The Experts below are selected from a list of 3015 Experts worldwide ranked by ideXlab platform
Weiping Luo - One of the best experts on this subject based on the ideXlab platform.
-
measurement and correlation for solubilities of succinic Acid and Glutaric Acid in e caprolactone acetic Acid mixtures and e caprolactone cyclohexanone mixtures
Journal of Chemical & Engineering Data, 2018Co-Authors: Weiping Luo, Dong Ruan, Kaili Xie, Bao Tao, Cancheng GuoAbstract:By using the method of dynamic laser, the solubilities of succinic Acid and Glutaric Acid in e-caprolactone + acetic Acid mixtures and e-caprolactone + cyclohexanone mixtures were determined under atmospheric pressure. The experimental temperature ranged from 293.35 to 340.65 K, and the mass fraction of e-caprolactone in the solvent mixtures ranged from 0.0 to 1.0, respectively. It was found that with the increase of the temperature at constant concentration, the measured solubilities of succinic Acid and Glutaric Acid in e-caprolactone + acetic Acid mixtures and e-caprolactone + cyclohexanone mixtures would increase. Moreover, when the mass fraction of e-caprolactone in e-caprolactone + acetic Acid mixtures increases at the same temperature, the measured solubilities of succinic Acid and Glutaric Acid would decrease. However, it would increase as the mass fraction of e-caprolactone increases for the system of e-caprolactone + cyclohexanone at the same temperature. The experimental data were correlated by...
-
measurement and correlation for the solubility of adipic Acid and succinic Acid in Glutaric Acid cyclohexanone and Glutaric Acid acetic Acid mixtures
Journal of Chemical & Engineering Data, 2017Co-Authors: Xiangji Liao, Yujun Han, Jun Song, Yingjie Gao, Ao Yang, Yan Zhu, Weiping LuoAbstract:In this work, the solubilities of adipic Acid and succinic Acid in Glutaric Acid + cyclohexanone and Glutaric Acid + acetic Acid mixtures were measured respectively by using the laser dynamic method under atmospheric pressure, in which the temperature ranged from 296.15 to 340.85 K and the mass fraction of Glutaric Acid in the binary solvent mixtures ranged from 0.00 to 0.30. The effects of Glutaric Acid on solubility of adipic Acid and succinic Acid have been discussed. It is found that the effects of Glutaric Acid on the solubility of adipic Acid and succinic Acid were negative and that with the increasing mass fraction of Glutaric Acid in the mixtures the solubilities of adipic Acid and succinic Acid would decrease. With the gradual increase of temperature, the measured solubility of adipic Acid and succinic Acid in Glutaric Acid + cyclohexanone and Glutaric Acid + acetic Acid mixtures would increase at the constant proportion of solvent mixtures. Then the experimental data were well-correlated by the ...
-
measurement and correlation for solubilities of adipic Acid Glutaric Acid and succinic Acid in dimethyl adipate methanol mixtures
Journal of Chemical & Engineering Data, 2017Co-Authors: Weiping Luo, Dawei Liu, Kaili Xie, Wei Deng, Qiang Liu, Bao Tao, Jing Hao, Cancheng GuoAbstract:The solubilities of adipic Acid, Glutaric Acid, and succinic Acid in dimethyl adipate + methanol solvent mixtures were measured by the method of dynamic laser under 101.3 kPa. The mass fraction of dimethyl adipate in the solvent mixtures ranged from 0.0 to 1.0, and the temperature ranged from 283.95 to 328.15 K. It was found that with the increase of mass fraction for dimethyl adipate in mixed solvents, the measured solubilities of adipic Acid, Glutaric Acid, and succinic Acid would decrease at the same temperature, and with the gradually increase of temperature the measured solubilities of adipic Acid, Glutaric Acid, and succinic Acid would increase at the constant proportion solvent mixtures. The experimental data were correlated by the Apelblat model, λh model, and the modified nonrandom two liquid activity coefficient model. Results showed that the largest values of relative average deviation and root-mean-square deviations obtained by the three models were 4.49% and 0.35%, respectively. The three mod...
-
measurement and correlation for solubilities of adipic Acid Glutaric Acid and succinic Acid in acetic Acid cyclohexanone mixtures
Journal of Chemical & Engineering Data, 2017Co-Authors: Weiping Luo, Dong Ruan, Dawei Liu, Kaili Xie, Jing Wang, Wei Deng, Qiang Liu, Zhaoke ChenAbstract:Under atmospheric pressure, the solubilities of adipic Acid, Glutaric Acid, and succinic Acid in acetic Acid + cyclohexanone mixtures were measured respectively by using the laser dynamic method in which the temperature ranged from 298.55 to 340.85 K and the mass fraction of cyclohexanone in the binary solvent mixtures ranged from 0.0 to 1.0. The results showed that the solubilities of adipic Acid, Glutaric Acid, and succinic Acid in acetic Acid + cyclohexanone solvent mixtures all increased with decreasing of the mass fraction of cyclohexanone in the solvent mixtures at the constant temperature, and with the gradually increasing of temperature the measured solubilities of adipic Acid, Glutaric Acid and succinic Acid in acetic Acid + cyclohexanone solvent mixtures would increase at the constant proportion solvent mixtures. The λh equation and the nonrandom two liquid (NRTL) activity coefficient model were used to correlate the experimental solubilities, and the average relative deviation was lesser than 2...
Xunqiu Wang - One of the best experts on this subject based on the ideXlab platform.
-
Effects of succinic Acid and adipic Acid on the metastable width of Glutaric Acid in acetic Acid
Journal of Crystal Growth, 2019Co-Authors: Yulan Huang, Weiwei Du, Honglin Chen, Jingjing Lu, Xunqiu WangAbstract:Abstract The influence of impurities on the solubility and metastable zone width (MSZW) of Glutaric Acid in acetic Acid solution was studied. At T = (300.15–340.15) K, the presence of impurity succinic Acid or adipic Acid increases the solubility of Glutaric Acid in acetic Acid solution, and the solubility increases with increasing mass fraction of impurities. In the study of the effects of saturation temperature, cooling rate, and impurities on MSZW, it was found that the MSZW widened with increasing cooling rate, but it narrowed with increasing saturation temperature and the mass fraction of impurities. The MSZW data was analyzed by using the self-consistent Nyvlt-like approach and the classical 3D nucleation theory-based approach to determine the nucleation kinetic parameters. The results show the increases of saturation temperature and the mass fraction of impurities significantly reduce the nucleation order m and the solid-liquid interfacial energy γ.
-
determination and correlation of solubilities for succinic Acid in the adipic Acid Glutaric Acid acetone mixture and adipic Acid in the succinic Acid Glutaric Acid acetone mixture
Journal of Chemical & Engineering Data, 2016Co-Authors: Fei Wang, Zhuoyuan Ning, Chunhua Jiang, Xunqiu WangAbstract:To provide fundamental thermodynamic data for the crystallization separation of succinic Acid and adipic Acid from mixed dibasic Acid, the solubilities of succinic Acid in various mass fractions of the adipic Acid + Glutaric Acid + acetone mixture and adipic Acid in various mass fractions of the succinic Acid + Glutaric Acid + acetone mixture were measured by the dynamic method at a temperature range of 277.85–327.95 K under atmospheric pressure. The results showed that the solubility of succinic Acid in acetone increased with increasing mass fraction of adipic Acid and Glutaric Acid in the mixed solvent at the same temperature. Similarly, the solubility of adipic Acid in acetone increased with increasing mass fraction of succinic Acid and Glutaric Acid in the mixed solvent at the same temperature. The ideal solution equation, Apelblat equation, λh equation, and nonrandom two-liquid (NRTL) equation were applied to correlate the experimental solubility data, which were all in good agreement with the four e...
-
solubilities of adipic Acid and succinic Acid in a Glutaric Acid acetone or n butanol mixture
Journal of Chemical & Engineering Data, 2014Co-Authors: Yatao Wang, Zhuoyuan Ning, Jianfang Cui, Xunqiu WangAbstract:In order to provide thermodynamic data for mixed dibasic Acid separation technology, the solubilities of adipic Acid (AA) and succinic Acid (SA) in Glutaric Acid (GA) + acetone mixture and GA + n-butanol mixture were measured by dynamic method at atmospheric pressure. The mass fraction of GA (wGA) ranged from (0 to 30.11) %. The results show that solubilities of AA and SA in acetone or n-butanol increased with increasing mass fraction of GA in the mixed solvent GA and acetone (or n-butanol) at the same temperature. The ideal solution equation, Apelblat equation, and λh equation were applied to correlation of the experimental solubility data, which were all in good agreement with the three equations. The Apelblat equation is regarded as the best one of the three equations for describing the dissolving of two Acids in solvent at the same time.
Reginald B. H. Tan - One of the best experts on this subject based on the ideXlab platform.
-
thermal and in situ x ray diffraction analysis of a dimorphic co crystal 1 1 caffeine Glutaric Acid
Crystal Growth & Design, 2016Co-Authors: Venu R Vangala, Pui Shan Chow, Reginald B. H. Tan, Grace Lau, Martin SchreyerAbstract:Spurred by the enormous interest in co-crystals from the pharmaceutical industry, many novel co-crystals of active pharmaceutical ingredients have been discovered in recent years, and this has in turn led to an increasing number of reports on polymorphs of co-crystals. Hence, a thorough characterization and understanding of co-crystal polymorphs is a valuable step during drug development. The purpose of this study is to perform in situ structural analysis and to determine thermodynamic stability of a dimorphic co-crystal system, 1:1 caffeine–Glutaric Acid (CA–GA, Forms I and II). We performed thermal and structural characterizations by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), hot-stage microscopy (HSM), and slurry and in situ variable temperature X-ray diffraction (VTXRD). For completeness, we have also redetermined crystal structures of CA–GA Forms I and II at 180 K using single crystal X-ray diffraction. Our results revealed that Form II is stable and Form I is metastab...
-
Supersaturation Control in Cooling Polymorphic Co-Crystallization of Caffeine and Glutaric Acid
Crystal Growth & Design, 2011Co-Authors: Pui Shan Chow, Reginald B. H. Tan, Wei Han AngAbstract:A model polymorphic co-crystallization process for caffeine-Glutaric Acid from acetonitrile was monitored and controlled using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and particle vision measurement (PVM). A new method to calculate supersaturation for co-crystallization systems was proposed and used in this study. Results showed that feedback control of supersaturation was effective in eliminating the nucleation of the metastable Form I of co-crystal and also produced the largest particles with the lowest proportion of fines.
-
operating regions in cooling cocrystallization of caffeine and Glutaric Acid in acetonitrile
Crystal Growth & Design, 2010Co-Authors: Pui Shan Chow, Reginald B. H. TanAbstract:A complete temperature-dependent solute−solute−solvent phase diagram is an essential starting point for cooling cocrystallization process development. In this study, the phase diagram of caffeine−Glutaric Acid−acetonitrile in the temperature range of 10−35 °C was charted using attenuated total reflectance−Fourier transform infrared (ATR-FTIR) spectroscopy to measure concentrations in situ. Solution-mediated phase transformation was exploited to locate the eutectic points. The operating region was then prescribed according to the stoichiometry of the cocrystal, and the boundary of stability zones at the initial and final temperatures of cooling crystallization. It was demonstrated that cocrystal purity could be compromised when crystallization occurs outside the safe operating region. The complete phase diagram has laid the foundation for further cocrystallization process development of the model system.
Cancheng Guo - One of the best experts on this subject based on the ideXlab platform.
-
measurement and correlation for solubilities of succinic Acid and Glutaric Acid in e caprolactone acetic Acid mixtures and e caprolactone cyclohexanone mixtures
Journal of Chemical & Engineering Data, 2018Co-Authors: Weiping Luo, Dong Ruan, Kaili Xie, Bao Tao, Cancheng GuoAbstract:By using the method of dynamic laser, the solubilities of succinic Acid and Glutaric Acid in e-caprolactone + acetic Acid mixtures and e-caprolactone + cyclohexanone mixtures were determined under atmospheric pressure. The experimental temperature ranged from 293.35 to 340.65 K, and the mass fraction of e-caprolactone in the solvent mixtures ranged from 0.0 to 1.0, respectively. It was found that with the increase of the temperature at constant concentration, the measured solubilities of succinic Acid and Glutaric Acid in e-caprolactone + acetic Acid mixtures and e-caprolactone + cyclohexanone mixtures would increase. Moreover, when the mass fraction of e-caprolactone in e-caprolactone + acetic Acid mixtures increases at the same temperature, the measured solubilities of succinic Acid and Glutaric Acid would decrease. However, it would increase as the mass fraction of e-caprolactone increases for the system of e-caprolactone + cyclohexanone at the same temperature. The experimental data were correlated by...
-
measurement and correlation for solubilities of adipic Acid Glutaric Acid and succinic Acid in dimethyl adipate methanol mixtures
Journal of Chemical & Engineering Data, 2017Co-Authors: Weiping Luo, Dawei Liu, Kaili Xie, Wei Deng, Qiang Liu, Bao Tao, Jing Hao, Cancheng GuoAbstract:The solubilities of adipic Acid, Glutaric Acid, and succinic Acid in dimethyl adipate + methanol solvent mixtures were measured by the method of dynamic laser under 101.3 kPa. The mass fraction of dimethyl adipate in the solvent mixtures ranged from 0.0 to 1.0, and the temperature ranged from 283.95 to 328.15 K. It was found that with the increase of mass fraction for dimethyl adipate in mixed solvents, the measured solubilities of adipic Acid, Glutaric Acid, and succinic Acid would decrease at the same temperature, and with the gradually increase of temperature the measured solubilities of adipic Acid, Glutaric Acid, and succinic Acid would increase at the constant proportion solvent mixtures. The experimental data were correlated by the Apelblat model, λh model, and the modified nonrandom two liquid activity coefficient model. Results showed that the largest values of relative average deviation and root-mean-square deviations obtained by the three models were 4.49% and 0.35%, respectively. The three mod...
Hongkun Zhao - One of the best experts on this subject based on the ideXlab platform.
-
determination and correlation of solid liquid phase equilibrium and phase diagram for multicomponent system of mixed dibasic Acids iv quaternary system of adipic Acid succinic Acid Glutaric Acid ethanol
The Journal of Chemical Thermodynamics, 2017Co-Authors: Mingju Wang, Yang Cong, Hongkun ZhaoAbstract:Abstract Solid-liquid phase equilibrium and solubility for the quaternary system of (adipic Acid + succinic Acid + Glutaric Acid + ethanol) at (283.15, 303.15, and 313.15) K were determined by using an isothermal saturation method under atmosphere pressure (101.2 kPa). Based on the determined mutual solubility, the quaternary phase diagrams were constructed at the studied temperatures according to the Janeck method. At each temperature, the quaternary phase diagram included three crystallization regions of pure solid, three co-saturated curves and one eutectic point. The three pure solids corresponded to pure adipic Acid, pure succinic Acid and pure Glutaric Acid, which were confirmed by Schreinemaker’s method of wet residue and X-ray powder diffraction. At the same temperature, the crystallization regions of succinic Acid and adipic Acid are larger than that of Glutaric Acid. Furthermore, the quaternary solid-liquid phase equilibrium was calculated by using the Wilson and NRTL models. The calculated quaternary phase diagrams agreed well with experimental results. The values of RMSD were 2.46 and 1.08 for Wilson model and NRTL model, respectively. The solid-liquid equilibrium phase diagrams and the thermodynamic models for the quaternary system could provide the fundamental basis for the separation process of a specific dibasic Acid from its mixtures via solvent crystallization.
-
ternary phase diagram for systems of succinic Acid urea water Glutaric Acid urea water and adipic Acid urea water at 288 15 and 303 15 k
Journal of Chemical & Engineering Data, 2014Co-Authors: Ganbing Yao, Ling Wang, Yaping Sun, Long Meng, Hongkun ZhaoAbstract:The solid–liquid phase equilibrium for three systems of succinic Acid + urea + water, Glutaric Acid + urea + water, and adipic Acid + urea + water was determined at (288.15 and 303.15) K under atmospheric pressure (0.1 MPa). Six isothermal phase diagrams for these systems were constructed based the measured solubility. The solid-phases were confirmed by Schreinemaker’s method of wet residue, which corresponded to urea, succinic Acid, and 2:1 urea-succinic Acid cocrystal (mole ratio) for the succinic Acid + urea + water system; urea, Glutaric Acid, 1:1 urea-Glutaric Acid cocrystal (mole ratio), and 2:1 urea-Glutaric Acid cocrystal (mole ratio) for the Glutaric Acid + urea + water system; and urea, adipic Acid, and 2:1 urea-adipic Acid cocrystal (mole ratio) for the adipic Acid + urea + water system. The ternary systems of succinic Acid + urea + water and adipic Acid + urea + water included five crystallization fields, three invariant curves, and two invariant points, respectively. The phase diagram of glut...