1,336 laparoscopic TAPP repairs.\n\nRESULTS: Standardized tests to detect sensitization, irritation, genotoxicity or systemic toxicity demonstrated the safety and biocompatibility of Histoacryl(®), which met all requirements, including those of ISO 10993. Histological long-term studies in rabbits yielded results comparable to routine suture fixations, with full integration of the mesh into the abdominal wall. The clinical results showed the following advantages: fast application of the Glue, reduced postoperative pain, 0.0% infection rate, continuously low recurrence rate and shorter hospital stay. No adverse effects and no complaints were recorded.\n\nCONCLUSION: The experimental and clinical data demonstrate the safe use and the excellent cost-benefit ratio of n-butyl cyanoacrylate compared with other techniques of mesh fixation.
John Mayo - One of the best experts on this subject based on the ideXlab platform.
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Fibrin versus cyanoacrylate Glue for fixation in laparoscopic inguinal hernia repair: a network meta-analysis and indirect comparison
Hernia, 2019Co-Authors: Kelli Tavares, John Mayo, Kenneth Bogenberger, S. Scott Davis, Christopher YheulonAbstract:Introduction Evidence has demonstrated that biosynthetic Glue for laparoscopic inguinal hernia repair results in decreased pain. However, the two Glue sub-types (biologic—fibrin based; synthetic—cyanoacrylate based) have never been compared. This study aims to assess the outcomes of those subtypes. Method and procedures A systematic review of the MEDLINE database was undertaken. Randomized trials assessing the outcomes of laparoscopic inguinal hernia repair with penetrating and Glue fixation methods were considered for inclusion and data analysis. Thirteen trials involving 1947 laparoscopic inguinal hernia repairs were identified with eight trials utilizing fibrin and five trials utilizing cyanoacrylate. Results There were no differences in recurrence or wound infection between the Glue subtypes when compared individually to penetrating fixation alone or indirectly to each other. There were non-significant trends in reduction of hematoma and seroma for both Glue subtypes when compared to penetrating fixation (OR 0.73, 95% CI 0.39–1.40). There was a significant reduction in urinary retention with Glue fixation (pooled results of both sub-types) when compared to penetrating fixation (OR 0.33, 95% CI 0.13–0.83). Conclusions Glue fixation in laparoscopic inguinal hernia repair reduces the incidence of urinary retention and may reduce the rate of hematoma or seroma formation. As there are no differences in outcomes when comparing fibrin or cyanoacrylate Glue, surgeons should choose the Glue that is available at the lowest cost at their respective institutions.
Kenneth Bogenberger - One of the best experts on this subject based on the ideXlab platform.
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Fibrin versus cyanoacrylate Glue for fixation in laparoscopic inguinal hernia repair: a network meta-analysis and indirect comparison
Hernia, 2019Co-Authors: Kelli Tavares, John Mayo, Kenneth Bogenberger, S. Scott Davis, Christopher YheulonAbstract:Introduction Evidence has demonstrated that biosynthetic Glue for laparoscopic inguinal hernia repair results in decreased pain. However, the two Glue sub-types (biologic—fibrin based; synthetic—cyanoacrylate based) have never been compared. This study aims to assess the outcomes of those subtypes. Method and procedures A systematic review of the MEDLINE database was undertaken. Randomized trials assessing the outcomes of laparoscopic inguinal hernia repair with penetrating and Glue fixation methods were considered for inclusion and data analysis. Thirteen trials involving 1947 laparoscopic inguinal hernia repairs were identified with eight trials utilizing fibrin and five trials utilizing cyanoacrylate. Results There were no differences in recurrence or wound infection between the Glue subtypes when compared individually to penetrating fixation alone or indirectly to each other. There were non-significant trends in reduction of hematoma and seroma for both Glue subtypes when compared to penetrating fixation (OR 0.73, 95% CI 0.39–1.40). There was a significant reduction in urinary retention with Glue fixation (pooled results of both sub-types) when compared to penetrating fixation (OR 0.33, 95% CI 0.13–0.83). Conclusions Glue fixation in laparoscopic inguinal hernia repair reduces the incidence of urinary retention and may reduce the rate of hematoma or seroma formation. As there are no differences in outcomes when comparing fibrin or cyanoacrylate Glue, surgeons should choose the Glue that is available at the lowest cost at their respective institutions.
