The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Zhenxin Wang - One of the best experts on this subject based on the ideXlab platform.

  • poly Glycidyl Methacrylate co 2 hydroxyethyl Methacrylate brushes as peptide protein microarray substrate for improving protein binding and functionality
    ACS Applied Materials & Interfaces, 2016
    Co-Authors: Zhen Lei, Jiaxue Gao, Xia Liu, Dianjun Liu, Zhenxin Wang
    Abstract:

    We developed a three-dimensional (3D) polymer-brush substrate for protein and peptide microarray fabrication, and this substrate was facilely prepared by copolymerization of Glycidyl Methacrylate (GMA) and 2-hydroxyethyl Methacrylate (HEMA) monomers via surface-initiated atom transfer radical polymerization (SI-ATRP) on a glass slide. The performance of obtained poly(Glycidyl Methacrylate-co-2-hydroxyethyl Methacrylate) (P(GMA-HEMA)) brush substrate was assessed by binding of human IgG with rabbit antihuman IgG antibodies on a protein microarray and by the determination of matrix metalloproteinase (MMP) activities on a peptide microarray. The P(GMA-HEMA) brush substrate exhibited higher immobilization capacities for proteins and peptides than those of a two-dimensional (2D) planar epoxy slide. Furthermore, the sensitivity of the P(GMA-HEMA) brush-based microarray on rabbit antihuman IgG antibody detection was much higher than that of its 2D counterpart. The enzyme activities of MMPs were determined specif...

  • Poly(Glycidyl Methacrylate-co-2-hydroxyethyl Methacrylate) Brushes as Peptide/Protein Microarray Substrate for Improving Protein Binding and Functionality
    2016
    Co-Authors: Zhen Lei, Jiaxue Gao, Xia Liu, Dianjun Liu, Zhenxin Wang
    Abstract:

    We developed a three-dimensional (3D) polymer-brush substrate for protein and peptide microarray fabrication, and this substrate was facilely prepared by copolymerization of Glycidyl Methacrylate (GMA) and 2-hydroxyethyl Methacrylate (HEMA) monomers via surface-initiated atom transfer radical polymerization (SI-ATRP) on a glass slide. The performance of obtained poly­(Glycidyl Methacrylate-co-2-hydroxyethyl Methacrylate) (P­(GMA-HEMA)) brush substrate was assessed by binding of human IgG with rabbit antihuman IgG antibodies on a protein microarray and by the determination of matrix metalloproteinase (MMP) activities on a peptide microarray. The P­(GMA-HEMA) brush substrate exhibited higher immobilization capacities for proteins and peptides than those of a two-dimensional (2D) planar epoxy slide. Furthermore, the sensitivity of the P­(GMA-HEMA) brush-based microarray on rabbit antihuman IgG antibody detection was much higher than that of its 2D counterpart. The enzyme activities of MMPs were determined specifically with a low detection limit of 6.0 pg mL–1 for MMP-2 and 5.7 pg mL–1 for MMP-9. By taking advantage of the biocompatibility of PHEMA, the P­(GMA-HEMA) brush-based peptide microarray was also employed to evaluate the secretion of MMP-2 and MMP-9 by cells cultured off the chip or directly on the chip, and satisfactory results were obtained

Yingwei Yang - One of the best experts on this subject based on the ideXlab platform.

  • self assembly and applications of poly Glycidyl Methacrylate s and their derivatives
    Chemical Communications, 2014
    Co-Authors: Hui Gao, Yingwei Yang
    Abstract:

    In this feature article, we give an overview of the preparation and application of self-assembled architectures based on an emerging area of polymers, i.e., poly(Glycidyl Methacrylate)s (PGMAs) and their derivatives. A series of PGMA-based aggregates and hybrids, such as micelles, reverse micelles, capsules, nanoparticles, and inorganic–organic hybrid materials, has been constructed, and diverse morphologies were formed, driven by hydrophobic interactions, hydrogen bonding, ionic complexation, host–guest interactions, etc. In particular, the assemblies have shown great potential applications as drug vectors, gene vectors, solubilizing agents, antimicrobial agent, and so forth. Herein, the general guidelines are elaborately selected from literature examples and partially from our own. Although still in its infancy, self-assembly of PGMA-based polymers is expected to become a hot topic in polymer chemistry and materials science.

  • stimuli responsive biocompatible nanovalves based on β cyclodextrin modified poly Glycidyl Methacrylate
    Polymer Chemistry, 2014
    Co-Authors: Lizhi Wang, Hui Gao, Xilong Qiu, Yulong Sun, Peixi Wang, Yu Liu, Yingwei Yang
    Abstract:

    β-Cyclodextrins (β-CDs) were grafted onto star-shaped poly(Glycidyl Methacrylate)s (S5-PGMAs) with a straightforward and efficient ring-opening addition of amine groups to result in PGMA–CDs, which not only possess good water-solubility and biocompatibility, but also can serve as polymeric supramolecular hosts to form inclusion complexes with suitable guests. They can be easily assembled on the surface of azobenzene-functionalized mesoporous silica nanoparticles (MSNs) via host–guest interactions to obtain MSN@PGMA–CD hybrid nanoparticles, which have been fully characterized by Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), transmission electron microscopy (TEM) and elemental analysis. The experimental results showed that these types of inorganic–organic hybrid mesoporous nanocomposites possess good cargo encapsulation and release properties, as compared with the simple supramolecular nanovalves with β-CD itself as the gating component, upon activation by light, temperature variation, and competitive binding agents. In addition, the extremely low cytotoxicity of the nanocomposites demonstrated by MTT assay can further broaden their applications in controlled drug release.

Aleksandra B Nastasovic - One of the best experts on this subject based on the ideXlab platform.

  • poly Glycidyl Methacrylate co ethylene glycol diMethacrylate clay composites
    Materials Chemistry and Physics, 2011
    Co-Authors: Sanja Marinovic, Zorica Vukovic, A Milutinovicnikolic, Aleksandra B Nastasovic, D Jovanovic
    Abstract:

    Abstract In this study, macroporous composites of poly(Glycidyl Methacrylate- co -ethylene glycol diMethacrylate) i.e. poly(GMA- co -EGDMA) and clay were prepared by radical suspension copolymerization. The composites with either raw (S 0 ) or acid-modified clay (S A ) were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric (TG) and textural analysis. The morphological, textural and thermal properties of the composite with raw clay (CP-S 0 ) differed slightly from those of the copolymer (CP), with exception of the thermal stability expressed in the shifting of the initial degradation temperature from 125 °C for CP to 210 °C for CP-S 0 . On the other hand, composite with modified clay (CP-S A ) was a material with significantly changed morphology, porous structure parameters and a qualitatively different thermal behavior in comparison to CP and CP-S 0 . CP-S A had mass residue, after heating at 600 °C, three times higher than the amount of S A introduced into the reaction system. This indicates a different manner of incorporation of S A , compared to S 0 , into the composite. Both the obtained composites retained their macroporosity and might be used in all applications that involve macroporous copolymers and, due to the altered thermal properties, their application may be extended.

  • kinetics of hexavalent chromium sorption on amino functionalized macroporous Glycidyl Methacrylate copolymer
    Journal of Hazardous Materials, 2009
    Co-Authors: Aleksandra B Nastasovic, Zvjezdana P Sandic, Lj Surucic, Danijela D Maksin, Dragica Jakovljevic, Antonije Onjia
    Abstract:

    Two samples of macroporous crosslinked poly(Glycidyl Methacrylate-co-ethylene glycol diMethacrylate), poly(GMA-co-EGDMA), with different porosity parameters were synthesized by suspension copolymerization and functionalized with ethylene diamine and diethylene triamine. The kinetics of Cr(VI) sorption by amino-functionalized poly(GMA-co-EGDMA) was investigated under non-competitive conditions. Competitive kinetics was studied from following multicomponent solutions: Cu(II) and Cr(VI); Cu(II), Co(II), Cd(II) and Ni(II); Cr(VI), Cu(II), Co(II) and Cd(II) solutions. Two kinetic models (the pseudo-first and pseudo-second-order) were used to determine the best-fit equation for the metals sorption by poly(GMA-co-EGDMA)-en and poly(GMA-co-EGDMA)-deta.

  • macroporous poly Glycidyl Methacrylate co ethylene glycol diMethacrylate resins versatile immobilization supports for biocatalysts
    Journal of Molecular Catalysis B-enzymatic, 2009
    Co-Authors: Nemanja Miletic, Zorica Vukovic, Aleksandra B Nastasovic, Katja Loos
    Abstract:

    Crosslinked macroporous hydrophilic poly(Glycidyl Methacrylate-co-ethylene glycol diMethacrylate)s [abbreviated poly(GMA-co-EGDMA)] with identical chemical structure (60% of Glycidyl Methacrylate) but with varied average pore sizes (from 30 to 560 nm), specific surface areas (from 13.2 to 106.0 m(2)/g), specific volumes (from 0.755 to 1.191 cm(3)/g) and particle sizes (less than 100-650 mu m) were synthesized via suspension polymerization. The influence of the resin properties on the loading of Candida antarctica lipase B (Cal-B) during immobilization and on the hydrolytic (hydrolysis of para-nitrophenyl acetate) and synthetic (ring-opening polymerization of e-caprolactone) activity of the immobilized CalB were studied. Immobilization of Cal-B was performed at different temperatures and pH values. Cal-B immobilized at 30 degrees C and pH 6.8 was leading to increased activities. By decreasing the resin diameter: (i) the amount of Cal-B adsorbed onto the resin decreases, (ii) the conversion of para-nitrophenyl acetate increases (hydrolytic activity) and (iii) the conversion of epsilon-caprolactone and the molecular weight of the synthesized poly-epsilon-caprolactone increases (synthetic activity). Varying the porosity parameters results in different hydrolytic and synthetic activities. Pore sizes of all synthesized resins (from 30 to 560nm) are big enough to overcome diffusion limitations. Therefore increasing the pore size of the resins resulted in a large increase in the hydrolytic and synthetic activity. Increasing the specific surface area resulted in an increase of activities, as the result of alleviated substrate approach to the immobilized enzyme zones. The obtained results were compared to results from dried Cal-B powder and Novozyme 435. Resin with particle size less than 100 mu m and pore size 48 nm had much higher hydrolytic activity than both dried Cal-B powder and Novozyme 435. Nearly similar trends were observed for the synthetic activity. Via the DMSO leaching technique we could show that about 80% of Cal-B was covalently attached to the macroporous resin. (C) 2008 Elsevier B.V. All rights reserved.

  • surface modification of macroporous poly Glycidyl Methacrylate co ethylene glycol diMethacrylate resins for improved candida antarctica lipase b immobilization
    Reactive & Functional Polymers, 2009
    Co-Authors: Nemanja Miletic, Randi Rohandi, Zorica Vukovic, Aleksandra B Nastasovic, Katja Loos
    Abstract:

    Abstract Crosslinked macroporous hydrophilic poly(Glycidyl Methacrylate-co-ethylene glycol diMethacrylate) [abbreviated poly(GMA-co-EGDMA)] with identical chemical structure (60% of Glycidyl Methacrylate) but with varied average pore sizes (from 30 to 560 nm), specific surface areas (from 13.2 to 106.0 m2/g), specific volumes (from 0.755 to 1.191 cm3/g) and particle sizes (

Marc Lemaire - One of the best experts on this subject based on the ideXlab platform.

  • preparation of monodisperse enantiomerically pure Glycidyl Methacrylate ethylene glycol diMethacrylate copolymers in dispersion copolymerization functionalization
    Reactive & Functional Polymers, 2006
    Co-Authors: Damien Herault, Christine Saluzzo, Marc Lemaire
    Abstract:

    Abstract Syntheses of monodisperse poly(Glycidyl Methacrylate)-co-(ethylene glycol diMethacrylate) were carried out by single stage dispersion radical copolymerization. Particles in the range of 1.0–3.0 μm were prepared in ethanol using 2,2′-azobisisobutyronitrile as the initiator and poly(vinyl pyrrolidone) as a polymeric stabilizer. The effects of different polymerization parameters, such as crosslinking monomer concentration, dispersant molecular weight, dilution and dispersant/monomer ratio on an average particle size and size distribution are reported. The best conditions were applied to (R) and (S)-Glycidyl Methacrylate in order to form poly((R) and (S)-Glycidyl Methacrylate)-co-(ethylene glycol diMethacrylate). Nucleophiles such as benzylamine, oxa-aza and aza crown ethers, l -methyl prolinate and β-cyclodextrine acting have been coupled to these oxirane containing polymers. The concentration of the added nucleophile on the modified resin varied from 0.26 to 3.35 mmol/g resin.

  • enantiopure poly Glycidyl Methacrylate co ethylene glycol diMethacrylate a new material for supported catalytic asymmetric hydrogen transfer reduction
    Tetrahedron-asymmetry, 2001
    Co-Authors: Alice Rolland, Christine Saluzzo, Francois Touchard, Raphael Duval, Damien Herault, Marc Lemaire
    Abstract:

    Abstract A novel copolymer containing chiral epoxy residues was prepared. Free radical initiated suspension copolymerization of ( R )- or ( S )-Glycidyl Methacrylate with ethylene glycol diMethacrylate afforded crosslinked copolymer 1 in high yield. Optically active polymers containing amino alcohol functionalities were then formed from 1 through epoxide ring opening with a number of achiral and homochiral amines. It was shown that ruthenium complexes based on these new polymeric amino alcohol ligands were effective catalysts for the asymmetric hydrogen transfer reduction of acetophenone.

Mohamed Taha - One of the best experts on this subject based on the ideXlab platform.

  • cross linking and damping properties of poly caprolactone co Glycidyl Methacrylate
    Polymer Journal, 2014
    Co-Authors: Hang Shen, Jianding Chen, Mohamed Taha
    Abstract:

    Poly(caprolactone-co-Glycidyl Methacrylate), p(CL-co-GMA), was prepared by ring-opening copolymerization in a one-step solvent-free process. 1,5,7-Triazabicyclo[4,4,0]dec-5-ene, stannous octoate and 4-hydroxybenzenesulfonic acid were tested separately as catalysts, and the copolymerization parameters were optimized. Analyses of the obtained copolymers, principally by matrix-assisted laser desorption/ionization–time of flight, confirmed the copolymerization, as macrocycles and linear chains were detected. Networks of p(CL-co-GMA) were prepared using 2-hydroxyethyl Methacrylate and/or multi-mercapto coupling agents. Thermomechanical analyses of the obtained networks were conducted. Of particular importance, damping over a wide range of temperatures was observed for some materials. Ring-opening copolymerization of caprolactone and Glycidyl Methacrylate can generate cyclic and linear double-bond-functionalized copolymers. These polymers can be cross-linked by thiol–ene click reaction, and/or radical copolymerized with 2-hydroxyethyl Methacrylate. Networks having interesting and variable damping properties were obtained.