The Experts below are selected from a list of 933 Experts worldwide ranked by ideXlab platform
Dipakranjan Mal - One of the best experts on this subject based on the ideXlab platform.
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Angucycline C5 Glycosides: Regio- and Stereocontrolled Synthesis and Cytotoxicity
2016Co-Authors: Prithiba Mitra, Birendra Behera, Tapas K Maiti, Dipakranjan MalAbstract:This study discloses a general and convergent route for the regio- and stereospecific construction of the C5 glycosyl angucycline framework of mayamycin. C-Glycosidation, dearomatization, and Hauser annulation are the key steps. The synthetic analogues show cytotoxicity against different human cancer cell lines with IC50 values between 16.4 and 1.2 μM
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angucycline c5 glycosides regio and stereocontrolled synthesis and cytotoxicity
Journal of Organic Chemistry, 2013Co-Authors: Prithiba Mitra, Birendra Behera, Tapas K Maiti, Dipakranjan MalAbstract:This study discloses a general and convergent route for the regio- and stereospecific construction of the C5 glycosyl angucycline framework of mayamycin. C-Glycosidation, dearomatization, and Hauser annulation are the key steps. The synthetic analogues show cytotoxicity against different human cancer cell lines with IC50 values between 16.4 and 1.2 μM.
Sanjay V Malhotra - One of the best experts on this subject based on the ideXlab platform.
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dual role of ionic liquids as phase transfer catalyst and solvent for Glycosidation reactions
RSC Advances, 2011Co-Authors: Vineet Kumar, Ian Jamie Talisman, Omar Bukhari, Jacqueline Razzaghy, Sanjay V MalhotraAbstract:This report describes the dual role of ionic liquids as phase transfer catalysts and reaction media in heterogeneous Glycosidation reactions. Thorough study using a diverse set of ionic liquids provided insight into the relationship between ionic liquid structure and catalytic activity in these reactions. For example, Glycosidation was efficient in ionic liquid 1-hexyl-3-methylimidazolium hexafluorophosphate (HxMIm.PF6), and the O- and S-glycosides were produced exclusively in moderate to good yields. As an outcome of the preliminary screen, a tailored novel ionic liquid, 1-hydroxyhexyl-3-methylimidazolium hexafluorophosphate (HOHxMIm.PF6) was rationally designed to be immiscible with water and traditional organic solvents. This provided an advantage in ionic liquid recycling and product recovery via convenient triphasic extraction. The versatility of this methodology was demonstrated through Glycosidation reaction on a wide variety of substrates including phenols (17–79%), thiophenols (24–97%), chalcone (44%), and flavone (50–67%). Furthermore, this study shows that the ionic liquid could be employed for at least three runs without apparent loss in activity.
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application of halide molten salts as novel reaction media for o glycosidic bond formation
ChemInform, 2010Co-Authors: Vineet Kumar, Ian Jamie Talisman, Sanjay V MalhotraAbstract:Molten halide are used as novel reaction media for Koenigs—Knorr-type O-Glycosidation reactions between glycosyl bromides and various phenolic acceptors.
Zunyi Yang - One of the best experts on this subject based on the ideXlab platform.
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stereoselective synthesis of 2 s phenyl 2 deoxy beta glycosides using phenyl 2 3 o thionocarbonyl 1 thioglycoside donors via 1 2 migration and concurrent Glycosidation
Organic Letters, 2001Co-Authors: Zunyi YangAbstract:1,2-Migration and concurrent Glycosidation of phenyl 2,3-O-thionocarbonyl-1-thio-α-l-rhamnopyranosides under the action of methyl trifluoromethanesulfonate (MeOTf) afforded in high yields the 3-O-(methylthio)carbonyl-2-S-phenyl-2,6-dideoxy-β-l-glucopyranosides, ready precursors to the corresponding 2-deoxy-β-glycosides.
K V Radhakrishnan - One of the best experts on this subject based on the ideXlab platform.
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ionic liquid bmim pf6 mediated synthesis of 1 2 orthoesters of carbohydrates and the Glycosidation reactions of 4 pentenyl orthoesters
Bulletin of the Chemical Society of Japan, 2007Co-Authors: Saithalavi Anas, V S Sajisha, Rani Rajan, Rajasekaran Thirumalai Kumaran, K V RadhakrishnanAbstract:A facile synthesis of the 1,2-orthoesters of carbohydrates in the ionic liquid [bmim]PF 6 without a quaternary ammonium salt like tetrabutylammonium iodide, is described. The Glycosidation reactions of 4-pentenyl orthoesters (NPOEs) with different alcohols are also discussed. The work described in this paper showed that [bmim]PF 6 is an efficient and recyclable solvent for the synthesis and Glycosidation reaction of orthoesters.
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one pot two donors one diol give one differentiated trisaccharide powerful evidence for reciprocal donor acceptor selectivity rdas
ChemInform, 2003Co-Authors: Bert Fraserreid, K V Radhakrishnan, Cristobal J Lopez, Ana M Gomez, M V Nandakumar, Clara UrielAbstract:Three component, one-pot reactions involving equimolar amounts of the acceptor diol and both armed and disarmed donors presented simultaneously, produce a single double-differential Glycosidation product; this phenomenon provides evidence for Reciprocal Donor Acceptor Selectivity (RDAS).
Christine L Willis - One of the best experts on this subject based on the ideXlab platform.
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total synthesis of a diastereomer of the marine natural product clavosolide a
Chemical Communications, 2005Co-Authors: Conor S Barry, Nick Bushby, Jonathan P H Charmant, Jon D Elsworth, John R Harding, Christine L WillisAbstract:The first total synthesis of the reported structure of the sponge metabolite clavosolide A is described using a Prins cyclisation to assemble the tetrahydropyran core followed by manipulation of the side-chain, dimerisation and finally Glycosidation.